Pharmaceutical Research (1984-1996)

Volume 1, Number 1 / January 1984

1EDITORIAL
2-10Controlled Release of Polypeptides and Other MacromoleculesRonald A. Siegel and Robert Langer
11-18The Potential of Nucleotide Analogs as Inhibitors of Retroviruses and TumorsRoland K. Robins
19-23New Lipophilic Terbutaline Ester Prodrugs with Long Effect DurationO. A. Torsten Olsson and Leif-Å. Svensson
23-27Influence of Bloodflow on the Absorption of Theophylline from the Jejunum of the RatNorbert Schurgers and Cornelis J. de Blaey
28-32The Hypolipidemic Activity of N-(p-Chlorobenzoyl)-sulfamate in Rodents and its Effect on Lipid MetabolismI. H. Hall, S. D. Wyrick, P. J. Voorstad and A. Dubey
33-38Pharmacokinetics of Anthracyclines in Dogs: Evidence for Structure-Related Body Distribution and Reduction to Their Hydroxy MetabolitesMarijn J. M. Oosterbaan, Rita J. M. Dirks, Tom B. Vree and Eppo van der Kleijn
39The Analgesic Activity of Neo-Kyotorphin: A Newly Identified Pentapeptide from Bovine Brain.Kiyoshi Fukui, Hiro Amano, Yoshiaki Kiso, Kouki Kitagawa and Hiroshi Takagi
40-43Continuous Measurements of ATP Secretion in VivoJ. Bryan Smith, Sandra E. Burke, Allan M. Lefer and Arthur Freilich
43-45High Pressure Liquid Chromatographic Analysis of Metoclopramide in SerumJordan L. Cohen, Gordon H. Jonathan E. Hisayasu and Stephen B. Strum
46-48WIN 44,441: A Stereospecific and Long-Acting Narcotic AntagonistPaul L. Wood, Carmencita Pilapil, Mira Thakur and Jean W. Richard
49Factors Affecting the Determination of Unbound Carbamazepine Concentrations in PlasmaJ. J. H. M. Lohman, F. W. H. M. Merkus, G. M. P. J. Costongs, E. P. J. M. H. Hegtermans and P. M. Hooymans
50Who Speaks for the Future?Jere E. Goyan

Volume 1, Number 2 / March 1984

51Research and PublicityWayne L. Pines
52-59Pyrrolo(l ,4)benzodiazepine Antitumor Antibiotics: Chemistry, Interaction with DNA, and Biological ImplicationsLaurence H. Hurley and David E. Thurston
59-62Drug Interactions Through Binding to Cytochrome P 450: The Experience with H2-Receptor Blocking AgentsUlrich Klotz and Ingrid W. Reimann
63-68The Hypolipidemic Activity of Benzenetricarboxylic Acids in RodentsIris H. Hall, James M. Chapman and Colleen Gilbert
69-75Effect of Uridine on the Metabolism of 5-Fluorouracil in the CD8F1 Murine Mammary Carcinoma SystemRobert C. Sawyer, Robert L. Stolfi, Sol Spiegelman and Daniel S. Martin
76-81Pharmacodynamic Measurements of Methyl Nicotinate Percutaneous AbsorptionRichard H. Guy, Ethel Tur, Barry Bugatto, Caroline Gaebel and Lewis B. Sheiner, et al.
82-88Pharmacokinetic Determinants in the Design and Evaluation of Sustained-Release Dosage FormsHarold Boxenbaum
89-92Proton Magnetic Resonance Studies of the Decomposition of 4-Hydroxycyclophosphamide, a Microsomal Metabolite of CyclophosphamideEdward J. Valente, Kenneth K. Chan and Kenneth L. Servis
93-95Retinylnitrones: A New Class of Retinoids with Chemopreventive ActionValeria Balogh-Nair and Koji Nakanishi
96-98Synthesis of 8-(3-Carboxy-l-methyl-propylammo)-6-methoxyquinoline: A Newly Characterized Primaquine MetaboliteJames D. McChesney and Srinivasan Sarangan
98-100Metabolism and Distribution of Primaquine in MonkeysJohn K. Baker, John A. Bedford, Alice M. Clark and James D. McChesney

Volume 1, Number 3 / May 1984

101EDITORIAL
102-105Drug Concentration, Binding, and Effect In VivoNicholas H. G. Holford
105-109Nephelometric Immunoassay for Therapeutic Drug Level MonitoringTakashi Nishikawa
110-115Studies on the Mechanism of Fluoropyrimidine Cytotoxicity in L1210 Cells: Correlation with Inhibition of Thymidylate Synthetase but Not with Incorporation into RNAKathleen D. Danenberg, Donna Becker, Mary A. Mulkins and Peter V. Danenberg
115-120An Efficient In Vitro Assay for Acetylcholinesterase Reactivators Using Immobilized EnzymeAndy M. Trammel, John E. Simmons and Ronald T. Borchardt
120-125Soft Drugs VI. The Application of the Inactive Metabolite Approach for Design of Soft β-Blockers1?2Nicholas Bodor, Yasuo Oshiro, Thorsteinn Loftsson, Michael Katovich and William Caldwell
126-129Irreversible Binding of Norethisterone to Human Serum Protein Induced by UV-B LightAad Sedee, Gerard Beijersbergen van Henegouwen, Klaas Lusthof and Gerrit Lodder
129-134Site Specific Rectal Drug Administration in Man with an Osmotic System: Influence on “First-Pass” Elimination of LidocaineLeo G. J. de Leede, Albertus G. de Boer, Cornelia D. Feijen and Douwe D. Breimer
135-137Effect of Thyrotropin-Releasing Hormone on Lipoxygenase-Induced Hypotension in the Unanesthetized Guinea PigWarren E. Lux, Jr, Giora Feuerstein and Alan I. Faden
137-139Importance of Structural Free Space to the Solvent Power of WaterReinhard Hüttenrauch, Petra Zielke and Sabine Fricke
140Lack of Tobramycin Distribution into SalivaJoel E. Houglum, Peter J. Cascella and Gary B. Edwards

Volume 1, Number 4 / July 1984

141-148Suicidal Destruction of Cytochrome P-450 by Ethynyl Substituted CompoundsIan N. H. White
148-153Skin Structure and Metabolism: Relevance to the Design of Cutaneous TherapeuticsDaniel A. W. Bucks
154-158Liquid Crystals in Emulsions, Creams, and Gels Containing Ethoxylated Sterols as SurfactantC. Müller-Goymann
159-163Stability of Liposomes on Storage: Freeze Dried, Frozen or as an Aqueous DispersionD. J. A. Crommelin and E. M. G. van Bommel
164-168Avoidance of “First-Pass” Elimination of Rectally Administered Propranolol in Relation to the Site of Absorption in RatsLeo G. J. de Leede, Albertus G. de Boer, Jacques P. J. M. Havermans and Douwe D. Breimer
168-173Improved Delivery Through Biological Membranes. XVII. A Site-Specific Chemical Delivery System as a Short-Acting Mydriatic AgentNicholas Bodor and Gary Visor
173-178Rectal Motility and BioavailabilityJosef J. Tukker, Cornelis J. de Blaey and Gerard A. Charbon
179-181Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein ConcentrationKathleen M. Giacomini, Fee Mi Wong and Thomas N. Tozer
181-183Experimental Combination Chemotherapy with Thymidylate Synthetase and Ribonucleotide Reductase InhibitorsShu Kobayashi, Takao Hoshino and Daniel V. Santi
184-186Rapid Aromatic Hydrogen Exchange in the Antimalarial PrimaquineJames D. McChesney and Srinivasin Sarangan
187-188Influence of Volume Shift in Equilibrium Dialysis to Estimate Plasma Protein Binding of DrugsJoseph J. H. M. Lohman, Piet M. Hooymans, Maurice T. J. M. Verhey, Marli L. P. Koten and Frans W. H. M. Merkus
188CONGRESS ANNOUNCEMENTS

Volume 1, Number 5 / September 1984

189-194Extraction of Natural Substances with Dense GasesEgon Stahl and Karl Werner Quirin
194-203Pyrazolopyrimidine Metabolism in Parasitic ProtozoaBuddy Ullman
203-209Pharmacokinetics and Metabolic Fate of Two Nitroxides Potentially Useful as Contrast Agents for Magnetic Resonance ImagingWilliam R. Couet, Ulf G. Eriksson, Thomas N. Tozer, L. Dallas Tuck and George E. Wesbey, et al.
209-214Radioreceptor Assay of Narcotic Analgesics in SerumJoachim Grevel, Jeff Thomas, Mark L. Richards and Wolfgang Sadée
215-220A Radioimmunoassay for Determination of Glibenclamide and Other SulfonylureasWolfgang Heptner, Mario Badian, Siegfried Baudner, Christa Hellstern and Robert Irmisch, et al.
221-224Transmucosal Passage of Liposomally-Entrapped Drugs in Rat Small IntestineToshikiro Kimura, Kazutaka Higaki and Hitoshi Sezaki
225-229Antipyrine - New Light on an Old DrugHartmut Derendorf, Gertrude Drehsen and Peter Rohdewald
229-231Prostaglandin E1-induced Catalepsy in the Rat: Role of Putative NeutrotransmittersSalil K. Bhattacharya, Patchala J. Mohan Rao and Dipankar Bhattacharya
231-233Morphine Inhibition of Theophylline ClearanceMario L. Rocci, Parviz Mojaverian and Consuelo L. Saccar
234-235Delayed Ethanol Elimination in Rats after Application of Cefamandole or CefoperazoneKlaus G. Römer, Klaus J. Freundt, Oscar Torres Alanis and Graciela Garcia de Torres
236BOOK REVIEWS

Volume 1, Number 6 / November 1984

237-244Drug Delivery by Program or Sensor Controlled Infusion DevicesManfred Franetzki
245-249Effect of Column Temperature and Eluent Flow Rate on the High Performance Liquid Chromatographic Analysis of Cyclosporin A and DKulthoum A. Mereish and Clarence T. Ueda
250-255The Hypolipidemic Activity of 3-Iminophthalimidine in RodentsP. Josée Voorstad, George H. Cocolas and Iris H. Hall
256-259Effect of Entrapped Markers on the in situ Jejunal Uptake from Liposomal SystemsD. L. Schwinke, M. G. Ganesan and Norman D. Weiner
259-266Relationship of Octanol/Water Partition Coefficient and Molecular Weight to Cellular Permeability and Partitioning in S49 Lymphoma CellsVictor A. Levin, Doug Dolginow, Herbert D. Landahl, Craig Yorke and Judit Csejtey
267-269Hypolipidemic Agents of Phthalimide Derivatives 6. Effects of Aromatic vs. Non-Aromatic ImidesJames M. Chapman, Steven D. Wyrick, James H. Maguire, George H. Cocolas and Iris H. Hall
269-271In Vitro Antimicrobial Activity of BenzoquinolinedionesAlice M. Clark, Debra L. Huddleston, Cheng Yu Ma and Chuen-Huei Ho
271-274Phosphorus GABA Analogues as Potential ProdrugsLindley A. Cates and Mohamed S. Rashed
274-276In vitro Metabolism of BumetanideGiorgio Grosa, Franca Viola, Otto Caputo and Giuseppe Biglino
277-279Replacing the Mixed Function Oxidase N-Demethylation by Hydrogen Peroxide and either Hemoglobin or Ferrous SulfateShmuel Zbaida, Dalia Gilhar and Judith Silman-Greenspan
279-282Effect of Mangiferin, a Naturally Occurring Glucosylxanthone, on Reproductive Function of RatsSukumar Chattopadhyay, Utpala Chattopadhyay, Santyeswar P. Shukla and Shibnath Ghosal
287-288Author's Index: Pharmaceutical Research 1984
289-290Subject Index: Pharmaceutical Research 1984

Volume 2, Number 1 / January 1985

1EDITORIAL
2List of Referees 1983–1984
3-14The Molecular Basis for the Mode of Action of Beta-Lactam Antibiotics and Mechanisms of ResistanceBarrie W. Bycroft and Richard E. Shute
14-18Properties of Film-Formers and Their Use in Aqueous SystemsHermann P. Osterwald
19-23Interaction Phenomena in some Aqueous-Based Tablet Coating Polymer SystemsAugustine O. Okhamafe and Peter York
23-29In Vitro and In Vivo-Release of Nitroglycerin From a New Transdermal Therapeutic SystemMichael Wolff, Günter Cordes and Volker Luckow
30-36Isosorbide-5-Nitrate Sustained-Release Pellets – An Example of Computer-Supported Drug DevelopmentHorst Zerbe, Volker Luckow, Willi Cawello and Günter Cordes
36-41Molecular Weights of Free and Drug-Loaded NanoparticlesLuc Vansnick, Patrick Couvreur, Dominique Christiaens-Leyh and Michel Roland
42-43Synthesis and Antimicrobial Activity of New Furan DerivativesHumeida A. El-Obeid, Elamin I. Elnima and Abdullah A. Al-Badr
44-46Determination of Dissolved Oxygen in Heterogenous Systems Particularly in Emulsions and Oily LiquidsKarl-Heinz Foiβner, Andreas Leonhardt, Gerhard Wegner and Kurt Heinz Bauer
46-49Chemistry of Primaquine I: Acylation of the Quinoline Ring PortionJames D. McChesney and R. C. Gupta
49-52Anticonvulsant and Monoamine Oxidase Inhibitory Activities of some Triazene N1-OxidesAshok Kumar, S. K. Mukerjee and S. K. Bhattacharya
53-54Avoidance of First-Pass Metabolism of Propranolol after Rectal Administration as a Function of the Absorption SiteKikuo Iwamoto and Jun Watanabe

Volume 2, Number 2 / March 1985

55-61The Molecular Basis of β-Lactamase Catalysis and InhibitionAnthony L. Fink
61-64Drug Release from SuppositoriesCornelis J. de Blaey and Jasper G. Fokkens
65-68pH-Solubility Profiles of Organic Bases and Their Hydrochloride SaltsAbu T. M. Serajuddin and Daniel Mufson
69-72Pharmacokinetics of Two Prototype Nitroxide Spin Labels for Contrast Enhancement in Magnetic Resonance ImagingWilliam R. Couet, Ulf G. Eriksson, Robert C. Brasch and Thomas N. Tozer
73-75HPLC Analysis of Thimerosal in Ophthalmic Solution. Comparing Electrochemical with Spectrophotometric DetectorsGary C. Visor, Richard A. Kenley, Jeffrey S. Fleitman, Daniel A. Neu and Irene W. Partridge
75-77Studies on the Dissolution of Drugs from Tablets using Perturbed Angular CorrelationMichael Jay, John T. Fell and George A. Digenis
77-80The Interaction of Cyanonaphthyridinomycin with DNAMilton J. Zmijewski and Marcia Mikolajczak
80-83Drug Distribution and Biliary Excretion Pattern of a Cyclic Somatostatin Analog: A Comparison of 14C Labeled Drug and a 131I lodinated Drug AnalogLarry J. Caldwell, Alan Parr, Robert M. Beihn, Bushra J. Agha and Arthur R. Mlodozeniec, et al.
83-86Effects of 5-Fluorouracil Prodrugs on the Central Nervous System in Mice and RatsKatsuo Toide, Norio Unemi and Tomio Segawa
87-90Differential Inhibitory Effects of Isosorbide Dinitrate and its Mononitrate Metabolites on Platelet Aggregation and Thromboxane FormationPierre H. Rolland, José Sampol, Bruno Lacarelle, Dominique Arnoux and François Leca, et al.
90-93Evidence for an Acute Antimagnesiuretic Effect of Triamterene DerivativesHelmut Priewer, Helga Kraft and Ernst Mutschler
94-95Verapamil Interacts Stereoselectively with the Muscarinic ReceptorJohn C. Giacomini, Ray H. Zobrist, Bharati Dave and Kathleen M. Giacomini
96Announcements

Volume 2, Number 3 / May 1985

97-107In Vitro-in Vivo Correlation: An Unrealistic ProblemReinhard Hüttenrauch and Peter Speiser
108-118Modification of Intestinal Absorption of Drugs by Lipoidal AdjuvantsShozo Muranishi
119-124The Thermodynamics of Partitioning of Phenothiazines between Phosphate Buffer and the Lipid Phases of Cyclohexane, n-Octanol and DMPC LiposomesAhmed M. S. Ahmed, Farah H. Farah and Ian W. Kellaway
124-130Pharmacokinetic Study of Cefotaxime (CTX) in DogsOsamu Togashi, Takumi Maeda, Mikio Omosu, Kazumi Fujimoto and Shun-ichi Naito
130-134Salutary Effects of Two Verapamil Analogs in Traumatic ShockCarl E. Hock, Jonathan S. Daitch and Allan M. Lefer
135-136Phosphinic Acid Analogues of Methylaspartic and Methylglutamic Acids as AntibacterialsLindley A. Cates and Ven-Shun Li
137-139Central Cholinergic Modulation of Carrageenin-induced Pedal Inflammation in RatsNeeta Das and Salil K. Bhattacharya
140-142Simultaneous Determination of Tiaramide and its Metabolites by High Performance Liquid ChromatographyShun-ichi Naito, Atsushi Tanase, Hisao Yoshihara and Hideharu Tominaga
143-145Amiloride: Biological Fluid Analysis by Reverse-Phase HPLCWilliam C. Vincek, Gene A. Hessey II, Marvin L. Constanzer and William F. Bayne
146-147Antifungal Activity of Some Substituted PyrimidinesJames D. McChesney and Manuel Gonzalez-Sierra
148-149Simultaneous Spectrofluorometric Determination of Aspirin and Salicylic Acid in Aqueous SolutionM. J. Habib and J. A. Rogers

Volume 2, Number 4 / July 1985

151-156Peptides and Proteins as DrugsBobbe L. Ferraiolo and Leslie Z. Benet
156-162Sympathomimetic Bronchodilators: Increased Selectivity with Lung-Specific ProdrugsLeif Å. Svensson
162-165Absorption of Etoposide (VP-16-213) from the Small Intestine of the Rat. The Potential Role of Mucus as an Absorption Rate Limiting BarrierN. Schurgers, Cornelis J. de Blaey and D. J. A. Crommelin
166-170Absorption and Bioavailability of Diclofenac after Rectal Administration of Diclofenac-Na Gel Preparation in Rat and ManKazuhiro Morimoto, Yoko Iwamoto, Takao Katashima, Toshiyuki Takeeda and Yasuo Nakamoto, et al.
170-175Adsorption and Chemical Stability of a Cationic Aggregating Ester – Propantheline Bromide – on Silica Surfaces in Aqueous DispersionsRolf Daniels and Herbert Rupprecht
176-177The Pharmacokinetics of Amrinone at Three Dose Levels in the RabbitGhassem E. Larijani, Mario L. Rocci, Deborah L. Newman and Hugh Wilson
178-181Buprenorphine is an Antagonist at the ϰ Opioid ReceptorMark L. Richards and Wolfgang Sadée
181-184A New Method for the Determination of Partition Coefficients of Air Sensitive Copper(I) ComplexesHans-Dieter Gaisser, Henk van der Goot and Henk Timmerman
185-187Mandibular and Parotid Salivary Levels of Indomethacin Following Intravenous Administration to RabbitsJun Watanabe, Tsutomu Setoyama, Kikuo Iwamoto, Yayoi Hayashi and Shoji Ozeki
188-191Pharmacokinetics of Pirazolac – a New Anti-Inflammatory Drug – in Human Volunteers II. Dose Linearity of Plasma Levels and ExcretionUlrich Täuber, Christian Weiss and Heinz Matthes
192-194Structure of a Neurotoxin that Induces Parkinsonism Symptoms; l-Methyl-4-phenyl-l,2,3,6-tetra-hydropyridine HydrochlorideCheryl L. Klein, Ronald F. Borne and Edwin D. Stevens

Volume 2, Number 5 / September 1985

195-198Prostaglandins and Central Serotonergic Activity in the RatSalil K. Bhattacharya
198-202Effect of Dextran on the Release of Gonadotropin-Releasing Hormone (GnRH) Injected into Rats: Plasma GnRH and Gonadotropin ResponseNadja Heinrich, Dorothea Lorenz, Hartmut Berger, Klaus Fechner and Hermann Eberhard Schmidt, et al.
202-206Cutaneous Absorption of Indomethacin From Two Topical Preparations in VolunteersHans Nowack, Udo Marin, Raimund Reger, Herta Böhme and Karl-H. Schriever, et al.
206-211Kinetic Analysis of Transdermal Nitroglycerin DeliveryRichard H. Guy and Jonathan Hadgraft
211-217Computer Modeling of the Pharmacokinetics of Fluorouracil and Thymine and Their Kinetic Interaction in Normal DogsJoseph M. Covey and James A. Straw
217-220Inosine Analogs as Anti-Leishmanial AgentsPetrie Rainey, Patricia A. Nolan, Leroy B. Townsend, Roland K. Robins and Jack J. Fox, et al.
221-224In Situ Intestinal Absorption of a Poorly Water-Soluble Drug From Mixed Micellar Solutions of Bile Salt and Lipolysis Products in RatsA.T.M. Serajuddin, M. Rosoff and A.H. Goldberg
225-230Thermodynamics of Distribution of Salicylates in Semi-Solid Ointment BasesStanley S. Davis, Khalil Al-Khamis and Jonathan Hadgraft
231-233Excretion of Metabolites in Bile Following the Administration of Primaquine to RatsJohn K. Baker, James D. McChesney and Larry A. Walker
233-238The Hypolipidemic Activity of Furoic Acid and Furylacrylic Acid Derivatives in RodentsIris H. Hall, Wallace L. Williams Jr, Kathryn A. Rhyne and Margaret Knowles
239-243Preparation of Gelatin Nanocapsules and Their Pharmaceutical CharacterizationHans-Jürgen Krause and Peter Rohdewald
243-245Effect of Salicylate on the Uptake of Cefmetazole into Brain of MiceHiroshi Yoshikawa, Kanji Takada, Yu-ichiro Satoh, Norio Naruse and Shozo Muranishi
246-248Use of Lymphoblastoid Namalva Cell Cultures in a Toxicity Test. Application to the Monitoring of Detoxification Procedures for Fluorocarbons to be used as Intravascular Oxygen-CarriersMaurice Le Blanc, Jean G. Riess, Daniel Poggi and R. Follana
249-250Potentiation of Enteral Absorption of Human Interferon Alpha and Selective Transfer into Lymphatics in RatsHiroshi Yoshikawa, Kanji Takada, Yu-ichiro Satoh, Norio Naruse and Shozo Muranishi
251-252Natural Occurrence of 11-O-Acetylambelline and 11-O-Acetyl-l ,2-β-epoxyambelline in Crinum latifolium: Immuno-regulant AlkaloidsShibnath Ghosal, Potharaju H. Rao and Kulwant S. Saini

Volume 2, Number 6 / November 1985

253-261Leukotriene Biosynthesis InhibitorsJohn R. Cashman
262-266Program for Evaluating Drug Dissolution Kinetics in PreformulationMartin Nicklasson and Anna-Britta Magnusson
266-271Synthesis and Pharmacological Characterization of Fluorescent Opioid Receptor ProbesVera M. Kolb, Ahmet Department of Pharmaceutical Pharmacology Koman and Anders Neil
271-278Lymphatic Transport of Liposome-Encapsulated Drugs Following Intraperitoneal Administration – Effect of Lipid CompositionKoichiro Hirano, C. Anthony Hunt, Anne Strubbe and Roderick D. MacGregor
279-284Effect of Age on the Disposition and Tissue Clearances of Fluorinated Pyrimidines in RatsJ. Lai-Sim Au
284-293In Vitro Drug Absorption Models. I. Brush Border Membrane Vesicles, Isolated Mucosal Cells and Everted Intestinal Rings: Characterization and Salicylate AccumulationIwona Osiecka, Patty A. Porter, Ronald T. Borchardt, Joseph A. Fix and Colin R. Gardner
293-298In Vitro Drug Absorption Models. II. Salicylate, Cefoxitin, α-Methyldopa and Theophylline Uptake in Cells and Rings: Correlation with In Vivo BioavailabilityPatty A. Porter, Iwona Osiecka, Ronald T. Borchardt, Joseph A. Fix and Linda Frost, et al.
298-301Role of Peripheral Adrenergic Responsiveness in the Development of DOCA/NaCl Hypertension in RatsEme L Iloeje, Michael J. Katovich, Edward E. Soltis and F. Peter Field
302-306Mechanical Activation of Pharmaceutical SystemsReinhard Hüttenrauch, Sabine Fricke and Petra Zielke
307-309Possible Mechanism Regulating Barrier Function of Rat Intestinal Mucosa against Permeation of Cefmetazole, a Hydrophilic DrugToshiaki Nishihata, Hideo Takahata and Akira Kamada
309-310Change of Phase-Solubility Behavior by Gamma-Cyclodextrin DerivatizationBernd W. Müller and Ulrich Brauns
311-313High-Performance Liquid Chromatographic Analysis of Tocainide in Human PlasmaLudo Conings and Norbert Verbeke
313-315Prostaglandin D2 Induced Potentiation of the Anticonvulsant Actions of Phenobarbitone and Phenytoin in Rats. Role of SerotoninSalil K. Bhattacharya and Surendra S. Parmar
315-318Central Serotonergic Modulation of Carrageenin-induced Pedal Inflammation in RatsSalil K. Bhattacharya and Neeta Das
319-320Announcements
323-324Author's Index: Pharmaceutical Research 1985
325-326Subject Index: Pharmaceutical Research 1985

Volume 3, Number 1 / February 1986

1-2EDITORIAL-INTRODUCTION
3-6Protein Drugs: A Revolution in Therapy?Wolfgang Sadée
7-11The Neurotoxin l-Methyl-4-Phenyl-l,2,3,6-Tetrahydropyridine (MPTP): A Key to Parkinson's Disease?Ian Irwin
12-22Fundamentals of Powder Compression. I. The Compactibility and Compressibility of Pharmaceutical PowdersHans Leuenberger and Bhagwan Dass Rohera
23-34Formation of Multilayered Vesicles from Water/Organic-Solvent (W/O) Emulsions: Theory and PracticeCharles Pidgeon, Ann H. Hunt and Katherine Dittrich
35-40Effect of Oleic Acid Vesicles on Intestinal Absorption of Carboxyfluorescein in RatsMasahiro Murakami, Hiroshi Yoshikawa, Kanji Takada and Shozo Muranishi
41-44Thermal Stability of Mefruside–Polyvinylpyrrolidone Solid DispersionsHans E. Junginger and Michael Wedler
45-47Determination of Codeine in Plasma by High-Performance Liquid ChromatographyDavid E. Easterling, Wayne R. Torres and Ravi K. Desiraju
48-51Enhanced Selective Lymphatic Delivery of Cyclosporin A by Solubilizers and Intensified Immunosuppressive Activity Against Mice Skin AllograftKanji Takada, Hiroyuki Yoshimura, Hiroshi Yoshikawa, Shozo Muranishi and Tadaki Yasumura, et al.
52-55Radioiodinated Cholesteryl lopanoate as a Potential Probe for the in Vivo Visualization of Atherosclerotic Lesions in AnimalsMark R. Galan, Susan W. Schwendner, Jamey P. Weichert and Raymond E. Counsell
56-60Prolonged Receptor Blockade by Opioid Receptor ProbesAhmet Koman, Vera M. Kolb and Lars Terenius
61-63Variations of in Vitro Nitroglycerine Permeation Through Human EpidermisPeter Langguth, Hildegard Spahn and Ernst Mutschler

Volume 3, Number 2 / April 1986

65-74Fundamentals of Powder Compression. II. The Compression of Binary Powder MixturesHans Leuenberger and Bhagwan Dass Rohera
75-80Treatment of Filariasis—Diethylcarbamazine and Its CongenersSatyavan Sharma
81-87Characterization of an In Vitro Blood–Brain Barrier Model System for Studying Drug Transport and MetabolismKenneth L. Audus and Ronald T. Borchardt
88-92An In Vitro Method of Evaluating Tolnaftate Release from Topical PowderTacey X. Viegas, Arthur H. Kibbe, Ahmed H. Hikal, Robert W. Cleary and Alan B. Jones
93-101The Hypolipidemic Activity of a Series of 2,3-Dihydrophthalazine-l,4-dione Derivatives in RodentsA. R. K. Murthy, I. H. Hall, J. M. Chapman, K. A. Rhyne and S. D. Wyrick
102-107Pharmacodynamics of Basic Triamterene DerivativesHelmut Priewer, Hildegard Spahn and Ernst Mutschler
108-111Bioavailability of Propranolol After Oral, Sublingual, and Intranasal AdministrationGuus S. M. J. E. Duchateau, Jan Zuidema and Frans W. H. M. Merkus
112-115A Radioimmunoassay Procedure for the Determination of the Antiviral Nucleoside DHPG (9-[(l,3-Dihydroxy-2-propoxy)-methyl]guanine) in Plasma or SerumClinton Nerenberg, Sherrie McClung, John Martin, Marian Fass and JoAnn Fargue, et al.
116-117Development of Interferon Suppositories. I. Enhanced Rectal Absorption of Human Fibroblast Interferon by Fusogenic Lipid via Lymphotropic Delivery in RatsHiroshi Yoshikawa, Kanji Takada, Yu-ichiro Satoh, Norio Naruse and Shozo Muranishi
118-121Stabilization of Sulfamerazine Suspensions by Xanthan GumJoel L. Zatz and Christine Yarus

Volume 3, Number 3 / June 1986

123-131Comparison of Canine and Human Gastrointestinal PhysiologyJennifer B. Dressman
132-141Characterization of the Urinary Metabolites of Primaquine in RatsJohn K. Baker, James D. McChesney and Lucia F. Jorge
142-149Determination of β-Endorphin and Fragments Thereof in Human Plasma Using High-Performance Liquid Chromatography and a Multiple Radioimmunoassay SystemKlaus Wiedemann and Hansjörg Teschemacher
150-155Saturable Processes Affecting Renal Clearance of Cefixime in DogsAlfred P. Tonelli, Meir Bialer, Zee M. Look, Steven Carson and Avraham Yacobi
156-161Correlation Between In Vivo Antipyrine Metabolite Formation and Theophylline Metabolism in RatsMichael W. E. Teunissen, Irinka O. N. Brorens, H. Joke De Langen, Anne M. Geerlings and Douwe D. Breimer
162-166Role of Putative Neurotransmitters in Bradykinin-Induced Catalepsy in the RatSalil K. Bhattacharya, Patchala J. R. Mohan Rao, Stanley J. Brumleve and Surendra S. Parmar
167-169The Effect of Amiodarone on Theophylline Pharmacokinetics in the RatGhassem E. Larijani, Mario L. Rocci, Parviz Mojaverian, Consuelo L. Saccar and Cindy Hoholick, et al.
170-172Fungal Metabolism of 4-MethylprimaquineAlice M. Clark, James D. McChesney and Charles D. Hufford
173-177Pharmacokinetics and Reversible Biotransformation of Sulfinpyrazone and Its Metabolites in Rabbits. I. Single-Dose StudyWolfgang A. Ritschel
178-183Pharmacokinetics and Reversible Biotransformation of Sulfinpyrazone and Its Metabolites in Rabbits. II. Multiple-Dose StudyBe-Sheng Kuo and Wolfgang A. Ritschel
184Announcement

Volume 3, Number 4 / August 1986

185Editorial
186AAPS and pharmaceutical researchLeslie Z. Benet
187-194The interactions of water with cellulose- and starch-derived pharmaceutical excipientsGeorge Zografi and Mark J. Kontny
195-207The applications of synthetic oligonucleotides to molecular biologyRonald W. Ellis
208-213The effect of density on the gastric emptying of single- and multiple-unit dosage formsStanley S. Davis, Anita F. Stockwell, Margaret J. Taylor, John G. Hardy and David R. Whalley, et al.
214-217Microviscosity and drug release from topical gel formulationsKhalil I. Al-Khamis, Stanley S. Davis and Jonathan Hadgraft
218-224Conformation and electrostatic potential surfaces of opiates: Relationship to µ- and λ-site bindingTerry P. Lybrand, Peter A. Kollman, Victor C. Yu and Wolfgang Sadée
225-229Systemic delivery of timolol after dermal application: Transdermal flux and skin irritation potential in the rat and dogRobyn Cargill, Karen Engle, Gerald Rork and Larry J. Caldwell
230-234Capsules with prolonged action. II. Capsule filling by a gelation processPeter C. Schmidt and B. Stockebrand
235-239Capsules with prolonged action. III. Release of active ingredients from cast filmsPeter C. Schmidt and B. Stockebrand
240-243Effect of lycoriside, an acylglucosyloxy alkaloid, on mast cellsShibnath Ghosal, Amirthalingam Shanthy, Mita Mukhopadhyay, Mihir K. Sarkar and Prasun K. Das
244-248In Vivo performance of ophthalmic preparations of betamethasone and phenylephrine hydrochloride in the rabbit eye: Effect of polyvinyl alcoholMahfouz A. Kassem, Mohamed A. Attia, Fawzia S. Habib and Abdel-Razak A. Mohamed
249-251Association news and announcements

Volume 3, Number 5 / October 1986

253-262The Bioavailability of Dermatological and Other Topically Administered DrugsRichard H. Guy, Anna H. Guy, Howard I. Maibach and Vinod P. Shah
263-270A Critical Analysis of the Experimental Evaluation of Nociceptive Reactions in AnimalsKrishnaswami Ramabadran and Mylarrao Bansinath
271-277New Class of 5-Lipoxygenase Inhibitors: Correlation Between Inhibition of LTB4 Production and Chemiluminescence of Human Polymorphonuclear GranulocytesDieter Steinhilber, Karlheinz Schmidt, Kurt Eger and Hermann J. Roth
278-285Improved Delivery Through Biological Membranes. XXIV. Synthesis, in Vitro Studies, and in Vivo Characterization of Brain-Specific and Sustained Progestin Delivery SystemsMarcus Eli Brewster, Kerry S. Estes and Nicholas Bodor
286-289The Synthesis of Homophthalimide and Related Derivatives and Their Hypolipidemic Activity in RodentsAkula R. K. Murthy, James M. Chapman, Steven D. Wyrick and Iris H. Hall
290-293Selective Toxicity of the Antimalarial Primaquine—Evidence for Both Uncoupling and Inhibitory Effects of a Metabolite on the Energetics of Mitochondria and Its ATP Synthase ComplexJohn K. Baker, Joanne M. Hullihen and Peter L. Pedersen
294-297The Influence of Urea on Percutaneous AbsorptionJanet Beastall, Richard H. Guy, Jonathan Hadgraft and Ian Wilding
298-301Thermal Decomposition of Thonzonium BromideLester Chafetz, R. Clive Greenough and John Frank
302-306In Vitro Cytotoxic Effects of Dibromodulcitol in 9L Rat Brain Tumor CellsStefan-M. Pulst, Victor A. Levin and Dennis F. Deen
307-308Immunostimulatory Activity of Mangiferin, A Naturally Occurring Xanthone-C-GlucosideU. Chattopadhyay, L. Chaudhuri and S. Ghosal
309-310Association News and Announcements

Volume 3, Number 6 / December 1986

311-317Polyamine–DNA Interactions: Possible Site of New Cancer Chemotherapeutic InterventionLaurence J. Marton and Burt G. Feuerstein
318-326lontophoretic Devices for Drug DeliveryPraveen Tyle
327-332Different Behavior Toward Muscarinic Receptor Binding Between Quaternary Anticholinergics and Their Tertiary AnaloguesKees Ensing and Rokus A. de Zeeuw
333-344Engineering Targeted In Vivo Drug Delivery. I. The Physiological and Physicochemical Principles Governing Opportunities and LimitationsC. Anthony Hunt, Roderick D. MacGregor and Ronald A. Siegel
345-351Changes in Intestinal Mucosal Permeability Caused by Nonprotein Thiol Loss in RatsToshiaki Nishihata, Ba Thu Nghiem, Hironori Yoshitomi, Chian-Shun Lee and Margaret Dillsaver, et al.
352-355Influence of Malnutrition on the Disposition of Metronidazole in RatsDonald Jung and Anita Shah
356-359An Examination of Excised Skin Tissues Used for In Vitro Membrane Permeation StudiesGeoffrey Lee and Prema Parlicharla
360-363Long-Term Stability Studies Using Radiopharmaceuticals: Consequence of Using Multiply Tritiated Compounds, with an Application to Fluocinolone AcetonideMichael F. Powell, Adina Magill and Allyn R. Becker
364-365Membrane Filter Sterility Test of Antihemophilic Factor ConcentrateLarry W. Gee, Rebecca Zeiner and W. P. Olson
366Association News and Announcements
367-368Author Index to Volume 3 (1986)
369-370Subject Index to Volume 3 (1986)

Volume 4, Number 1 / February 1987

1-2EDITORIAL
3-4Targeted Drug Delivery-Some Pharmacokinetic ConsiderationsGerhard Levy
5-15Fast Atom Bombardment Mass Spectrometry and Its Application to the Analysis of Some Peptides and ProteinsMark E. Hemling
16-20N-(2-Cyanoethyl)tranylcypromine, a Potential Prodrug of Tranylcypromine: Its Disposition and Interaction with Catecholamine Neurotransmitters in BrainAdil J. Nazarali, Glen B. Baker, Ronald T. Coutts and T. F. James Wong
21-27Synthesis and Hypolipidemic Activity of 3-Imino-l-oxoisoindolines in RodentsAkula R. K. Murthy, Oi T. Wong, David J. Reynolds and Iris H. Hall
28-32A Reversed-Phase High-Performance Liquid Chromatography Assay Procedure for Progabide and Its Related Metabolic DerivativesNidal F. Farraj, Stanley S. Davis, Graham D. Parr and Howard N. E. Stevens
33-37Dose-Dependent Pharmacokinetics of a New Oral Cephalosporin, Cefixime, in the DogMeir Bialer, Vijay K. Batra, John A. Morrison, B. Michael Silber and Zee M. Look, et al.
38-41High-Performance Liquid Chromatographic Assay for Thyrotropin Releasing Hormone and Benzyl Alcohol in Injectable FormulationGowdahalli N. Subba Rao, Jerry W. Sutherland and Gopi N. Menon
42-45Stability of Lidocaine in Aqueous Solution: Effect of Temperature, pH, Buffer, and Metal Ions on Amide HydrolysisMichael F. Powell
46-49Improved Radioreceptor Assay of Opiate Narcotics in Human Serum: Application to Fentanyl and Morphine MetabolismViktorya Levi, James C. Scott, Paul F. White and Wolfgang Sadée
50-53Subcellular Distribution of Basic Drugs Accumulated in the Isolated Perfused LungHisahiro Yoshida, Katsuhiko Okumura and Ryohei Hori
54-58Automated Stability-Indicating High-Performance Liquid Chromatographic Assay for Ethinyl Estradiol and (Levo)norgestrel TabletsVan D. Reif, W. Mark Eickhoff, John K. Jackman and Nicholas J. DeAngelis
59-61Application of Moment Analysis to Nonlinear Drug Disposition Described by the Michaelis–Menten EquationAndrew T. Chow and William J. Jusko
62-65Effects of Plasma Proteins on Degradation Properties of Poly(L-lactide) MicrocapsulesKimiko Makino, Hiroyuki Ohshima and Tamotsu Kondo
66-69Dissociation of the Natriuretic and Antikaliuretic Properties of Triamterene Derivatives by Dose–Response ExperimentsHelmut Priewer, Erwin Wolf, Helga Kraft, Heinrich Knauf and Ernst Mutschler
70-74Drug Release from Tablets Containing Cellulose Acetate Phthalate As an Additive or Enteric-Coating MaterialShan-Yang Lin and Y. Kawashima
75-77Report of the Workshop on Controlled-Release Dosage Forms: Issues and ControversiesJerome P. Skelly, William H. Barr, Leslie Z. Benet, James T. Doluisio and Arthur H. Goldberg, et al.
78The Effect of Density on the Gastric Emptying and Intestinal Transit of Solid Dosage Forms: Comments on the Article by Davis et al.Lydia C. Kaus
79-81Association News and Announcements

Volume 4, Number 2 / April 1987

83-85Managing Potential Conflicts of Interest in University-Industrial PartnershipsMichael A. Schwartz
86-91Kinetic-Effect Models and Their ApplicationsJoachim Grevel
92-97Use of Vaccinia Virus to Express Biopharmaceutical ProductsDennis E. Hruby and Gary Thomas
98-103Kinetics and Mechanism of Captopril Oxidation in Aqueous Solution Under Controlled Oxygen Partial PressureTak-Yee Lee and Robert E. Notari
104-112Water Vapor Sorption of Water-Soluble Substances: Studies of Crystalline Solids Below Their Critical Relative HumiditiesMark J. Kontny, George P. Grandolfi and George Zografi
113-119Effect of Pyrimidine Nucleosides on Body Temperatures of Man and Rabbit in Relation to Pharmacokinetic DataGodefridus J. Peters, Cees J. van Groeningen, Emile Laurensse, Ineke Kraal and Albert Leyva, et al.
120-125Selection of a Derivative of the Antiviral Agent 9-[(1,3-Dihydroxy-2-propoxy)-methyl]Guanine (DHPG) with Improved Oral AbsorptionEric J. Benjamin, Bruce A. Firestone, Robert Bergstrom, Marian Fass and Ian Massey, et al.
126-129Identification of Prescription Drugs in Adulterated Chinese Herbal MedicationsThomas Cairns, Emil G. Siegmund and Bobby R. Rader
130-132Prostaglandin Derivative PGBX Improves Neurologic Recovery After Ischemic Spinal InjuryThomas P. Jacobs, John M. Hallenbeck, Thomas M. Devlin and Giora Z. Feuerstein
133-136A High-Performance Liquid Chromatographic Microassay Employing a Liquid–Solid Extraction Technique for Etintidine in PlasmaShiew-Mei Huang, Elaine Rubin and Thomas B. Marriott
137-141The Solid-State Decarboxylation of the Diammonium Salt of MoxalactamStephen R. Byrn, Phillipe Perrier, Chung-Tang Lin, Herberto Martinez and Ralph R. Pfeiffer
142-146Binding of Basic Drugs to Rat Lung MitochondriaRyohei Hori, Katsuhiko Okumura and Hisahiro Yoshida
147-149A Naloxone–Steroid Hybrid Azine with Selective and Long-Acting Opioid Antagonism at Delta Receptors In VitroAhmet Koman, Vera M. Kolb and Lars Terenius
150-153Influence of Tablet Dissolution on Furosemide Bioavailability: A Bioequivalence StudyPatrick J. McNamara, Thomas S. Foster, George A. Digenis, Rajani B. Patel and William A. Craig, et al.
154-157A Novel Method for the Synthesis of Kyotorphin, Tyr-Arg, and 3H-Tyr-Arg, Catalyzed by Tyrosyl-tRNA Synthetase from Bacillus stearothermophilusSenji Kitabatake, Ryoichi Tsurutani, Hiroshi Nakajima, Kosuke Tomita and Yoshihiro Yoshihara, et al.
158-161Phenolic Cyclization of Epinephrine, Metaproterenol, Metaraminol, Phenylephrine, and Terbutaline with FormaldehydeLester Chafetz and Ramazan Turdiu
162-165A New Parenteral Emulsion for the Administration of TaxolB. D. Tarr, T. G. Sambandan and S. H. Yalkowsky
166-170Synthesis and Pharmacological Activity of N- Alkyl-1,2-DiphenylethanolaminesHumeida A. El-Obeid, Abdul Azim E. Madani, Khalid A. Al-Rashood, Kamal E. H. El Tahir and Abdul Karim Tilmisani, et al.
171-172In Vitro and In Vivo Interactions of Furosemide and SucralfateAhmed H. Hikal, Larry A. Walker and Thirucote Ramachandran
173-175Association News and Announcements

Volume 4, Number 3 / June 1987

177-180A Critical Appraisal of Drug Stability Testing MethodsRobert B. Taylor and Amin S. H. Shivji
181-188Immunoconjugates: Applications in Targeted Drug Delivery for Cancer TherapyBhanu P. Ram and Praveen Tyle
189-194Radioreceptor Assay for Insulin FormulationsLars Sjödin and Eila Viitanen
195-199An Equation for the Systemic Availability of Drugs Undergoing Simultaneous Enterohepatic Cycling, First-Pass Metabolism, and Intestinal EliminationTheresa A. Shepard and Richard H. Reuning
200-206Efficacy of 5-Vinyl-l-β-D-arabinofuranosyluracil (VaraU) Against Herpes Simplex Virus Type 2 Strains in Cell Cultures and Against Experimental Herpes Encephalitis in Mice: Comparison with Acyclovir and FoscarnetJürgen Reefschläger, Peter Wutzler, Klaus-Dieter Thiel and Gottfried Herrmann
207-213Synthesis and Properties of Haptens for the Development of Radioimmunoassays for Thioridazine, Mesoridazine, and SulforidazineBhaswat S. Chakraborty, Manik S. Sardessai, Theodore J. Jaworski, Kamal K. Midha and Edward M. Hawes
214-219Kinetics and Mechanism of Zinc Ion-Mediated Degradation of Cephalosporins in Tromethamine SolutionHisao Tomida, Kazuya Kohashi, Yasuto Tsuruta, Setsuo Kiryu and Michael A. Schwartz
220-230Cosolvency and Cosolvent PolarityJoseph T. Rubino and Samuel H. Yalkowsky
231-236Cosolvency and Deviations from Log-Linear SolubilizationJoseph T. Rubino and Samuel H. Yalkowsky
237-239Identification of Phenolic Antioxidants in Elastomers for Pharmaceutical and Medical UseCharles B. Airaudo, André Gayte-Sorbier, Roland Creusevau and Régine Dumont
240-243Kinetics of Drug Action in Disease States. XXII. Effects of Contraceptive Steroids on the Pharmacodynamics of Ethanol in RatsSompon Wanwimolruk and Gerhard Levy
244-247Adsorption of Inorganic and Organic Ions to Polycarbophil as a Means of Sustained-Release Dosage FormulationNorman A. See, James Russell, Kenneth A. Connors and Paul Bass
248-250Effects of Hypothermia on Drug AbsorptionSalomon Stavchansky and I-lan Tung
251-254Effect of Amiodarone and Desethylamiodarone on the Pharmacokinetics of Antipyrine in the RatCraig K. Svensson, Li-Ling Liu and Philip W. Knowlton
255-257Preformulation Salt Selection. Physical Property Comparisons of the Tris(hydroxymethyl)aminomethane (THAM) Salts of Four Analgesic/Antiinflammatory Agents with the Sodium Salts and the Free AcidsLeo Gu and Robert G. Strickley
258-260Analysis of the Antimalarial Sesquiterpene Artemisinin in Artemisia annua by High-Performance Liquid Chromatography (HPLC) with Postcolumn Derivatization and Ultraviolet DetectionHala N. ElSohly, E. M. Croom and M. A. ElSohly
261-262A Reversed-Phase High-Performance Liquid Chromatographic (HPLC) Assay for the Determination of Biotin in Multivitamin–Multimineral PreparationsSharon L. Crivelli, Peter F. Quirk, Daniel J. Steible and S. P. Assenza
263-264Obituary: Dr. Takeru Higuchi (1918-1987)
265-267FDA and AAPS Report of the Workshop on Principles and Practices of In Vitro Percutaneous Penetration Studies: Relevance to Bioavailability and BioequivalenceJerome P. Skelly, Vinod P. Shah, Howard I. Maibach, Richard H. Guy and Ronald C. Wester, et al.
268-270Association News and Announcements

Volume 4, Number 4 / August 1987

271-277The Lipoidal Permeability Barriers of the Skin and Alimentary TractWilliam Curatolo
278-284Protein Degradation: The Role of Mixed-Function OxidasesValeric Daggett
285-292Enantiomeric Resolution of Drug Compounds by Liquid ChromatographyH.Thomas Karnes and Mohamadi A. Sarkar
293-300Disposition and Tumor Localization of Mitomycin C–Dextran Conjugates in MiceYoshinobu Takakura, Akira Takagi, Mitsuru Hashida and Hitoshi Sezaki
301-304Validation of Fiber-Optic Doppler Anemometry (FODA) for Characterizing the Droplet Size of EmulsionsBarbara J. Floy, Joe L. White and Stanley L. Hem
305-310Coupling of Naltrexone to Biodegradable Poly(α-Amino Acids)Naoki Negishi, David B. Bennett, Chong-Su Cho, SeoYoung Jeong and Wolfgang A. R. Heeswijk, et al.
311-316Computer-Aided Dosage Form Design. I. Methods for Defining a Long-Acting First-Order Delivery System of Maximum Formulating FlexibilityTak-Yee Lee and Robert E. Notari
317-320N-Mannich-Base Prodrugs of 5-Iodo-2′-deoxycytidine as Topical Delivery EnhancersSuzanne A. M. Koch and Kenneth B. Sloan
321-326Synthesis and Biological Activity of Isodithiobiurets, Dithiobiurets, and DithiazolesSurendra N. Pandeya, Ashok Kumar, Bhav N. Singh and Dina N. Mishra
327-331High-Performance Liquid Chromatographic (HPLC) Assay Using Fluorescence Detection for the Simultaneous Determination of Gallopamil and Norgallopamil in Human PlasmaAngus M. McLean, Elizabeth Babcock-Atkinson, Kathleen Rein, Donald A. Ruggirello and Mario A. Gonzalez, et al.
332-336Pharmacokinetics of Gold Sodium Thiomalate in RabbitsSrikumaran Melethil and Darryle Schoepp
337-341Validation of a Flow-Through Diffusion Cell for Use in Transdermal ResearchWilliam J. Addicks, Gordon L. Flynn and Norman Weiner
342-347Temperature and pH Dependence of Fluocinolone Acetonide Degradation in a Topical Cream FormulationRichard A. Kenley, MaryannOtt Lee, Lakshmi Sukumar and Michael F. Powell
348-352Effects of Formulation and Food on the Absorption of Hydrochlorothiazide and Triamterene or Amiloride from Combination Diuretic ProductsRoger L. Williams, Joyce Mordenti, Robert A. Upton, Emil T. Lin and Winnie L. Gee, et al.
353-354Microbial Transformation of TamoxifenSaleh El-Sharkawy and Yusuf J. Abul-Hajj
355-357Binding of Piroxicam to Human Serum Albumin: Effect of Piroxicam on Warfarin and Diazepam BindingKenji Matsuyama, Asok C. Sen and John H. Perrin
358EDITORIAL
359Association News and Announcements

Volume 4, Number 5 / October 1987

361-363Emerging Trends in Biotechnology: A Perspective from the Pharmaceutical IndustryWilliam Szkrybalo
364-374Renin InhibitorsWilliam J. Greenlee
375-378Recombinant Tissue Plasminogen Activator: A Brief ReviewElliott B. Grossbard
379-384Development of Acute Tolerance to Bumetanide: Bolus Injection StudiesJack A. Cook and David E. Smith
385-391Computer-Aided Dosage Form Design. II. Methods for Defining a Zero-Order Sustained-Release Delivery System of Maximum Formulating FlexibilityTak-Yee Lee and Robert E. Notari
392-397Diketopiperazine Formation, Hydrolysis, and Epimerization of the New Dipeptide Angiotensin-Converting Enzyme Inhibitor RS-10085Leo Gu and Robert G. Strickley
398-401Estimation of Surface Polarity of Silicas by Absorption Spectroscopy of Glycerin Suspensions of Adsorbed 6-NitrobenzoindolinopyranMichael J. Jozwiakowski and Kenneth A. Connors
402-405Multiple-Dose Pharmacokinetics of Clozapine in PatientsMiles G. Choc, Robert G. Lehr, Frances Hsuan, Gilbert Honigfeld and Harold T. Smith, et al.
406-408Prostaglandin D2 Inhibits Pentylenetetrazole-Induced Convulsions in Rats by a Serotonin-Mediated MechanismSalil K. Bhattacharya and Surendra S. Parmar
409-411Bioavailability and Pharmacokinetics of a New Sustained-Release Potassium Chloride TabletCharles J. Betlach, John D. Arnold, R. Wayne Frost, Philip T. Leese and Mario A. Gonzalez
412-415Quantitative Analysis of Hydroxyurea and Urea by Proton Nuclear Magnetic Resonance (NMR) SpectroscopyKaren B. Main, Thomas Medwick, Leonard C. Bailey and John H. Shinkai
416-419Analysis of in Vitro Dissolution of Whole vs. Half Controlled-Release Theophylline TabletsVinod P. Shah, Lawrence A. Yamamoto, Donald Schuirman, Jerome Elkins and Jerome P. Skelly
420-424Dose-Proportional Absorption of Etretinate After Doses of 25, 50, 75, and 100 mgRobert J. Wills, Lolita C. Rodriguez, Amy H. Lin, Clara Puccini and Wayne A. Colburn
425-428Inhibition of Intestinal Pyrimidine Nucleoside PhosphorylasesM. Guill Wientjes and J. Lai-Sim Au
429-432Polymorphism of l,2-Dihydro-6-neopentyl-2-oxonicotinic Acid: Characterization, Interconversion, and QuantitationRobert S. Chao and Kenneth C. Vail
433-435Pharmacokinetics of Pentoxifylline During Concomitant Theophylline Administration to RatsMario L. Rocci, David R. Luke and Consuelo L. Saccar
436-437The Effect of Vehicle Additives on the Transdermal Delivery of NitroglycerinThorsteinn Loftsson, Nancy Gildersleeve and Nicholas Bodor
438Electrode Material in IontophoresisLars Erik Linblad and Lena Ekenvall
439-442Bio-organic and Natural Products Chemistry Molecular Biology WorkshopLaurence H. Hurley, John Kozarich and Michael Rogers
443EDITORIAL
444Association News and Announcements

Volume 4, Number 6 / December 1987

445-449The Influence of Drugs on Nasal Ciliary MovementWalter A. J. J. Hermens and Frans W. H. M. Merkus
450-456Electron-Transfer and Charge-Transfer Clastic Binding Hypotheses for Drug–Receptor InteractionsVera M. Kolb
457-464Mechanisms of Mucoadhesion of Poly(acrylic Acid) HydrogelsHaesun Park and Joseph R. Robinson
465-471The Preparation and Evaluation of Drug-Containing Poly(dl-lactide) Microspheres Formed by the Solvent Evaporation MethodRoland Bodmeier and James W. McGinity
472-479Hypolipidemic Activity of o-(N-Phthalimido)acetophenone in Sprague Dawley RatsIris H. Hall, David J. Reynolds, Oi T. Wong, C. Brent Oswald and Akula R. K. Murthy
480-485Investigation of the Gastrointestinal Transit and In Vivo Drug Release of Isosorbide-5-Nitrate PelletsWilfried Fischer, Anna Boertz, Stanley S. Davis, Raj Khosla and Willi Cawello, et al.
486-489Correlation of Ibuprofen Bioavailability with Gastrointestinal Transit by Scintigraphic Monitoring of 171Er-Labeled Sustained-Release TabletsAlan F. Parr, Robert M. Beihn, Robert M. Franz, Gregory J. Szpunar and Michael Jay
490-494Tissue Tolerance of Intramuscular Injectables and Plasma Enzyme Activities in RatsChristian Surber and Heinz Sucker
495-498In Vivo Efficacy of Antifungal Oxoaporphine Alkaloids in Experimental Disseminated CandidiasisAlice M. Clark, E. Sue Watson, M. Khalid Ashfaq and Charles D. Hufford
499-503Between-Lot and Within-Lot Comparisons of Bioavailability of Macrocrystalline Nitrofurantoin CapsulesWilliam D. Mason, John D. Conklin and Francis J. Hailey
504-508Measurement of the Particle Size of Tablet Excipients with the Aid of Video RecordingKanneganti P. P. Prasad and Lucy S. C. Wan
509-514Effect of Helenalin and Bis(helenalinyl)malonate on Nucleic Acid and Protein Synthesis in Human KB Carcinoma CellsIris H. Hall, Anne A. Grippo, Kuo-Hsiung Lee, Stephen G. Chaney and David J. Holbrook
515-518Effect of Hydralazine on the Elimination of Antipyrine in the RatCraig K. Svensson, Philip W. Knowlton and Joseph A. Ware
519-523Percutaneous Absorption and Elimination of the Penetration Enhancer Azone in HumansJohann W. Wiechers, Ben F. H. Drenth, Jan H. G. Jonkman and Rokus A. de Zeeuw
524-526Radiolabeling of Intact Dosage Forms by Neutron Activation: Effects on In Vitro PerformanceAlan Parr and Michael Jay
527-530Therapeutic Effect of Dexamethasone in T-2 ToxicosisEsther Shohami, Burt Wisotsky, Oliver Kempski and Giora Feuerstein
531-535Kinetics of Potassium Excretion Following Oral Supplements: Evidence of Induced NatriuresisAshok Rakhit, Srikumaran Melethil, John D. Arnold and William E. Wagner
536Assessment of Variance in Bioavailability Studies: Comments on the Article by McNamara et al.Carl M. Metzler
537Association News and Announcements
538-540Reviewers for Pharmaceutical Research (1987)
541-543Author Index to Volume 4 (1987)
544-548Subject Index to Volume 4 (1987)

Volume 5, Number 1 / January 1988

1-9Monoclonal Antibodies as Magic BulletsFrances M. Brodsky
10-15Liquid Chromatographic Analysis of Di(2-ethylhexyl) Phthalate: Application to Pharmacokinetic Studies in the Mongrel DogDavid B. Haughey, William F. Elmquist, David A. Breutzmann, D. Gary Hemphill and Edward G. Constantini
16-20Release of Lonapalene from Two-Phase Emulsion-Type Ointment SystemsJohn T. H. Ong and Elizabeth Manoukian
21-30Porous Biodegradable Microspheres for Controlled Drug Delivery. I. Assessment of Processing Conditions and Solvent Removal TechniquesToyomi Sato, Motoko Kanke, Hans G. Schroeder and Patrick P. DeLuca
31-35Structural Determination of Testosterone Esters in Oil Injectables by Thermospray Mass SpectrometryThomas Cairns, Emil G. Siegmund and Thomas S. Savage
36-39Comparison of Output Particle Size Distributions from Pressurized Aerosols Formulated as Solutions or SuspensionsRichard N. Dalby and Peter R. Byron
40-43Pharmacokinetics of Ibuprofen Enantiomers in Humans Following Oral Administration of Tablets with Different Absorption RatesFakhreddin Jamali, Nikhilesh N. Singh, Franco M. Pasutto, Anthony S. Russell and Ronald T. Coutts
44-47Prodrugs for Improved Oral β-Estradiol BioavailabilityMunir A. Hussain, Bruce J. Aungst and Eli Shefter
48-52The Effect of Food on the Absorption of Controlled-Release Theophylline in Mini-SwineGerald K. Shiu, Arlen O. Sager, Raja B. Velagapudi, Vadlamani K. Prasad and Jerome P. Skelly
53-56Stereospecific High-Performance Liquid Chromatographic (HPLC) Assay of Fenoprofen Enantiomers in Plasma and UrineReza Mehvar and Fakhreddin Jamali
57-60An Area Function Method for Estimating the Apparent Absorption Rate ConstantHaiyung Cheng, Alfred E. Staubus and Linyee Shum
61-64Effect of Taurolithocholate on In Vivo Sulfation and Glucuronidation of Acetaminophen in RatsRaymond E. Galinsky and Barbara Chalasinska
65Editorial
66Association News and Announcements

Volume 5, Number 2 / February 1988

67-75Cytochrome P450: Molecular Architecture, Mechanism, and Prospects for Rational Inhibitor DesignThomas L. Poulos
76-79Pharmacokinetic Analysis of the Enantiomeric Inversion of Chiral Nonsteroidal Antiinflammatory DrugsReza Mehvar and Fakhreddin Jamali
80-85Saturable Binding of Cyclosporin A to Erythrocytes: Estimation of Binding Parameters in Renal Transplant Patients and Implications for Bioavailability AssessmentBrian Legg and Malcolm Rowland
86-91Development of Acute Tolerance to Bumetanide: Constant-Rate Infusion StudiesJack A. Cook and David E. Smith
92-98Oxygen Diffusion Coefficients in Commonly Used Topical Semisolid CreamsJonas C. T. Wang, Lu-Kwang Ju and Chester S. Ho
99-102Capillary Gas Chromatographic (GC) Analysis of Nitroglycerin and Its Denitration Products in PlasmaAlan S. Carlin, John E. Simmons, Gerald K. Shiu, Arlen O. Sager and Vadlamani K. Prasad, et al.
103-106Transdermal Controlled Administration of Indomethacin. I. Enhancement of Skin PermeabilityYie W. Chien, Heliang Xu, Chin-Chih Chiang and Yih-Chain Huang
107-112Enantiospecific High-Performance Liquid Chromatographic (HPLC) Determination of Baclofen and Its Fluoro Analogue in Biological MaterialHildegard Spahn, Dorit Krauβ and Ernst Mutschler
113-115Naltrexone-3-salicylate (a Prodrug of Naltrexone): Synthesis and Pharmacokinetics in DogsMunir A. Hussain and Eli Shefter
116-119Transdermal Delivery of Isoproterenol HC1: An Investigation of Stability, Solubility, Partition Coefficient, and Vehicle EffectsRajesh A. Patel and Ravindra C. Vasavada
120-122The Effect of Urinary pH Modification on the Disposition of PhenylpropanolamineCheryl L. Zimmerman
123-125Stereospecific High-Performance Liquid Chromatographic (HPLC) Assay of Flurbiprofen in Biological SpecimensBrian W. Berry and Fakhreddin Jamali
126-128Association News and Announcements

Volume 5, Number 3 / March 1988

129-139The Role of Tumor Necrosis Factor and Interleukin 1 in the Immunoinflammatory ResponseJames W. Larrick and Steven L. Kunkel
140-150The Role of Protein and Lipid Domains in the Uptake of Solutes by Human Stratum CorneumPrakash V. Raykar, Man-Cheong Fung and Bradley D. Anderson
151-155Bambuterol: Uptake and Metabolism in Guinea Pig Isolated LungsÅke Ryrfeldt, Elisabeth Nilsson, Anders Tunek and Leif-Åke Svensson
156-164Mean Residence Time Concepts for Pharmacokinetic Systems with Nonlinear Drug Elimination Described by the Michaelis–Menten EquationHaiyung Cheng and William J. Jusko
165-171Assessment and Validation of Animal Models to Evaluate Topical Effects of Substances on Gastrointestinal MucosaJohn W. Fara, Larry D. Anderson, Alfred G. T. Casper and Robert E. Myrback
172-177High-Performance Liquid Chromatographic Assay of a Central Nervous System (CNS)-Directed Estradiol Chemical Delivery System and Its Application After Intravenous Administration to RatsGotelind Mullersman, Hartmut Derendorf, Marcus E. Brewster, Kerry S. Estes and Nicholas Bodor
178-182Relation Between Individual and Ensemble Release Kinetics of Indomethacin from MicrospheresSimon Benita, Dany Babay, Amnon Hoffman and Max Donbrow
183-186Phenobarbital Adsorption from Simulated Intestinal Fluid, U.S.P., and Simulated Gastric Fluid, U.S.P., by Two Activated CharcoalsDale Eric Wurster, Gerald M. Burke, Mary J. Berg, Peter Veng-Pedersen and Dorothy D. Schottelius
187-189Measurement of Underivatized Propranolol Enantiomers in Serum Using a Cellulose –Tris(3,5 -Dimethylphenylcarbamate) High-Performance Liquid Chromatographic (HPLC) Chiral Stationary PhaseRobert J. Straka, Richard L. Lalonde and Irving W. Wainer
190-192Determination of a Novel Antiarrhythmic Agent ACC-9358 in Human Plasma by High-Performance Liquid ChromatographyRamanuj Achari and David A. Thomas
193-195The Estimation of Solubility in Binary Solvents: Application of the Reduced 3-Suffix Solubility Equation to Ethanol–Water MixturesN. Adeyinka Williams and Gordon L. Amidon
196Calculations and Application of Mean Residence Times for Drugs Which Demonstrate One-Compartment Distribution and Michaelis-Menten EliminationJack A. Cook and Peter R. Gwilt
197-198Association News and Announcements

Volume 5, Number 4 / April 1988

199-200Genes and the Pharmaceutical SciencesWolfgang Sadée
201-208Quantitative Structure–Activity Study on Human Pharmacokinetic Parameters of Benzodiazepines Using the Graph Theoretical ApproachRodney S. Markin, Wallace J. Murray and Harold Boxenbaum
209-213Role of Phosphatidylserine in the Cellular and Subcellular Lung Distribution of Quinidine in RatsAkio Nishiura, Teruo Murakami, Yutaka Higashi and Noboru Yata
214-219Stability of Prostacyclin Analogues: An Unusual Lack of Reactivity in Acid-Catalyzed Alkene HydrationAdina Magill, Counde O'Yang and Michael F. Powell
220-225Capillary Gas Chromatography and Thermionic N-P-Specific Detection of 13-Bis(2-chloroethyl)-l-nitrosourea (BCNU) or l-(2-Chloroethyl)-3-cyclohexyl-l-nitrosourea (CCNU) in Stability and Pharmacokinetic StudiesAdnan El-Yazigi and Cazemiro R. Martin
226-231The Stability and Solubility of Progabide and Its Related Metabolic DerivativesNidal F. Farraj, Stanley S. Davis, Graham D. Parr and Howard N. E. Stevens
232-235A Biotin–Avidin-Based Enzyme Immunoassay for βh-EndorphinGuenther Hochhaus and Wolfgang Sadée
236-237Antimuscarinic Effects of (R)- and (S)-Oxyphencyclimine HydrochlorideLise Schjelderup, Michael R. Kozlowski, Albert Weissman and Arne J. Aasen
238-241The Effect of Azone on Ocular Levobunolol Absorption: Calculating the Area Under the Curve and Its Standard Error Using Tissue Sampling CompartmentsDiane D.-S. Tang-Liu and P. Joshua Burke
242-244Antihypertensive Activity of 2[(2-Hydroxyphenyl) amino] -4(3H)-quinazolinoneMunir A. Hussain, Andrew T. Chiu, William A. Price, Pieter B. Timmermans and Eli Shefter
245-246Comparing the Biological Activity of Humulin R and Novolin R Using an Intravenous BioassayGhana R. Kowarski, Senshang Lin, Lora M. Michalek and A. Avinoam Kowarski
247-248ABSPLOTS: A LOTUS 123 Spreadsheet for Calculating and Plotting Drug Absorption RatesRobert C. Shumaker, Harold Boxenbaum and Gary A. Thompson
249Interpretation of Drug Stability TestingLester Chafetz
250Approaches to Drug StabilityRobert B. Taylor
251Electrode Material in IontophoresisPraveen Tyle
252Association News and Announcements

Volume 5, Number 5 / May 1988

253-260Free Radicals and Oxygen ToxicityDouglas D. Buechter
261-265The Protein Binding of Phenytoin, Propranolol, Diazepam, and AL01576 (an Aldose Reductase Inhibitor) in Human and Rat Diabetic SerumPatrick J. McNamara, Robert A. Blouin and Romulus K. Brazzell
266-271Epimerization Kinetics of Moxalactam in Frozen SolutionNaofumi Hashimoto, Teruhisa Ichihashi, Etsuko Yamamoto, Koichiro Hirano and Masayoshi Inoue, et al.
272-282Dissolution of lonizable Drugs in Buffered and Unbuffered SolutionsSadettin S. Ozturk, Bernhard O. Palsson and Jennifer B. Dressman
283-287Development of a Radioreceptor Assay for the D2-Selective Dopamine Agonist N-0437Kees Ensing, Dick A. Bloemhof, Willy G. in't Hout, Jan van der Lende and Rokus A. de Zeeuw
288-296Potential Improvement in the Shelf Life of Parenterals Using the Prodrug Approach: Bacampicillin and Talampicillin Hydrolysis Kinetics and Utilization TimeNgoc-Anh T. Nguyen, Lobna M. Mortada and Robert E. Notari
297-299Thiol Reduction of 3′-Azidothymidine to 3′-Aminothymidine: Kinetics and Biomedical ImplicationsAnthony L. Handlon and Norman J. Oppenheimer
300-304Receptor-Mediated Magnetic Carriers: Basis for TargetingJames M. Gallo and Emad Eldin Hassan
305-308Site Dependence of Absorption-Promoting Actions of Laureth-9, Na Salicylate, Na2EDTA, and Aprotinin on Rectal, Nasal, and Buccal Insulin DeliveryBruce J. Aungst and Nancy J. Rogers
309-312Enhanced Membrane Permeability to Phenol Red by Medium-Chain Glycerides: Studies on the Membrane Permeability and MicroviscosityKazutaka Higaki, Muneyoshi Kato, Mitsuru Hashida and Hitoshi Sezaki
313-315Mass Balance and Dose Accountability in Percutaneous Absorption Studies: Development of a Nonocclusive Application SystemDaniel A. W. Bucks, Howard I. Maibach and Richard H. Guy
316-318Stereoselective Binding of Disopyramide to Plasma ProteinsLuisa Valdivieso, Kathleen M. Giacomini, Wendel L. Nelson, Robert Pershe and Terrence F. Blaschke
319-321Serum Protein Binding of AL01576, a New Aldose Reductase InhibitorPatrick J. McNamara, Robert A. Blouin and R. K. Brazzell
322Reply to “Assessment of Variance in Bioavailability Studies: Comments on the Article by McNamara et al.” by Carl M. Metzler.Jerome P. Skelly, Vinod P. Shah and Donald J. Schuirmann
323-324Association News and Announcements

Volume 5, Number 6 / June 1988

325-334Approaches to Radiolabeling of Antibodies for Diagnosis and Therapy of CancerAlan R. Fritzberg, Ronald W. Berninger, Stephen W. Hadley and Dennis W. Wester
335-340Disposition of Detirelix, A Potent Luteinizing Hormone-Releasing Hormone Antagonist, in Rats and MonkeysRebecca L. Chan, William Ho, Austin S. Webb, JoAnn LaFargue and Clinton A. Nerenberg
341-346Enhancement of Colonic Drug Absorption by the Paracellular Permeation RouteMikio Tomita, Masaharu Shiga, Masahiro Hayashi and Shoji Awazu
347-351Metabolite Formation Pharmacokinetics: Rate and Extent of Metabolite Formation Determined by DeconvolutionMichael D. Karol and Scott Goodrich
352-358Cellular Uptake of a Fluid-Phase Marker by Human Neutrophils from Solutions and LiposomesJeffrey F. Scieszka and Moo J. Cho
359-364Structure–Activity Relationship Studies of Hemicholinium (HC-3) CongenersJoseph G. Cannon, Teresa M.-L. Lee, Y.-a. Chang, Alfred M. Nyanda and Bula Bhattacharyya, et al.
365-368Liquid Chromatographic Assay and Pharmacokinetics of Quazepam and Its Metabolites Following Sublingual Administration of QuazepamSamir K. Gupta and Everett H. Ellinwood
369-371Carrier-Mediated Transport of Baclofen Across Monolayers of Bovine Brain Endothelial Cells in Primary CultureJoost B. M. M van Bree, Kenneth L. Audus and Ronald T. Borchardt
372-376In Vitro Measurement of Gastrointestinal Tissue Permeability Using a New Diffusion CellGeorge M. Grass and Stephanie A. Sweetana
377-382Drug Transport from Thin Applications of Topical Dosage Forms: Development of MethodologyWilliam J. Addicks, Gordon L. Flynn, Norman Weiner and Chia-Ming Chiang
383-386Assay for Hydralazine as Its Stable p-Nitrobenzaldehyde HydrazoneHugh A. Semple, Yun K. Tam, Sarah Tin and Ronald T. Courts
387-390Time-Dependent Absorption of Phenprobamate Following Multiple Dosing in RatsJim Xin-Sheng Sun, Koral Embil and Ching-San C. Lee
391-395Thermodynamics in the Prediction of the Solubilities of Binary Mixtures of the Diastereoisomers and Enantiomers of EphedrineWalter F. Schmidt, William Porter and Jens. T. Carstensen
396Association News and Announcements

Volume 5, Number 7 / July 1988

397-400Drug Discovery—Today and Tomorrow: The Role of Medicinal ChemistryKurt R. Freter
401-407Pharmacodynamics of Zoxazolamine and Chlorzoxazone in RatsMasato Yasuhara and Gerhard Levy
408-412Searching for the Endogenous Benzodiazepine Using the Graph Theoretical ApproachRodney S. Markin and Wallace J. Murray
413-420The Effects of Phthalimide and Saccharin Derivatives on Low-Density Lipoprotein (LDL) and High-Density Lipoprotein (HDL) Receptor Activity and Related Enzyme ActivitiesIris H. Hall, Oi T. Wong and Steven D. Wyrick
421-425Hygroscopicity of Cefazolin Sodium: Application to Evaluate the Crystallinity of Freeze-Dried ProductsTakashi Osawa, Madhav S. Kamat and Patrick P. DeLuca
426-429Estimation of the Degree of Crystallinity of Cefazolin Sodium by X-Ray and Infrared MethodsMadhav S. Kamat, Takashi Osawa, Robert J. DeAngelis, Yasuto Koyama and Patrick P. DeLuca
430-433Receptor Binding Studies of the Flavone, REC 15/2053, and Other Bladder SpasmolyticsGianAlfredo Abbiati, Roberto Ceserani, Dante Nardi, Claudio Pietra and Rodolfo Testa
434-436Evidence for the Involvement of a Nitrenium Ion in the Covalent Binding of Nitrofurazone to DNAAnthony J. Streeter and Betty-ann Hoener
437-439Dextromethorphan Pretreatment Induces Antipyrine Clearance in the RatCraig K. Svensson and Joseph A. Ware
440-442Protein Binding of Cocaine in Human SerumDavid J. Edwards and Susan K. Bowles
443-446A New System for In Vitro Studies of IontophoresisPeretz Glikfeld, Christopher Cullander, Robert S. Hinz and Richard H. Guy
447-452Teratogenic and Behavioral Anomalies Induced by Acute Exposure of Mice to Ethanol and Their Possible Relation to Fetal Brain DNA SynthesisArthur A. Ciociola and Ronald F. Gautieri
453-456Absorption Enhancement of Rectally Infused Cefoxitin Sodium by Medium-Chain Fatty Acids in Conscious Rats: Concentration–Effect RelationshipEwoud J. van Hoogdalem, Martin A. Hardens, Albertus G. de Boer and Douwe D. Breimer
457-462Percutaneous Absorption of Nicardipine and Ketorolac in Rhesus MonkeysDiana Yu, Lynda M. Sanders, George W. R. Davidson III, Martha J. Marvin and Teck Ling
463Association News and Announcements

Volume 5, Number 8 / August 1988

465-471Renal Transport of Drugs: An Overview of Methodology with Application to CimetidineKathleen M. Giacomini, Poe-Hirr Hsyu and Lee G. Gisclon
472-476Recombinant Human Interferon Alpha-2a: Delivery to Lymphoid Tissue by Selected Modes of ApplicationAndreas Supersaxo, Wayne Hein, Harald Gallati and Hans Steffen
477-481Percutaneous and Systemic Disposition of Hexamethylene Lauramide and Its Penetration Enhancement Effect on Hydrocortisone in a Rat Sandwich Skin-Flap ModelDiane D-S. Tang-Liu, John Neff, Heraldo Zolezio and Rhonda Sandri
482-487Determination of the pH-Dependent Phase Distribution of Prostaglandin El in a Lipid Emulsion by UltrafiltrationDirk L. Teagarden, Bradley D. Anderson and William J. Petre
488-494Drug/Polymer Matrix Swelling and DissolutionRonald S. Harland, Andrea Gazzaniga, M. Edvige Sangalli, Paolo Colombo and Nikolaos A. Peppas
495-500Dissolution Rate Studies from a Stationary Disk/Rotating Fluid SystemNahla Khoury, John W. Mauger and Stephen Howard
501-505Mineral Metabolism of Aging Female Rats Fed Various Commercially Available Calcium Supplements or YogurtAlison R. Behling and Janet L. Greger
506-508Turbuhaler: A New Powder Inhaler for Administration of Drugs to the AirwaysKjell Wetterlin
509-513Comparative Pharmacokinetics of Methylprednisolone Phosphate and Hemisuccinate in High DosesHelmut Möllmann, Peter Rohdewald, Jürgen Barth, Carsten Möllmann and Matthi Verho, et al.
514-517An Accurate Prediction of the pH Change Due to Degradation: Correction for a “Produced” Secondary Buffering SystemLeonard S. Rosenberg, Cheryl K. Hostetler, Dietmar M. Wagenknecht and Diane A. Aunet
518-522Dynamics of Bromodeoxyuridine Incorporation into DNA of Squamous Carcinoma Cells During Mid and Late Logarithmic GrowthAmnon Shapira, John G. ***MISSING END TAG*** Ira S. Wagner, Jonathan Phillip L. Maybaum, William D. Ensminger and Thomas E. Carey
523-527Formulation of Vaccine Adjuvant Muramyldipeptides (MDP). 1. Characterization of Amorphous and Crystalline Forms of a Muramyldipeptide AnalogueTai Wah Chan and Allyn Becker
528-532Formulation of Vaccine Adjuvant Muramyldipeptides (MDP). 2. The Thermal Reactivity and pH of Maximum Stability of MDP Compounds in Aqueous SolutionMichael F. Powell, Linda C. Foster, Allyn R. Becker and William Lee
533-536Controlled Gastric Emptying. 1. Effects of Physical Properties on Gastric Residence Times of Nondisintegrating Geometric Shapes in Beagle DogsRobyn Cargill, Larry J. Caldwell, Karen Engle, Joseph A. Fix and Patricia A. Porter, et al.
537-538Association News and Announcements

Volume 5, Number 9 / September 1988

539-549Oligonucleotide Analogues as Potential Chemotherapeutic AgentsGerald Zon
550-565Kinetics of Release from Enteric-Coated TabletsSadettin S. Ozturk, Bernhard O. Palsson, Bruce Donohoe and Jennifer B. Dressman
566-573Heterogeneity Effects on Permeability–Partition Coefficient Relationships in Human Stratum CorneumBradley D. Anderson, William I. Higuchi and Prakash V. Raykar
574-579Solute Absorption from the Airways of the Isolated Rat Lung. I. The Use of Absorption Data to Quantify Drug Dissolution or Release in the Respiratory TractRalph W. Niven and Peter R. Byron
580-586Solubility and Related Physicochemical Properties of Narcotic AnalgesicsSamir D. Roy and Gordon L. Flynn
587-591The Effects of Carbidopa Dose and Time and Route of Administration on Systemic L-Dopa Levels in RatsPaula S. Leppert, Margot Cortese and Joseph A. Fix
592-597pH-Dependent Swelling and Solute Diffusion Characteristics of Poly(Hydroxyethyl Methacrylate–CO–Methacrylie Acid) HydrogelsJim H. Kou, Gordon L. Amidon and Ping I. Lee
598-603Intestinal 5-Fluorouracil Absorption: Use of Ussing Chambers to Assess Transport and MetabolismPhilip Smith, Christopher Mirabelli, Joseph Fondacaro, Frederick Ryan and John Dent
604-606Structure and Permeability of Composite Films of Two Analogous Acrylate Methacrylate CopolymersR.S. Okor
607-610Size Characterization of Mycobacterium bovis BCG (Bacillus Calmette Guérin) Vaccine, Tice™ SubstrainAmy Zhang and Michael J. Groves
611-614Application of Solid-State Nuclear Magnetic Resonance (NMR) to the Study of Skin HydrationTimothy Wiedmann
615-618Improved Buccal Delivery of Opioid Analgesics and Antagonists with Bitterless ProdrugsMunir A. Hussain, Bruce J. Aungst, Christopher A. Koval and Eli Shefter
619-620The Effect of pH on Gallopamil Protein BindingDavid R. Rutledge and Mark Szlaczky
621Editorial
622Association News and Announcements

Volume 5, Number 10 / October 1988

623-627Glucocorticoid Receptors in Human Synovial Tissue and Relative Receptor Affinities of Glucocorticoid-21-EstersMartin Pörtner, Helmut Möllmann and Peter Rohdewald
628-633Cimetidine Elimination from the Cerebrospinal Fluid of the RatMathew T. Whittico and Kathleen M. Giacomini
634-638Potential Improvement in Shelf Life Using the Prodrug Approach. II. A Systematic Examination of Kinetic RequirementsNgoc-Anh T. Nguyen and Robert E. Notari
639-644Effects of Gender, Posture, and Age on Gastric Residence Time of an Indigestible Solid: Pharmaceutical ConsiderationsParviz Mojaverian, Peter H. Vlasses, Paul E. Kellner and Mario L. Rocci
645-650Characterization of the Oral Absorption of β-Lactam Antibiotics. I. Cephalosporins: Determination of Intrinsic Membrane Absorption Parameters in the Rat Intestine In SituPatrick J. Sinko and Gordon L. Amidon
651-654Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated CompoundsGordon L. Amidon, Patrick J. Sinko and David Fleisher
655-659Complexation of Nifedipine with Substituted Phenolic LigandsKathleen M. Boje, Marion Sak and Ho-Leung Fung
660-663The Relationship of pKa and Acute Skin Irritation in ManBret Berner, Donald R. Wilson, Richard H. Guy, Gerard C. Mazzenga and Frank H. Clarke, et al.
664-667Determination of Spectinomycin Dihydrochloride by Liquid Chromatography with Electrochemical DetectionLee Elrod, John F. Bauer and Stacy L. Messner
668-672Correlation of Unbound Plasma Clearances of Fifteen Extensively Metabolized Drugs Between Humans and RatsWin L. Chiou and Fung-Hwa Hsu
673-676In Vitro Model for Ciclosporin Intestinal Absorption in Lipid VehiclesJean-Philippe Reymond and Heinz Sucker
677-679In Vivo Model for Ciclosporin Intestinal Absorption in Lipid VehiclesJean-Philippe Reymond, Heinz Sucker and Jacky Vonderscher
680-683The Measurement of Warfarin Enantiomers in Serum Using Coupled Achiral/Chiral, High-Performance Liquid Chromatography (HPLC)Ya-Qin Chu and Irving W. Wainer
684-686A Precolumn Derivatization High-Performance Liquid Chromatographic (HPLC) Procedure for the Quantitation of Difluoromethylornithine in PlasmaJacquelyn Smithers
687-688Association News and Announcements

Volume 5, Number 11 / November 1988

689-693The Adjuvant Effect of Bacitracin on Nasal Absorption of Gonadorelin and Buserelin in RatsSusanne C. Raehs, Jürgen Sandow, Klaus Wirth and Hans P. Merkle
694-698A Quantitative Method of Evaluating the Diuretic Response to Furosemide in RatsRyohei Hori, Katsuhiko Okumura, Ken-ichi Inui, Takashi Shibata and Toshihiro Kikkoji, et al.
699-703Urinary Excretion and Diuretic Action of Furosemide in Rats: Increased Response to the Urinary Excretion Rate of Furosemide in Rats with Acute Renal FailureToshihiro Kikkoji, Akira Kamiya, Ken-ichi Inui and Ryohei Hori
704-708Micellar Solubilization of Timobesone Acetate in Aqueous and Aqueous Propylene Glycol Solutions of Nonionic SurfactantsJohn T. H. Ong and Elizabeth Manoukian
709-712Determination of Amiodarone Hydrochloride in Pharmaceutical Formulations by Derivative UV Spectrophotometry and High-Performance Liquid Chromatography (HPLC)Anna M. Di Pietra, Vanni Cavrini, Rita Gatti and Maria A. Raggi
713-717Amorphous Water-Soluble Cyclodextrin Derivatives: 2-Hydroxyethyl, 3-Hydroxypropyl, 2-Hydroxyisobutyl, and Carboxamidomethyl Derivatives of β-CyclodextrinTetsumi Irie, Kazuhiro Fukunaga, Atsuya Yoshida, Kaneto Uekama and Henry M. Fales, et al.
718-721Pharmacokinetics and Bioavailability of Hydromorphone: Effect of Various Routes of AdministrationShyi-Feu Chang, Luana Moore and Yie W. Chien
722-725Thermal Behavior of Poly Hydroxy Ethyl Methacrylate (pHEMA) HydrogelsWouter E. Roorda, Johanna A. Bouwstra, Mattina A. de Vries and Hans E. Junginger
726-728Experimental Confirmation of the Change of Water Structure in the Critical Range of Micelle Formation: A New Method of Critical Micelle Concentration (CMC) DeterminationReinhard Hüttenrauch, Sabine Fricke and Marion Köhler
729-733The Reversibility of Absorption Promoter Interaction with Red Blood Cell Membranes Studied with Differential Scanning CalorimetryJurij Holinej, Howard Y. Ando and Julian W. Snow
734-737Synthesis, Physicochemical Properties, and Cytotoxicity of a Series of 5′-Ester Prodrugs of 5-Iodo-2′-deoxyuridineMilind M. Narurkar and Ashim K. Mitra
738-740Effects of Dithiothreitol and Ascorbate on the Penetration of Diclofenac Across Excised Rat Dorsal SkinToshiaki Nishihata, J. Howard Rytting, Koich Takahashi and Kiyoshi Sakai
741-744Nonenzymatic and Enzymatic Hydrolysis of 5-Fluoro-2′-deoxyuridine (FUdR) EstersTakeo Kawaguchi, Shoji Fukushima, Yoshiki Hayashi and Masahiro Nakano
745-747Renal Excretion and Metabolism of p-Aminohippurate in the Isolated Perfused Rat KidneyLing-Jar Lee and David E. Smith
748Association News and Announcements

Volume 5, Number 12 / December 1988

749-752Exogenous Methemoglobin as a Cyanide Antidote in RatsGarry W. Boswell, Daniel E. Brooks, Alison J. Murray, Angelia A. Doye and David J. Disselhorst, et al.
753-758Physicochemical Aspects of Percutaneous Penetration and Its EnhancementRichard H. Guy and Jonathan Hadgraft
759-764In Vitro and In Vivo Studies Evaluating a Liposome System for Drug SolubilizationDeborah M. Lidgate, Philip L. Feigner, Jeffrey S. Fleitman, John Whatley and Roger Cherng-Chi Fu
765-771Preformulation Stability Studies of the New Dipeptide Angiotensin-Converting Enzyme Inhibitor RS-10029Leo Gu and Robert G. Strickley
772-775Limiting Solubilities and lonization Constants of Sparingly Soluble Compounds: Determination from Aqueous Potentiometric Titration Data OnlyAdriaan P. IJzerman
776-780The Effect of Compactional Pressure on Urease ActivityChing-Ling Diana Teng and Michael J. Groves
781-785An Implantable Pump for Intrarenal Infusion of Immunosuppressants in a Canine Autotransplant ModelScott A. Gruber, Robert J. Cipolle, Daniel M. Canafax, Gary R. Erdmann and Barbara A. Burke, et al.
786-789Enhancement of Colonic Drug Absorption by the Transcellular Permeation RouteMikio Tomita, Masahiro Hayashi, Toshiharu Horie, Takayuki Ishizawa and Shoji Awazu
790-794[Biocytin13]Dynorphin A 1-13 Amide: A Potential Probe for the κ-Opioid ReceptorGuenther Hochhaus, Andreas Patthy, Reinier Schwietert, Daniel V. Santi and Wolfgang Sadée
795-799Agonist-Induced Substance P Receptor Down-Regulation in Rat Central Nervous SystemAtsuko Inoue, Ryoko Takeda, Takeshi Fukuyasu, Yoshihiro Nakata and Tomio Segawa
800-802Physical Stability of a Recombinant Alpha1-Antitrypsin InjectionCheng-Der Yu, Niek Roosdorp and Shamim Pushpala
803-805Phenobarbital Stability in Different Dosage Forms: Alternatives for ElixirsNancy J. Dietz, Peter J. Cascella, Joel E. Houglum, Gary S. Chappell and Ronald M. Sieve
806Association News and Announcements
807-808Reviewers for Pharmaceutical Research (1988)
809-811Author Index to Volume 5 (1988)
812-818Subject Index to Volume 5 (1988)

Volume 6, Number 1 / January 1989

1-3Benzodiazepines: Are They of Natural Origin?Elisabeth Unseld and Ulrich Klotz
4-12Application of Mean Residence-Time Concepts to Pharmacokinetic Systems with Noninstantaneous Input and Nonlinear EliminationHaiyung Cheng and William J. Jusko
13-19Phenotypic Differences in Dextromethorphan MetabolismSantosh J. Vetticaden, Bernard E. Cabana, Vadlamani K. Prasad, Edward D. Purich and Jan H. J. Jonkman, et al.
20-27Kinetics of Drug Decomposition by Heat Conduction CalorimetryLee D. Hansen, Edwin A. Lewis, Delbert J. Eatough, Robert G. Bergstrom and Damans DeGraft-Johnson
28-32Isolation of a Novel Morphinan 3-O-Diglucuronide Metabolite from Dog UrineRoss Dixon, Jane Hsiao, Hon-Bin Hsu, Maciej Smulkowski and Tze-Ming Chan, et al.
33-39Transdermal Drug Transport and Metabolism. I. Comparison of In Vitro and In Vivo ResultsDonald B. Guzek, Alane H. Kennedy, Stephen C. McNeill, E. Wakshull and Russell O. Potts
40-43Enhanced Intestinal Absorption of Cyclosporine in Rats Through the Reduction of Emulsion Droplet SizeBryan D. Tarr and Samuel H. Yalkowsky
44-48Influence of Indomethacin Amphoteric Gel on Gastric Ulcerogenicity and Absorption of Indomethacin in RatsGary G. Liversidge, John Dent and W. Mark Eickhoff
49-52Hollow Fibers as an Oral Sustained-Release Delivery SystemMunir A. Hussain, Robert C. DiLuccio and Eli Shefter
53-57Pharmacokinetics of Furegrelate After Oral Administration to Normal HumansDuane B. Lakings, Janice M. Friis, Cynthia M. Lunan, James T. VanderLugt and J. Scott Mohrland
58-61Complex Formation Between Metronidazole and Sodium Urate: Effect on Photodegradation of MetronidazoleMuhammed J. Habib and Ahmed F. Asker
62-65Pharmacokinetics of Ketorolac and p-Hydroxyketorolac Following Oral and Intramuscular Administration of Ketorolac TromethamineDonald Jung, Edward J. Mroszczak, Anne Wu, Teck L. Ling and Hilli Sevelius, et al.
66-70Use of the Peptide Carrier System to Improve the Intestinal Absorption of L-α-Methyldopa: Carrier Kinetics, Intestinal Permeabilities, and In Vitro Hydrolysis of Dipeptidyl Derivatives of L-α-MethyldopaMing Hu, Pullachipatti Subramanian, Henry I. Mosberg and Gordon L. Amidon
71-77The Madin Darby Canine Kidney (MDCK) Epithelial Cell Monolayer as a Model Cellular Transport BarrierMoo J. Cho, David P. Thompson, Clay T. Cramer, Thomas J. Vidmar and Jeffrey F. Scieszka
78-84Neutrophil-Mediated Transport of Liposomes Across the Madin Darby Canine Kidney Epithelial Cell MonolayerMoo J. Cho, Jeffrey F. Scieszka, Clay T. Cramer, David P. Thompson and Thomas J. Vidmar
85-90lontophoretic Transport of a Homologous Series of Ionized and Nonionized Model Compounds: Influence of Hydrophobicity and Mechanistic InterpretationSam Del Terzo, Charanjit R. Behl and Robert A. Nash
91-95Rectal Absorption Enhancement of Des-Enkephalin-γ-Endorphin (DEγE) by Medium-Chain Glycerides and EDTA in Conscious RatsEwoud J. van Hoogdalem, Cornelia D. Heijligers-Feijen, Albertus G. de Boer, J. Coos Verhoef and Douwe D. Breimer
96-99Drug Delivery via Ion Exchange Across a Fiber MembraneDennis R. Jenke
100-102Reversed-Phase High-Performance Liquid Chromatographic Analysis of Oligoglycines (One to Six Amino Acid Residues)Ian G. Tucker, Martin E. Dowty, Michel Veillard, Mark A. Longer and Joseph R. Robinson
103-104Association News and Announcements

Volume 6, Number 2 / February 1989

105-118Covalent and Noncovalent Protein Binding of Drugs: Implications for Hepatic Clearance, Storage, and Cell-Specific Drug DeliveryDirk K. F. Meijer and Peter van der Sluijs
119-124Transdermal Drug Transport and Metabolism. II. The Role of Competing Kinetic EventsRussell O. Potts, Stephen C. McNeill, Charlene R. Desbonnet and E. Wakshull
125-132Procedures to Characterize In Vivo and In Vitro Enantioselective Glucuronidation Properly: Studies with Benoxaprofen GlucuronidesHildegard Spahn, Seigo Iwakawa, Emil T. Lin and Leslie Z. Benet
133-139The Area Function Method for Assessing the Drug Absorption Rate in Linear Systems with Zero-Order InputHaiyung Cheng and William J. Jusko
140-146Statistical Moment Analysis of Hepatobiliary Transport of Phenol Red in the Perfused Rat LiverKoyo Nishida, Chiaki Tonegawa, Toshiyuki Kakutani, Mitsuru Hashida and Hitoshi Sezaki
147-151Solubility Behavior of Narcotic Analgesics in Aqueous Media: Solubilities and Dissociation Constants of Morphine, Fentanyl, and SufentanilSamir D. Roy and Gordon L. Flynn
152-155Radioreceptor Assay of Metoprolol in Human Plasma: Comparison with an Enantiospecific High-Performance Liquid Chromatographic (HPLC) ProcedureHildegard Spahn, Anton Wellstein, Gabriele Pflugmann, Ernst Mutschler and Dieter Palm
156-159Drug Binding to α1-Acid Glycoprotein Studied by Circular DichroismMasaki Otagiri, Ryuji Yamamichi, Toru Marayama, Teruko Imai and Ayaka Suenaga, et al.
160-166Cultured Buccal Epithelium: An In Vitro Model Derived from the Hamster Pouch for Studying Drug Transport and MetabolismM. Reza Tavakoli-Saberi and Kenneth L. Audus
167-170An In Vitro Model to Evaluate Muscle Damage Following Intramuscular InjectionsGayle A. Brazeau and Ho-Leung Fung
171-176Synthesis of Palmitoyl Derivatives of Insulin and Their Biological ActivitiesMuneaki Hashimoto, Kanji Takada, Yoshiaki Kiso and Shozo Muranishi
177-181The Determination of Microscopic lonization Constants of a Substituted Piperazine Using Estimates from Model CompoundsNivedita K. Pandit and John M. Sisco
182-185Racial Differences in Drug Response: Isoproterenol Effects on Heart Rate in Healthy MalesDavid R. Rutledge, Lavoisier Cardozo and Joel D. Steinberg
186-189The Use of α-Aminoboronic Acid Derivatives to Stabilize Peptide Drugs During Their Intranasal AbsorptionMunir A. Hussain, Ashok B. Shenvi, Susan M. Rowe and Eli Shefter
190Association News and Announcements

Volume 6, Number 3 / March 1989

191Editorial
192-202Receptor-Mediated Transport of Peptide Hormones and Its Importance in the Overall Hormone Disposition in the BodyYuichi Sugiyama and Manabu Hanano
203-209Binding of Sulfonamides to Carbonic Anhydrase: Influence on Distribution Within Blood and on PharmacokineticsAlan Boddy, Phillip Edwards and Malcolm Rowland
210-215Dehydration Kinetics of Prostaglandin E1 in a Lipid EmulsionDirk L. Teagarden, Bradley D. Anderson and William J. Petre
216-224Synthesis and Biological Evaluation of Ether-Linked Derivatives of PhosphatidylinositolKhalid S. Ishaq, Maria Capobianco, Claude Piantadosi, Alessandro Noseda and Larry W. Daniel, et al.
225-229Optimized Inhalation Aerosols. I. The Effects of Spherical Baffle Size and Position upon the Output of Several Pressurized Nonaqueous Suspension FormulationsPeter R. Byron, Richard N. Dalby and Anthony J. Hickey
230-234The Hypolipidemic Activity of l-N-3-Methylphthalimido-butan-3-semicarbazone in RodentsOi T. Wong, Iris H. Hall and James M. Chapman
235-238Uptake of Colchicine, a Microtubular System Disrupting Agent, by Isolated Rat HepatocytesKonstanty Wierzba, Yuichi Sugiyama, Kazuho Okudaira, Tatsuji Iga and Manabu Hanano
239-243Controlled Release of Steroids Through Microporous Membranes with Sodium Dodecyl Sulfate MicellesKeith A. Johnson, Gerald B. Westermann-Clark and Dinesh O. Shah
244-247Structure/Effect Studies of Fatty Acid Isomers as Skin Penetration Enhancers and Skin IrritantsBruce J. Aungst
248-251Nonlinear Distribution of Atenolol Between Plasma and Cerebrospinal FluidFrancis M. Gengo, Susan C. Pagan, L. Nelson Hopkins, Debby Wagner and David P. Schuster
252-254The Antiarrhythmic Activity of N- Alkyl-1,2-diphenylethanolaminesKamal E. H. El Tahir, Humeida A. Al-Obeid, Khalid A. Al-Rashood, Abdul Azim E. Madani and Abdulrahman M. Ageel
255-257The Effect of End-to-Side Portacaval Shunt on Cyclosporine Pharmacokinetics in RatsJoachim Grevel, Paolo Rigotti, Franco Citterio, Mario Plebani and Barry D. Kahan
258-261Mean Residence Time of Drugs Showing Simultaneous First-Order and Michaelis–Menten Elimination KineticsHaiyung Cheng and William J. Jusko
262Association News and Announcements

Volume 6, Number 4 / April 1989

265-273Idiosyncratic Drug Reactions: Possible Role of Reactive Metabolites Generated by LeukocytesJack P. Uetrecht
274-278Correlation of Phenylpropanolamine Bioavailability with Gastrointestinal Transit by Scintigraphic Monitoring of 111In-Labeled Hydroxypropylmethylcellulose MatricesLiam C. Feely and Stanley S. Davis
279-285Experimental Animal Models for Studying Antimicrobial Pharmacokinetics in Otitis MediaDaniel M. Canafax, Naobumi Nonomura, Gary R. Erdmann, Chap T. Le and Steven K. Juhn, et al.
286-295New Alkyl N,N-Dialkyl-Substituted Amino Acetates as Transdermal Penetration EnhancersOoi Wong, James Huntington, Toshiaki Nishihata and J. Howard Rytting
296-301Protein Precoating of Polylactide Microspheres Containing a Lipophilic Immunopotentiator for Enhancement of Macrophage Phagocytosis and ActivationYasuhiko Tabata and Yoshito Ikada
302-307Transport Characteristics of Ceftibuten (7432-S), a New Oral Cephem, in Rat Intestinal Brush-Border Membrane Vesicles: Proton-Coupled and Stereoselective Transport of CeftibutenTakayoshi Yoshikawa, Noriyuki Muranushi, Mariko Yoshida, Takayoshi Oguma and Koichiro Hirano, et al.
308-312Transport Characteristics of Ceftibuten, a New Oral Cephem, in Rat Intestinal Brush-Border Membrane Vesicles: Relationship to Oligopeptide and Amino β-Lactam TransportNoriyuki Muranushi, Takayoshi Yoshikawa, Mariko Yoshida, Takayoshi Oguma and Koichiro Hirano, et al.
313-317Zero-Order Release Formulation of Oxprenolol Hydrochloride with Swelling and Erosion ControlKanikanti Padmalatha Devi, Kanikanti V. Ranga Rao, Srikrishan Baveja, Marc Fathi and Marc Roth
318-322Biologic Activity of 5′-Deoxy-5-fluorouridine by Rectal AdministrationSteven L. Bramer, Lena C. Gunnarsson and J. Lai-Sim Au
323-327Absorption of 5′-Deoxy-5-fluorouridine from ColonJ. Lai-Sim Au and Lena C. Gunnarsson
328-331Intra- and Intersubject Variability: Mixed-Effects Statistical Analysis of Repeated Doses of an Angiotensin Converting Enzyme Inhibitor, CGS 16617Gregory M. Kochak, Robert A. Smith, R. Leslie Choi, Vivian John and Vijay Tipnis, et al.
332-337Nutrient Influences on Rat Intestinal Phenytoin UptakeDavid Fleisher, Neel Sheth, Heidi Griffin, Martin McFadden and Gregory Aspacher
338-341Evaluation of Polyvinyl Alcohol Hydrogel as a Sustained-Release Vehicle for Rectal Administration of IndomethacinKazuhiro Morimoto, Atsushi Nagayasu, Shinichi Fukanoki, Katsuaki Morisaka and Suong-Hyu Hyon, et al.
342-345Tissue Distribution of Cisplatin After Hepatic Arterial Injection of a Cisplatin–Lipiodol Suspension Containing Phosphatidylcholine to Rabbits Carrying VX-2 Hepatic CarcinomaMikiro Nakashima, Mihoko Nakano, Yoshikazu Ishii, Kenji Matsuyama and Masataka Ichikawa, et al.
346-351In Vitro Release Profiles of Clonidine Transdermal Therapeutic Systems and Scopolamine Transdermal PatchesVinod P. Shah, Norlin W. Tymes and Jerome P. Skelly
352-353Association News and Announcements

Volume 6, Number 5 / May 1989

355-361Drug Delivery by PhonophoresisPraveen Tyle and Praful Agrawala
362-366Interactions Between Aminoglycosides and Phospholipids Using Liposomes: A Possible Mechanism of NephrotoxicityYukihiko Aramaki and Seishi Tsuchiya
367-372Efficiency of Drug Targeting: Steady-State Considerations Using a Three-Compartment ModelAlan Boddy, Leon Aarons and Karel Petrak
373-378Evaluating the Fracture Toughness of Sucrose Crystals Using Microindentation TechniquesWendy C. Duncan-Hewitt and George C. Weatherly
379-386Multiple-Dose Pharmacokinetics and Pharmacodynamics of Adinazolam in Elderly SubjectsJoseph C. Fleishaker, J. Paul Phillips, Thomas C. Smith and Randall B. Smith
387-393Kinetics of the Aspartyl Transpeptidation of Daptomycin, a Novel Lipopeptide AntibioticLee E. Kirsch, R. Michael Molloy, Manual Debono, Patrick Baker and Khadiga Z. Farid
394-398Study on the Renal and Cardiovascular Activities of Aminouracil DerivativesAli A. Mustafa, Abdulgader A. Alhaider and Abdullah A. Hijazi
399-403Correlation of Partitioning of Nitroimidazoles in the n-Octanol/Saline and Liposome Systems with Pharmacokinetic Parameters and Quantitative Structure–Activity Relationships (QSAR)Gurupadappa V. Betageri and James A. Rogers
404-407Kinetics of Drug Action in Disease States. XXXI. Effect of Experimental Hyperthyroidism on the Hypnotic Activity of a Benzodiazepine (Oxazepam) in RatsJudith S. Walker, Patricia M. Klockowski and Gerhard Levy
408-412Preformulation Study of Etoposide: Identification of Physicochemical Characteristics Responsible for the Low and Erratic Oral Bioavailability of EtoposideJaymin C. Shah, Jivn R. Chen and Diana Chow
413-417A Novel Approach to the Oral Delivery of Micro- or NanoparticlesRoland Bodmeier, Huagang Chen and Ornlaksana Paeratakul
418-421Effect of Drug (Core) Particle Size on the Dissolution of Theophylline from Microspheres Made from Low Molecular Weight Cellulose Acetate PropionateAtul J. Shukla and James C. Price
422-427Synthesis of Gelatin Microspheres Containing InterferonYasuhiko Tabata and Yoshito Ikada
428-430Analysis of Diltiazem and Desacetyldiltiazem in Plasma Using Modified High-Performance Liquid Chromatography: Improved Sensitivity and ReproducibilityHong Zhao and Moses S. S. Chow
431-435In Vitro Diffusion Cell Design and Validation. I. A Stability-Indicating High-Performance Liquid Chromatographic Assay for Betamethasone 17-Valerate in Purified Isopropyl Myristate Receptor PhaseEric W. Smith and John M. Haigh
436-437Letter to the EditorKenneth J. Himmelstein
438-439Letter to the EditorBernhard Palsson, Sadettin Ozturk and Jennifer B. Dressman
440-441Association News and Announcements

Volume 6, Number 6 / June 1989

443-448Facilitated Transport of Basic and Acidic Drugs in Solutions Through Snakeskin by a New Enhancer—Dodecyl N,N-Dimethylamino AcetateChristine Flecker, Ooi Wong and J. Howard Rytting
449-457The Role of Calcium Ions and Bile Salts on the Pancreatic Lipase-Catalyzed Hydrolysis of Triglyceride Emulsions Stabilized with LecithinFrancisco J. Alvarez and Valentine J. Stella
458-465Stability of Phenobarbital N-Glucosides: Identification of Hydrolysis Products and Kinetics of DecompositionFloyd B. Vest, William H. Soine, Richard B. Westkaemper and Phyllis J. Soine
466-473Permeability and Mechanism of Albumin, Cationized Albumin, and Glycosylated Albumin Transcellular Transport Across Monolayers of Cultured Bovine Brain Capillary Endothelial CellsKevin R. Smith and Ronald T. Borchardt
474-476Synthesis and Receptor Binding Studies of (±)l-Iodo-MK-801David J. Yang, Brian J. Ciliax, Marcian E. Van Dort, David L. Gildersleeve and Jean-Luc Pirat, et al.
477-480Effect of the Immunomodulator Tilorone on the in Vivo Acetylation of Procainamide in the RatCraig K. Svensson and Philip W. Knowlton
481-485Pharmacokinetics and Oral Bioavailability of Scopolamine in Normal SubjectsLakshmi Putcha, Nitza M. Cintrón, James Tsui, James M. Vanderploeg and William G. Kramer
486-491Prediction of the Distribution Volumes of Cefazolin and Tobramycin in Obese Children Based on Physiological Pharmacokinetic ConceptsRie Koshida, Emi Nakashima, Noboru Taniguchi, Akira Tsuji and Leslie Z. Benet, et al.
492-496Pharmacokinetics of Platinum in Cancer Patients Treated with Carboplatin in Combination with High-Dose MethotrexateAdnan El-Yazigi, Magid Amer and Cazemiro R. Martin
497-500Differential Molecular Connectivity in Data-Base Fragment SearchingLemont B. Kier and Lowell H. Hall
501-505Short-Chain Alkyl Esters of L-Dopa as Prodrugs for Rectal AbsorptionJoseph A. Fix, Jose Alexander, Margot Cortese, Karen Engle and Paula Leppert, et al.
506-509Controlled Gastric Emptying. II. In Vitro Erosion and Gastric Residence Times of an Erodible Device in Beagle DogsRobyn Cargill, Karen Engle, Colin R. Gardner, Patricia Porter and Randall V. Sparer, et al.
510-516Side-Effect Evaluation of a New Diazepam Formulation: Venous Sequela Reduction Following Intravenous (iv) Injection of a Diazepam Emulsion in RabbitsMenashe Yoram Levy, Lev Langerman, Shoshanna Gottschalk-Sabag and Simon Benita
517-520Modification of Gelatin Beadlets for Zero-Order Sustained ReleaseCharles S. L. Chiao and James C. Price
521-524Determination of Reserpine by Circular DichroismKathy A. Swallows and Neil Purdie
525-527Summary of Drug Needs in Cystic FibrosisRichard C. Boucher and Robert J. Beall
528ERRATUM
529Association News and Announcements

Volume 6, Number 7 / July 1989

531-554Current Aspects of Practical Two-Dimensional (2D) Nuclear Magnetic Resonance (NMR) Spectroscopy: Applications to Structure ElucidationRichard W. Kriwacki and T. Phil Pitner
555-563Pancreatic Lipase-Catalyzed Hydrolysis of Esters of Hydroxymethyl Phenytoin Dissolved in Various Metabolizable Vehicles, Dispersed in Micellar Systems, and in Aqueous SuspensionsFrancisco J. Alvarez and Valentine J. Stella
564-570Temperature Dependence of Non-Fickian Water Transport and Swelling in Glassy Gelatin MatricesCathy M. Klech and Jill H. Pari
571-577Profile of in Vitro Binding Affinities of Neuroleptics at Different Rat Brain Receptors: Cluster Analysis Comparison with Pharmacological and Clinical ProfilesRodolfo Testa, Gianalfredo Abbiati, Roberto Ceserani, Gianvico Restelli and Alessandro Vanasia, et al.
578-584Effect of Polymeric Network Structure on Drug Release from Cross-Linked Poly(Vinyl Alcohol) MicromatricesBruno Gander, Robert Gurny, Eric Doelker and Nikolaos A. Peppas
585-591Relationship Between Receptor Occupancy at 37°C and the Anticonvulsant Effect of Flunitrazepam in RatsMarijke Hollander-Jansen, Jasper Dingemanse, Mariska W. E. Langemeijer and Meindert Danhof
592-600Effects of a Brain-Enhanced Chemical Delivery System for Estradiol on Body Weight and Food Intake in Intact and Ovariectomized RatsJames W. Simpkins, Wesley R. Anderson, Ralph Dawson and Nicholas Bodor
601-607Liposomal Formulation Eliminates Acute Toxicity and Pump Incompatibility of Parenteral CyclosporineScott A. Gruber, Suresh Venkataram, Daniel M. Canafax, Robert J. Cipolle and Larry Bowers, et al.
608-611Quantitative Fourier Transform-Infrared/Attenuated Total Reflectance (FT-IR/ATR) Analysis of Trimethoprim and Sulfamethoxazole in a Pharmaceutical Formulation Using Partial Least SquaresKerry J. Hartauer and J. Keith Guillory
612-618In Vitro Dissolution Profile of Water-Insoluble Drug Dosage Forms in the Presence of SurfactantsVinod P. Shah, John J. Konecny, Richard L. Everett, Brace McCullough and A. Carol Noorizadeh, et al.
619-623In Vitro Adsorption of Bile Salts by Colestipol HydrochlorideThomas J. Konechnik, Rosemary Kos, Joe L. White, Stanley L. Hem and Marie T. Borin
624-627The Application of Bovine Brain Microvessel Endothelial-Cell Monolayers Grown onto Polycarbonate Membranes in Vitro to Estimate the Potential Permeability of Solutes Through the Blood–Brain BarrierMandar V. Shah, Kenneth L. Audus and Ronald T. Borchardt
628-632Enhanced in Vitro Skin Permeation of Cationic DrugsPhilip G. Green, Jonathan Hadgraft and Geoffrey Ridout
633-636The Influence of Liposomal Encapsulation on Sodium Cromoglycate Pharmacokinetics in ManKevin M. G. Taylor, Glyn Taylor, Ian W. Kellaway and John Stevens
637-640Kmeriol and Other Aromatic Constituents of Kmeria DuperreanaXiaoping Dong, Ing-On Mondranondra, Chun-tao Che, Harry H. S. Fong and Norman R. Farnsworth
641-646Testosterone in a Cyclodextrin-Containing Formulation: Behavioral and Physiological Effects of Episode-like Pulses in RatsGeorge T. Taylor, Jürgen Weiss and Josef Pitha
647-649Association News and Announcements

Volume 6, Number 8 / August 1989

651-659Endothelium-Derived Nitric Oxide: Pharmacology and Relationship to the Actions of Organic Nitrate EstersLouis J. Ignarro
660-666Route of Administration and Sex Differences in the Pharmacokinetics of Aspirin, Administered as Its Lysine SaltLeon Aarons, Katie Hopkins, Malcolm Rowland, S. Brossel and Jean-François Thiercelin
667-676Improved Delivery Through Biological Membranes. XXXVII. Synthesis and Stability of Novel Redox Derivatives of Naproxen and IndomethacinMichael J. Phelan and Nicholas Bodor
677-682A Pharmacokinetic Model of Intravenously Administered Hyaluronan in SheepLena Lebel, J. Robert E. Fraser, Wayne S. Kimpton, Johan Gabrielsson and Bengt Gerdin, et al.
683-689Structure–Pharmacokinetic Relationships in a Series of Valpromide Derivatives with Antiepileptic ActivityAbdulla Haj-Yehia and Meir Bialer
690-696Saturable Process Involved in Active Efflux of Vincristine as a Mechanism of Multidrug Resistance in P388 Leukemia CellsTohru Watanabe, Makoto Inaba and Yuichi Sugiyama
697-701The Effect of Ultrasound on the in Vitro Penetration of Ibuprofen Through Human EpidermisRichard Brucks, Maulik Nanavaty, Donald Jung and Frederick Siegel
702-705A Retrospective Analysis of Fenoldopam Renal Excretion in 65 Subjects: Evidence for Possible Intrarenal Formation of Fenoldopam from Its MetabolitesJohn A. Ziemniak, Venkata K. Boppana, Matthew J. Cyronak and Robert M. Stote
706-708A Nuclear Magnetic Resonance (NMR) Method for the Determination of the cis/trans Isomeric Content of ChlorprothixeneKarl-Heinz A. Rosler, Jeremy Wright, Kristine M. Fox, Rolland M. Waters and Patrick S. Callery
709-713A Comparison of the Cholinergic Activity of Selected H2-Antagonists and Sulfoxide MetabolitesJoseph W. Kosh, J. Walter Sowell and James M. Chapman
714-718Nylon Microcapsules. II. Effect of Selected Variables on Theophylline ReleaseP. L. Madan and P. Chareonboonsit
719-724Gastrointestinal Transit of a Solid Indigestible Capsule as Measured by Radiotelemetry and Dual Gamma ScintigraphyParviz Mojaverian, Keith Chan, Anil Desai and Vivian John
725-730Evaluation of Drug-Containing Polymer Films Prepared from Aqueous LatexesRoland Bodmeier and Ornlaksana Paeratakul
731-733Noncompartmental Analysis for a One-Compartment Model with Equal Absorption and Elimination Rate ConstantsHoward Ko, James F. Caputo and Wade J. Adams
734-736Dose-Ranging Pharmacokinetics of Zidovudine (Azidothymidine) in the RatJashvant D. Unadkat, Ji Ping Wang, David Pulham and Robin L. O. Semmes
737-739Phosphorus–Nitrogen Compounds. 31. N-Phosphinylamino-1,2,5,6-tetrahydropyridines: Analgesic Activity and Effect on Blood GlucoseLindley A. Cates, Ven-Shun Li and Sharathchandra S. Hegde
740-741A Simple Microwave Technique for the Separation of Epidermis and Dermis in Skin Uptake StudiesSaran Kumar, Charan R. Behl, Sunil B. Patel and A. Waseem Malick
742Association News and Announcements

Volume 6, Number 9 / September 1989

743-747Ion Pair Transport Across MembranesReinhard Neubert
748-752Formulation of Vaccine Adjuvant Muramyldipeptides. 3. Processing Optimization, Characterization, and Bioactivity of an Emulsion VehicleDeborah M. Lidgate, Roger C. Fu, Noelene E. Byars, Linda C. Foster and Jeffrey S. Fleitman
753-758Transdermal Controlled Delivery of Propranolol from a Multilaminate Adhesive DeviceMichael Corbo, Jue-Chen Liu and Yie W. Chien
759-765Evidence for Site-Specific Absorption of a Novel ACE InhibitorGeorge M. Grass and William T. Morehead
766-771Use of an in Vitro Model for the Assessment of Muscle Damage from Intramuscular Injections: in Vitro-in Vivo Correlation and Predictability with Mixed Solvent SystemsGayle A. Brazeau and Ho-Leung Fung
772-778The Kinetics of Timolol in the Rabbit Lens: Implications for Ocular Drug DeliveryImran Ahmed, Michael L. Francoeur, Avinash G. Thombre and Thomas F. Patton
779-786Amino Acids Bracketing the Predicted Transmembrane Domains of Membrane ProteinsCharles Pidgeon, Renee L. Williard and Susan C. Schroeder
787-793Chloroquine Blood Levels After Administration of the Liposome-Encapsulated Drug in Relation to Therapy of Murine MalariaPierre A. M. Peeters, Karen de Leest, Wijnand M. C. Eling and Daan J. A. Crommelin
794-797Effect of Anions on Adsorption of Bile Salts by Colestipol HydrochlorideChristine V. Bilicki, Joe L. White, Stanley L. Hem and Marie T. Borin
798-803Dose-Dependent Enhancement Effects of Azone on Skin PermeabilityWilliam J. Lambert, William I. Higuchi, Kristine Knutson and Steven L. Krill
804-808Solid-State Interaction of Magnesium Oxide and Ibuprofen to Form a SaltTugrul T. Kararli, Thomas E. Needham, Clifford J. Seul and Pat M. Finnegan
809-812A Graph-Theoretical Approach to the Prediction of Physical Properties of Alkanes Based on the Distance MatrixJames F. Caputo and Kathleen J. Cook
813-816Enhanced Bioavailability of Subcutaneously Injected Insulin Coadministered with Collagen in Rats and HumansRyohei Hori, Fusao Komada, Seigo Iwakawa, Yutaka Seino and Katsuhiko Okumura
817-821Estimation of Bioavailability on a Single Occasion After Semisimultaneous Drug AdministrationMats O. Karlsson and Ulf Bredberg
822-823Association News and Announcements

Volume 6, Number 10 / October 1989

825-832Transdermal Delivery of Narcotic Analgesics: Comparative Permeabilities of Narcotic Analgesics Through Human Cadaver SkinSamir D. Roy and Gordon L. Flynn
833-839Erythrocytes as Barriers for Drug Elimination in the Isolated Rat Liver. I. DoxorubicinHye-Jung Lee and Win L. Chiou
840-843Erythrocytes as Barriers for Drug Elimination in the Isolated Rat Liver. II. PropranololHye-Jung Lee and Win L. Chiou
844-847Polyvinyl Alcohol–Methyl Acrylate Copolymers as a Sustained-Release Oral Delivery SystemRobert C. DiLuccio, Munir A. Hussain, David CoffinBeach, George Torosian and Eli Shefter, et al.
848-852Drug Absorption Through Mucosal Membranes: Effect of Mucosal Route and Penetrant HydrophilicityDiane C. Corbo, Jue-Chen Liu and Yie W. Chien
853-856Absorption Enhancement of Intranasally Administered Insulin by Sodium Taurodihydrofusidate (STDHF) in Rabbits and RatsMarc J. M. Deurloo, Walter A. J. J. Hermens, Stefan G. Romeyn, J. Coos Verhoef and Frans W. H. M. Merkus
857-862A Correlation of Permeabilities for Passively Transported Compounds in Monkey and Rabbit JejunumGeorge M. Grass and Stephanie A. Sweetana
863-866Effect of Uridine Diphosphoglucose on Levels of 5-Phosphoribosyl Pyrophosphate and Uridine Triphosphate in Murine TissuesJoseph R. Colofiore, Robert C. Sawyer, M. Earl Balis and Daniel S. Martin
867-873Synthesis and Biological Evaluation of Ω-(N,N,N-Trialkylammonium)alkyl Esters and Thioesters of Carboxylic Acid Nonsteroidal Antiinflammatory AgentsMichael C. Venuti, John M. Young, Patrick J. Maloney, David Johnson and Kenneth McGreevy
874-876Influence of Unbound Fraction and Perfusate Flow Rate on Taurocholate Elimination by Perfused Rat Liver: Applicability of Three Distributed ModelsDenis J. Morgan
877-882Contribution of Monoamine Oxidase (MAO) to the Binding of Tertiary Basic Drugs in Lung MitochondriaHisahiro Yoshida, Akira Kamiya, Katsuhiko Okumura and Ryohei Hori
883-886Antiperspirant Activity of H1-Histamine Blockers as Determined by a Modified Rat Foot Pad AssayMichael D. Helman, Thomas A. Re and Alison B. Lukacsko
887-891Prodrugs of 5-Iodo-2′-Deoxyuridine for Enhanced Ocular TransportMilind M. Narurkar and Ashim K. Mitra
892-894Gas Chromatographic/Mass Spectrometric (GC/MS) Analysis of N-Nitrosodiisopropanolamine at the Nanogram-per-Gram Level in a Gel Formulation Containing a Nonsteroidal Antiinflammatory AgentJohn C. James, Michael J. Pastel, Katherine A. Ledoux and John M. Baldoni
895-899Analytical Method for the Quantification of 2′,3′-Didehydro-3′-Deoxythymidine, a New Anti-Human Immunodeficiency Virus (HIV) Agent, by High-Performance Liquid Chromatography (HPLC) and Ultraviolet (UV) Detection in Rat and Monkey PlasmaSanjeev Kaul, Kishor A. Dandekar and Kenneth A. Pittman
900BOOK REVIEWS
901Association News and Announcements

Volume 6, Number 11 / November 1989

903-918Stability of Protein PharmaceuticalsMark C. Manning, Kamlesh Patel and Ronald T. Borchardt
919-923Macromolecular Prodrugs. XV. Colon-Targeted Delivery—Bioavailability of Naproxen from Orally Administered Dextran–Naproxen Ester Prodrugs Varying in Molecular Size in the PigElin Harboe, Claus Larsen, Marianne Johansen and Henning Peter Olesen
924-932Quantitative Whole-Body Autoradiographic Determination of Tacrine Tissue Distribution in Rats Following Intravenous or Oral DoseWilliam McNally, Michelle Roth, Remedios Young, Howard Bockbrader and Tsun Chang
931-937Analysis of Drug Penetration Through the Skin by the Two-Layer Skin ModeHirokazu Okamoto, Fumiyoshi Yamashita, Kyoko Saito and Mitsuru Hashida
938-944Transdermal Delivery of Levonorgestrel. V. Preparation of Devices and Evaluation in VitroDavid R. Friend, Paul Catz, Jorge Heller and Michael Okagaki
945-948Design and in Vitro Evaluation of Dapsone-Loaded Micropellets of Ethyl CelluloseSuranjana Roy, Sudip K. Das, Manjusree Pal and Bijan K. Gupta
949-953Assessment of Skin Barrier Function Using Transepidermal Water Loss: Effect of AgeKathleen V. Roskos and Richard H. Guy
954-957Decreased Transport of p-Aminohippurate in Renal Basolateral Membranes Isolated from Rats with Acute Renal FailureKen-ichi Inui, Mikihisa Takano, Hitoshi Maegawa, Miyako Kato and Ryohei Hori
958-960Solid Surfactant Solutions of Active Ingredients in Sugar EstersLorenz Hahn and Heinz Sucker
961-965Near-Infrared Spectroscopic Determination of Residual Moisture in Lyophilized Sucrose Through Intact Glass VialsMadhav S. Kamat, Robert A. Lodder and Patrick P. DeLuca
966-970Buccal Absorption. III. Simultaneous Diffusion and Metabolism of an Aminopeptidase Substrate in the Hamster Cheek PouchKevin W. Garren, Elizabeth M. Topp and A. J. Repta
971-975An Unexpected pH Effect on the Stability of Moexipril Lyophilized PowderRobert G. Strickley, Gary C. Visor, Li-Hwa Lin and Leo Gu
976-981Gender Differences in the Pharmacodynamics of Barbiturates in RatsAmnon Hoffman and Gerhard Levy
982-987Microbial Models of Mammalian Metabolism: Stereoselective Metabolism of Warfarin in the Fungus Cunninghamella elegansYiu W. J. Wong and Patrick J. Davis
988-990Noninvasive Sampling of Biological Fluids by IontophoresisPeretz Glikfeld, Robert S. Hinz and Richard H. Guy
991-993High-Performance Liquid Chromatographic Determination and Pharmacokinetics of Methyl N-[5[[4-(2-Pyridinyl)-l-piperazinyl]carbonyl]-1H-benzimidazol-2-yl] Carbamate (CDRI Compound 81-470), a New Anthelmintic Agent in RatsJyoti Kumar Paliwal, Ram Chandra Gupta and Pyara Krishen Grover
994Association News and Announcements

Volume 6, Number 12 / December 1989

995-999Macromolecular Prodrugs. XVI. Colon-Targeted Delivery—Comparison of the Rate of Release of Naproxen from Dextran Ester Prodrugs in Homogenates of Various Segments of the Pig Gastrointestinal (GI) TractClaus Larsen, Elin Harboe, Marianne Johansen and Henning Peter Olesen
1000-1010Transdermal Dual-Controlled Delivery of Contraceptive Drugs: Formulation Development, in Vitro and in Vivo Evaluations, and Clinical PerformanceYie W. Chien, Te-yen Chien, Robert E. Bagdon, Yih C. Huang and Robert H. Bierman
1011-1016Noninvasive Assessment of Lipid Disposition in Treated and Untreated Atherosclerotic RabbitsLaura E. DeForge, Susan W. Schwendner, Mark R. DeGalan, Daniel S. McConnell and Raymond E. Counsell
1017-1024Determination of the Relative Amounts of Anhydrous Carbamazepine (C15H12N2O) and Carbamazepine Dihydrate (C15H12N2O · 2H2O) in a Mixture by Powder X-ray DiffractometryRaj Suryanarayanan
1025-1031Intrahepatic Delivery of Glutathione by Conjugation to DextranYoshiharu Kaneo, Yumie Fujihara, Tetsuro Tanaka, Yoko Kozawa and Hideki Mori, et al.
1032-1038Dextrose Adduct Formation in Aqueous Teicoplanin SolutionsWilliam H. Streng and Nicholas W. Brake
1039-1042The Beagle Dog as an Animal Model for a Bioavailability Study of Controlled-Release Theophylline Under the Influence of FoodGerald K. Shiu, Armelle LeMarchand, Arlan O. Sager, Raja B. Velagapudi and Jerome P. Skelly
1043-1047Passive and Carrier-Mediated Intestinal Absorption Components of Two Angiotensin Converting Enzyme (ACE) Inhibitor Prodrugs in Rats: Enalapril and FosinoprilDoron I. Friedman and Gordon L. Amidon
1048-1051High Performance Liquid Chromatographic (HPLC) Determination of Centchroman in Human Serum and Application to Single-Dose PharmacokineticsJyoti Kumar Paliwal, Ram Chandra Gupta, Pyara Krishen Grover, Omkar P. Asthana and Jagdishwar Sahai Srivastava, et al.
1052-1055Hollow Fibers as an Oral Sustained-Release Delivery System Using Propranolol HydrochlorideMunir A. Hussain, Robert C. DiLuccio, Eli Shefter and Arthur R. Hurwitz
1056-1059Effect of a Change in the Luminal Perfusion Rate on Intestinal Drug Absorption Studied by a Simple Unified Organ Clearance ApproachWin L. Chiou
1060-1066Evaluating the Deformation Kinetics of Sucrose Crystals Using Microindentation TechniquesWendy C. Duncan-Hewitt and George C. Weatherly
1067-1072Pharmacokinetics of Sulfasalazine Metabolites in Rats Following Concomitant Oral Administration of RiboflavinVinod S. Chungi, Lewis W. Dittert and Leon Shargel
1073Association News and Announcements
1074-1076Reviewers for Pharmaceutical Research (1989)
1077-1079Author Index to Volume 6 (1989)
1080-1088Subject Index to Volume 6 (1989)

Volume 7, Number 1 / January 1990

1-7Amplification of Butyrylcholinesterase and Acetylcholinesterase Genes in Normal and Tumor Tissues: Putative Relationship to Organophosphorous PoisoningHermona Soreq and Haim Zakut
8-13Solute Absorption from the Airways of the Isolated Rat Lung. II. Effect of Surfactants on Absorption of FluoresceinRalph W. Niven and Peter R. Byron
14-20Pharmacokinetics of Methylergometrine in the Rat: Evidence for Enterohepatic Recirculation by a Linked-Rat ModelUlf Bredberg and Lennart Paalzow
21-27Irreversible Binding of Tolmetin Glucuronic Acid Esters to Albumin in VitroAlain Munafo, Antony F. McDonagh, Philip C. Smith and Leslie Z. Benet
28-33Conversion of Ouabain-Induced Ventricular Tachycardia in Dogs with Epicardial Lidocaine: Pharmacodynamics and Functional EffectsAmnon Sintov, William A. Scott, Kim P. Gallagher and Robert J. Levy
34-40Enhancement of the in Vitro Skin Permeability of Azidothymidine (AZT) via Iontophoresis and Chemical EnhancerLorraine Wearley and Yie W. Chien
41-45Differential Effects of Anesthetic Regimens on Gentamicin Pharmacokinetics in the Rat: A Comparison with Chronically Catheterized Conscious AnimalsMark Gumbleton, Paul J. Nicholls and Glyn Taylor
46-48High-Fat Meals Increase the Clearance of CyclosporineSuneel K. Gupta and Leslie Z. Benet
49-53Mucoadhesion of Hydroxypropylmethacrylate Nanoparticles to Rat Intestinal Ileal Segments in VitroClara Pimienta, Vincent Lenaerts, Céline Cadieux, Philippe Raymond and Julianna Juhasz, et al.
54-58Plasma Concentrations of Remoxipride and the Gastrointestinal Transit of 111ln-Marked Extended-Release Coated SpheresChristina Graffner, Zoltan Wagner, Maj-Inger Nilsson and Erik Widerlöv
59-63Effects of First-Pass Metabolism on Metabolite Mean Residence Time Determination After Oral Administration of Parent DrugKeith K. H. Chan and Milo Gibaldi
64-68Percutaneous Penetration of Acyclovir Through Excised Hairless Mouse and Rat Skin: Effect of Vehicle and Percutaneous Penetration EnhancerHirokazu Okamoto, Kenji Muta, Mitsuru Hashida and Hitoshi Sezaki
69-75Model of Disposition of Drugs Administered into the Human Nasal CavityIgor Gonda and Elizabeth Gipps
76-79Effects of Variation in Drug Elimination on Five Methods for Assessing Zero-Order Drug Absorption RatesHaiyung Cheng and William J. Jusko
80-86Intrinsic Dissolution Rates of Tablet Filler-Binders and Their Influence on the Dissolution of Drugs from Tablet FormulationsArun D. Koparkar, Larry L. Augsburger and Ralph F. Shangraw
87-90The Biliary Elimination and Enterohepatic Circulation of Ibuprofen in RatsKlaus Dietzel, Winfried S. Beck, Hans-Th. Schneider, Gerd Geisslinger and Kay Brune
91-95Effect of Aliphatic Side-Chain Substituents on the Antimalarial Activity and on the Metabolism of Primaquine Studied Using Mitochondria and Microsome PreparationsJohn K. Baker, Robert H. Yarber, N. P. D. Nanayakkara, James D. McChesney and Frederic Homo, et al.
96-102The Effects of Urine pH Modification on the Pharmacokinetics and Pharmacodynamics of PhenylpropanolamineCheryl L. Zimmerman, Mary Beth O'Connell and Inmaculada Soria
103-107Mean Residence Times of Multicompartmental Drugs Undergoing Reversible MetabolismHaiyung Cheng and William J. Jusko
108-109Reimbursement for Drugs Under Third-Party ProgramsFrancis B. Palumbo
110BOOK REVIEWS
111Editorial
112Association News and Announcements

Volume 7, Number 2 / February 1990

113-117Percolation Theory and Compactibility of Binary Powder SystemsDieter Blattner, Max Kolb and Hans Leuenberger
118-126Transport Mechanisms in Iontophoresis. I. A Theoretical Model for the Effect of Electroosmotic Flow on Flux Enhancement in Transdermal IontophoresisMichael J. Pikal
127-133Bile Salt–Fatty Acid Mixed Micelles as Nasal Absorption Promoters of Peptides. I. Effects of Ionic Strength, Adjuvant Composition, and Lipid Structure on the Nasal Absorption of [D-Arg2]KyotorphinParkpoom Tengamnuay and Ashim K. Mitra
134-143DC Electrical Properties of Frozen, Excised Human SkinGerald B. Kasting and Lisa A. Bowman
144-146Effects of Absorption Enhancers on Human Nasal Tissue Ciliary Movement in VitroWalter A. J. J. Hermens, Piet M. Hooymans, J. Coos Verhoef and Frans W. H. M. Merkus
147-153Solid-State Chemistry and Crystal Structure of Cefaclor DihydrateHeriberto Martinez, Stephen R. Byrn and Ralph R. Pfeiffer
154-160Method Validation Revisited: A Chemometric ApproachMario J. Cardone, Susan A. Willavize and Mark E. Lacy
161-166Bioavailability Improvement of Mycophenolic Acid Through Amino Ester DerivatizationWilliam A. Lee, Leo Gu, Andrew R. Miksztal, Nancy Chu and Kwan Leung, et al.
167-169Effect of Molecular Weight on the Lymphatic Absorption of Water-Soluble Compounds Following Subcutaneous AdministrationAndreas Supersaxo, Wayne R. Hein and Hans Steffen
170-175Mechanism of Ethanol-Enhanced Estradiol Permeation Across Human Skin in VivoLynn K. Pershing, Lyssa D. Lambert and Kristine Knutson
176-179Determination of Potential Migrants from Commercial Amber Polyethylene Terephthalate Bottle WallHeasook Kim, Seymour G. Gilbert and James B. Johnson
180-183Absorption Enhancement of Rectally Infused Insulin by Sodium Tauro-24,25-Dihydrofusidate (STDHF) in RatsEwoud J. van Hoogdalem, Corrie D. Heijligers-Feijen, J. Coos Verhoef, Albertus G. de Boer and Douwe D. Breimer
184-187Quantitation of the Relative Amounts of Anhydrous Carbamazepine (C15H12N2O) and Carbamazepine Dihydrate (C15H12N2O · 2H2O) in a Mixture by Solid-State Nuclear Magnetic Resonance (NMR)Raj Suryanarayanan and Timothy S. Wiedmann
188-191Disposition of Bismuth in the Rat. I. Red Blood Cell and Plasma Protein BindingNiranjan Rao and Stuart Feldman
192-198Pharmacokinetics of the Aldose Reductase Inhibitor Imirestat Following Topical Ocular AdministrationR. Kim Brazzell, C. Bradley Wooldridge, Robert B. Hackett and Bette A. McCue
199-203Microbial Metabolism Studies of the Antimalarial Drug ArteetherIk-Soo Lee, Hala N. ElSohly and Charles D. Hufford
204-207Disposition of Antipyrine and Acetaminophen Given Alone and in Combination to Human SubjectsWalid M. Awni, John V. St. Peter, John M. Kovarik and Gary R. Matzke
208BOOK REVIEWS
209BOOK REVIEWS
210ERRATUM
211-212Association News and Announcements

Volume 7, Number 3 / March 1990

213-221Transport Mechanisms in Iontophoresis. II. Electroosmotic Flow and Transference Number Measurements for Hairless Mouse SkinMichael J. Pikal and Saroj Shah
222-229Transport Mechanisms in Iontophoresis. III. An Experimental Study of the Contributions of Electroosmotic Flow and Permeability Change in Transport of Low and High Molecular Weight SolutesMichael J. Pikal and Saroj Shah
230-236Percutaneous Absorption of Benzoic Acid Across Human Skin. I. In Vitro Experiments and Mathematical ModelingGregory E. Parry, Annette L. Bunge, Geoffrey D. Silcox, Lynn K. Pershing and David W. Pershing
237-241Disposition of Bismuth in the Rat. II. Pharmacokinetics and Biliary ExcretionNiranjan Rao and Stuart Feldman
242-246Kinetics of Drug Action in Disease States. XXXIX. Effect of Orally Administered Activated Charcoal on the Hypnotic Activity of Phenobarbital and the Neurotoxicity of Theophylline Administered Intravenously to Rats with Renal FailureAmnon Hoffman and Gerhard Levy
247-250The Effect of Compactional Pressure on a Wheat Germ Lipase PreparationM. Hossein Zarrintan, C. Diana Teng and Michael J. Groves
251-255Carboxylic Ester Hydrolase Activity in Hairless and Athymic Nude Mouse SkinMridul K. Ghosh and Ashim K. Mitra
256-261Effect of Antihepatotoxic Agents Against Microcystin-LR Toxicity in Cultured Rat HepatocytesKay A. Mereish and Rikki Solow
260-263Antiendotoxin Activity of Lipid A Analogues: Requirements of the Chemical StructureRobert L. Danner, Alan L. Van Dervort, Martin E. Doerfler, Peter Stuetz and Joseph E. Parrillo
264-269Manufacture and Properties of Erythromycin Beads Containing Neutron-Activated Erbium-171Alan F. Parr, George A. Digenis, Erik P. Sandefer, Isaac Ghebre-Sellassie and Uma Iyer, et al.
270-273Microbial Biotransformation of Retinoic Acid by Cunninghamella echinulata and Cunninghamella blakesleeanaDavid A. Hartman, Jack B. Basil, Larry W. Robertson and Robert W. Curley
274-279Hydralazine Pharmacokinetics and Interaction with Food: An Evaluation of the Dog as an Animal ModelHugh A. Semple, Yun K. Tam and Ronald T. Coutts
280-282Interactions of 7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)-propoxy]-2(lH)-quinolinone (OPC-4392) with 3H-Spiperone and 3H-SCH 23390 Binding in Rat Striatum: Effects of LesionsXiao Zhang, Yoshihiro Nakata, Tetsuro Kikuchi and Tomio Segawa
283-288Are Reduction Potentials of Antifungal Agents Relevant to Activity?Peter Kovacic, Patrick F. Kiser and Benjamin A. Feinberg
289-292Applications of Oxygen Polarography to Drug Stability Testing and Formulation Development: Solution-Phase Oxidation of Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase InhibitorsMichael J. Kaufman
293-298Transport of Desglycinamide-Arginine Vasopressin Across the Blood–Brain Barrier in Rats as Evaluated by the Unit Impulse Response MethodologyJoost B. M. M. van Bree, Susan Tio, Albertus G. de Boer, J. Coos Verhoef and Douwe D. Breimer
299-303Mechanism of Acyclovir Uptake in Rat JejunumKem C. Meadows and Jennifer B. Dressman
304-307The Effect of Food on Gastrointestinal (GI) Transit of Sustained-Release Ibuprofen Tablets as Evaluated by Gamma ScintigraphyMarie T. Borin, Subhash Khare, Robert M. Beihn and Michael Jay
308-309Mechanism of Absorption of the Dipeptide α-Methyldopa-phe in Intestinal Brush-Border Membrane VesiclesAkira Tsuji, Ikumi Tamai, Masaru Nakanishi and Gordon L. Amidon
310-312Association News and Announcements

Volume 7, Number 4 / April 1990

313-317Sustained-Release Delivery Systems for Treatment of Dental DiseasesMichael Friedman and Doron Steinberg
318-324Altered Pharmacokinetics and Dynamics of Apomorphine in the Malnourished Rat: Modeling of the Composed Relationship Between Concentration and Heart-Rate ResponseEva Bredberg and Lennart K. Paalzow
325-331Transepithelial Transport of Aliphatic Carboxylic Acids Studied in Madin Darby Canine Kidney (MDCK) Cell MonolayersMoo J. Cho, Anthony Adson and F. J. Kezdy
332-338Modeling the Enhanced Uptake of Zidovudine (AZT) into Cerebrospinal Fluid. 1. Effect of ProbenecidRonald J. Sawchuk and Mohsen A. Hedaya
339-346Disposition Characteristics of Macromolecules in Tumor-Bearing MiceYoshinobu Takakura, Takuya Fujita, Mitsuru Hashida and Hitoshi Sezaki
347-351Single- vs Multiple-Dose Pharmacokinetics of Clozapine in Psychiatric PatientsMiles G. Choc, Francis Hsuan, Gilbert Honigfeld, William T. Robinson and Larry Ereshefsky, et al.
352-358Percutaneous Absorption of Benzoic Acid Across Human Skin. II. Prediction of an in Vivo, Skin-Flap System Using in Vitro ParametersGeoffrey D. Silcox, Gregory E. Parry, Annette L. Bunge, Lynn K. Pershing and David W. Pershing
359-363Formulation and in Vitro-in Vivo Evaluation of Sustained-Release Lithium Carbonate TabletsKadriye Çiftçi, Yilmaz Çapan, Orhan Öztürk and A. Atilla Hincal
364-369Epimerization Kinetics of Moxalactam in Frozen Urine and Plasma SamplesNaofumi Hashimoto, Teruhisa Ichihashi, Koichiro Hirano and Hideo Yamada
370-375Bile Salt–Fatty Acid Mixed Micelles as Nasal Absorption Promoters of Peptides. II. In Vivo Nasal Absorption of Insulin in Rats and Effects of Mixed Micelles on the Morphological Integrity of the Nasal MucosaParkpoom Tengamnuay and Ashim K. Mitra
376-37816α-Hydroxy-(–)-kauranoic Acid: A Selectively Cytotoxic Diterpene from Annona bullataYu-hua Hui, Ching-jer Chang, David L. Smith and Jerry L. McLaughlin
379-383Drug-Excipient Incompatibility Studies of the Dipeptide Angiotensin-Converting Enzyme Inhibitor, Moexipril Hydrochloride: Dry Powder vs Wet GranulationLeo Gu, Robert G. Strickley, Li-Hua Chi and Zak T. Chowhan
384-387A Comparison of Oral and Rectal Absorption of L-Dopa Esters in Rats and MiceJoseph A. Fix, Jose Alexander, Margot Cortese, Karen Engle and Paula Leppert, et al.
388-391Isothermal and Nonisothermal Kinetics in the Stability Prediction of Vitamin A PreparationsSumie Yoshioka, Yukio Aso and Yasushi Takeda
392-397Intestinal Absorption of Drugs. III. The Influence of Taurocholate on the Disappearance Kinetics of Hydrophilic and Lipophilic Drugs from the Small Intestine of the RatFred G. J. Poelma, Ria Breäs and Josef J. Tukker
398-401Contribution of Monoamine Oxidase(MAO) to the Binding of Tertiary Basic Drugs in Isolated Perfused Rat LungHisahiro Yoshida, Katsuhiko Okumura and Ryohei Hori
402-406Stereochemical Characterization of the Diastereomers of the Phenobarbital N-β-D-Glucose Conjugate Excreted in Human UrineWilliam H. Soine, Phyllis J. Soine, Suzanne E. Mongrain and Terry M. England
407-410Development of a Sensitive Activity Assay for High-Volume Evaluation of Human Renin Inhibitory Peptides in Rat Serum: Results with U-71,038Mary J. Ruwart, Satish K. Sharma, Douglas W. Harris, Duane B. Lakings and Bob D. Rush, et al.
411-417Probenecid Inhibits the Metabolic and Renal Clearances of Zidovudine (AZT) in Human VolunteersMohsen A. Hedaya, William F. Elmquist and Ronald J. Sawchuk
418-421Synthesis, Characterization, and in Vitro Stability of Chitosan-Methotrexate ConjugatesYeshwant D. Sanzgiri, C. Dewitt Blanton and James M. Gallo
422-424Evaluation of Free Tissue Concentrations of Fleroxacin After Oral AdministrationJobst Limberg, Marc LeBel and Hartmut Derendorf
425-429On the Use of the Quasi-Equilibrium Assumption for Drug DissolutionSadettin S. Ozturk, Jennifer B. Dressman and Bernhard O. Palsson
430BOOK REVIEWS
431-432Letters to the EditorPaolo Colombo, Ping I. Lee, Nikolaos A. Peppas and K. Padmalatha Devi
433-434Editorial

Volume 7, Number 5 / May 1990

435-451The Use of Cultured Epithelial and Endothelial Cells for Drug Transport and Metabolism StudiesKenneth L. Audus, Ronnda L. Bartel, Ismael J. Hidalgo and Ronald T. Borchardt
452-460Chemical Stability of Pentostatin (NSC-218321), a Cytotoxic and Immunosuppressant AgentLaman A. Al-Razzak, Annalisa E. Benedetti, Wanda N. Waugh and Valentine J. Stella
461-467Nonlinear Binding of Valproic Acid (VPA) and E-Δ2-Valproic Acid to Rat Plasma ProteinsRobin L. O. Semmes and Danny D. Shen
468-475The Effects of Permeation Enhancers on the Surface Morphology of the Rat Nasal Mucosa: A Scanning Electron Microscopy StudyRichard D. Ennis, Lucy Borden and William A. Lee
476-483Ocular Pharmacokinetics and Pharmacodynamics of Phenylephrine and Phenylephrine Oxazolidine in Rabbit EyesDu-Shieng Chien and Ronald D. Schoenwald
484-490Effect of Cyclodextrin Derivatives on Indomethacin Stability in Aqueous SolutionThomas Backensfeld, Bernd W. Müller, Michael Wiese and Joachim K. Seydel
491-495A Simple Rheological Method for the in Vitro Assessment of Mucin-Polymer Bioadhesive Bond StrengthEmad Eldin Hassan and James M. Gallo
496-499Disposition and Metabolic Profiling of the Penetration Enhancer Azone. I. In Vivo Studies: Urinary Profiles of Hamster, Rat, Monkey, and ManJohann W. Wiechers, Ben F. H. Drenth, Frank A. W. Adolfsen, Lia Prins and Rokus A. de Zeeuw
500-503Nasal Absorption Enhancement of 17β-Estradiol by Dimethyl-β-Cyclodextrin in Rabbits and RatsWalter A. J. J. Hermens, Marc J. M. Deurloo, Stefan G. Romeyn, J. Coos Verhoef and Frans W. H. M. Merkus
504-507Quantification of Three Lidocaine Metabolites and Their ConjugatesYun K. Tam, June Ke, Ronald T. Coutts, D. George Wyse and Murray R. Gray
508-512The Liposome as a Model Membrane in Correlations of Partitioning with α-Adrenoceptor Agonist ActivitiesYoung W. Choi and James A. Rogers
513-517Dose-Dependent Pharmacokinetics of Carbamazepine in Rats: Determination of the Formation Clearance of Carbamazepine-10,11-epoxideRory P. Remmel, Michael W. Sinz and James C. Cloyd
518-522Estimate of Volume/Flow Ratio of Gastrointestinal (GI) Fluids in Humans Using Pharmacokinetic DataPanayotis Macheras, Christos Reppas and Jennifer B. Dressman
523-529Solvent Interaction with Polydimethylsiloxane Membranes and Its Effects on Benzocaine Solubility and DiffusionKarl M. Gelotte and Richard T. Lostritto
530-536High-Performance Liquid Chromatographic (HPLC) and HPLC-Mass Spectrometric (MS) Analysis of the Degradation of the Luteinizing Hormone-Releasing Hormone (LH-RH) Antagonist RS-26306 in Aqueous SolutionRobert G. Strickley, Michael Brandl, Kelvin W. Chan, Kenneth Straub and Leo Gu
537-541Drug Binding and Solubility in MilkPanayotis E. Macheras, Michael A. Koupparis and Sophia G. Antimisiaris
542-546Preparation of Asialofetuin-Labeled Liposomes with Encapsulated Human Interferon-γ and Their Uptake by Isolated Rat HepatocytesHiroshi Ishihara, Toshifumi Hara, Yukihiko Aramaki, Seishi Tsuchiya and Kaoru Hosoi
547-552The Effect of Sodium Tauro-24,25-Dihydrofusidate on the Nasal Absorption of Human Growth Hormone in Three Animal ModelsPatricia A. Baldwin, Corine K. Klingbeil, Carla J. Grimm and John P. Longenecker
553-557Adenosine Triphosphate Liposomes: Encapsulation and Distribution StudiesXu Guo-Xing, Xie Xing-Hui, Liu Fang-Yu, Zang De-Liang and Zheng Dao-Sheng, et al.
558-560Oral Bioavailability of Triamcinolone Tablets and a Triamcinolone Diacetate SuspensionGünther Hochhaus, Martin Pörtner, Jürgen Barth, Helmut Möllmann and Peter Rohdewald
561A Better Way to Present PostersLewis J. Leeson and Gerhard Levy
561-562BOOK REVIEWS
562BOOK REVIEWS
563BOOK REVIEWS
563ADDENDUM
564Association News and Announcements

Volume 7, Number 6 / June 1990

565-569Pulmonary Delivery of Peptide Drugs: Effect of Particle Size on Bioavailability of Leuprolide Acetate in Healthy Male VolunteersAkwete Adjei and Julie Garren
570-576Simultaneous Modeling of the Pharmacokinetic and Pharmacodynamic Properties of Benzodiazepines. II. TriazolamSamir K. Gupta, Everett H. Ellinwood, Arlene M. Nikaido and Douglas G. Heatherly
577-586Development of a Preformulation Lipophilicity Screen Utilizing a C-18-Derivatized Polystyrene-Divinylbenzene High-Performance Liquid Chromatographic (HPLC) ColumnWilliam J. Lambert and Latrelle A. Wright
587-592Pharmacokinetics of a Mouse/Human Chimeric Monoclonal Antibody (C-17-1 A) in Metastatic Adenocarcinoma PatientsJohn M. Trang, Albert F. LoBuglio, Richard H. Wheeler, Elizabeth B. Harvey and Lee Sun, et al.
593-599Chemical Pathways of Peptide Degradation. I. Deamidation of Adrenocorticotropic HormoneNeelima P. Bhatt, Kamlesh Patel and Ronald T. Borchardt
600-605Testing of Insulin Hexamer-Stabilizing Ligands Using Theoretical Binding, Microcalorimetry, and Nuclear Magnetic Resonance (NMR) Line Broadening TechniquesScott E. McGraw, David J. Craik and Siegfried Lindenbaum
606-611The Use of Microcalorimetry to Measure Thermodynamic Parameters of the Binding of Ligands to InsulinScott E. McGraw and Siegfried Lindenbaum
612-615Pharmaceutical Usefulness of Hydroxypropylcyclodextrins: "E Pluribus Unum” Is an Essential FeatureC. Trinadha Rao, Henry M. Fales and Josef Pitha
616-620Formulation and Dosage Form Design in Drug-Induced Topical Irritation of the Gastrointestinal TractJohn W. Fara and Robert E. Myrback
621-627Oleic Acid: Its Effects on Stratum Corneum in Relation to (Trans)Dermal Drug DeliveryMichael L. Francoeur, Guia M. Golden and Russell O. Potts
628-632Constant-Rate Intravenous Infusion Methods for Estimating Steady-State Volumes of Distribution and Mean Residence Times in the Body for Drugs Undergoing Reversible MetabolismHaiyung Cheng and William J. Jusko
633-637Binding of Drugs in Milk: The Role of Casein in Milk Protein BindingThomas Stebler and Theodor W. Guentert
638-643Metabolic Conversion of Cyoctol During Skin Passage in HumansRokus A. de Zeeuw, Renella E. Herder, Johann W. Wiechers and Ben F. H. Drenth
644-647Effect of Dextran Sulfate on Renal Accumulation of GentamicinShinji Kikuchi, Yukihiko Aramaki, Homare Nonaka and Seishi Tsuchiya
648-653The Effect of Physical Aging on the Dissolution Rate of Anionic PolyelectrolytesChristopher M. Sinko, Albert F. Yee and Gordon L. Amidon
654-657The Relationship Between the Glass Transition Temperature and Water Vapor Absorption by Poly(vinylpyrrolidone)Cynthia A. Oksanen and George Zografi
658-664Application of a Brain-Targeting Chemical Delivery System to 9-Amino-1,2,3,4-TetrahydroacridineEmil Pop, Katalin Prókai-Tátrai, James D. Scott, Marcus E. Brewster and Nicholas Bodor
665-669Characterization of Epidermal Growth Factor Receptors on Plasma Membranes Isolated from Rat Gastric MucosaRyohei Hori, Hisashi Nomura, Seigo Iwakawa and Katsuhiko Okumura
670-672Effects of Amantadine on Dopaminergic Neurons in Discrete Regions of the Rat BrainKatsuo Toide
673-676Comparisons of in Vitro Nitroglycerin (TNG) Flux Across Yucatan Pig, Hairless Mouse, and Human SkinsMary E. Roberts and Karl R. Mueller
677-680Influence of Absorption Rate, Dosing Frequency, and Intrinsic Pharmacokinetic Profile on Steady-State Drug ConcentrationsMichael A. Eldon and Wayne A. Colburn
681BOOK REVIEWS
682Association News and Announcements

Volume 7, Number 7 / July 1990

683-690Crystallographic Consequences of Molecular DissymmetryHarry G. Brittain
691-696Relationships in the Structure–Tissue Distribution of Basic Drugs in the RabbitKoichi Yokogawa, Emi Nakashima, Junko Ishizaki, Hitoshi Maeda and Taizo Nagano, et al.
697-702Optimization of the Therapeutic Index by Adjustment of the Rate of Drug Administration or Use of Drug Combinations: Exploratory Studies of DiureticsJianguo Zhi and Gerhard Levy
703-711Chemical Pathways of Peptide Degradation. II. Kinetics of Deamidation of an Asparaginyl Residue in a Model HexapeptideKamlesh Patel and Ronald T. Borchardt
712-718Contributions of Drug Solubilization, Partitioning, Barrier Disruption, and Solvent Permeation to the Enhancement of Skin Permeation of Various Compounds with Fatty Acids and AminesBruce J. Aungst, Judy A. Blake and Munir A. Hussain
719-722Sulfate Homeostasis. II. Influence of Chronic Aspirin Administration on Inorganic Sulfate in HumansMarilyn E. Morris and Lisa Jo Benincosa
723-725Site- and Stereospecific Ocular Drug Delivery by Sequential Enzymatic BioactivationNicholas Bodor and Laszlo Prokai
726-729Optical Purity Determination of threo-Methylphenidate Hydrochloride Using a Chiral Europium Nuclear Magnetic Resonance (NMR) Shift ReagentGeorge M. Hanna and Cesar A. Lau-Cam
730-735Influence of Temperature and Hydrophobic Group-Associated Icebergs on the Activation Energy of Drug Decomposition and Its Implication in Drug Shelf-Life PredictionAnil K. Kishore and Janardan B. Nagwekar
736-741Vidarabine-Loaded Nanoparticles: A Physicochemical StudyVéronique Guise, Jehan-Yves Drouin, Jacqueline Benoit, Jacqueline Mahuteau and Pierre Dumont, et al.
742-745The Metabolism of CGP-291: The Use of Microorganisms as Models of Mammalian MetabolismTannis M. Jürgens and Alice M. Clark
746-750Quantitative Correlations and Reexamination of the Importance of Hydrophobic and Steric Factors in Anticholinergic Drug Receptor InteractionsSamitendu Banerjee and Eric J. Lien
751-755Kinetics and Pattern of Degradation of Thyrotropin-Releasing Hormone (TRH) in Human PlasmaJudi Møss and Hans Bundgaard
756-761Upper Gastrointestinal (GI) pH in Young, Healthy Men and WomenJennifer B. Dressman, Rosemary R. Berardi, Lambros C. Dermentzoglou, Tanya L. Russell and Stephen P. Schmaltz, et al.
762-766Percutaneous Absorption Enhancement of an Ionic Molecule by Ethanol–Water Systems in Human SkinTamie Kurihara-Bergstrom, Kristine Knutson, Linda J. DeNoble and Cynthia Y. Goates
767-771Intestinal Transport of Sulfanilic Acid in Rats Immunized with Protein–Sulfanilic Acid ConjugateA. Yamamoto, T. Kawaratani, K. Kawashima, M. Hashida and H. Sezaki
772-776Nasal Absorption Enhancers for Biosynthetic Human Growth Hormone in RatsDerek T. O'Hagan, Helen Critchley, Nidal F. Farraj, Anthony N. Fisher and Bente R. Johansen, et al.
777-779Influence of Food on the Bioavailability of Ro 15-0778 in HumansAlice A. Holazo, Evelyn E. Pinili, Francis T. De Grazia and Indravadan H. Patel
780BOOK REVIEWS
780BOOK REVIEWS
780-781BOOK REVIEWS
782-785Academic Pharmaceutics: The Challenge of ExcellenceAAPS Task Force
786Comment on “Academic Pharmaceutics: The Challenge of Excellence”Wayne A. Colburn

Volume 7, Number 8 / August 1990

787-793Chemical Pathways of Peptide Degradation. III. Effect of Primary Sequence on the Pathways of Deamidation of Asparaginyl Residues in HexapeptidesKamlesh Patel and Ronald T. Borchardt
794-800Stereochemical Characterization of the Diastereomers of the Amobarbital N-Glucosides Excreted in Human UrineWilliam H. Soine, Phyllis J. Soine, Fred C. Wireko and Donald J. Abraham
801-807An Electrotopological-State Index for Atoms in MoleculesLemont B. Kier and Lowell H. Hall
808-815The Molecular Weight Dependence of Nasal Absorption: The Effect of Absorption EnhancersMaureen D. Donovan, Gordon L. Flynn and Gordon L. Amidon
816-823Biochemical and Mechanical Characterization of Enzyme-Digestible HydrogelsWaleed S. W. Shalaby and Kinam Park
824-834Efficiency of Cytoplasmic Delivery by pH-Sensitive Liposomes to Cells in CultureChun-Jung Chu, Jan Dijkstra, Ming-Zong Lai, Keelung Hong and Francis C. Szoka
835-841Percutaneous Penetration Enhancement in Vivo Measured by Attenuated Total Reflectance Infrared SpectroscopyVivien H. W. Mak, Russell O. Potts and Richard H. Guy
842-847Transdermal Delivery of Narcotic Analgesics: pH, Anatomical, and Subject Influences on Cutaneous Permeability of Fentanyl and SufentanilSamir D. Roy and Gordon L. Flynn
848-851A Method for Quantifying Particle Absorption from the Small Intestine of the MouseJames P. Ebel
852-855Enhanced Intestinal Absorption of a Hydrophobic Polymer-Conjugated Protein Drug, Smancs, in an Oily FormulationKiichiro Oka, Yoichi Miyamoto, Yasuhiro Matsumura, Shohei Tanaka and Tatsuya Oda, et al.
856-862Thermodynamics and Mathematical Modeling of the Partitioning of Chlorpromazine Between n-Octanol and Aqueous BufferShiaw-Wen Cheng, Ravi Shanker and Siegfried Lindenbaum
863-868Absorption of Polyethylene Glycols 600 Through 2000: The Molecular Weight Dependence of Gastrointestinal and Nasal AbsorptionMaureen D. Donovan, Gordon L. Flynn and Gordon L. Amidon
869-873Beta-Cyclodextrin/Steroid Complexation: Effect of Steroid Structure on Association EquilibriaFang-yu Liu, Dane O. Kildsig and Ashim K. Mitra
874-878Performance of Diltiazem Tablet and Multiparticulate Osmotic Formulations in the DogSteven C. Sutton, Karen Engle, Rodney A. Deeken, Kathleen E. Plute and Richard D. Shaffer
879-883A Redox-Based System that Enhances Delivery of Estradiol to the Brain: Pharmacokinetic Evaluation in the DogKlaus Dietzel, Volker Keuth, Kerry S. Estes, Marcus E. Brewster and Roger M. Clemmons, et al.
884BOOK REVIEWS
884BOOK REVIEWS

Volume 7, Number 9 / September 1990

885-892Prodrugs of Peptides. 6. Bioreversible Derivatives of Thyrotropin-Releasing Hormone (TRH) with Increased Lipophilicity and Resistance to Cleavage by the TRH-Specific Serum EnzymeHans Bundgaard and Judi Møss
893-901Diffusion in Porous Materials Above the Percolation ThresholdJayne E. Hastedt and James L. Wright
902-910Caco-2 Cell Monolayers as a Model for Drug Transport Across the Intestinal MucosaAllen R. Hilgers, Robert A. Conradi and Philip S. Burton
911-918Determination of Solute–Polymer Interaction Properties and Their Application to Parenteral Product Container Compatibility EvaluationsRichard A. Kenley and Dennis R. Jenke
919-922Synthesis and Calcium Channel Antagonist Activity of 3-Arylmethyl 5-Isopropyl l,4-Dihydro-2,6-dimethyl-4-(pyridyl)-3,5-pyridinedicarboxylatesMurthy R. Akula, Wandikayi C. Matowe, Michael W. Wolowyk and Edward E. Knaus
923-927Structure Elucidation and Thermospray High-Performance Liquid Chromatography/Mass Spectroscopy (HPLC/MS) of the Microbial and Mammalian Metabolites of the Antimalarial ArteetherCharles D. Hufford, Ik-Soo Lee, Hala N. ElSohly, Hsien Tao Chi and John K. Baker
928-934Influence of Average Molecular Weights of Poly(DL-Lactic Acid-Co-Glycolic Acid) Copolymers 50/50 on Phase Separation and in Vitro Drug Release from MicrospheresJean-Marc Ruiz, Jean-Pierre Busnel and Jean-Pierre Benoît
935-941Physicochemical Factors Associated with Binding and Retention of Compounds in Ocular Melanin of Rats: Correlations Using Data from Whole-Body Autoradiography and Molecular Modeling for Multiple Linear Regression AnalysesPatricia A. Zane, Shirley D. Brindle, Douglas O. Gause, Arlene J. O'Buck and Palayakotai R. Raghavan, et al.
942-947Melting Point, Boiling Point, and SymmetryRobert Abramowitz and Samuel H. Yalkowsky
948-952Enhanced Delivery of Zidovudine Through Rat and Human Skin via Ester ProdrugsToshinobu Seki, Takeo Kawaguchi and Kazuhiko Juni
953-956Comparison of Single-Dose and Steady-State Nadolol Plasma ConcentrationsJulie J. Krukemyer, Harisios Boudoulas, Philip F. Binkley and John J. Lima
957-961Solubilization of Liposomes by Weak Electrolyte Drugs. I. PropranololJames A. Rogers, Gurupadappa V. Betageri and Young W. Choi
962-966Particle Size and Content UniformitySamuel H. Yalkowsky and Sanford Bolton
967-972Influence of Solute Degradation on the Accumulation of Solutes Migrating into Solution from Polymeric Parenteral ContainersLawrence A. Cruz, Mai P. Jenke, Richard A. Kenley, Ming J. Chen and Dennis R. Jenke
973BOOK REVIEWS
973BOOK REVIEWS
973BOOK REVIEWS
974ERRATUM
975-982In Vitro and in Vivo Testing and Correlation for Oral Controlled/Modified-Release Dosage FormsJerome P. Skelly, Gordon L. Amidon, William H. Barr, Leslie Z. Benet and James E. Carter, et al.

Volume 7, Number 10 / October 1990

983-987The Development of USP Dissolution and Drug Release StandardsJordan L. Cohen, Barbara B. Hubert, Lewis J. Leeson, Christopher T. Rhodes and Joseph R. Robinson, et al.
988-989Treating Seriously Ill Patients with Experimental DrugsFrancis B. Palumbo
990-994Solute Absorption from the Airways of the Isolated Rat Lung. III. Absorption of Several Peptidase-Resistant, Synthetic Polypeptides: Poly-(2-Hydroxyethyl)-AspartamidesRalph W. Niven, Frantisek Rypacek and Peter R. Byron
995-1002In Vitro Skin Permeation and Bioassay of Chlorhexidine Phosphanilate, a New Antimicrobial AgentJonas C. T. Wang, Robert R. Williams, Lotte Wang and John Loder
1003-1010Mean Interconversion Times and Distribution Rate Parameters for Drugs Undergoing Reversible MetabolismHaiyung Cheng and William J. Jusko
1011-1018Growth Hormone (GH) Secretory Dynamics in Animals Administered Estradiol Utilizing a Chemical Delivery SystemWilliam J. Millard, Teresa M. Romano, Nicholas Bodor and James W. Simpkins
1019-1025Phosphatidylserine as a Determinant for the Tissue Distribution of Weakly Basic Drugs in RatsNoboru Yata, Toshihiko Toyoda, Teruo Murakami, Akio Nishiura and Yutaka Higashi
1026-1032Application of Radiotelemetric Technique in Evaluating Diclofenac Sodium Absorption After Oral Administration of Various Dosage Forms in Healthy VolunteersKeith K. H. Chan, Parviz Mojaverian, Barbara A. Ziehmer and Vivian A. John
1033-1037Evaluation of a Noninvasive Method for Monitoring Percutaneous Absorption of Lidocaine in VivoGregory P. Kushla and Joel L. Zatz
1038-1041Analysis of Hepatic Transport of Cefpiramide in Rats with Obstructive Jaundice by Using Isolated HepatocytesTadanao Yamao, Seiya Nakayama, Yuji Kurosaki, Taiji Nakayama and Toshikiro Kimura
1042-1047Use of Shed Snake Skin as a Model Membrane for in Vitro Percutaneous Penetration Studies: Comparison with Human SkinTomoo Itoh, Jun Xia, Ravi Magavi, Toshiaki Nishihata and J. Howard Rytting
1048-1054Topical Drug Delivery from Thin Applications: Theoretical Predictions and Experimental ResultsWilliam Addicks, Norman Weiner, Gordon Flynn, Rane Curl and Elizabeth Topp
1055-1060Binding of Pyrimethamine to Human Plasma Proteins and ErythrocytesAnita C. Rudy and Wesley J. Poynor
1061-1067Dose and Time-Course Evaluation of a Redox-Based Estradiol-Chemical Delivery System for the Brain. I. Tissue DistributionMohamad H. Rahimy, James W. Simpkins and Nicholas Bodor
1068-1070A Method for Determination of the Absolute Pulmonary Bioavailability of Inhaled Drugs: TerbutalineLars Borgström and Marita Nilsson
1071-1076Pharmacokinetic Screening of o-Naphthoquinone 5-Lipoxygenase InhibitorsAshok Rakhit, Steve K. Kuwahara, David R. Jones, Victor F. Soliman and Alvin N. Kotake, et al.
1077-1081Microdialysis Sampling for Determination of Plasma Protein Binding of DrugsAda M. Herrera, Dennis O. Scott and Craig E. Lunte
1082-1085Ultraviolet (UV) Absorption and Circular Dichroism (CD) Spectra of CaptoprilHarry G. Brittain and Harold Kadin
1086-1091The Effects of Formulation Additives on the Degradation of Freeze-Dried Ribonuclease AMichael W. Townsend, Peter R. Byron and Patrick P. DeLuca
1092-1097A Statistical Approach for the Development of an Oral Controlled-Release Matrix TabletAlton D. Johnson, Virgil L. Anderson and Garnet E. Peck
1098Association News and Announcements

Volume 7, Number 11 / November 1990

1099-1106Transdermal Delivery of Bioactive Peptides: The Effect of n-Decylmethyl Sulfoxide, pH, and Inhibitors on Enkephalin Metabolism and TransportHoo-Kyun Choi, Gordon L. Flynn and Gordon L. Amidon
1107-1112Dose and Time-Course Evaluation of a Redox-Based Estradiol-Chemical Delivery System for the Brain. II. Pharmacodynamic ResponsesMohamad H. Rahimy, James W. Simpkins and Nicholas Bodor
1113-1118A Sensitive and Specific Liquid-Chromatographic Assay for Determination of Ganciclovir in Plasma and Urine and Its Application to Pharmacokinetic Studies in the RabbitMohsen A. Hedaya and Ronald J. Sawchuk
1119-1126Characterization of a Hot-Melt Fluid Bed Coating Process for Fine GranulesMichael J. Jozwiakowski, David M. Jones and Robert M. Franz
1127-1133Nebulization of Liposomes. I. Effects of Lipid CompositionRalph W. Niven and Hans Schreier
1134-1140Theophylline-Controlled Release Preparations and Fatty Food: An in Vitro Study Using the Rotating Dialysis Cell MethodSilvia K. El-Arini, Gerald K. Shiu and Jerome P. Skelly
1141-1146Electrical Analysis of Fresh, Excised Human Skin: A Comparison with Frozen SkinGerald B. Kasting and Lisa A. Bowman
1147-1151In Vitro Skin Absorption and Metabolism of Benzoic Acid, p-Aminobenzoic Acid, and Benzocaine in the Hairless Guinea PigDavid Nathan, Adel Sakr, J. Leon Lichtin and Robert L. Bronaugh
1152-1156Enhancement of the Antiinflammatory Effect of Ethyl 4-Biphenylyl Acetate in Ointment by β-Cyclodextrin Derivatives: Increased Absorption and Localized Activation of the Prodrug in RatsHidetoshi Arima, Hirotoshi Adachi, Tetsumi Irie, Kaneto Uekama and Josef Pitha
1157-1162Solid and Liquid Heat Capacities of n-Alkyl Para-aminobenzoates Near the Melting PointSteven H. Neau and Gordon L. Flynn
1163-1166Gastrointestinal Transit of Nondisintegrating, Nonerodible Oral Dosage Forms in PigsMohammad Hossain, Wattanaporn Abramowitz, Barbara J. Watrous, Gregory J. Szpunar and James W. Ayres
1167-1171Release and Absorption Characteristics of Novel Theophylline Sustained-Release Formulations: In Vitro-in Vivo CorrelationZiad Hussein and Michael Friedman
1172-1176Evaluation of the Pharmacokinetic Interaction Between Diazepam and ACC-9653 (a Phenytoin Prodrug) in Healthy Male VolunteersElizabeth K. Hussey, George E. Dukes, John A. Messenheimer, Kim L. R. Brouwer and Karl H. Donn, et al.
1177-1180Determination of Temafloxacin, Sarafloxacin, and Difloxacin in Bulk Drug and Dosage Forms by High-Performance Liquid ChromatographyJohn F. Bauer, Lee Elrod, Jr., Joseph R. Fornnarino, Douglas E. Heathcote and Sue K. Krogh, et al.
1181-1185Physical State of Misoprostol in Hydroxypropyl Methylcellulose FilmsTugrul T. Kararli, Thomas E. Needham, Cliff J. Seul, Pat M. Finnegan and Marianne I. Hidvegi, et al.
1186-1189Stabilization of Misoprostol with Hydroxypropyl Methylcellulose (HPMC) Against Degradation by WaterTugrul T. Kararli and Thomas Catalano
1190-1194Release of Human Serum Albumin from Poly(lactide-co-glycolide) MicrospheresManinder S. Hora, Rajsharan K. Rana, Jack H. Nunberg, Thomas R. Tice and Richard M. Gilley, et al.
1195-1197A Flat Circular Hole Device for Zero-Order Release of Drugs: Characterization of the Moving Dissolution BoundaryDinesh S. Mishra and Samuel H. Yalkowsky
1198-1200Scintigraphic Evaluation of the Ocular Disposition of 18F-Imirestat in RabbitsGanesan Vaidyanathan, Michael Jay, Ranajit K. Bera, Philip R. Mayer and R. K. Brazzell
1201-1204Epidermal Differentiation and Permeability in Fetal Pig SkinTamie Kurihara-Bergstrom, William R. Good, Carol Signer and Marguerite Woodworth
1205-1207Morphine Impurity with Opioid Activity Is Identified as 10α-HydroxymorphineHassan Farsam, Steven Eiger, Jelveh Lameh, Ahmad Rezvani and Bradford W. Gibson, et al.
1208-1209Effects of a Diluent on the Retarded–Release Property of Acrylate Methacrylate–Salicylic Acid CoacervatesR. S. Okor and M. A. Yahaya
1210BOOK REVIEWS
1210BOOK REVIEWS
1211BOOK REVIEWS
1212Association News and Announcements

Volume 7, Number 12 / December 1990

1213-1221Structure and Function of G Protein Coupled ReceptorsJelveh Lameh, Ric I. Cone, Sadaaki Maeda, Mohan Philip and Maithe Corbani, et al.
1222-1227Pharmacokinetics of a Single Intravenous and Oral Dose of Pafenolol—a Beta1Adrenoceptor Antagonist with Atypical Absorption and Disposition Properties—in ManCarl G. Regårdh, Per Lundborg, Margareth Gabrielsson, Asger Heggelund and Kerstin Kylberg-Hanssen
1228-1233Optimized Inhalation Aerosols. II. Inertial Testing Methods for Particle Size Analysis of Pressurized InhalersElaine M. Phillips, Peter R. Byron, Kristen Fults and Anthony J. Hickey
1234-1241Analytical Approaches to the Study of Monoclonal Antibody StabilityWim Jiskoot, E. Coen Beuvery, Ada A. M. de Koning, James N. Herron and Daan J. A. Crommelin
1242-1247An Experimental Model for Measuring Middle Ear Antimicrobial Drug Penetration in Otitis MediaGregg H. Jossart, Gary R. Erdmann, David G. Levitt, Peter Kucera and Chap T. Le, et al.
1248-1252The Pharmacokinetics of β-Cyclodextrin and Hydroxypropyl-β-cyclodextrin in the RatHenderik W. Frijlink, Jan Visser, Nanco R. Hefting, Roelof Oosting and Dirk K. F. Meijer, et al.
1253-1256Stability of Gonadorelin and Triptorelin in Aqueous SolutionVolker J. Helm and Bernd W. Müller
1257-1261Column-Switching High-Performance Liquid Chromatographic (HPLC) Determination of Hydrochlorothiazide in Rat, Dog, and Human PlasmaBe-Sheng Kuo, Arun Mandagere, David R. Osborne and Kin-Kai Hwang
1262-1268Chiral Amines Derived from 2-Arylpropionic Acids: Novel Reagents for the Liquid Chromatographic (LC) Fluorescence Assay of Optically Active Carboxylic Acid XenobioticsHildegard Spahn and Peter Langguth
1269-1272Sesquiterpene Lactones and Other Constituents from a Cytotoxic Extract of Michelia floribundaIng-On Mondranondra, Chun-tao Che, Agnes M. Rimando, Srunya Vajrodaya and Harry H. S. Fong, et al.
1273-1277Heat Sterilization of Bioindicators in Propylene Glycol and Propylene Glycol–Water Mixtures: Arrhenius Equation, Thermodynamic Data, and Z ValuesBrigitte Philipp and Heinz Sucker
1278-1281Amorphous-to-Crystalline Transformation of SucroseJens T. Carstensen and Kurt Van Scoik
1282-1288Aluminum Compounds Used as Adjuvants in VaccinesSuhag Shirodkar, Robert L. Hutchinson, Darold L. Perry, Joe L. White and Stanley L. Hem
1289-1293Improvement in Wound Healing by Epidermal Growth Factor (EGF) Ointment. I. Effect of Nafamostat, Gabexate, or Gelatin on Stabilization and Efficacy of EGFKatsuhiko Okumura, Yoshifumi Kiyohara, Fusao Komada, Seigo Iwakawa and Midori Hirai, et al.
1294-1297Cytotoxicity of Three Novel Fluoropyrimidines in Cultured L1210 Murine Lymphocytic Leukemia CellsAnnette M. Shipp, Mark H. Holshouser and Paul W. Ferguson
1298-1301Cutaneous Pharmacodynamics of Transdermally Delivered Isosorbide DinitrateMitsuhiko Hori, Saburoh Ohtsuka, Masaki Sunami, Richard H. Guy and Howard I. Maibach
1302-1306A Method to Predict the Percutaneous Permeability of Various Compounds: Shed Snake Skin as a Model MembraneTomoo Itoh, Ravi Magavi, Roger L. Casady, Toshiaki Nishihata and J. Howard Rytting
1307-1312Investigations on the Percutaneous Absorption of the Antidepressant Rolipram in Vitro and in VivoJonathan Hadgraft, Stephanie Hill, Michael Hümpel, Linda R. Johnston and Lawrence R. Lever, et al.
1313-1319Mechanism of L-α-Methyldopa Transport Through a Monolayer of Polarized Human Intestinal Epithelial Cells (Caco-2)Ming Hu and Ronald T. Borchardt
1320-1324Optimization of Topical Therapy: Partitioning of Drugs into Stratum CorneumChristian Surber, Klaus-P. Wilhelm, Mitsuhiko Hori, Howard I. Maibach and Richard H. Guy
1325-1328Solubility and lonization Behavior of the Antiarrhythmic 4-hydroxy-N-phenyl-3,5-bis(l-pyrrolidinylmethyl)benzamide dihydrochloride (DuP 923)Michael B. Maurin, George Dowuona-Owoo and George Torosian
1329BOOK REVIEWS
1329-1330BOOK REVIEWS
1330BOOK REVIEWS
1330-1331BOOK REVIEWS
1331Letters to the EditorKlaus G. Florey, John W. Fara and Robert E. Myrback
1332-1333Reviewers for Pharmaceutical Research (October 1989-October 1990)
1334-1336Author Index to Volume 7 (1990)
1337-1345Subject Index to Volume 1 (1990)
1346Association News and Announcements

Volume 8, Number 1 / January 1991

1-8Development of Delta Opioid Peptides as Nonaddicting AnalgesicsRao S. Rapaka and Frank Porreca
9-16The Effect of Parenterally Administered Cyclodextrins on Cholesterol Levels in the RatHenderik W. Frijlink, Anko C. Eissens, Nanco R. Hefting, Klaas Poelstra and Coenraad F. Lerk, et al.
17-24Terpenes and the Lipid–Protein–Partitioning Theory of Skin Penetration EnhancementAdrian C. Williams and Brian W. Barry
25-32The Role of Metabolites in Bioequivalency Assessment. I. Linear Pharmacokinetics without First-Pass EffectMei-Ling Chen and André J. Jackson
33-39Quantification of Imipenem’s Primary Metabolite in Plasma by Postcolumn Chemical Rearrangement and UV DetectionDonald G. Musson, Richard Hajdu, William F. Bayne and John D. Rogers
40-42Absorption and Disposition of Colloidal Drug Delivery Systems. I. High-Performance Liquid Chromatographic (HPLC) Analysis of a Cyclosporin EmulsionSusan J. Corvari, R. Gary Hollenbeck, James Leslie, Karen I. Plaisance and David Young
43-46Quantitative Structure–Activity Relationships (QSARs) of Pyrimidine Nucleosides as HIV-1 Antiviral AgentsMassoud Mahmoudian
47-54Optimization of Spray-Dried and -Congealed Lipid Micropellets and Characterization of Their Surface Morphology by Scanning Electron MicroscopyTürkan Eldem, Peter Speiser and Atilla Hincal
55-59In Vitro Release of Hydrocortisone from Topical Preparations and Automated ProcedureVinod P. Shah, Jerome Elkins, James Hanus, Carol Noorizadeh and Jerome P. Skelly
60-64Enhanced Bioavailability of Subcutaneously Injected Insulin by Pretreatment with Ointment Containing Protease InhibitorsMasaharu Takeyama, Toshihiko Ishida, Noriko Kokubu, Fusao Komada and Seigo Iwakawa, et al.
65-69Role of Complements C3 and C5 in the Phagocytosis of Liposomes by Human NeutrophilsJeffrey F. Scieszka, Linda L. Maggiora, Samuel D. Wright and M. J. Cho
70-75A Comparison of Peptidase Activities and Peptide Metabolism in Cultured Mouse Keratinocytes and Neonatal Mouse EpidermisPraful K. Shah and Ronald T. Borchardt
76-79Studies in Phlebitis: Detection and Quantitation Using a Thermographic CameraGary H. Ward, Paul E. Nolan, Monica Chawla and Samuel H. Yalkowsky
80-83Precipitation of the Renin Inhibitor Ditekiren Upon iv Infusion; in Vitro Studies and Their Relationship to in Vivo Precipitation in the Cynomolgus MonkeyStephen R. Davio, Margaret M. McShane, Thomas J. Kakuk, Renee M. Zaya and Serena L. Cole
84-87Relationship Between Drug Absorption Enhancing Activity and Membrane Perturbing Effects of AcylcarnitinesEdward L. LeCluyse, Leah E. Appel and Steven C. Sutton
88-92The Solubility-Modulated Osmotic Pump: In Vitro/in Vivo Release of Diltiazem HydrochlorideGregory A. McClelland, Steven C. Sutton, Karen Engle and Gaylen M. Zentner
93-96Oral Absorption of Peptides: Influence of pH and Inhibitors on the Intestinal Hydrolysis of Leu-Enkephalin and AnaloguesDoron I. Friedman and Gordon L. Amidon
97-100Mechanism of Gastric Emptying of a Nondisintegrating Radiotelemetry Capsule in ManParviz Mojaverian, James C. Reynolds, Ann Ouyang, Fern Wirth and Paul E. Kellner, et al.
101-105Jejunal Absorption, Pharmacological Activity, and Pharmacokinetic Evaluation of Indomethacin-Loaded Poly(d,l-Lactide) and Poly(Isobutyl-Cyanoacrylate) Nanocapsules in RatsNazih Ammoury, Hatem Fessi, Jean-Philippe Devissaguet, Marcelle Dubrasquet and Simon Benita
106-111Thermal Injury Decreases Hepatic Blood Flow and the Intrinsic Clearance of Indocyanine Green in the RatGary M. Pollack and Kim L. R. Brouwer
112-118Dose-Dependent Pharmacokinetics of the Aldose Reductase Inhibitor Imirestat in ManR. Kim Brazzell, Philip R. Mayer, Richard Dobbs, Patrick J. McNamara and Renli Teng, et al.
119-122Structural Confirmation of Ampicillin Polymers Formed in Aqueous SolutionHatsumi Aki, Nobuyoshi Sawai, Kenji Yamamoto and Magobei Yamamoto
123-126Examination of Arrhenius Kinetics for an Antiarrhythmic CompoundTugrul T. Kararli, Thomas Catalano and Richard M. Bittman
127-130The Effects Of Hemodilution, pH, and Protamine on Lidocaine Plasma Protein Binding and Red Blood-Cell Uptake in VitroRory P. Remmel, Alan K. Copa and David M. Angaran
131-133Self-Release of Lipase from Compacts MaterialsM. Hossein Zarrintan and Michael J. Groves
134-135Intranasal Delivery of RS-93522, a Dihydropyridine-Type Calcium-Channel AntagonistRoger Cherng-Chi Fu, John L. Whatley and Jeffrey S. Fleitman
136-138Consensus Report on "Issues in the Evaluation of Bioavailability"Iain J. McGilveray
139Editorial
140Reviewers for Pharmaceutical Research (November 1989-November 1990)

Volume 8, Number 2 / February 1991

141-147Mass Receptor Screening for New DrugsRonald M. Burch and Donald J. Kyle
148-155Solid-State Phase Transitions Initiated by Water Vapor Sorption of Crystalline L-660,711, a Leukotriene D4 Receptor AntagonistElizabeth B. Vadas, Pascal Toma and George Zografi
156-161Design and Manufacture of a Zero-Order Sustained-Release Pellet Dosage Form Through Nonuniform Drug Distribution in a Diffusional MatrixDouglas C. Scott and R. Gary Hollenbeck
162-167Extent and Variability of the First-Pass Elimination of Adinazolam Mesylate in Healthy Male VolunteersJoseph C. Fleishaker, H. Friedman and Steven R. Pollock
168-173A Method to Study Drug Concentration–Depth Profiles in Tissues: Mitomycin C in Dog Bladder WallM. Guillaume Wientjes, James T. Dalton, Robert A. Badalament, Bharat M. Dasani and Joseph R. Drago, et al.
174-177Synthesis and in Vitro Receptor Binding Studies of Fluorotamoxifen AnaloguesDavid J. Yang, Sidney Wallace, Wayne Tansey, Kenneth C. Wright and Li-Ren Kuang, et al.
178-184Polymorphic Behavior of Sprayed Lipid Micropellets and Its Evaluation by Differential Scanning Calorimetry and Scanning Electron MicroscopyTürkan Eldem, Peter Speiser and Hans Altorfer
185-190In Vitro Release Profile of Mitomycin C from Albumin Microspheres: Extrapolation from Macrospheres to MicrospheresHideshi Natsume, Kenji Sugibayashi and Yasunori Morimoto
191-195Water Vapor Adsorption and Desorption Isotherms of Biologically Active ProteinsC. Diana Teng, M. Hossein Zarrintan and Michael J. Groves
196-199Opioid-Induced Respiratory Depression and Analgesia May Be Mediated by Different SubreceptorsEnno Freye, Martina Schnitzler and Gustav Schenk
200-203High-Affinity [3H]THA (Tetrahydroaminoacridine) Binding Sites in Rat BrainE. Edward Mena and Manoj C. Desai
204-209Influence of Ultrasound on the Percutaneous Absorption of Nicotinate EstersHeather A. E. Benson, James C. McElnay, Robin Harland and Jonathan Hadgraft
210-216A Model of Human Small Intestinal Absorptive Cells. 1. Transport BarrierJ. Nita Cogburn, Matthew G. Donovan and Charles S. Schasteen
217-221Nebulization of Liposomes. II. The Effects of Size and Modeling of Solute Release ProfilesRalph W. Niven, Melissa Speer and Hans Schreier
222-227Characterization of the Unstirred Water Layer in Caco-2 Cell Monolayers Using a Novel Diffusion ApparatusIsmael J. Hidalgo, Kathleen M. Hillgren, George M. Grass and Ronald T. Borchardt
228-231Model Selection for the Adsorption of Phenobarbital by Activated CharcoalGerald M. Burke, Dale Eric Wurster, Varaporn Buraphacheep, Mary J. Berg and Peter Veng-Pedersen, et al.
232-237Computer-Aided Dosage Form Design. III. Feasibility Assessment for an Oral Prolonged-Release Phenytoin ProductJoy R. Irvin and Robert E. Notari
238-241Effect of Competing Anions on Binding of Bile Salts by CholestyramineRosemary Kos, Joe L. White, Stanley L. Hem and Marie T. Borin
242-246Sulfate Homeostasis. III. Effect of Chronic Naproxen or Sulindac Treatment on Inorganic Sulfate Disposition in Arthritic Patients with Renal ImpairmentMarilyn E. Morris, Jack P. Freer and William A. Watson
247-253Hybrid Pharmacokinetic Models to Describe Anti-HIV Nucleoside Brain Disposition Following Parent and Prodrug Administration in MiceJames M. Gallo, Joseph T. Etse, Kokila J. Doshi, F. Douglas Boudinot and Chung K. Chu
254-258Simple Methods for Estimation of Mean Residence Time and Steady-State Volume of Distribution from Continuous-Infusion DataWilliam R. Gillespie
259-262Stereoselective Transport of Baclofen Across the Blood–Brain Barrier in Rats as Determined by the Unit Impulse Response MethodologyJoost B. M. M. van Bree, Corrie D. Heijligers-Feijen, Albertus G. de Boer, Meindert Danhof and Douwe D. Breimer
263-268Pharmacodynamics of Methylprednisolone Phosphate After Single Intravenous Administration to Healthy VolunteersHartmut Derendorf, Helmut Möllmann, Michael Krieg, Sabine Tunn and Carsten Möllmann, et al.
269-272Simplified Determination of Antipyrine Clearance by Liquid Chromatography of a Microsample of Saliva or PlasmaAdnan El-Yazigi, Dale A. Raines, Hatim Ali, Jens Sieck and Peter Ernst, et al.
273-277Protection Against Microcystin-LR-Induced Hepatotoxicity by Silymarin: Biochemistry, Histopathology, and LethalityKay A. Mereish, David L. Bunner, Danny R. Ragland and Donald A. Creasia
278-281Prediction of Acute Graft Rejection in Renal Transplantation: The Utility of Cyclosporine Blood ConcentrationsJoachim Grevel, Kimberly L. Napoli, Maria S. Welsh, Neely E. Atkinson and Barry D. Kahan
282-284The Relationship Between Urine and Plasma Concentrations of Carbamazepine: Implications for Therapeutic Drug MonitoringWilliam F. Elmquist, Lillian E. Riad, Ilo E. Leppik and Ronald J. Sawchuk

Volume 8, Number 3 / March 1991

285-291Protein–Solvent Interactions in Pharmaceutical FormulationsTsutomu Arakawa, Yoshiko Kita and John F. Carpenter
292-297Preformulation Studies Involving Moisture Uptake in Solid Dosage FormsDorothy R. Heidemann and Paul J. Jarosz
298-305Calculation of the Aqueous Diffusion Layer Resistance for Absorption in a Tube: Application to Intestinal Membrane Permeability DeterminationJim H. Kou, David Fleisher and Gordon L. Amidon
306-312Relationship of Apparent Systemic Clearance to Individual Organ Clearances: Effect of Pulmonary Clearance and Site of Drug Administration and MeasurementReza Mehvar
313-322Prodrugs of Peptides. 9. Bioreversible N-α-Hydroxyalkylation of the Peptide Bond to Effect Protection Against Carboxypeptidase or Other Proteolytic EnzymesHans Bundgaard and GitteJuel Rasmussen
323-330Amine Prodrugs Which Utilize Hydroxy Amide Lactonization. I. A Potential Redox-Sensitive Amide ProdrugKent L. Amsberry and Ronald T. Borchardt
331-335Bead Coating. I. Change in Release Kinetics (and Mechanism) Due to Coating LevelsGuohua Zhang, Joseph B. Schwartz and Roger L. Schnaare
336-340Effect of Moisture Content on Compression Properties of Two Dextrose-Based Directly Compressible DiluentsAtul J. Shukla and James C. Price
341-344Production of 5–15 µm Diameter Alginate-Polylysine Microcapsules by an Air-Atomization TechniqueK.Keith Kwok, Michael J. Groves and Diane J. Burgess
345-349Thermorheologic Properties of Aqueous Solutions and Gels of Tetronic 1508Christopher W. Spancake, Dane O. Kildsig and Ashim K. Mitra
350-354Evidence that Oleic Acid Exists in a Separate Phase Within Stratum Corneum LipidsBoonsri Ongpipattanakul, Ronald R. Burnette, Russell O. Potts and Michael L. Francoeur
355-359Constant Potassium Chloride Release from Microporous Membrane-Coated Tablets Prepared with Aqueous Colloidal Polymer DispersionsRoland Bodmeier and Ornlaksana Paeratakul
360-364Variation in Gastrointestinal Transit of Pharmaceutical Dosage Forms in Healthy SubjectsAlastair J. Coupe, Stanley S. Davis and Ian R. Wilding
365-369Study of the Mechanisms of Flux Enhancement Through Hairless Mouse Skin by Pulsed DC IontophoresisMichael J. Pikal and Saroj Shah
370-375Sites of First-Pass Bioactivation (Hydrolysis) of Orally Administered Zofenopril Calcium in DogsRichard A. Morrison, Dennis E. Burkett, Mark E. Arnold, Celia J. D'Arienzo and Stephen H. Weinstein
376-379Sulfate Homeostasis. IV. Probenecid-Induced Alterations of Inorganic Sulfate in RatsInger M. Darling and Marilyn E. Morris
380-384The Effects of Cyclodextrins on the Disposition of Intravenously Injected Drugs in the RatHenderik W. Frijlink, Eric J. F. Franssen, Anko C. Eissens, Roelof Oosting and Coenraad F. Lerk, et al.
385-388Pharmacokinetics of Multiple Daily Transdermal Doses of Nicotine in Healthy SmokersHolly D. Ross, Keith K. H. Chan, Anthony J. Piraino and Vivian A. John
389-392In Vivo Microdialysis Sampling for Pharmacokinetic InvestigationsDennis O. Scott, Lori R. Sorenson, Karla L. Steele, DeAnna L. Puckett and Craig E. Lunte
393-399Quantitative Analysis of the Active Tablet Ingredient by Powder X-Ray DiffractometryRaj Suryanarayanan and Craig S. Herman
400-402Determination of Degree of Substitution of Formyl Groups in Polyaldehyde Dextran by the Hydroxylamine Hydrochloride MethodHuiru Zhao and Ned D. Heindel
403-408Solubilization and in Vitro Spermicidal Assessment of Nonoxynol-9 and Selected Fractions Using Rabbit SpermatozoaBrian A. Walter, Amale A. Hawi, Panayiotis M. Zavos and George A. Digenis
409-411High-Performance Liquid Chromatographic (HPLC) Analysis of Oligomeric Components of the Spermicide Nonoxynol-9Brian A. Walter and George A. Digenis
412-414The Effect of Pancreatin on the Dissolution Performance of Gelatin-Coated Tablets Exposed to High-Humidity ConditionsTerrence C. Dahl, I-Lan T. Sue and Alicia Yum
415-417Kinetics of Drug Action in Disease States. XL. Effect of the Dialyzable Component(s) of Uremic Blood on Theophylline Neurotoxicity in RatsAmnon Hoffman and Gerhard Levy
418BOOK REVIEWS
419Letters to the EditorHenry C. Caldwell and Samuel H. Yalkowsky
420Association News and Announcements

Volume 8, Number 4 / April 1991

421-426Validation of Bioanalytical MethodsH. Thomas Karnes, Gerald Shiu and Vinod P. Shah
427-436The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth HormoneMichael J. Pikal, Karen M. Dellerman, Michael L. Roy and Ralph M. Riggin
437-444Hepatic Disposition Characteristics of Electrically Charged Macromolecules in Rat in Vivo and in the Perfused LiverKoyo Nishida, Kiyoshi Mihara, Toichi Takino, Sachi Nakane and Yoshinobu Takakura, et al.
445-454Colon-Specific Delivery of Dexamethasone from a Glucoside Prodrug in the Guinea PigThomas N. Tozer, Jean Rigod, Andrew D. McLeod, Ramon Gungon and M. Kim Hoag, et al.
455-461Amine Prodrugs Which Utilize Hydroxy Amide Lactonization. II. A Potential Esterase-Sensitive Amide ProdrugKent L. Amsberry, A. Elise Gerstenberger and Ronald T. Borchardt
462-470Molecular Structure and Dynamics of cis(Z)- and trans(E)-Flupenthixol and ClopenthixolIngebrigt Sylte and Svein G. Dahl
471-474Effects of Viscous Hyaluronate–Sodium Solutions on the Nasal Absorption of Vasopressin and An AnalogueKazuhiro Morimoto, Hiroshi Yamaguchi, Yasushi Iwakura, Katsuaki Morisaka and Yoshihiro Ohashi, et al.
475-479In Vitro Evaluation of the Plasma and Blood Compatibility of a Parenteral Formulation for Ditekiren, a Novel Renin Inhibitor PseudopeptideJohn C. Greenfield, Sheryl J. Loux, Virendra K. Sood, Kathryn M. Jenkins and Stephen R. Davio
480-484Inactivation Kinetics of Enzyme Pharmaceuticals in Aqueous SolutionSumie Yoshioka, Ken-ichi Izutsu, Yukio Aso and Yasushi Takeda
485-490Stability of Interleukin 1β (IL-1β) in Aqueous Solution: Analytical Methods, Kinetics, Products, and Solution Formulation ImplicationsLeo C. Gu, Elizabeth A. Erdös, Hi-Shi Chiang, Thomas Calderwood and Kelly Tsai, et al.
491-497Effect of Polyethylene Glycol 400 on the Intestinal Permeability of Carbamazepine in the RabbitLillian E. Riad and Ronald J. Sawchuk
498-501Effects of Deoxycholate on the Transepithelial Transport of Sucrose and Horseradish Peroxidase in Filter-Grown Madin–Darby Canine Kidney (MDCK) CellsYi-Jing Lin and Wei-Chiang Shen
502-504Cosolvency of Dimethyl Isosorbide for Steroid SolubilityHossein Zia, Joseph K. H. Ma, John P. O'Donnell and Louis A. Luzzi
505-507Molecular Motion of Drugs in Hydrocolloids Measured by Electron Paramagnetic ResonanceJulijana Kristl, Slavko Pečar, Jelka Šmid-Korbar and Milan Schara
508-511Mean Residence Times and Distribution Volumes for Drugs Undergoing Linear Reversible Metabolism and Tissue Distribution and Linear or Nonlinear Elimination from the Central CompartmentsHaiyung Cheng and William J. Jusko
512-517Suitability of Various Noninfinity Area Under the Plasma Concentration–Time Curve (AUC) Estimates for Use in Bioequivalence Determinations: Relationship to AUC from Zero to Time Infinity (AUCO–INF)Marilyn N. Martinez and Andre J. Jackson
518-522The Preparation and Evaluation of a Tablet Dosage Form of Cyclosporine in DogsHisham Y. Abdallah and Michael Mayersohn
523-526High-Performance Liquid Chromatographic (HPLC) Determination of Lobenzarit in Plasma and Its Application to a Bioavailability Study in Beagle DogsFrancis J. Schwende and Scott W. Turner
527-530Synthesis of Poly(Hydroxypropylglutamine-Prazosin Carbamate) and Release StudiesXiaoling Li, Nathan W. Adams, David B. Bennett, Jan Feijen and Sung Wan Kim
531-537“On–Off” Thermocontrol of Solute Transport. I. Temperature Dependence of Swelling of N-Isopropylacrylamide Networks Modified with Hydrophobic Components in WaterYou Han Bae, Teruo Okano and Sung Wan Kim
538-540In Vitro Binding of Lorazepam and Lorazepam Glucuronide to Cholestyramine, Colestipol, and Activated CharcoalRobert J. Herman and Archana Chaudhary
541-543Determination of the Relative Formation and Elimination Clearance of Two Major Carbamazepine Metabolites in Humans: A Comparison Between Traditional and Pooled Sample AnalysisLillian E. Riad, Keith K. Chan and Ronald J. Sawchuk
544-546Drug Metabolism and Laboratory Anesthetic Protocols in the Rat: Examination of Antipyrine PharmacokineticsMark Gumbleton and Leslie Z. Benet
547-549Rapid High-Performance Liquid Chromatographic Analysis and Stability Study of Hydrocortisone 17-Butyrate in Cream PreparationsSompon Wanwimolruk
550Letters to the EditorP. Macheras, C. Reppas, S. Antimisiaris, T. Stebler and T. W. Guentert

Volume 8, Number 5 / May 1991

551-556Stereoselectivity in Pharmacokinetics: A General TheoryRené H. Levy and Alan V. Boddy
557-562Comparison of the Methods for Determining Cell-Surface and Intracellular Receptors for Epidermal Growth Factor in the Rat LiverShigeo Yanai, Yuichi Sugiyama, Tatsuji Iga, Tohru Fuwa and Manabu Hanano
563-569Effect of Receptor Up-Regulation on Insulin Pharmacokinetics in Streptozotocin-Treated Diabetic RatsHitoshi Sato, Tetsuya Terasaki, Kiminori Okumura and Akira Tsuji
570-575Nonisothermal Stability Assessment of Stable Pharmaceuticals: Testing of a Clindamycin Phosphate FormulationJames E. Kipp and John J. Hlavaty
576-583A Novel, Self-Correcting Membrane Coating TechniqueHitesh R. Bhagat, Robert W. Mendes, Edith Mathiowitz and Hridaya N. Bhargava
584-587Sustained Pharmacological Activities in Rats Following Single and Repeated Administration of Once-a-Month Injectable Microspheres of Leuprolide AcetateHiroaki Okada, Toshiro Heya, Yasuaki Ogawa, Hajime Toguchi and Tsugio Shimamoto
588-592Absorption Enhancing Effect of Cyclodextrins on Intranasally Administered Insulin in RatsFrans W. H. M. Merkus, J. Coos Verhoef, Stefan G. Romeijn and Nicolaas G. M. Schipper
593-599Structural Requirements for the Intestinal Mucosal-Cell Peptide Transporter: The Need for N-Terminal α-Amino GroupPel-Fan Bai, Pullachipatti Subramanian, Henry I. Mosberg and Gordon L. Amidon
600-604Use of Modified Ethylcellulose Lattices for Microporous Coating of Osmotic TabletsLeah E. Appel and Gaylen M. Zentner
605-607Bioavailability of Flurbiprofen Following Buccal AdministrationDennis J. Stalker and Steven R. Pollock
608-614Dose-Dependent Pharmacokinetics of MK-417, a Potent Carbonic Anhydrase Inhibitor, in Experimental Polycythemic and Anemic RatsJiunn H. Lin, I-Wu Chen and Florencia A. deLuna
615-618Determination of Sodium and Chloride Ions in Teicoplanin Lyophilized Vials by Nonsuppressed, Single-Column Ion ChromatographyMiguel A. de Soto-Perera
619-623High-Performance Liquid Chromatographic Determination of 2′, 3′ -Didehydro-3′ -deoxythymidine (d4T) in Human and Rabbit Plasma and Urine and Its Application to Pharmacokinetic Studies in the RabbitShekman L. Wong and Ronald J. Sawchuk
624-628“On–Off“ Thermocontrol of Solute Transport. II. Solute Release from Thermosensitive HydrogelsYou Han Bae, Teruo Okano and Sung Wan Kirn
629-635Formulation and in Vitro Evaluation of Pressurized Inhalation Aerosols Containing Isotropic Systems of Lecithin and WaterRichard M. Evans, Stephen J. Farr, N. Anthony Armstrong and Sarah M. Chatham
636-642Significance of Partial and Total Cohesion Parameters of Pharmaceutical Solids Determined from Dissolution Calorimetric MeasurementsCatherine Rey-Mermet, Paul Ruelle, Hô Nam-Trân, Michel Buchmann and Ulrich W. Kesselring
643-648Crystal Growth Kinetics of Theophylline MonohydrateNaír Rodríguez-Hornedo and Hsiu-Jean Wu
649-652Lipophilic Peptides: Synthesis of Lauroyl Thyrotropin-Releasing Hormone and Its Biological ActivityShozo Muranishi, Atsushi Sakai, Keigo Yamada, Masahiro Murakami and Kanji Takada, et al.
653-655Determination of Allopurinol and Oxypurinol in Rat Plasma, Intestinal Wash, and Bile by High-Performance Liquid Chromatography with Electrochemical Detection (HPLC/EC) Following Automated Solid Phase ExtractionEugene J. Eisenberg, Phil Conzentino, Gary G. Liversidge and Kenneth C. Cundy
656-657The Cytotoxicity of p-Chloro-m-xylenol in Primary Culture of Rat HepatocytesJulio C. Davila, Angelica Dorantes, Salomon A. Stavchansky and Daniel Acosta
658-660Low First-Spray Drug Content in Albuterol Metered-Dose InhalersTerry D. Cyr, Susan J. Graham, K. Y. Robert Li and Edward G. Levering
661-662Letters to the EditorBradley D. Anderson, Richard T. Darrington and Janardan B. Nagwekar

Volume 8, Number 6 / June 1991

663-675Introduction to Fourier Transform Infrared Spectroscopy and Applications in the Pharmaceutical SciencesRobert J. Markovich and Charles Pidgeon
676-682Pharmaceutical Sciences' Manpower Supply and Internal Rate of ReturnAbraham G. Hartzema and Eleanor Perfetto
683-689Assessment of Drug Disposition in the Perfused Rat Brain by Statistical Moment AnalysisToshiyasu Sakane, Michiko Nakatsu, Akira Yamamoto, Mitsuru Hashida and Hitoshi Sezaki, et al.
690-697In Vitro and in Vivo Investigations of Dihydropyridine-Based Chemical Delivery Systems for AnticonvulsantsAlan V. Boddy, Kanyin Zhang, Francis Lepage, Francis Tombret and J. Greg Slatter, et al.
698-705Prediction of Physical Aging in Controlled-Release Coatings: The Application of the Relaxation Coupling Model to Glassy Cellulose AcetateChristopher M. Sinko, Albert F. Yee and Gordon L. Amidon
706-712A Polymer Carrier System for Taste Masking of Macrolide AntibioticsMou-ying Fu Lu, Saul Borodkin, Linda Woodward, Ping Li and Curt Diesner, et al.
713-720Controlled Delivery Systems for Proteins Based on Poly(Lactic/Glycolic Acid) MicrospheresSmadar Cohen, Toshio Yoshioka, Melissa Lucarelli, Lena H. Hwang and Robert Langer
721-727Degradation of Insulin by Trypsin and Alpha-ChymotrypsinRobert J. Schilling and Ashim K. Mitra
728-733Role of Enzymatic Lability in the Corneal and Conjunctival Penetration of Timolol Ester Prodrugs in the Pigmented RabbitDu-Shieng Chien, Hitoshi Sasaki, Hans Bundgaard, Anders Buur and Vincent H. L. Lee
734-738The Preparation and Acute Antihypertensive Effects of a Nanocapsular Form of Darodipine, a Dihydropyridine Calcium Entry BlockerBrigitte Hubert, Jeffrey Atkinson, Madeleine Guerret, Maurice Hoffman and Jean Philippe Devissaguet, et al.
739-743The Bioavailability and Nonlinear Clearance of (–)-Carbovir in the RatShu-hui Huang, Rory P. Remmel and Cheryl L. Zimmerman
744-749Nitroglycerin Absorption from Transdermal Systems: Formulation Effects and Metabolite ConcentrationsRoger L. Williams, Kamlesh M. Thakker, Vivian John, Emil T. Lin and Winnie Liang-Gee, et al.
750-753Pharmacokinetics and Anticonvulsant Activity of Three Monoesteric Prodrugs of Valproic AcidKhalil Badir, Abdulla Haj-Yehia, Tom B. Vree, Eppo Kleijn and Meir Bialer
754-757Racial Differences in Drug Response: Isoproterenol Effects Before and After PropranololDavid R. Rutledge, Ann Wallace, Joel D. Steinberg, Lavoisier Cardozo and Steven J. Lavine
758-762A High-Performance Liquid Chromatographic Assay for the Enantiomers of Bevantolol in Human PlasmaSteven E. Rose and Edward J. Randinitis
763-770One-Dimensional and Two-Dimensional 1H- and 13C-Nuclear Magnetic Resonance (NMR) Analysis of Vitamin E Raw Materials or Analytical Reference StandardsJohn K. Baker and Chris W. Myers
771-775Effects of 5′-Ester Modification on the Physicochemical Properties and Plasma Protein Binding of 5-Iodo-2′-deoxyuridineMridul K. Ghosh and Ashim K. Mitra
776-781Quantitative Structure–Activity Relationship Analysis of Combretastatins: A Class of Novel Antimitotic AgentsPartha Nandy, Samitendu Banerjee, Hua Gao, Mary B. V. Hui and Eric J. Lien
782-786Effect of Solution Phase Composition on the Interaction Between Aqueous Model Solutes and Polymeric Container MaterialsDennis R. Jenke
787-791Pharmacokinetics of Once-a-Month Injectable Microspheres of Leuprolide AcetateHiroaki Okada, Yayoi Inoue, Toshiro Heya, Hayao Ueno and Yasuaki Ogawa, et al.
792-795Use of 2-Hydroxypropyl-β-cyclodextrin as a Solubilizing and Stabilizing Excipient for Protein DrugsMarcus E. Brewster, Maninder S. Hora, James W. Simpkins and Nicholas Bodor
796-800Influence of Antibiotics on the Recovery and Kinetics of Saccharomyces boulardii in RatsAlan V. Boddy, Gary W. Elmer, Lynne V. McFarland and René H. Levy
801-803Studies in Phlebitis. II. Early Detection of Amiodarone-Induced Phlebitis in a Rabbit ModelGary H. Ward, Paul E. Nolan, Milissa White and Samuel H. Yalkowsky
804-805Pharmaceutical Marketing in the European Community: The 1992 ChangesMichael Dickson
806Association News and Announcements

Volume 8, Number 7 / July 1991

807-814The Nasal Mucociliary Clearance: Relevance to Nasal Drug DeliveryNicolaas G. M. Schipper, J. Coos Verhoef and Frans W. H. M. Merkus
815-820In Vivo Transport of a Dynorphin-like Analgesic Peptide, E-2078, Through the Blood–Brain Barrier: An Application of Brain MicrodialysisTetsuya Terasaki, Yoshiharu Deguchi, Hitoshi Sato, Ken-ichi Hirai and Akira Tsuji
821-825Gas Chromatographic–Mass Spectrometric (GC-MS) Determination of MDL 72,222 and Four Metabolites in Monkey PlasmaHaiyung Cheng and Jonathan A. Ragner
826-831Triplet-Sensitized Photooxygenation of Therapeutic RetinoidsKeith A. Humphries and Robert W. Curley
832-839Structure–Metabolism Relationships in the Hydrolysis of Nicotinate Esters by Rat Liver and Brain Subcellular FractionsAnne Durrer, Bernard Walther, Antonio Racciatti, Gilles Boss and Bernard Testa
840-850A New Predictive Equation for the Solubility of Drugs Based on the Thermodynamics of Mobile DisorderPaul Ruelle, Catherine Rey-Mermet, Michel Buchmann, Hô Nam-Tran and Ulrich W. Kesselring, et al.
851-858The Importance of Surface Charge in the Optimization of Antigen–Adjuvant InteractionsPatricia M. Callahan, Andrew L. Shorter and Stanley L. Hem
859-864Effects of Palytoxin on Guinea Pig Tracheal StripsCasey P. Robinson and David R. Franz
865-872Quantitative Evaluation of Ethanol Effects on Diffusion and Metabolism of β-Estradiol in Hairless Mouse SkinPuchun Liu, William I. Higuchi, Wei-qi Song, Tamie Kurihara-Bergstrom and William R. Good
873-876Enhancement of 3-Hydroxy-3-methylglutaryl–Coenzyme A (HMG–CoA) Reductase Inhibitor Efficacy Through Administration of a Controlled-Porosity Osmotic Pump Dosage FormGregory A. McClelland, R. John Stubbs, Joseph A. Fix, Stefano A. Pogany and Gaylen M. Zentner
877-882Variable Glyceryl Dinitrate Formation Following Infusions of Glyceryl Trinitrate at Different Vascular Sites in the RatEmi Nakashima, David T.-W. Lau and Leslie Z. Benet
883-887Steady-State Pharmacokinetics and Pharmacodynamics of Benazeprilat in Spontaneously Hypertensive Rats (SHR) and Wistar–Kyoto (WKY) RatsSheryl LeRoy and Bret Berner
888-892Binding Study of the Fluorescence Probe l-Anilino-8-naphthalenesulfonate to Human Plasma and Human and Bovine Serum Albumin Using Potentiometric TitrationGeorgia N. Valsami, Panayotis E. Macheras and Michael A. Koupparis
893-898The Relationship of Diastereomer Hydrolysis Kinetics to Shelf-Life Predictions for Cefuroxime AxetilNgoc-Anh T. Nguyen
899-902A Simple and Rapid Method for the Quantification of Eudragit RS100 and RL100 Poly(methacrylates) in Sustained-Release Dosage FormsColin D. Melia, Bashir R. Hansraj, Karrar A. Khan and Ian R. Wilding
903-907Electroanalytical Characteristics of the Cardiotonics, Enoximone and PiroximoneCarl L. Housmyer and Roy L. Lewis
908-912X-Ray Structure and Crystal Lattice Interactions of the Taxol Side-Chain Methyl EsterJohn R. Peterson, Hoang D. Do and Robin D. Rogers
913-918An Electrically Modulated Drug Delivery Device: IAntony D'Emanuele and John N. Staniforth
919-924Tablet Formulation Study of Spray-Dried Sodium Diclofenac Enteric-Coated MicrocapsulesShan-Yang Lin and Yuh-Horng Kao
925-929Insulin Aggregation in Aqueous Media and Its Effect on Alpha-Chymotrypsin-Mediated Proteolytic DegradationFang-yu Liu, Dane O. Kildsig and Ashim K. Mitra
930-932Pharmacodynamics and Biophasic Drug Levels of Methionine EnkephalinRandall J. Erb, Lih-Min Her, Anna Abdallah and Ashim K. Mitra
933-937Dodecyl N,N-Dimethylamino Acetate and Azone Enhance Drug Penetration Across Human, Snake, and Rabbit SkinJouni Hirvonen, J. Howard Rytting, Petteri Paronen and Arto Urtti
938-944Cotransport of Estradiol and Ethanol Through Human Skin in Vitro: Understanding the Permeant/Enhancer Flux RelationshipPuchun Liu, Tamie Kurihara-Bergstrom and William R. Good
945-950Rectal Mucosa Damage in Rabbits After Subchronical Application of Suppository BasesChristian De Muynck, Claude Cuvelier, Danny Van Steenkiste, Luc Bonnarens and Jean Paul Remon
951-957Structural Effects on the Binding of Amine Drugs with the Diphenylmethyl Functionality to Cyclodextrins. I. A Microcalorimetric StudyWei-Qin Tong, John L. Lach, Ting-Fong Chin and J. Keith Guillory
958-961Controlled Delivery of Diphtheria Toxoid Using Biodegradable Poly(D,L-Lactide) MicrocapsulesManmohan Singh, Amarjit Singh and Gursharan Prasad Talwar
962BOOK REVIEWS
962BOOK REVIEWS

Volume 8, Number 8 / August 1991

963-973Physical Characterization of Pharmaceutical SolidsHarry G. Brittain, Susan J. Bogdanowich, David E. Bugay, Joseph DeVincentis and Geoffrey Lewen, et al.
974-978Spectrophotometric Prediction of the Dissolution Rate of Carbamazepine TabletsPeter N. Zannikos, Wen-I Li, James K. Drennen and Robert A. Lodder
979-988Predicting Fraction Dose Absorbed in Humans Using a Macroscopic Mass Balance ApproachPatrick J. Sinko, Glen D. Leesman and Gordon L. Amidon
989-991Determination of Clarithromycin as a Contaminant on Surfaces by High-Performance Liquid Chromatography Using Electrochemical DetectionTerry D. Rotsch, Meredith Spanton, Phyllis Cugier and Andrew C. Plasz
992-996Simultaneous High-Performance Liquid Chromatographic Analysis of Cefprozil Diastereomers in a Pharmacokinetic StudyWen Chyi Shyu, Umesh A. Shukla, Vinod R. Shah, Eugene A. Papp and Rashmi H. Barbhaiya
997-1001Column-Switching High-Performance Liquid Chromatography for On-Line Simultaneous Determination and Resolution of Enantiomers of Verapamil and Its Metabolites in PlasmaYoshiya Oda, Naoki Asakawa, Takashi Kajima, Yutaka Yoshida and Tadashi Sato
1002-1005Synthesis of the Enantiomers of Reduced HaloperidolJuan C. Jaen, Bradley W. Caprathe, Stephen Priebe and Lawrence D. Wise
1006-1012Quantitative Structure–Activity Relationship (QSAR) Analysis of the Cytotoxicities Of Aminohydroxyguanidine Derivatives and Their Antiviral Activities in VitroPou-Hsiung Wang, Mary B. V. Hui, Partha Nandy, Samitendu Banerjee and Hua Gao, et al.
1013-1020The Solution Conformations of Lidocaine AnaloguesPaul D. McMaster, Valerie J. Noris, Charles E. Stankard, Eugene W. Byrnes and Peter R. Guzzo
1021-1026The Cryopreservation of Liposomes. 1. A Differential Scanning Calorimetry Study of the Thermal Behavior of a Liposome Dispersion Containing Mannitol During Freezing/ThawingHerre Talsma, Mies J. van Steenbergen, Paul J. M. Salemink and Daan J. A. Crommelin
1027-1031Biodegradable Nanospheres Containing Phthalocyanines and Naphthalocyanines for Targeted Photodynamic Tumor TherapyAkbiri Labib, Vincent Lenaerts, Francois Chouinard, Jean-Christophe Leroux and René Ouellet, et al.
1032-1038The Pharmacokinetics and Metabolism of Human Relaxins in Rhesus MonkeysBobbe L. Ferraiolo, John Winslow, Gary Laramee, Abbie Celniker and Paul Johnston
1039-1043Evaluation of Mucoadhesive Polymers in Ocular Drug Delivery. I. Viscous SolutionsNigel M. Davies, Stephen J. Fair, Jonathan Hadgraft and Ian W. Kellaway
1044-1049Solubilization and Stabilization of a Benzylpenicillin Chemical Delivery System by 2-Hydroxypropyl-β-cyclodextrinEmil Pop, Thorsteinn Loftsson and Nicholas Bodor
1050-1055Absorptive Clearance of Carbamazepine and Selected Metabolites in Rabbit IntestineLillian E. Riad and Ronald J. Sawchuk
1056-1058Bioavailability of Erythromycin Acistrate from Hard Gelatin Capsules Containing Sodium BicarbonateMartti Marvola, Sirkka Nykänen and Marja Nokelainen
1059-1063Pharmacokinetic Study of an Iridoid Glucoside: AucubinNan-Joo Suh, Chang-Koo Shim, Min Hwa Lee, Shin Keun Kim and Il-Moo Chang
1064-1065Does Hydration Affect Intercellular Lipid Organization in the Stratum Corneum?Vivien H. W. Mak, Russell O. Potts and Richard H. Guy
1066-1068Physicochemical Stability of Nitrofurantoin Anhydrate and Monohydrate Under Various Temperature and Humidity ConditionsMakoto Otsuka, Reiko Teraoka and Yoshihisa Matsuda
1069-1070Disposition of Sulfamethazine and N-Acetylsulfamethazine in the RatCraig K. Svensson, Hani Zaher and Mark Tomilo
1071-1075In Vivo Percutaneous Penetration/Absorption, Washington, D.C., May 1989Vinod P. Shah, Gordon L. Flynn, Richard H. Guy, Howard I. Maibach and Hans Schaefer, et al.
1076-1077Letters to the EditorH. Egermann, Sanford Bolton and Samuel Yalkowsky
1078ERRATUM

Volume 8, Number 9 / September 1991

1079-1086Liposomes and Nanoparticles in the Treatment of Intracellular Bacterial InfectionsPatrick Couvreur, Elias Fattal and Antoine Andremont
1087-1093Water-Soluble, Solution-Stable, and Biolabile N-Substituted (Aminomethyl)benzoate Ester Prodrugs of AcyclovirHans Bundgaard, Ejvind Jensen and Erik Falch
1094-1102Valerian-Derived Sedative Agents. I. On the Structure and Spectral Assignment of the Constituents of Valmane Using the Selective INEPT Nuclear Magnetic Resonance TechniqueLee-Juian Lin, Geoffrey A. Cordell and Manuel F. Balandrin
1103-1112Stability of the Thrombolytic Protein Fibrolase: Effect of Temperature and pH on Activity and ConformationDenise Pretzer, Brenda S. Schulteis, Christopher D. Smith, David G. Vander Velde and James W. Mitchell, et al.
1113-1120lontophoretic Delivery of Amino Acids and Amino Acid Derivatives Across the Skin in VitroPhilip G. Green, Robert S. Hinz, Christopher Cullander, Grace Yamane and Richard H. Guy
1121-1127lontophoretic Delivery of a Series of Tripeptides Across the Skin in VitroPhilip G. Green, Robert S. Hinz, Aeri Kim, Francis C. Szoka and Richard H. Guy
1128-1136Nuclear Magnetic Resonance (NMR) Spectroscopic Investigation of Interaction Energies of Ephedrine Stereoisomers in Noncrystalline Solids and Its Correlation with Thermodynamic DataWalter F. Schmidt and Irwin L. Honigberg
1137-1143The Effect of Plasticizers on Compatibility, Mechanical Properties, and Adhesion Strength of Drug-Free Eudragit E FilmsShan-Yang Lin, Chau-Jen Lee and Yih-Yih Lin
1144-1150Self-Association of Nicotinamide in Aqueous Solution: Mass Transport, Freezing-Point Depression, and Partition Coefficient StudiesWilliam N. Charman, Christine S. C. Lai, Barrie C. Finnin and Barry L. Reed
1151-1154Cyclodextrin Sulfates: Characterization as Polydisperse and Amorphous MixturesJosef Pitha, Larry M. Mallis, Diane J. Lamb, Tetsumi Irie and Kaneto Uekama
1155-1158Catalysis of Carbaryl Hydrolysis in Micellar Solutions of Cetyltrimethylammonium BromideJatin M. Patel and Dale Eric Wurster
1159-1165Solid-State Properties of TobramycinAlekha K. Dash and Raj Suryanarayanan
1166-1174Formulation Influence on Conjunctival Penetration of Four Beta Blockers in the Pigmented Rabbit: A Comparison with Corneal PenetrationPaul Ashton, Samir K. Podder and Vincent H. L. Lee
1175-1179Effects of Proteolytic Enzyme Inhibitors on the Nasal Absorption of Vasopressin and an AnalogueKazuhiro Morimoto, Hiroshi Yamaguchi, Yasushi Iwakura, Makoto Miyazaki and Emi Nakatani, et al.
1180-1185A Redox-Based Chemical Delivery System that Enhances Estradiol Distribution to the Brain: Disposition Studies in the RatKerry S. Estes, Volker Keuth, Klaus Dietzel, Marcus E. Brewster and Nicholas S. Bodor, et al.
1186-1190Stereoselective Systemic Disposition of Ibuprofen Enantiomers in the DogHae-Young Ahn, Gordon L. Amidon and David E. Smith
1191-1194Operational Evaluation of Three Commercial Configurations of Atropine/HI-6 Wet/Dry AutoinjectorsJanis W. Schlager, Theodore W. Dolzine, James R. Stewart, Gerald L. Wannarka and Ming L. Shih
1195-1198Stereospeciflc High-Performance Liquid Chromatographic Assay of Sotalol in PlasmaRobert A. Carr, Robert T. Foster and Nadeem H. Bhanji
1199-1202Permselective Characteristics of Rabbit Buccal MucosaRajesh B. Gandhi and Joseph R. Robinson
1203-1205Solubility of Mefenamic Acid Under Simulated Fed- and Fasted-State ConditionsChristopher N. TenHoor, Vassiliki Bakatselou and Jennifer Dressman
1206-1209Determination of Drug Solubility in Aerosol PropellantsRichard N. Dalby, Elaine M. Phillips and Peter R. Byron
1210-1213Determination of Release Limits: A General MethodologyPaul V. Allen, Gary R. Dukes and Mark E. Gerger
1214Editorial

Volume 8, Number 10 / October 1991

1215-1222Photoreactivity of LY277359 Maleate, a 5-Hydroxytryptamine3 (5-HT3) Receptor Antagonist, in SolutionGerold L. Mosher and Julianne McBee
1223-1230Low Molecular Weight Proteins as Carriers for Renal Drug Targeting: Naproxen–LysozymeEric J. F. Franssen, Ronald G. M. van Amsterdam, Jan Visser, Frits Moolenaar and Dick de Zeeuw, et al.
1231-1237Percutaneous Penetration Kinetics of Nitroglycerin and Its Dinitrate Metabolites Across Hairless Mouse Skin in VitroToshihiro Kikkoji, Mark Gumbleton, Naruhito Higo, Richard H. Guy and Leslie Z. Benet
1238-1242Prodrugs of Peptides. 11. Chemical and Enzymatic Hydrolysis Kinetics of N-Acyloxymethyl Derivatives of a Peptide-like BondHans Bundgaard and Gitte Juel Rasmussen
1243-1247Antimicrobial Diterpenes of Croton sonderianus. II. ent-Beyer-15-en-18-oic AcidJames D. McChesney, Alice M. Clark and Edilberto R. Silveira
1248-1252Application of Neural Computing in Pharmaceutical Product DevelopmentAjaz S. Hussain, Xuanqiang Yu and Robert D. Johnson
1253-1257Hepatic Disposition Characteristics of 111In-Labeled Lactosaminated Bovine Serum Albumin in RatsKoyo Nishida, Yukiko Eguchi, Toichi Takino, Yoshinobu Takakura and Mitsuru Hashida, et al.
1258-1263Parenteral Peptide Formulations: Chemical and Physical Properties of Native Luteinizing Hormone-Releasing Hormone (LHRH) and Hydrophobic Analogues in Aqueous SolutionMichael F. Powell, Lynda M. Sanders, Alan Rogerson and Vicki Si
1264-1269Solution Stability of the Monoclonal Antibody–Vinca Alkaloid Conjugate, KS1/4-DAVLBAlice Riggin, Dean Clodfelter, Ann Maloney, Eugene Rickard and Eddie Massey
1270-1273Assessment of Antiinflammatory Agents Using 125I-Labeled Human Serum Albumin to Quantify Footpad Edema Volume in the RatDouglas J. Ormrod and Thomas E. Miller
1274-1280Differences in Transport Rate of Oxytocin and Vasopressin Analogues Across Proximal and Distal Isolated Segments of the Small Intestine of the RatStefan Lundin, Niclas Pantzar, Anja Broeders, Mats Ohlin and Björn R. Weström
1281-1285Correlation of the Gastric Emptying of Nondisintegrating Tablets with Gastrointestinal MotilityAlastair J. Coupe, Stanley S. Davis, David F. Evans and Ian R. Wilding
1286-1291Mixed Micelles as a Proliposomal, Lymphotropic Drug CarrierAndreas Supersaxo, Wayne R. Hein and Hans Steffen
1292-1296In Vitro Evaluation of Sustained Drug Release from Biodegradable ElastomerRyoichi Wada, Suong-Hyu Hyon, Takayuhi Nakamura and Yoshito Ikada
1297-1301Regional Variation in Oral Mucosal Drug Absorption: Permeability and Degree of Keratinization in Hamster Oral CavityYuji Kurosaki, Toshihito Takatori, Hidekatsu Nishimura, Taiji Nakayama and Toshikiro Kimura
1302-1306Intrinsic Lymphatic Partition Rate of Mepitiostane, Epitiostanol, and Oleic Acid Absorbed from Rat IntestineTeruhisa Ichihashi, Haruki Kinoshita, Yasushi Takagishi and Hideo Yamada
1307-1312Structural Effects on the Binding of Amine Drugs with the Diphenylmethyl Functionality to Cyclodextrins. II. A Molecular Modeling StudyWei-Qin Tong, John L. Lach, Ting-Fong Chin and J. Keith Guillory
1313-1317Formulation, Bioavailability, and Pharmacokinetics of Sustained-Release Potassium Chloride TabletsSevda Şenel, Yilmaz Çapan, Turgay Dalkara, Neriman İnanç and A. Atillâ Hincal
1318-1322Evaluation of “True” Creatinine Clearance in Rats Reveals Extensive Renal SecretionInger M. Darling and Marilyn E. Morris
1323-1328Fourier Transform-Raman Spectroscopy for the Qualitative and Quantitative Characterization of Sulfasalazine-Containing Polymeric MicrospheresPeter J. Watts, Andrew Tudor, Stephen J. Church, Patrick J. Hendra and Paul Turner, et al.
1329-1334Chemical Stabilization of a Vasoactive S-Nitrosothiol with Cyclodextrins Without Loss of Pharmacologic ActivityJohn Anthony Bauer and Ho-Leung Fung
1335-1340Dual-Isotope Imaging of Neutron-Activated Erbium-171 and Samarium-153 and the in Vivo Evaluation of a Dual-Labeled Bilayer Tablet by Gamma ScintigraphyGeorge A. Digenis, Erik P. Sandefer, Robert M. Beihn and Alan F. Parr
1341-1342Studies in Phlebitis. III. Evaluation of Diazepam and PhenytoinMilissa White and Samuel H. Yalkowsky
1343Interspecies Differences in the Nasal Absorption of InsulinF. W. H. M. Merkus, J. C. Verhoef, S. G. Romeijn and N. G. M. Schipper
1344Association News and Announcements

Volume 8, Number 11 / November 1991

1345-1350Delivering Peptides to the Central Nervous System: Dilemmas and StrategiesWilliam A. Banks, Abba J. Kastin and Carlos M. Barrera
1351-1359Interspecies Scaling of Clearance and Volume of Distribution Data for Five Therapeutic ProteinsJoyce Mordenti, Sharon A. Chen, Jerome A. Moore, Bobbe L. Ferraiolo and James D. Green
1360-1364Effect of Freezing on Aggregation of Human Growth HormoneBrigitte M. Eckhardt, James Q. Oeswein and Thomas A. Bewley
1365-1371Role of Paracellular Pathway in Nonelectrolyte Permeation Across Rat Colon Epithelium Enhanced by Sodium Caprate and Sodium CaprylateToyohiro Sawada, Takahiro Ogawa, Mikio Tomita, Masahiro Hayashi and Shoji Awazu
1372-1376Synthesis and the Biological Evaluation of the Structural Units of Drummondin CHiranthi Jayasuriya, John K. Baker, Alice M. Clark and James D. McChesney
1377-1383Development and Evaluation of Sustained-Release Ibuprofen-Wax Microspheres. I. Effect of Formulation Variables on Physical CharacteristicsChristianah M. Adeyeye and James C. Price
1384-1388113Cd Nuclear Magnetic Resonance (NMR) Study of the Inhibitory Effect of Methylvinylether/Maleic Acid (PVM/MA) Copolymer on the Alkaline Phosphatase of Escherichia coliJohn Afflitto, Karen Ann Smith, Manoj Patel, Anthony Esposito and Elke Jensen, et al.
1389-1395Improved Delivery Through Biological Membranes. LVI. Pharmacological Evaluation of Alprenoxime—A New Potential Antiglaucoma AgentNicholas Bodor and Alaaeldin Elkoussi
1396-1400Effect of Drug Loading and Molecular Weight of Cellulose Acetate Propionate on the Release Characteristics of Theophylline MicrospheresAtul J. Shukla and James C. Price
1401-1407Mixture Experimental Design in the Development of a Mucoadhesive Gel FormulationJames S. Chu, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg
1408-1412Viscometric Study of Polyacrylic Acid Systems as Mucoadhesive Sustained-Release GelsJames S. Chu, Ramachandran Chandrasekharan, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg
1413-141714C-Isomazole Disposition in Man After Oral AdministrationJames R. Woodworth, Allyn F. DeLong, A.F. Fasola and Samuel Oldham
1418-1423Chemical and Enzymatic Degradation of Ganciclovir Prodrugs: Enhanced Stability of the Diadamantoate Prodrug Under Acid ConditionsMichael F. Powell, Adina Magill, Nancy Chu, Kyle Hama and Cheng I. Mau, et al.
1424-1429Interaction of Metronidazole with Antibiotics Containing the 2-Aminothiazole MoietyAjit B. Thakur, Mohamed Abdelnasser, Abu T. M. Serajuddin and Deodatt A. Wadke
1430-1433Liquid Chromatographic Analysis of the Enantiomeric Impurities in Various (+)-Pseudoephedrine SamplesSarma P. Duddu, Reza Mehvar and David J. W. Grant
1434-1440A Sensitive Method for Quantitation of Rifabutin and Its Desacetyl Metabolite in Human Biological Fluids by High-Performance Liquid Chromatography (HPLC)Richard C. Lewis, Naomi Z. Hatfield and Prem K. Narang
1441-1443Evidence for Glucuronide Conjugation of p-Nitrophenol in the Caco-2 Cell ModelSusan Bjorge, Katherine L. Hamelehle, Reynold Homan, Steven E. Rose and Daniel A. Turluck, et al.
1444-1447Racemization of Ibutilide in Solution: A Factor to Consider When Choosing to Develop the Racemate or a Single EnantiomerWilliam J. Lambert and Paula G. Timmer
1448-1451Sensitive High-Performance Liquid Chromatographic (HPLC) Determination of Diphenhydramine in Plasma Using Fluorescence DetectionChristine L. Webb and Michael A. Eldon
1452Association News and Announcements

Volume 8, Number 12 / December 1991

1453-1460The Influence of Peptide Structure on Transport Across Caco-2 CellsRobert A. Conradi, Allen R. Hilgers, Norman F. H. Ho and Philip S. Burton
1461-1469Solubilization and Wetting Effects of Bile Salts on the Dissolution of SteroidsVassiliki Bakatselou, Richard C. Oppenheim and Jennifer B. Dressman
1470-1476The Pharmacokinetics of Antipyrine and Three of Its Metabolites in the Rabbit: Intravenous Administration of Pure MetabolitesJohn V. St. Peter, Yusuf Abul-Hajj and Walid M. Awni
1477-1481Desolvation Energy: A Major Determinant of Absorption, But Not Clearance, of Peptides in RatsMichael S. Karls, Bob D. Rush, Karen F. Wilkinson, Thomas J. Vidmar and Philip S. Burton, et al.
1482-1488In Vitro and in Vivo Evaluation of Whole and Half Tablets of Sustained-Release Adinazolam MesylateJohn W. Skoug, Marie T. Borin, Joseph C. Fleishaker and Anne M. Cooper
1489-1494Experimental Determinations of Diffusion Coefficients in Dilute Aqueous Solution Using the Method of Hydrodynamic StabilityMarylee Z. Southard, Lloyd J. Dias, Kenneth J. Himmelstein and Valentino J. Stella
1495-1499Effect of 2-Hydroxypropyl-β-cyclodextrin on the Ocular Absorption of Dexamethasone and Dexamethasone AcetateArunya Usayapant, Adel H. Karara and Milind M. Narurkar
1500-1504Influence of Physical Aging on Mechanical Properties of Polymer Free Films: The Prediction of Long-Term Aging Effects on the Water Permeability and Dissolution Rate of Polymer Film-Coated TabletsJian-Hwa Guo, Richard E. Robertson and Gordon L. Amidon
1505-1510Simultaneous Modeling of the Pharmacokinetics and Methemoglobin Pharmacodynamics of an 8-Aminoquinoline Candidate Antimalarial (WR 238605)Ralf P. Brueckner and Lawrence Fleckenstein
1511-1515Pharmacokinetics of Zopolrestat, a Carboxylic Acid Aldose Reductase Inhibitor, in Normal and Diabetic RatsPhilip B. Inskeep, Anne E. Reed and Robert A. Ronfeld
1516-1519The Effect of Raising Gastric pH with Ranitidine on the Absorption and Elimination of Theophylline from a Sustained-Release Theophylline TabletCharles J. Betlach, Arthur B. Straughn, Marvin C. Meyer, Meir Bialer and V. I. Vashi, et al.
1520-1524Stereoselective Disposition of Ibuprofen Enantiomers in the Isolated Perfused Rat KidneyHae-Young Ahn, Fakhreddin Jamali, Steven R. Cox, Dangnoi Kittayanond and David E. Smith
1525-1527Determination of Cefsulodin, Cefmenoxime, and Cefadroxil as Residues on SurfacesRonald J. Gorski, Andrew C. Plasz, Lee Elrod, John Yoder and Landy B. White
1528-1532The Stereospecific Determination of Fluoxetine and Norfluoxetine Enantiomers in Human Plasma by High-Pressure Liquid Chromatography (HPLC) with Fluorescence DetectionAlbert L. Peyton, Russell Carpenter and Kathleen Rutkowski
1533-1538Prodrugs of Peptides. 13. Stabilization of Peptide Amides Against α-Chymotrypsin by the Prodrug ApproachAnne H. Kahns and Hans Bundgaard
1539-1542Improved Corneal Pilocarpine Permeability with O,O′-(l,4-Xylylene) Bispilocarpic Acid Ester Double ProdrugsPekka Suhonen, Tomi Järvinen, Päivi Rytkönen, Pekka Peura and Arto Urtti
1543-1544Reviewers for Pharmaceutical Research (October 1990-October 1991)
1545-1548Author Index to Volume 8 (1991)
1549-1557Subject Index to Volume 8 (1991)
1558Association News and Announcements

Volume 9, Number 1 / January 1992

1-9Drug Metabolism in the Nasal MucosaMohamadi A. Sarkar
10-16Composite Poly(vinyl alcohol) Beads for Controlled Drug DeliveryCherng-Ju Kim and Ping I. Lee
17-25Estimation of Permanence Time, Exit Time, Dilution Factor, and Steady-State Volume of DistributionJoyce Mordenti and Aldo Rescigno
26-32The Influence of Polymer Glass Transition Temperature and Molecular Weight on Drug Release from Tablets Containing Poly(DL-lactic Acid)Marcelo O. Omelczuk and James W. McGinity
33-36Lyophilized Formulations of Recombinant Tumor Necrosis FactorManinder S. Hora, Rajsharan K. Rana and Flint W. Smith
37-39Controlled Protein Release from Polyethyleneimine-Coated Poly(L-lactic Acid)/Pluronic Blend MatricesTae Gwan Park, Smadar Cohen and Robert Langer
40-44Localization of Epidermal Growth Factor (EGF) Binding Sites on Antiluminal Plasma Membrane of Rat Kidney: Autoradiographic Study Using Nonfiltering Perfused Rat KidneyDong Chool Kim, Yuichi Sugiyama, Yasushi Kanai, Norio Ohnuma and Manabu Hanano
45-51Feasibility of Measuring the Bioavailability of Topical Betamethasone Dipropionate in Commercial Formulations Using Drug Content in Skin and a Skin Blanching BioassayLynn K. Pershing, Barbara S. Silver, Gerald G. Krueger, Vinod P. Shah and Jerome P. Skelley
52-57Tolerability and Absorption Enhancement of Intranasally Administered Octreotide by Sodium Taurodihydrofusidate in Healthy SubjectsThomas Kissel, Juergen Drewe, Siegfried Bantle, Andreas Rummelt and Christoph Beglinger
58-69Dissolution of lonizable Drugs into Unbuffered Solution: A Comprehensive Model for Mass Transport and Reaction in the Rotating Disk GeometryMarylee Z. Southard, Don W. Green, Valentino J. Stella and Kenneth J. Himmelstein
70-75A Surface Energy Analysis of Mucoadhesion: Contact Angle Measurements on Polycarbophil and Pig Intestinal Mucosa in Physiologically Relevant FluidsClaus-Michael Lehr, Joke A. Bouwstra, Harry E. Boddé and Hans E. Junginger
76-81Buffer Effects on Swelling Kinetics in Polybasic GelsRonald A. Siegel, Ingegerd Johannes, C. Anthony Hunt and Bruce A. Firestone
82-86Influence of Formulation, Receptor Fluid, and Occlusion, on in Vitro Drug Release from Topical Dosage Forms, Using an Automated Flow-Through Diffusion CellAlain Rolland, Gilles Demichelis, Jean-Claude Jamoulle and Braham Shroot
87-93Self-Emulsifying Drug Delivery Systems: Formulation and Biopharmaceutic Evaluation of an Investigational Lipophilic CompoundSusan A. Charman, William N. Charman, Mark C. Rogge, Terry D. Wilson and Frank J. Dutko, et al.
94-100Complexation Studies of Cyclodextrins with Tricyclic Antidepressants Using Ion-Selective ElectrodesGeorgia N. Valsami, Michael A. Koupparis and Panayotis E. Macheras
101-108A Sensitive and Specific Procedure for Quantitation of ADR-529 in Biological Fluids by High-Performance Liquid Chromatography (HPLC) with Column Switching and Amperometric DetectionRichard C. Lewis, Barbara A. Phillips, John R. Baldwin, David T. Rossi and Prem K. Narang
109-114Evaluation of the Physical Stability of Freeze-Dried Sucrose-Containing Formulations by Differential Scanning CalorimetryMarcel P. W. M. te Booy, Rien A. de Ruiter and André L. J. de Meere
115-118Analysis of Hydroxyurea in Capsules and Aqueous Solution and Stability Study with Capillary Gas Chromatography and Thermionic (N–P) Specific DetectionAdnan El-Yazigi and Sameer Al-Rawithi
119-125Validation of a Column-Switching High-Performance Liquid Chromatographic (HPLC) Method for Determination of ML-1035 and Its Five Metabolites in PlasmaBe-Sheng Kuo, James C. Poole and Kin-Kai Hwang
126-130Surface Characterization of Activated Charcoal by X-Ray Photoelectron Spectroscopy (XPS): Correlation with Phenobarbital Adsorption DataGerald M. Burke, Dale Eric Wurster, Mary J. Berg, Peter Veng-Pedersen and Dorothy D. Schottelius
131-137Kinetics of Degradation of Levothyroxine in Aqueous Solution and in Solid StateChong Min Won
138-142Kinetic Study of the Transformation from Tetrahydrate to Monohydrate of a New Antiallergic, Sodium 5-(4-oxo-phenoxy-4H-quinolizine-3-carboxamide)-tetrazolateSatoshi Kitamura, Toshiji Tada, Yoshihiko Okamoto and Tsutomu Yasuda
143-148Bisacylphosphonates Inhibit Hydroxyapatite Formation and Dissolution in Vitro and Dystrophic Calcification in VivoGershon Golomb, Ada Schlossman, Hanan Saadeh, Matilda Levi and Joel M. Van Gelder, et al.
149-154Poly(L-lactic Acid) Microspheres Containing Neutron-Activatable Holmium-165: A Study of the Physical Characteristics of Microspheres Before and After Irradiation in a Nuclear ReactorRussell J. Mumper and Michael Jay
155-158Potential Use of Microdialysis in Pharmacokinetics: A Protein Binding StudyMarianne Ekblom, Margareta Hammarlund-Udenaes, Thomas Lundqvist and Per Sjöberg
159-160Iceberg Formation and the Resulting Effects on Rates of Hydrolysis of AspirinRichard J. Prankerd
160Editorial

Volume 9, Number 2 / February 1992

161-168Pharmacokinetic Analysis of Drug Absorption from Muscle Based on a Physiological Diffusion Model: Effect of Molecular Size on AbsorptionEiji Nara, Masaaki Masegi, Tetsuya Hatono and Mitsuru Hashida
169-177An Experimental Design Strategy for Quantitating Complex Pharmacokinetic Models: Enterohepatic Circulation with Time-Varying Gallbladder Emptying as an ExampleYow-MingChen Wang and Richard H. Reuning
178-181Potentiation of Cytotoxicity of Mitoxantrone Toward CHO-K1 Cells in Vitro by DipyridamolePankaj B. Desai and Rajagopalan Sridhar
182-186A Novel Approach for the Determination of the Pain-Producing Potential of Intravenously Injected Substances in the Conscious RatJohn M. Marcek, William J. Seaman and Royal J. Weaver
187-190Cutaneous Metabolism of Nitroglycerin in Vitro. I. Homogenized Versus Intact SkinNaruhito Higo, Robert S. Hinz, David T. W. Lau, Leslie Z. Benet and Richard H. Guy
191-194Enhanced Bioavailability of Cefoxitin Using Palmitoyl L-Carnitine. I. Enhancer Activity in Different Intestinal RegionsSteven C. Sutton, Edward L. LeCluyse, Leilani Cammack and Joseph A. Fix
195-199Hydrophobic Anionic Gel Beads for Swelling-Controlled Drug DeliveryCherng-Ju Kim and Ping I. Lee
200-205Biodegradable Pseudolatexes: The Chemical Stability of Poly(D,L-Lactide) and Poly (ε-Caprolactone) Nanoparticles in Aqueous MediaMark D. Coffin and James W. McGinity
206-210Development of Extended-Release Solid Dispersions of Nonsteroidal Antiinflammatory Drugs with Aqueous Polymeric Dispersions: Optimization of Drug Release via a Curve-Fitting TechniqueChris Ho and GeorgeChiaw-Chi Hwang
211-214Determination of Lidocaine Concentrations in Skin After Transdermal Iontophoresis: Effects of Vasoactive DrugsJ.Edmond Riviere, Nancy A. Monteiro-Riviere and Alfred O. Inman
215-219An Electrically Modulated Drug Delivery Device. II. Effect of Ionic Strength, Drug Concentration, and TemperatureAntony D'Emanuele and John N. Staniforth
220-223Factors Affecting the Release Rate of Terbutaline from Liposome Formulations After Intratracheal Instillation in the Guinea PigRobert M. Fielding and Robert M. Abra
224-227Pharmacokinetic Evaluation of Drug Interactions with Anti-Human Immunotrophic Virus (HIV) Drugs. III. 2′,3′-Dideoxycytidine (ddC) and Zidovudine in MonkeysMingxin Qian, Anne R. Swagler, Mehul Mehta, C. T. Vishwanathan and James M. Gallo
228-235Competitive Inhibition of Zidovudine Clearance by Probenecid During Continuous CoadministrationShekman L. Wong, Mohsen A. Hedaya and Ronald J. Sawchuk
236-243Effect of Chronic Hypertension on the Blood–Brain Barrier Permeability of LibenzaprilJian-ping Tang, Ashok Rakhit, Frank L. Douglas and Srikumaran Melethil
244-249Bioavailability of Leuprolide Acetate Following Nasal and Inhalation Delivery to Rats and Healthy HumansAkwete Adjei, Dean Sundberg, James Miller and Alexander Chun
250-254Pharmaceutical Properties of Loracarbef: The Remarkable Solution Stability of an Oral 1-Carba-l-dethiacephalosporin AntibioticCarol E. Pasini and Joseph M. Indelicato
255-259Development and Evaluation of a Novel Dissolution Apparatus for Medicated Chewing Gum ProductsJames N. Rider, Ed L. Brunson, Walter G. Chambliss, Robert W. Cleary and Ahmed H. Hikal, et al.
260-265Prolonged Systemic Delivery of Peptide Drugs by Long-Circulating Liposomes: Illustration with Vasopressin in the Brattleboro RatMartin C. Woodle, Gert Storm, Mary S. Newman, Jill J. Jekot and Lila R. Collins, et al.
266-270The Influence of Sucrose, Dextran, and Hydroxypropyl-β-cyclodextrin as Lyoprotectants for a Freeze-Dried Mouse IgG2a Monoclonal Antibody (MN12)Maaike E. Ressing, Wim Jiskoot, Herre Talsma, Cor W. van Ingen and E.Coen Beuvery, et al.
271-275Renal Tubular Handling of p-Aminohippurate and Epidermal Growth Factor (EGF) in Filtering and Nonfiltering Perfused Rat KidneysDong-Chool Kim, Yuichi Sugiyama, Yasufumi Sawada and Manabu Hanano
276-278Colonic Drug Delivery: Enhanced Release of Indomethacin from Cross-Linked Chondroitin Matrix in Rat Cecal ContentAbraham Rubinstein, David Nakar and Amnon Sintov
279-280European Reviewers for Pharmaceutical Research (November 1990-November 1991)
281Association News and Announcements

Volume 9, Number 3 / March 1992

283-290Hydrogels: Swelling, Drug Loading, and ReleaseSung Wan Kim, You Han Bae and Teruo Okano
291-297Pharmacokinetic/Dynamic Correlation of Pulmonary and Cardiac Effects of Fenoterol in Asthmatic Patients After Different Routes of AdministrationGünther Hochhaus, Ernst-Wilhelm Schmidt, Karl L. Rominger and Helmut Möllmann
298-302The Bilayer Floating Capsule: A Stomach-Directed Drug Delivery System for MisoprostolMarianne Oth, Michel Franz, Jacques Timmermans and Andre Möes
303-306Cutaneous Metabolism of Nitroglycerin in Vitro. II. Effects of Skin Condition and Penetration EnhancementNaruhito Higo, Robert S. Hinz, David T. W. Lau, Leslie Z. Benet and Richard H. Guy
307-311Rotating-Disk Dissolution Kinetics of Nitrofurantoin Anhydrate and Monohydrate at Various TemperaturesMakoto Otsuka, Reiko Teraoka and Yoshihisa Matsuda
312-315An Electrically Modulated Drug Delivery Device. III. Factors Affecting Drug Stability During ElectrophoresisAntony D'Emanuele and John N. Staniforth
316-319Simultaneous in Vitro Measurement of Intestinal Tissue Permeability and Transepithelial Electrical Resistance (TEER) Using Sweetana–Grass Diffusion CellsSteven C. Sutton, Alexander E. Forbes, Robyn Cargill, Jerome H. Hochman and Edward L. LeCluyse
320-325Intestinal Absorption of Peptides and Peptide Analogues: Implications of Fasting Pancreatic Serine Protease Levels and pH on the Extent of Oral Absorption in Dogs and HumansPatrick J. Sinko
326-331Mechanism and Site Dependency of Intestinal Mucosal Transport and Metabolism of Thymidine AnaloguesGee-Bae Park and Ashim K. Mitra
332-338Analysis of Zidovudine Distribution to Specific Regions in Rabbit Brain Using MicrodialysisShekman L. Wong, Yanfeng Wang and Ronald J. Sawchuk
339-344Uptake and Stereoselective Binding of the Enantiomers of MK-927, a Potent Carbonic Anhydrase Inhibitor, by Human Erythrocytes in VitroJiunn H. Lin, Tsu-Han Lin and Haiyung Cheng
345-349Population Characteristics of Biological Systems Influenced by Multicomponent Random and Uniform VariationGregory M. Kochak
350-356Use of a Pharmacokinetic Model Incorporating Discontinuous Gastrointestinal Absorption to Examine the Occurrence of Double Peaks in Oral Concentration–Time ProfilesA. Benjamin Suttle, Gary M. Pollack and Kirn L. R. Brouwer
357-364Bacterial Monitoring in Vials Using a Spectrophotometric Assimilation MethodLeonard J. Galante, Michael A. Brinkley and Robert A. Lodder
365-371The Structure of CeliprololNarendra Kumar, Christianna Strohbeck and Herman L. Ammon
372-377New Water-Soluble Pilocarpine Derivatives with Enhanced and Sustained Muscarinic ActivityPascal Druzgala, David Winwood, Malgorzata Drewniak-Deyrup, Scott Smith and Nicholas Bodor, et al.
378-384The Anomalous Hydrolytic Behavior of 1-Phenylvinyl PhosphateAlbert S. Kearney and Valentino J. Stella
385-389Evaluation of the Poisson Distribution for Estimating the Quality of Drug/Diluent Random Powder Mixtures. I. High Particle Size of the Drug ConstituentHerbert Egermann, Peter Frank and Anna Krumphuber
390-397Optimized Formulation of Magnetic Chitosan Microspheres Containing the Anticancer Agent, OxantrazoleEmad Eldin Hassan, Roy C. Parish and James M. Gallo
398-405Mechanisms to Control Drug Release from Pellets Coated with a Silicone Elastomer Aqueous DispersionTerrence C. Dahl and I-Ian T. Sue
406-409Effect of Surfactant Phase in Perfluorocarbon Emulsification EfficiencyJean M. Pasternacki-Surian, Roger L. Schnaare and Edwin T. Sugita
410-413A Novel Method for Determination of Sterility of Microcapsules and Measurement of Viability of Encapsulated OrganismsK. Keith Kwok and Diane J. Burgess
414-418Application of Curdlan to Controlled Drug Delivery. I. The Preparation and Evaluation of Theophylline-Containing Curdlan TabletsMotoko Kanke, Keiko Koda, Yoko Koda and Hirokazu Katayama
419-424The Disposition of a Human Relaxin (hRlx-2) in Pregnant and Nonpregnant RatsPaul A. Cossum, Kevin A. Dwyer, Michael Roth, Sharon A. Chen and Barbara Moffat, et al.
425-434Sustained Delivery of Interleukin-2 from a Poloxamer 407 Gel Matrix Following Intraperitoneal Injection in MiceThomas P. Johnston, Monika A. Punjabi and Christopher J. Froelich
435-439The Influence of Peptide Structure on Transport Across Caco-2 Cells. II. Peptide Bond Modification Which Results in Improved PermeabilityRobert A. Conradi, Alien R. Hilgers, Norman F. H. Ho and Philip S. Burton
440Association News and Announcements

Volume 9, Number 4 / April 1992

441-449Polyalkylcyanoacrylate Nanoparticles as Polymeric Carriers for Antisense OligonucleotidesChristine Chavany, Trung Le Doan, Patrick Couvreur, Francis Puisieux and Claude Hélèna
450-456Correlation of in Vitro Release Rate and in Vivo Absorption Characteristics of Four Chlorpheniramine Maleate Extended-Release FormulationsParviz Mojaverian, Elaine Radwanski, Chin-Chung Lin, Phillip Cho and Winston A. Vadino, et al.
457-463Pharmacokinetic and Pharmacodynamic Comparison of Immediate-Release and Sustained-Release Adinazolam Mesylate Tablets After Single- and Multiple-Dose AdministrationJoseph C. Fleishaker and C. Eugene Wright
464-468The Pharmacokinetics of Trilostane and Ketotrilostane in an Interconverting System in the RatJ. Paul McGee and P. Nicholas Shaw
469-473Saturable Tissue Binding and Imirestat Pharmacokinetics in RatsJenny Y. Chien, Christopher R. Banfield, Romulus K. Brazzell, Philip R. Mayer and John T. Slattery
474-479Significance of Binding to Na,K-ATPase in the Tissue Distribution of Ouabain in Guinea PigsHideyoshi Harashima, Michio Mamiya, Masayo Yamazaki, Yuichi Sugiyama and Yasufumi Sawada, et al.
480-484The in Situ Acetylation of an Immobilized Human Serum Albumin Chiral Stationary Phase for High-Performance Liquid Chromatography in the Examination of Drug–Protein Binding PhenomenaTerence A. G. Noctor and Irving W. Wainer
485-491An Air-Gap Enzyme Electrode: Development and ApplicationsRavi M. Shanker, Nashed E. Nashed and Siegfried Lindenbaum
492-496Stereoselective Enzymatic Hydrolysis of Various Ester Prodrugs of Ibuprofen and Flurbiprofen in Human PlasmaNiels Mørk and Hans Bundgaard
497-503The in Vitro Enzymic Labilities of Chemically Distinct Phosphomonoester ProdrugsAlbert S. Kearney and Valentine J. Stella
504-514Amino Acid Side-Chain Contributions to Free Energy of Transfer of Tripeptides from Water to OctanolAeri Kim and Francis C. Szoka Jr
515-520Nebulization of Liposomes. III. The Effects of Operating Conditions and Local EnvironmentRalph W. Niven, Teresa M. Carvajal and Hans Schreier
521-528Infrared Imaging of Pharmaceutical Materials Undergoing CompactionSimon R. Bechard and G. R. B. Down
529-534Absorptive-Mediated Endocytosis of an Adrenocorticotropic Hormone (ACTH) Analogue, Ebiratide, into the Blood–Brain Barrier: Studies with Monolayers of Primary Cultured Bovine Brain Capillary Endothelial CellsTetsuya Terasaki, Susumu Takakuwa, Akira Saheki, Shuzo Moritani and Takesada Shimura, et al.
535-540Aminopeptidase Activity in the Jejunal and Heal Peyer's Patches of the Albino RabbitEiji Hayakawa and Vincent H. L. Lee
541-546Phagocytosis of Nanoparticles by Human Immunodeficiency Virus (HlV)-Infected Macrophages: A Possibility for Antiviral Drug TargetingVolker Schäfer, Hagen von Briesen, Reinhard Andreesen, Anne-Marie Steffan and Cathy Royer, et al.
547-553Bioadhesion by Means of Specific Binding of Tomato LectinClaus-Michael Lehr, Joke A. Bouwstra, Wouter Kok, Arthur B. J. Noach and Albertus G. de Boer, et al.
554-558Influence of Supersaturation on the Pharmacodynamic Effect of Bupranolol After Dermal Administration Using Microemulsions as VehicleJens Kemken, Albrecht Ziegler and Bernd W. Müller
559-564Sonophoresis. I. The Use of High-Frequency Ultrasound to Enhance Transdermal Drug DeliveryD. Bommannan, Hirohisa Okuyama, Paul Stauffer and Richard H. Guy
565-569Characteristics of Association of Oleoyl Derivatives of 5-Fluorodeoxyuridine and Methotrexate with Low-Density Lipoproteins (LDL)P. Chris de Smidt and Theo J. C. van Berkel
570-574Physicochemical Properties of the Novel Heteropolyanion Antiviral Hexapotassium-α-vanado-11-tungstoborate (DuP 925)Michael B. Maurin, Rodney D. Vickery, W. M. Bryant, III and Munir A. Hussain
575-5771H-Nuclear Magnetic Resonance (NMR) Studies on the Inclusion Complex of Prostaglandin El (PGE1 with α-CyclodextrinBert Steffan, Wilfried Fischer, Günther Cordes, Ilona Habon and Robert Müller
578-581A Flexible Automated Dissolution Testing System for Use with Either USP Apparatus 1 or USP Apparatus 2Jeanette D. Dunkle, Daniel J. Gleason and Gerard C. Hokanson
582-584Determination of Dissociation Constants of Selected Cyclodextrin–Benzaldehyde Inclusion Complexes Using Pulse Polarography1Hee-Sook Choi, Ching-jer Chang and Adelbert M. Knevel
585BOOK REVIEWS
585-586BOOK REVIEWS
586-587BOOK REVIEWS
586-587BOOK REVIEWS
588-592Analytical Methods Validation: Bioavailability, Bioequivalence and Pharmacokinetic StudiesVinod P. Shah, Kamal K. Midha, Shrikant Dighe, Iain J. McGilveray and Jerome P. Skelly, et al.
593-594Association News and Announcements

Volume 9, Number 5 / May 1992

595-600Stability Studies of Gabapentin in Aqueous SolutionsElena Zour, Shahid A. Lodhi, Russell U. Nesbitt, Steven B. Silbering and Pravin R. Chaturvedi
601-606Analytical Method Comparison Based upon Statistical Power CalculationsDavid J. Mazzo and Margaret Connolly
607-612Effect of Water Mobility on Drug Hydrolysis Rates in Gelatin GelsSumie Yoshioka, Yukio Aso and Tadao Terao
613-616Initial Studies on the N-Glucosylation of Phenobarbital by Mouse Liver Microsomes Using a Radiochemical High-Performance Liquid Chromatographic (HPLC) MethodWilliam H. Soine, Hosai Safi and Richard B. Westkaemper
617-622Kinetics and Mechanism of Isomerization of Cyclosporin AReza Oliyai and Valentino J. Stella
623-625Microbial Production of a Crisnatol MetaboliteCharles D. Hufford, Saleh H. El-Sharkawy, Tannis M. Jurgens and Julie R. Mikell
626-628A Phosphinic Acid Dipeptide Analogue to Stabilize Peptide Drugs During Their Intranasal AbsorptionMunir A. Hussain, Marguerita S. L. Lim, Krishnaswamy S. Raghavan, Nancy J. Rogers and Rommel Hidalgo, et al.
629-635Adsorption of Fluorescein Dyes on Albumin MicrospheresKamel Egbaria and Michael Friedman
636-642Prediction and Assessment of Flammability Hazards Associated with Metered-Dose Inhalers Containing Flammable PropellantsRichard N. Dalby
643-647Analytical Control Procedures of Immunoreactivity for IgG and Fab Fragments Specific to HaptensNathalie J. Cano, Alain E. Sabouraud, Michel Urtizberea, Jean Carcagne and Michel Grandgeorge, et al.
648-653Differences in the Enhancing Effects of Sodium Caprate on Colonic and Jejimal Drug AbsorptionMikio Tomita, Toyohiro Sawada, Takahiro Ogawa, Hiroyuki Ouchi and Masahiro Hayashi, et al.
654-657Gastrointestinal Transit and Systemic Absorption of Captopril from a Pulsed-Release FormulationIan R. Wilding, Stanley S. Davis, Massoud Bakhshaee, Howard N. E. Stevens and Robert A. Sparrow, et al.
658-662Heat-Induced Drug Release Rate and Maximal Targeting Index of Thermosensitive Liposome in Tumor-Bearing MiceKatsumi Iga, Yasuaki Ogawa and Hajime Toguchi
663-669Predicting Skin PermeabilityRussell O. Potts and Richard H. Guy
670-676Equilibrium and Kinetic Factors Influencing Bile Sequestrant EfficacyPaul E. Luner and Gordon L. Amidon
677-682Pharmacokinetic and Metabolic Disposition of p-Chloro-m-xylenol (PCMX) in DogsAngelica Dorantes and Salomon Stavchansky
683-686Effect of an Acute Dose of Alcohol on the Pharmacokinetics of Oral Nifedipine in HumansSaeed Qureshi, Sylvie Laganière, Gilles Caillé, Denys Gossard and Yves Lacasse, et al.
687-689Esterase Activity Toward the Diastereomers of Cefuroxime Axetil in the Rat and DogGerold L. Mosher, Julianne McBee and David B. Shaw
690-693Molecular Complexation: β-Cyclodextrin and Benzaldehyde Inclusion ComplexHee-Sook Choi, Adelbert M. Knevel and Ching-jer Chang
694-696Pharmacokinetics of Droperidol in Healthy Volunteers Following Intravenous Infusion and Rectal Administration from an Osmotic Drug Delivery ModuleSuneel K. Gupta, Mary Southam and Stephen Hwang
697-699Enhanced Bioavailability of 6-Mercaptopurine After Rectal Administration in RatsYasuhisa Kato, Takeji Matsushita, Tomomasa Yokoyama and Kiminori Mohri
700BOOK REVIEWS
700-701BOOK REVIEWS
702Association News and Announcements

Volume 9, Number 6 / June 1992

703-714Anti-AIDS Drug Development: Challenges and StrategiesPrem Mohan
715-726Chemical Stability of Insulin. 1. Hydrolytic Degradation During Storage of Pharmaceutical PreparationsJens Brange, Liselotte Langkj\sgmaelig;r, Svend Havelund and Aage Vølund
727-734Chemical Stability of Insulin. 2. Formation of Higher Molecular Weight Transformation Products During Storage of Pharmaceutical PreparationsJens Brange, Svend Havelund and Philip Hougaard
735-738Derivatives of 4-(2-N,N-Di-n-propylaminoethyl)-5-hydroxyindole: Synthesis and Pharmacological EffectsJoseph G. Cannon, Ioannis Roufos, Sheng Xing Ma and John Paul Long
739-742Structural Modification Study of Anthracyclinones: Synthesis and Biological Activity of Several Derivatives of η-PyrromycinoneDun-Fu Liu, Hui Xiong and Chia-Chung Cheng
743-749Improved Delivery Through Biological Membranes. XLV. Synthesis, Physical-Chemical Evaluation, and Brain Uptake Studies of 2-Chloroethyl Nitrosourea Delivery SystemsKrishnaswamy Raghavan, Thorsteinn Loftsson, Marcus E. Brewster and Nicholas Bodor
750-752Parenteral Formulation of the Kappa Agonist Analgesic, DuP 747, via Micellar SolubilizationMunir A. Hussain, Lei-Shu Wu, Christopher Koval and Arthur R. Hurwitz
753-758Acceleration of Heat Transfer in Vial Freeze-Drying of Pharmaceuticals. II. A Fluid Cushion DeviceSamuel H. Yalkowsky and Suresh D. Patel
759-763Microencapsulation of Solid Dispersions: Release of Griseofulvin from Griseofulvin:Phospholipid Coprecipitates in MicrospheresGopi K. Vudathala and James A. Rogers
764-768The Pharmacokinetics of Pulmonary-Delivered Insulin: A Comparison of Intratracheal and Aerosol Administration to the RabbitPaul Colthorpe, Stephen J. Farr, Glyn Taylor, lan J. Smith and David Wyatt
769-775Conjunctival Penetration of Insulin and Peptide Drugs in the Albino RabbitEiji Hayakawa, Du-Shieng Chien, Kazuhiro Inagaki, Akira Yamamoto and Wei Wang, et al.
776-781Immobilization of Active Urokinase on Albumin Microspheres: Use of a Chemical Dehydrant and Process MonitoringKumaril Bhargava and Howard Y. Ando
782-787Macrophage Activation by Polymeric Nanoparticles of Polyalkylcyanoacrylates: Activity Against Intracellular Leishmania donovani Associated with Hydrogen Peroxide ProductionRogério Gaspar, Veronique Préat, Fred R. Opperdoes and Michel Roland
788-791The Mobile Order Theory Versus UNIFAC and Regular Solution Theory-Derived Models for Predicting the Solubility of Solid SubstancesPaul Ruelle, Michel Buchmann, Hô Nam-Tran and Ulrich W. Kesselring
792-799Cholesterol (Thermodynamic) Activity Determinations in Bile Salt–Lecithin–Cholesterol Systems and Cholesterol-Rich Liquid Crystalline Mesophase FormationUday K. Jain, William I. Higuchi, Chen L. Liu, Paul H. Lee and Norman A. Mazer
800-807Plasma Concentration Clamping in the Rat Using a Computer-Controlled Infusion PumpLars L. Gustafsson, William F. Ebling, Eileen Osaki, Sandy Harapat and Donald R. Stanski, et al.
808-811Stability of the New Anticancer Platinum Analogue 1,2-Diaminomethyl-Cyclobutane-Platinum(II)-Lactate (Lobaplatin; D19466) in Intravenous SolutionsHenk-Jan Guchelaar, Donald R. A. Uges, Paul Aulenbacher, Elisabeth G. E. de Vries and Nanno H. Mulder
812-816Simultaneous Microdetermination of Rifampin, Deacetylrifampin, Isoniazid, and Acetylisoniazid in Plasma by Liquid Chromatography with Dual Electrochemical and Spectrophotometric DetectionAdnan El-Yazigi and Dale A. Raines
817-821Comparison of Azone and Hexamethylene Lauramide in Toxicologic Effects and Penetration Enhancement of Cimetidine in Rabbit EyesI. Maged Ismail, Chi-Chu Chen, Joseph B. Richman, Jon S. Andersen and Diane D.-S. Tang-Liu
822-825Pharmacokinetics of Oral 2′,3′-Dideoxyinosine in RatsM. Guillaume Wientjes and Jessie L.-S. Au
826-833Opportunities for Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug DevelopmentCarl C. Peck, William H. Barr, Leslie Z. Benet, Jerry Collins and Robert E. Desjardins, et al.
834Association News and Announcements

Volume 9, Number 7 / July 1992

835-844Biosensor DevelopmentJeffrey N. Roe
845-849Reversal of Signs of Induced Cotton Effects of Dicumarol-α1-Acid Glycoprotein Systems by Phenothiazine Neuroleptics Through Ternary ComplexationToshimi Miyoshi, Ryuji Yamamichi, Toru Maruyama and Masaki Otagiri
850-855The Enantiomers of the Valproic Acid Analogue 2-n-Propyl-4-pentynoic Acid (4-yn-VPA): Asymmetric Synthesis and Highly Stereoselective Teratogenicity in MiceRalf-Siegbert Hauck and Heinz Nau
856-859Microscopic Characterization of Particle Size and Shape: An Inexpensive and Versatile MethodMichael E. Houghton and Gregory E. Amidon
860-863Sterile Filtration of a Parenteral EmulsionDeborah M. Lidgate, Thomas Trattner, Richard M. Shultz and Richard Maskiewicz
864-869Dissociation of Insulin Oligomers by Bile Salt Micelles and Its Effect on α-Chymotrypsin-Mediated Proteolytic DegradationYuping Li, Zezhi Shao and Ashim K. Mitra
870-877Effect of Zinc Binding on the Structure and Stability of Fibrolase, a Fibrinolytic Protein from Snake VenomDenise Pretzer, Brenda Schulteis, David G. Vander Velde, Christopher D. Smith and James W. Mitchell, et al.
878-883Vaginal Absorption of Insulin in the Rat: Effect of Penetration Enhancers on Insulin Uptake and Mucosal HistologyJulie L. Richardson, Lisbeth Illum and Norman W. Thomas
884-887The Influence of Different Strains and Age on in Vitro Rat Skin Permeability to Water and MannitolIan P. Dick and Robert C. Scott
888-893Oral Delivery of a Renin Inhibitor Compound Using Emulsion FormulationsTugrul T. Kararli, Thomas E. Needham, Marty Griffin, Grant Schoenhard and Leonard J. Ferro, et al.
894-900Intestinal Water and Solute Absorption Studies: Comparison of in Situ Perfusion with Chronic Isolated Loops in RatsHsiao-Hwa Lu, James D. Thomas, Josef J. Tukker and David Fleisher
901-907Absorption of Flurbiprofen in the Fed and Fasted StatesJennifer B. Dressman, Rosemary R. Berardi, Grace H. Elta, Thomas M. Gray and Patricia A. Montgomery, et al.
908-914Effect of Chronic Administration of Phenobarbital on the Hepatobiliary Transport of Phenol Red: Assessment by Statistical Moment AnalysisToshiyuki Kakutani, Kaori Endo, Eiji Nara, Shigenobu Nakazora and Mitsuru Hashida
915-919Multiple Oral Administration of a Ketoprofen–Dextran Ester Prodrug in Pigs: Assessment of Gastrointestinal Unavailability by DeconvolutionFrank Larsen, Bodil Hamborg Jensen, Henning Peter Olesen and Claus Larsen
920-924An in Vitro Pharmacodynamic Model to Simulate Antibiotic Behavior of Acute Otitis Media with EffusionKyle Vance-Bryan, Tom A. Larson, Mark W. Garrison, John P. Toscano and Daniel M. Canafax, et al.
925-928BioequivalenceAldo Rescigno
929-932Method for the Determination of Diphenhydramine in Rabbit Whole Blood by High-Performance Liquid Chromatography (HPLC) with Ultraviolet (UV) Detection in Conjunction with Gas Chromatography (GC) with Mass Selective Detection (MSD)Karen M. Walters-Thompson and William D. Mason
933-938Investigation of the Degradation Mechanism of 5-Aminosalicylic Acid in Aqueous SolutionRita K. Palsmeier, Donna M. Radzik and Craig E. Lunte
939-944Solid-State Stability Testing of Drugs by Isothermal CalorimetryMichael J. Koenigbauer, Stephen H. Brooks, Gregory Rullo and Richard A. Couch
945-951Application of Electrospray Mass Spectrometry (ES-MS) for the Analysis of Monoclonal Antibody Fc SubunitsWim Jiskoot, Gerrit van de Werken, José M. Coco Martin, Brian N. Green and E. Coen Beuvery, et al.
952-954Transdermal Delivery of Insulin to Alloxan-Diabetic Rabbits by Ultrasound ExposureKatsuro Tachibana
955-957Electric Current-Sensitive Drug Delivery Systems Using Sodium Alginate/Polyacrylic Acid CompositesSoon Hong Yuk, Sun Hang Cho and Hai Bang Lee
958-959Ideal Solubility of a Solid Solute: Effect of Heat Capacity AssumptionsDinesh S. Mishra and Samuel H. Yalkowsky
960-962Physical Properties of Fast-Release Nonreverting Hydrochlorothiazide Solid DispersionsMahasen M. Meshali and Khairy E. Gabr
963-965Etorphine Is an Opiate Analgesic Physicochemically Suited to Transdermal DeliveryLynn M. Jolicoeur, M. Reza Nassiri, Charles Shipman Jr, Hoo-Kyun Choi and Gordon L. Flynn
966BOOK REVIEWS
966-967BOOK REVIEWS
968Association News and Announcements

Volume 9, Number 8 / August 1992

969-978Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug DeliveryJane P. F. Bai and Gordon L. Amidon
979-989Novel Animal Model for Evaluating Topical Efficacy of Antiviral Agents: Flux Versus Efficacy Correlations in the Acyclovir Treatment of Cutaneous Herpes Simplex Virus Type 1 (HSV-1) Infections in Hairless MicePaul H. Lee, Muh-Hwan Su, Earl R. Kern and William I. Higuchi
990-992Protein–Peptide Interactions as Probed by Tryptophan Fluorescence: Serum Albumins and Enkephalin MetabolitesSunil Jain, C. Vijaya Kumar and Devendra S. Kalonia
993-1002An Implantable Dosage Form for the Treatment of Bone InfectionsAlekha K. Dash and Raj Suryanarayanan
1003-1009Pharmacodynamics of Insulin Following Intravenous and Enteral Administrations of Porcine-Zinc Insulin to RatsRobert J. Schilling and Ashim K. Mitra
1010-1017Antisense c-myc Oligodeoxyribonucleotide Cellular UptakeSusanna Wu-Pong, Tania L. Weiss and C. Anthony Hunt
1018-1023Measurement of Serum [3H]Tetracycline Kinetics and Indices of Kidney Function Facilitate Study of the Activity and Toxic Effects of Bisphosphonates in Bone ResorptionGershon Golomb, Yael Eitan and Amnon Hoffman
1024-1028Enhancement of Nasal Delivery of a Renin Inhibitor in the Rat Using Emulsion FormulationsTugrul T. Kararli, Thomas E. Needham, Grant Schoenhard, David A. Baron and R. Eric Schmidt, et al.
1029-1034The Transport Barrier of Epithelia: A Comparative Study on Membrane Permeability and Charge Selectivity in the RabbitYongyut Rojanasakul, Li-Ying Wang, Meenakshi Bhat, Douglas D. Glover and Carl J. Malanga, et al.
1035-1042Quantitative Evaluation of Aqueous Isopropanol Enhancement of Skin Flux of Terbutaline (Sulfate). I. Ion Associations and Species Equilibria in the FormulationPuchun Liu, Tamie Kurihara-Bergstrom, Frank H. Clarke, Nina Gonnella and William R. Good
1043-1047Sonophoresis. II. Examination of the Mechanism(s) of Ultrasound-Enhanced Transdermal Drug DeliveryD. Bommannan, Gopinathan K. Menon, Hirohisa Okuyama, Peter M. Elias and Richard H. Guy
1048-1052Brain Parenchymal Metabolism of 5-Iodo-2′-Deoxyuridine and 5′-Ester ProdrugsMridul K. Ghosh and Ashim K. Mitra
1053-1057Disposition, Bioavailability, and Serum Protein Binding of Pentachlorophenol in the B6C3F1 MouseBruno G. Reigner, Jean F. Rigod and Thomas N. Tozer
1058-1063Pharmacokinetic Analysis of the Structural Requirements for Forming “Stable” Analogues of ValpromideAbdulla Haj-Yehia, Salim Hadad and Meir Bialer
1064-1069Pilocarpine Disposition and Salivary Flow Responses Following Intravenous Administration to DogsMargaret L. Weaver, Jason M. Tanzer and Paul A. Kramer
1070-1075Nonlinear Disposition of Intravenous 2′,3′-Dideoxyinosine in RatsM. Guillaume Wientjes, Elora Mukherji and Jessie L-S. Au
1076-1082Is ICRF-187 [(+)-1,2-Bis(3,5-dioxopiperazinyl-1-yl)propane] Unusually Reactive for an Imide?Jay M. Sisco and Valentino J. Stella
1083-1091Formation of the Racemic Compound of Ephedrine Base from a Physical Mixture of Its Enantiomers in the Solid, Liquid, Solution, or Vapor StateSarma P. Duddu and David J. W. Grant
1092-1095Aqueous Stability and Solubility of CI-988, a Novel “Dipeptoid” Cholecystokinin-B Receptor AntagonistAlbert S. Kearney, Surendra C. Mehta and Galen W. Radebaugh
1096-1098Corticosteroid Pharmacodynamic Modeling: Osteocalcin Suppression by PrednisoloneJeffrey A. Wald and William J. Jusko
1099-1102Inhibition of Hepatic and Cutaneous Biotransformation of Resorufin Ethers Following Intraperitoneal Administration of 1-AminobenzotriazoleNeil F. Oldfield, Mildred Mortillo, William A. Garland and Bruce A. Mico
1103-1106Peptides Are Better Absorbed from the Lung than the Gut in the RatJennifer L. Hoover, Bob D. Rush, Karen F. Wilkinson, Jeff S. Day and Philip S. Burton, et al.
1107-1112Principles and Criteria in the Development and Optimization of Topical Therapeutic ProductsVinod P. Shah, Charan R. Behl, Gordon L. Flynn, William I. Higuchi and Hans Schaefer

Volume 9, Number 9 / September 1992

1113-1122Transport of Thyrotropin Releasing Hormone in Rabbit Buccal Mucosa in VitroMartin E. Dowty, Kim E. Knuth, Brian K. Irons and Joseph R. Robinson
1123-1127Assessment of the Twin Impinger for Size Measurement of Metered-Dose Inhaler SpraysNicholas C. Miller, Virgil A. Marple, Robert K. Schultz and Wai Sing Poon
1128-1131Calcium Alginate Beads as Core Carriers of 5-Aminosalicylic AcidShun Y. Lin and James W. Ayres
1132-1136Indomethacin-Loaded Microspheres: Design and Preparation by a Multiple-Emulsification Technique and Their in Vitro EvaluationSuranjana Roy, Manjusree Pal and Bijan K. Gupta
1137-1144Evaluation of Mucoadhesive Polymers in Ocular Drug Delivery. II. Polymer-Coated VesiclesNigel M. Davies, Stephen J. Farr, Jonathan Hadgraft and Ian W. Kellaway
1145-1151Percutaneous Absorption and Metabolism of Lonapalene in Psoriatic SkinPaul A. Lehman, Raymond V. Tomlinson, Jerry I. Johnson, John E. Olerud and William A. Akers, et al.
1152-1156Correlation Between the Inhibitory Effects of Basic Drugs on the Uptake of Cardiac Glycosides and Taurocholate by Isolated Rat HepatocytesKazuho Okudaira, Masayo Yamazaki, Yasufumi Sawada, Yuichi Sugiyama and Tatsuji Iga, et al.
1157-1163Cyclodextrins as Nasal Absorption Promoters of Insulin: Mechanistic EvaluationsZezhi Shao, Ramesh Krishnamoorthy and Ashim K. Mitra
1164-1167In Vivo Percutaneous Absorption of Hydrocortisone: Multiple-Application Dosing in ManJoseph L. Melendres, Daniel A. W. Bucks, Etienne Camel, Ronald C. Wester and Howard I. Maibach
1168-1172Effects of Transdermal Penetration Enhancers on the Permeability of Shed SnakeskinTomoo Itoh, Lori Wasinger, T. Marjukka Turunen and J. Howard Rytting
1173-1176Enhanced Delivery of 5-Iodo-2′-Deoxyuridine to the Brain ParenchymaMridul K. Ghosh and Ashim K. Mitra
1177-1183Direct Suppression of Phagocytosis by Amphipathic Polymeric SurfactantsNancy Watrous-Peltier, Joanne Uhl, Vivian Steel, Lynne Brophy and Elaine Merisko-Liversidge
1184-1189Nasal Membrane and Intracellular Protein and Enzyme Release by Bile Salts and Bile Salt-Fatty Acid Mixed Micelles: Correlation with Facilitated Drug TransportZezhi Shao and Ashim K. Mitra
1190-1194Influence of Gastrointestinal Site of Drug Delivery on the Absorption Characteristics of RanitidineMelissa F. Williams, George E. Dukes, William Heizer, Yieng-Hau Han and David J. Hermann, et al.
1195-1198Molecular Weight-Dependent Lymphatic Transfer of Exogenous Macromolecules from Large Intestine of Renal Insufficiency RatsHiroshi Yoshikawa, Kanji Takada and Shozo Muranishi
1199-1202Quantitative Analysis of Mercaptoundecahydrododecaborate by Fourier Transform Infrared SpectroscopyD. Robert Lu and Corey Munro
1203-1208Solid-State Stability Studies of 13-cis-Retinoic Acid and All-trans-Retinoic Acid Using Microcalorimetry and HPLC AnalysisXinyi Tan, Noel Meltzer and Siegfried Lindenbaum
1209-1214An Unexpected Hydrolysis pH-Rate Profile, at pH Values Less than 7, of the Labile Imide, ICRF-187: (+)-1,2-Bis-(3,5 -dioxopiperazin-1-yl)propaneJay M. Sisco and Valentino J. Stella
1215-1218A New Application Chamber for Skin Penetration Studies in Vivo with Liquid PreparationsClaudia S. Leopold and Bernhard C. Lippold
1219-1223Analysis of Pilocarpine and Its Degradation Products by Micellar Electrokinetic Capillary ChromatographyWilliam N. Charman, Andrew J. Humberstone and Susan A. Charman
1224-1226Survey of Chlorinated Hydrocarbons and Other Organic Volatile Impurities in Captopril Raw Materials and TabletsTerry D. Cyr, Robert C. Lawrence and Edward G. Lovering
1227-1230Determination of a Novel Calcium Channel Antagonist, Mepirodipine, in Plasma by Radioreceptor Assay Using (+)-[3H]PN 200-110Shizuo Yamada, Youmei Matsuoka, Naoko Suzuki, Noriaki Sugimoto and Yoshihisa Kato, et al.
1231BOOK REVIEWS
1231-1232BOOK REVIEWS
1233-1234Letters to the EditorWolfgang Klement, Detlef Kindgen-Milles, John M. Marcek, William J. Seaman and Royal J. Weaver
1234Obituary for Razia Zaman and Shahanara Zaman SaroyaL. Bernstam, I. Bernstein, K. Brabec, M. Brabec and R. Brown, et al.

Volume 9, Number 10 / October 1992

1235-1242Delivery of Plasmid DNA into Mammalian Cell Lines Using pH-Sensitive Liposomes: Comparison with Cationic LiposomesJean-Yves Legendre and Francis C. Szoka Jr
1243-1251Regional Jejunal Perfusion, a New in Vivo Approach to Study Oral Drug Absorption in ManHans Lennernäs, Örjan Ahrenstedt, Roger Hällgren, Lars Knutson and Märta Ryde, et al.
1252-1255Suppression of Inflammation by Cyclosporin A Is Mediated via a T Lymphocyte-Independent ProcessThomas E. Miller, Glenne Findon and Douglas J. Ormrod
1256-1261Microdialysis Sampling for the Investigation of Dermal Drug TransportJoseph M. Ault, Craig E. Lunte, Noel M. Meltzer and Christopher M. Riley
1262-1267Acyclovir Permeation Enhancement Across Intestinal and Nasal Mucosae by Bile Salt-Acylcarnitine Mixed MicellesGee-Bae Park, Zezhi Shao and Ashim K. Mitra
1268-1274Effect of Loading on Swelling-Controlled Drug Release from Hydrophobic Polyelectrolyte Gel BeadsCherng-Ju Kim and Ping I. Lee
1275-1278Metabolism, Distribution, and Transdermal Permeation of a Soft Corticosteroid, Loteprednol EtabonateNicholas Bodor, Thorsteinn Loftsson and Whei-mei Wu
1279-1283Molecular Weight Changes in Polymer ErosionAntony D’Emanuele, Jennifer Hill, Janet A. Tamada, Abraham J. Domb and Robert Langer
1284-1289Dose Proportionality of Transdermal NitroglycerinR. C. Jewell, C. R. Banfield, D. A. Ruggirello, Y. W. Huang and P. K. Noonan, et al.
1290-1294Metabolism of Testosterone During in Vitro Transport Across CACO-2 Cell Monolayers: Evidence for β-Hydroxysteroid Dehydrogenase Activity in Differentiated CACO-2 CellsAnders Buur and Niels Mørk
1295-1298High-Dose Methotrexate Does Not Affect the Pharmacodynamics of Phenobarbital Hypnotic Action but Decreases the Central Nervous System (CNS) Sensitivity to Pentylenetetrazol-Induced Maximal Seizures in RatsAmnon Hoffman and Jose Alfon
1299-1305Studies on the Excretion of Diazepam and Nordazepam into Milk for the Prediction of Milk-to-Plasma Drug Concentration RatiosThomas Stebler and Theodor W. Guentert
1306-1313General Treatment of the Enterohepatic Recirculation of Drugs and Its Influence on the Area Under the Plasma Level Curves, Bioavailability, and ClearanceJosé-Esteban Peris-Ribera, Francisca Torres-Molina, M. Carmen Garcia-Carbonell, Juan Carlos Aristorena and Luis Granero
1314-1320Kinetics and Mechanism of Degradation of a Cyclic Hexapeptide (Somatostatin Analogue) in Aqueous SolutionRamesh Krishnamoorthy and Ashim K. Mitra
1321-1323A Quantitative Structure-Activity Relationship (QSAR) Study of Alkylpyrazine Odor ModalitiesAnna Tsantili-Kakoulidou and Lemont B. Kier
1324-1329The Effects of N(4-Methylphenyl)diphenimide on Lipid Metabolism of Sprague Dawley RatsIris H. Hall, O. T. Wong, Rupendra Simlot and David J. Reynolds
1330-1335Microparticles of Polyvinyl Alcohol for Nasal Delivery. I. Generation by Spray-Drying and Spray-DesolvationTeck-Yeo Ting, Igor Gonda and Elizabeth M. Gipps
1336-1340Participation of Macrogolstearate 400 Lamellar Phases in Hydrophilic Creams and VesiclesValentina Paspaleeva-Kühn and Eberhard Nürnberg
1341-1346Benzoyl Peroxide Solubility and Stability in Hydric SolventsEric M. Chellquist and William G. Gorman
1347-1350Predicting the Effect of Nonionic Surfactants on Dispersed Droplet Radii in Submicron Oil-in-Water EmulsionsShawn Silvestri, Nandita Ganguly and Esmail Tabibi
1351-1358Powdered Solution Technology: Principles and MechanismSpiros S. Spireas, Charles I. Jarowski and Bhagwan D. Rohera
1359-1361In Vitro Oral Mucosal Absorption of Liposomal Triamcinolone AcetonideStefan J. Sveinsson and Michael Mezei
1362-1364Nasal Absorption of Leucine Enkephalin in Rats and the Effects of Aminopeptidase Inhibition, as Determined from the Percentage of the Dose UnabsorbedMunir A. Hussain and Bruce J. Aungst
1365-1369High-Performance Liquid Chromatography Determination of Acitretin in Plasma and Its Application to a Pharmacokinetic Study in Human SubjectsChristian Surber, Jean-Philippe Laugier, Jean-Marie Geiger, Hot Bun and Alain Durand, et al.
1370-1373Inhibition of myo-Inositol 1-Phosphatase by cis-l,2,3-Cyclohexanetriol 1-Phosphate, a Molecular Simplification of the Natural SubstrateMarc W. Harrold, Anong Sriburi, Paul Caimano, Hansheng Qi and David Seybert, et al.
1374Association News and Announcements

Volume 9, Number 11 / November 1992

1375-1379Monoclonal Antibodies in Hapten ImmunoassaysOlivier N. Chappey, Pierre Sandouk and Jean-Michel G. Scherrmann
1380-1385An Alternative Approach for Assessment of Rate of Absorption in Bioequivalence StudiesMei-Ling Chen
1386-1393Identification of Sites of Degradation in a Therapeutic Monoclonal Antibody by Peptide MappingDaniel J. Kroon, Alysia Baldwin-Ferro and Praful Lalan
1394-1401Localization of Binding Sites for Epidermal Growth Factor (EGF) in Rat Kidney: Evidence for the Existence of Low Affinity EGF Binding Sites on the Brush Border MembraneDong Chool Kim, Manabu Hanano, Yasushi Kanai, Norio Ohnuma and Yuichi Sugiyama
1402-1409Skin Alteration and Convective Solvent Flow Effects During Iontophoresis II. Monovalent Anion and Cation Transport Across Human SkinSandra M. Sims, William I. Higuchi and V. Srinivasan
1410-1414Noninvasive in Vivo Percutaneous Absorption Measurements Using X-Ray FluorescenceJ. David Robertson, Elizabeth Ferguson, Michael Jay and Dennis J. Stalker
1415-1421Lamellar Structures Formed by Stratum Corneum Lipids in Vitro: A Deuterium Nuclear Magnetic Resonance (NMR) StudyWilliam Abraham and Donald T. Downing
1422-1427Local Enhanced Topical Delivery (LETD) of Drugs: Does It Truly Exist?Stephen C. McNeill, Russell O. Potts and Michael L. Francoeur
1428-1435Physicochemical Properties of Salts of p-Aminosalicylic Acid. I. Correlation of Crystal Structure and Hydrate StabilityRobert T. Forbes, Peter York, Victor Fawcett and Leonard Shields
1436-1441In Vivo Evaluation of Enteric-Coated Naproxen Tablets Using Gamma ScintigraphyIan R. Wilding, John G. Hardy, R. Andrew Sparrow, Stanley S. Davis and Paul B. Daly, et al.
1442-1450Distribution and Elimination of the Glycosidase Inhibitors 1-Deoxymannojirimycin and N-Methyl-1-Deoxynojirimycin in the Rat in VivoEsther D. Faber, Roelof Oosting, Jacques J. Neefjes, Hidde L. Ploegh and Dirk K. F. Meijer
1451-1455Pharmacokinetic Disposition of Multiple-Dose Transdermal Nicotine in Healthy Adult SmokersGregory M. Kochak, Jim X. Sun, R. Leslie Choi and Anthony J. Piraino
1456-1459Age and the Pharmacokinetic-Pharmacodynamic Relationship of Phenobarbital in Rats: “Pseudo”-Longitudinal vs Cross-Sectional Study DesignAnnemiek M. Stijnen, Meindert Danhof and Cornelius F. A. Bezooijen
1460-1464Glutathione S-Transferase-Mediated Metabolism of Glyceryl Trinitrate in Subcellular Fractions of Bovine Coronary ArteriesDavid T.-W. Lau, Elaine K. Chan and Leslie Z. Benet
1465-1473Kinetics and Mechanism of Degradation of Zileuton, a Potent 5-Lipoxygenase InhibitorFrancisco J. Alvarez and Russell T. Slade
1474-1479Synthesis of 2-(3-Substituted-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]octanes and 2α-(3-Substituted-1,2,4-oxadiazol-5-yl)-8-methyl-8-azabicyclo[3.2.1]oct-2-enes as Potential Muscarinic AgonistsDavid J. Triggle, Yong Wha Kwon, Philip Abraham, M. Abdur Rahman and F. Ivy Carroll
1480-1486Relative Lipophilicities and Structural-Pharmacological Considerations of Various Angiotensin-Converting Enzyme (ACE) InhibitorsSunanda A. Ranadive, Andrew X. Chen and Abu T. M. Serajuddin
1487-1492The Development of a Microwave Fluid-Bed Processor. I. Construction and Qualification of a Prototype Laboratory UnitMichael K. Doelling, David M. Jones, Richard A. Smith and Robert A. Nash
1493-1501The Development of a Microwave Fluid-Bed Processor. II. Drying Performance and Physical Characteristics of Typical Pharmaceutical GranulationsMichael K. Doelling and Robert A. Nash
1502-1506In Vivo Evaluation of Biodegradable Progesterone Microspheres in MaresPramod K. Gupta, Rahul C. Mehta, Robert H. Douglas and Patrick P. Luca
1507-1509Sustained Propranolol Delivery and Increased Oral Bioavailability in Dogs Given a Propranolol Laurate SaltBrace J. Aungst and Munir A. Hussain
1510-1514Relationship Between Polymer Viscosity and Drug Release from a Matrix SystemLucy Wan Sai Cheong, Paul Wan Sia Heng and Lee Fun Wong
1515-1517Effect of Isoflurane Anesthesia on Antipyrine Pharmacokinetics in the RatFrancis L. S. Tse, David F. Nickerson and Renee Aim
1518-1520Employing lonization Behaviors to Resolve a Trace-Level Impurity: Determination of l,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedi-carboxylic Acid Di-2-[methyl-(phenylmethyl)amino]ethyl Ester in Nicardipine Drug SubstanceMichael B. Maurin, Rodney D. Vickery, Philip Ma, Joseph Manalo and Munir A. Hussain
1521-1523Degradation of Synthetic Salmon Calcitonin in Aqueous SolutionKang Choon Lee, Yoon Joong Lee, Hyun Myo Song, Chang Ju Chun and Patrick P. Luca
1524Association News and Announcements

Volume 9, Number 12 / December 1992

1525-1533Instrumentation of a High-Shear Mixer: Evaluation and Comparison of a New Capacitive Sensor, a Watt Meter, and a Strain-Gage Torque Sensor for Wet Granulation MonitoringVincent Corvari, William C. Fry, William L. Seibert and Larry Augsburger
1534-1539Lymphatic Targeting of Polymeric Nanoparticles After Intraperitoneal Administration in RatsPhilippe Maincent, Pierre Thouvenot, Claude Amicabile, Maurice Hoffman and Jörg Kreuter, et al.
1540-1545Hydrogels for Site-Specific Drug Delivery to the Colon: In Vitro and in Vivo DegradationHelle Brøndsted and Jindřich Kopeček
1546-1549The Influence of Liquid Crystalline Phases on Drug Percutaneous Absorption. I. Development of a VehicleJames Swarbrick and James R. Siverly
1550-1555The Influence of Liquid Crystalline Phases on Drug Percutaneous Absorption. II. Permeation Studies Through Excised Human SkinJames Swarbrick and James R. Siverly
1556-1562Mixed Micelles as Proliposomes for the Solubilization of TeniposideHayat Alkan-Onyuksel and Kyonghee Son
1563-1567Mucoadhesion of Copolymers and Mixtures Containing Polyacrylic AcidFlorence Thermes, Jeffrey Grove, Annouk Rozier, Bernard Plazonnet and Alain Constancis, et al.
1568-1574Determination of Association Constants in Cyclodextrin/Drug Complexation Using the Scatchard Plot: Application to β-Cyclodextrin-AnilinonaphthalenesulfonatesEvangelos E. Sideris, Georgia N. Valsami, Michael A. Koupparis and Panayotis E. Macheras
1575-1579Percutaneous Absorption Enhancement of LeuprolideMou-ying Fu Lu, Dennis Lee and G. Subba Rao
1580-1586Permeability Characteristics of Various Intestinal Regions of Rabbit, Dog, and MonkeyNancy Jezyk, Werner Rubas and George M. Grass
1587-1591Influence of Permanent Cannulation of the Jugular Vein on Pharmacokinetics of Amoxycillin and Antipyrine in the RatFrancisca Torres-Molina, Juan-Carlos Aristorena, Carmen Garcia-Carbonell, Luis Granero and Jesús Chesa-Jiménez, et al.
1592-1598Validation of Different Microdialysis Methods for the Determination of Unbound Steady-State Concentrations of Theophylline in Blood and Brain TissuePer Sjöberg, Ing-Marie Olofsson and Thomas Lundqvist
1599-1606Decreased Systemic Clearance of Diltiazem with Increased Hepatic Metabolism in Rats with Uranyl Nitrate-Induced Acute Renal FailureYong-Hee Lee, Min-Hwa Lee and Chang-Koo Shim
1607-1611Kinetic Modeling of Ouabain Tissue Distribution Based on Slow and Saturable Binding to Na,K-ATPaseHideyoshi Harashima, Michio Mamiya, Masayo Yamazaki, Yasufumi Sawada and Tatsuji Iga, et al.
1612-1616The Bioinequivalence of Carbamazepine Tablets with a History of Clinical FailuresMarvin C. Meyer, Arthur B. Straughn, Eric J. Jarvi, George C. Wood and Francis R. Pelsor, et al.
1617-1621Factors Determining the Intrinsic Lymphatic Partition Rate of Epitiostanol and MepitiostaneTeruhisa Ichihashi, Yasushi Takagishi and Hideo Yamada
1622-1628The Effect of Valproate on the Metabolism of Phenobarbital in the RatGail D. Anderson and René H. Levy
1629-1633Influence of Age and Gender on the Plasma Profiles of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitory Activity Following Multiple Doses of Lovastatin and SimvastatinHaiyung Cheng, J. Douglas Rogers, Anna E. Sweany, Michael R. Dobrinska and Evan A. Stein, et al.
1634-1639Use of Analytically Defined Estimates of Aerosol Respirable Fraction to Predict Lung Deposition PatternsTed B. Martonen, Ira Katz, Kristen Fults and Anthony J. Hickey
1640-1643A High-Performance Liquid Chromatographic Method for the Quantitative Enantioselective Analysis of Mefloquine StereoisomersYihong Qiu, Satoshi Kitamura and J. Keith Guillory
1644-1647Mapping the Ligand Binding Pocket of the Human Muscarinic Cholinergic Receptor Hml: Contribution of Tyrosine-82Volkmar Drübbisch, Jelveh Lameh, Mohan Philip, Yogesh K. Sharma and Wolfgang Sadée
1648-1653Effects of Diethyl Phthalate and Other Plasticizers on Laurate Hydroxylation in Rat Liver MicrosomesRichard T. Okita and Janice Rice Okita
1654-1658Drug Delivery via Ion Exchange Across a MicromembraneDennis R. Jenke, Christopher D. Baron and Carol L. Mayers
1659-1663Viscoelastic Properties of Polyacrylic Acid Gels in Mixed SolventsJames S. Chu, Danny M. Yu, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg
1664-1667Formulation and Optimization of a Modified Microporous Cellulose Acetate Latex Coating for Osmotic PumpsLeah E. Appel, James H. Clair and Gaylen M. Zentner
1668-1670Chemoprevention of Chemically Induced Skin Tumor Development by Diallyl Sulfide and Diallyl DisulfideChandradhar Dwivedi, Stacie Rohlfs, Donnita Jarvis and Ferzaan N. Engineer
1671-1672Cyclodextrin/Weak-Electrolyte Complexation: Interpretation and Estimation of Association Constants from Phase Solubility DiagramsFang-yu Liu, Dane O. Kildsig and Ashim K. Mitra
1673-1676Chemical Stability of Ethyl Icosapentate Against Autoxidation. I. Effect of Temperature on Oxidation KineticsReiko Teraoka, Makoto Otsuka and Yoshihisa Matsuda
1677BOOK REVIEWS
1677BOOK REVIEWS
1678-1681Author Index to Volume 9 (1992)
1682-1686Subject Index to Volume 9 (1992)

Volume 10, Number 1 / January 1993

1-7Behavior of Hygroscopic Pharmaceutical Aerosols and the Influence of Hydrophobic AdditivesAnthony J. Hickey and Ted B. Martonen
8-13Mean Residence Time of Oral Drugs Undergoing First-Pass and Linear Reversible MetabolismHaiyung Cheng and William J. Jusko
14-21Enantioselective Pharmacokinetics of dl-threo-Methylphenidate in HumansNuggehally R. Srinivas, John W. Hubbard, Elarien D. Korchinski and Kamal K. Midha
22-27Pharmacokinetics of Stereomeric 1,4:3,6-Dianhydrohexitol Mononitrates in RatsTsang-Bin Tzeng and Ho-Leung Fung
28-34Steady-State Bioavailability and Day-to-Day Variability of a Multiple-Unit (CR/ZOK) and a Single-Unit (OROS) Delivery System of Metoprolol After Once-Daily DosingAnders Sandberg, Bertil Abrahamsson, Agneta Svenheden, Bertil Olofsson and Robert Bergstrand
35-43Time-Dependent Disposition of β-Naphthoflavone in the RatAdedayo Adedoyin, Leon Aarons and J. Brian Houston
44-48Distribution of Tacrine Across the Blood–Brain Barrier in Awake, Freely Moving Rats Using in Vivo Microdialysis SamplingMartin Telting-Diaz and Craig E. Lunte
49-55Prinomide Tromethamine Pharmacokinetics: Mutually Dependent Saturable and Competitive Protein Binding Between Prinomide and Its Own MetaboliteGregory M. Kochak, Sudhakar Pai, Robert Iannucci, Frank Honc and Deborah Kachmar, et al.
56-60Column-Switching High-Performance Liquid Chromatographic Determination of a 2-Pyridinone-Based Human Immunodeficiency Virus Type 1 (HlV-l)-Specific Reverse Transcriptase Inhibitor in Human PlasmaEric J. Woolf and Bogdan K. Matuszewski
61-67Changes in Material Properties Accompanying the National Formulary (NF) Identity Test for Microcrystalline CelluloseHarry G. Brittain, Geoffrey Lewen, Ann W. Newman, Kenneth Fiorelli and Susan Bogdanowich
68-74Prodrugs of Peptides. 18. Synthesis and Evaluation of Various Esters of Desmopressin (dDAVP)Anne H. Kahns, Anders Buur and Hans Bundgaard
75-79The 3′-Keto–Diol Equilibrium of Trospectomycin Sulfate Bulk Drug and Freeze-Dried Formulation: Solid-State Carbon-13 Cross-Polarization Magic Angle Spinning (CP/MAS) and High-Resolution Carbon-13 Nuclear Magnetic Resonance (NMR) Spectroscopy StudiesMichael D. Likar, Richard J. Taylor, Paul E. Fagerness, Yukio Hiyama and Russell H. Robins
80-87Design of New Formulations for Topical Ocular Administration: Polymeric Nanocapsules Containing MetipranololCándida Losa, Laurent Marchal-Heussler, Francisco Orallo, José L. Vila Jato and Maria J. Alonso
88-94Compression Characteristics of Granulated Materials. VII. The Effect of Intragranular Binder Distribution on the Compactibility of Some Lactose GranulationsMartin Wikberg and Göran Alderborn
95-102Chemical Pathways of Peptide Degradation. IV. Pathways, Kinetics, and Mechanism of Degradation of an Aspartyl Residue in a Model HexapeptideCecilia Oliyai and Ronald T. Borchardt
103-108Stability of β-Galactosidase, a Model Protein Drug, Is Related to Water Mobility as Measured by 17O Nuclear Magnetic Resonance (NMR)Sumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and Tadao Terao
109-112Controlled Delivery of Pilocarpine. 1. In Vitro Characterization of Gelfoam® MatricesSreekant R. Nadkarni and Samuel H. Yalkowsky
113-118Comparison of the Permeability Characteristics of a Human Colonic Epithelial (Caco-2) Cell Line to Colon of Rabbit, Monkey, and Dog Intestine and Human Drug AbsorptionWerner Rubas, Nancy Jezyk and George M. Grass
119-125Sustained Bronchodilation with Isoproterenol Poly(Glycolide-co-Lactide) MicrospheresYih-Loong Lai, Rahul C. Mehta, Arthur A. Thacker, Sun-Dong Yoo and Patrick J. McNamara, et al.
126-129Human Transbuccal Absorption of Diclofenac Sodium from a Prototype Hydrogel Delivery DeviceJames Cassidy, Bret Berner, Keith Chan, Vivian John and Stephen Toon, et al.
130-135Regional Gastrointestinal Absorption of the Beta-Blocker Pafenolol in the Rat and Intestinal Transit Rate Determined by Movement of 14C-Polyethylene Glycol (PEG) 4000Hans Lennernäs and Carl-Gunnar Regårdh
136-140Relationship Among Physicochemical Properties, Skin Permeability, and Topical Activity of the Racemic Compound and Pure Enantiomers of a New AntifungalLorraine Wearley, Barry Antonacci, Anthony Cacciapuoti, Seb Assenza and Imtiaz Chaudry, et al.
141-146Acacia-Gelatin Microencapsulated Liposomes: Preparation, Stability, and Release of Acetylsalicylic AcidCunji Dong and James A. Rogers
147-151Comparison of the Leakage of Carboxyfluorescein from Symmetric-and Asymmetric-Acyl Chain Phosphatidylcholine VesiclesTimothy S. Wiedmann, Amir Salmon and Walter R. Perkins
152-155Effect of Humidity and Occlusion on the Percutaneous Absorption of Parathion in VitroShao-Kaung Chang and Jim E. Riviere
156-159Kinetics of Aspirin Hydrolysis and Stabilization in the Presence of 2-Hydroxypropyl-β-CyclodextrinSomesh Choudhury and Ashim K. Mitra
160-161Reviewers for Pharmaceutical Research (October 1, 1991-October 19, 1992)
162European Reviewers for Pharmaceutical Research (October 1991-October 1992)
162Japanese Reviewers for Pharmaceutical Research (May 1992-September 1992)
163Association News and Announcements
164HANS BUNDGAARD IN MEMORIAMHenning G. Kristensen and Douwe D. Breimer

Volume 10, Number 2 / February 1993

165-170Introduction to Backpropagation Neural Network ComputationRandall J. Erb
171-186Applications of Capillary Electrophoresis in Pharmaceutical AnalysisShelley R. Rabel and John F. Stobaugh
187-196Upper Gastrointestinal pH in Seventy-Nine Healthy, Elderly, North American Men and WomenTanya L. Russell, Rosemary R. Berardi, Jeffrey L. Barnett, Lambros C. Dermentzoglou and Kathleen M. Jarvenpaa, et al.
197-203Solid-State Nuclear Magnetic Resonance (NMR) Spectra of Pharmaceutical Dosage FormsPatricia J. Saindon, Nina S. Cauchon, Paul A. Sutton, C.-j. Chang and Garnet E. Peck, et al.
204-207A Fluorescence Quenching Method for Estimating Chelating Groups in Chelate-Conjugated MacromoleculesWanlong Ma, Karl J. Hwang and Vincent H. L. Lee
208-213Preparation of Heptakis(2,6-di-O-ethyl)-β-cyclodextrin and Its Nuclear Magnetic Resonance Spectroscopic CharacterizationFumitoshi Hirayama, Masahiko Kurihara, Yasuhide Horiuchi, Tadanobu Utsuki and Kaneto Uekama, et al.
214-219Antitumor Agents. 125. New 4β-Benzoylamino Derivatives of 4′-O-Demethyl-4-desoxypodophyllotoxin and 4β-Benzoyl Derivatives of 4′-O-Demethylpodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase IIXiao-Ming Zhou, Zhe-Qing Wang, Hong-Xing Chen, Yung-Chi Cheng and Kuo-Hsiung Lee
220-222The Effect of Phenol on the Electrolyte Flocculation of Certain Polymeric Dispersions to Thixotropic GelsRoland S. Okor
223-227The Pharmacokinetics and Absorption of Recombinant Human Relaxin in Nonpregnant Rabbits and Rhesus Monkeys After Intravenous and Intravaginal AdministrationSharon A. Chen, Baron Reed, Tue Nguyen, Natalie Gaylord and Gene B. Fuller, et al.
228-232Pulmonary Delivery of Free and Liposomal InsulinFang-yu Liu, Zezhi Shao, Dane O. Kildsig and Ashim K. Mitra
233-238An in Vitro/in Vivo Correlation for the Disintegration and Onset of Drug Release from Enteric-Coated PelletsJames P. Ebel, Michael Jay and Robert M. Beihn
239-242Correlation Between the Disintegration Time and the Bioavailability of Vitamin C TabletsHemmige N. Bhagavan and Brigitte I. Wolkoff
243-251Differential Effects of Anionic, Cationic, Nonionic, and Physiologic Surfactants on the Dissociation, α-Chymotryptic Degradation, and Enteral Absorption of Insulin HexamersZezhi Shao, Yuping Li, Ramesh Krishnamoorthy, Todd Chermak and Ashim K. Mitra
252-257Use of the Gamma-Ray Perturbed Angular Correlation (PAC) Technique for Monitoring Liposomal Phospholipid Bilayer IntegrityWanlong Ma, Karl J. Hwang and Vincent H. L. Lee
258-263In Vitro Evaluation of Calcium Pectinate: A Potential Colon-Specific Drug Delivery CarrierAbraham Rubinstein, Raphael Radai, Miriam Ezra, Seema Pathak and J. Stefan Rokem
264-270Estimating the Fraction Dose Absorbed from Suspensions of Poorly Soluble Compounds in Humans: A Mathematical ModelDoo-Man Oh, Rane L. Curl and Gordon L. Amidon
271-275Mass Balance Approaches for Estimating the Intestinal Absorption and Metabolism of Peptides and Analogues: Theoretical Development and ApplicationsPatrick J. Sinko, Glen D. Leesman and Gordon L. Amidon
276-281A Saturable Transport Mechanism in the Intestinal Absorption of Gabapentin Is the Underlying Cause of the Lack of Proportionality Between Increasing Dose and Drug Levels in PlasmaBarbra H. Stewart, Alan R. Kugler, Paul R. Thompson and Howard N. Bockbrader
282-288Biotin Uptake and Transport Across Bovine Brain Microvessel Endothelial Cell MonolayersFenglin Shi, Carole Bailey, A. Waseem Malick and Kenneth L. Audus
289-293Influence of Dose Range on Degree of Nonlinearity Detected in Dose-Proportionality Studies for Drugs with Saturable Elimination: Single-Dose and Steady-State StudiesTheresa A. Shepard, Nicholas Lordi and Philip E. Sparrow
294-299Selective Effect of Adjuvant Arthritis on the Disposition of Propranolol Enantiomers in Rats Detected Using a Stereospecific HPLC AssayMicheline Piquette-Miller and Fakhreddin Jamali
300-304Effect of Plasma Protein Binding on Kinetics of Capillary Uptake and EffluxDenis J. Morgan and Jiu Li Huang
305-308A Spectrophotometric Modification of the Winkler Method for Measurement of Dissolved OxygenFrancis J. Nowaczyk Jr, Roger L. Schnaare, Clyde M. Ofner III and Rodney J. Wigent
309-312Physical Chemical Properties of Alpha Styryl Carbinol Antifungal AgentsMichael B. Maurin, William J. Addicks, Susan M. Rowe and Robert Hogan
313-316Scaleup of Immediate Release Oral Solid Dosage FormsJ. P. Skelly, G. A. Van Buskirk, D. R. Savello, G. L. Amidon and H. M. Arbit, et al.

Volume 10, Number 3 / March 1993

317-327Solid-State Nuclear Magnetic Resonance Spectroscopy: Theory and Pharmaceutical ApplicationsDavid E. Bugay
328-334Solid-State Diode Laser-Induced Fluorescence Detection in High-Performance Liquid ChromatographySadayappan V. Rahavendran and H. Thomas Karnes
335-342In Vivo Microdialysis Sampling in the Bile, Blood, and Liver of Rats to Study the Disposition of PhenolDennis O. Scott and Craig E. Lunte
343-350Antitumor Agents 126. Novel 4β-Substituted Anilino Derivatives of 3′,4′ -O, O-Didemethylpodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase IIZhe-Qing Wang, Ya-Ching Shen, Hong-Xing Chen, Jang-Yang Chang and Xin Guo, et al.
351-355Low-Substituted Hydroxypropylcellulose as a Sustained-Drug Release Matrix Base or Disintegrant Depending on Its Particle Size and Loading in FormulationYoshiaki Kawashima, Hirofumi Takeuchi, Tomoaki Hino, Toshiyuki Niwa and Tzu-Lang Lin, et al.
356-361Drug Release Mechanism from a Microcrystalline Cellulose Pellet SystemRobert E. O'Connor and Joseph B. Schwartz
362-368The Preparation and Characterization of Poly(lactide-co-glycolide) Microparticles. II. The Entrapment of a Model Protein Using a (Water-in-Oil)-in-Water Emulsion Solvent Evaporation TechniqueHayley Jeffery, Stanley S. Davis and Derek T. O'Hagan
369-380Tissue Response to Bioerodible, Subcutaneous Drug Implants: A Possible Determinant of Drug Absorption KineticsF. D. Anderson, D. F. Archer, S. M. Harman, R. J. Leonard and W. H. Wilborn
381-385Electrochemical Characterization of Human Skin by Impedance Spectroscopy: The Effect of Penetration EnhancersKyösti Kontturi, Lasse Murtomäki, Jouni Hirvonen, Petteri Paronen and Arto Urtti
386-390Poly(ε-Caprolactone) Nanocapsules in Carteolol Ophthalmic DeliveryLaurent Marchal-Heussler, Daniel Sirbat, Maurice Hoffman and Philippe Maincent
391-399Polyanhydride Mierospheres that Display Near-Constant Release of Water-Soluble Model Drug CompoundsYasuhiko Tabata and Robert Langer
400-404Peptide Carrier-Mediated Transport in Intestinal Brush Border Membrane Vesicles of Rats and Rabbits: Cephradine Uptake and InhibitionHiroaki Yuasa, Gordon L. Amidon and David Fleisher
405-410An Investigation into the Mechanical and Transport Properties of Aqueous Latex Films: A New Hypothesis for the Film-Forming Mechanism of Aqueous Dispersion SystemJian-Hwa Guo, Richard E. Robertson and Gordon L. Amidon
411-417Viscoelasticity of Anionic Polymers and Their Mucociliary Transport on the Frog PalateShun Y. Lin, Gordon L. Amidon, Norman D. Weiner and Arthur H. Goldberg
418-422Disposition of Azole Antifungal Agents. I. Nonlinearities in Ketoconazole Clearance and Binding in Rat LiverDiane Matthew, Beverley Brennan, Katayoun Zomorodi and J. Brian Houston
423-426Interaction of Nucleoside Analogues with the Sodium–Nucleoside Transport System in Brush Border Membrane Vesicles from Human KidneyClaire M. Brett, Carla B. Washington, Ronda J. Ott, Marcelo M. Gutierrez and Kathleen M. Giacomini
427-433Pharmacokinetics of a Novel Antiarrhythmic Drug, ActisomideChyung S. Cook, Leonard F. Rozek, James Stolzenbach, Steve Anderson and Grant L. Schoenhard, et al.
434-440Comparison of the Hepatic Uptake Clearances of Fifteen Drugs with a Wide Range of Membrane Permeabilities in Isolated Rat Hepatocytes and Perfused Rat LiversSeiji Miyauchi, Yasufumi Sawada, Tatsuji Iga, Manabu Hanano and Yuichi Sugiyama
441-444Rapid Determination of Methadone in Plasma, Cerebrospinal Fluid, and Urine by Gas Chromatography and Its Application to Routine Drug MonitoringNorbert Schmidt, Reinhard Sittl, Kay Brune and Gerd Geisslinger
445-448Stabilization of Oxygen-Sensitive Formulations via a Secondary Oxygen ScavengerCarol L. Mayers and Dennis R. Jenke
449-453Three Approaches to the Analysis of Trace Formaldehyde in Bulk and Dosage Form PharmaceuticalsGerald J. Manius, Lan-Fun Li Wen and David Palling
454-456Axial Ratio Measurements for Early Detection of Crystal Growth in Suspension-Type Metered Dose InhalersElaine M. Phillips, Peter R. Byron and Richard N. Dalby
457-460Loading of Bovine Serum Albumin into Hydrogels by an Electrophoretic Process and Its Potential Application to Protein DrugsWaleed S. W. Shalaby, Anna A. Abdallah, Haesun Park and Kinam Park
461-465Molecular Cloning of Two cDNAs Encoding the Mouse Bilirubin/Phenol Family of UDP-Glucuronosyltransferases (mUGTBr/p)Ah-Ng Tony Kong, Meihui Ma, Deling Tao and Linding Yang
466-469Feasibility of Developing a Neural Network for Prediction of Human Pharmacokinetic Parameters from Animal DataAjaz S. Hussain, Robert D. Johnson, Nimish N. Vachharajani and Wolfgang A. Ritschel
470-472Formation of a Chromophoric Complex Between Alendronate and Copper(II) IonsDražen Ostović, Christine Stelmach and Becky Hulshizer
473BOOK REVIEWS
473BOOK REVIEWS
474BOOK REVIEWS

Volume 10, Number 4 / April 1993

475-486Strategies for Indirect Computer-Aided Drug DesignGilda H. Loew, Hugo O. Villar and Ibon Alkorta
487-496Controlled Delivery Systems for Proteins Using Polyanhydride MicrospheresYasuhiko Tabata, Sunitha Gutta and Robert Langer
497-506A New Method for Estimating Dermal Absorption from Chemical Exposure. 1. General ApproachRobert L. Cleek and Annette L. Bunge
507-514Immunotargeting of Liposomes Containing Lipophilic Antitumor ProdrugsAtsuhide Mori, Stephen J. Kennel and Leaf Huang
515-520Synthesis and Testing of New Antileukemic Schiff Bases of N-Hydroxy-N′ - Aminoguanidine Against CCRF-CEM/0 Human Leukemia Cells in Vitro and Synergism Studies with Cytarabine (Ara-C)Phanesh B. Koneru, Eric J. Lien and Vassilios I. Avramis
521-524Taxol and Related Taxanes. I. Taxanes of Taxus brevifolia BarkKoppaka V. Rao
525-534Aqueous Ethylcellulose Dispersion of Ethylcellulose. I. Evaluation of Coating Process VariablesNilesh H. Parikh, Stuart C. Porter and Bhagwan D. Rohera
535-541A Method for the Early Evaluation of the Effects of Storage and Additives on the Stability of Parenteral Fat EmulsionsJianmin Li, Karin D. Caldwell and Bradley D. Anderson
542-548The Influence of Thermal Treatment on the Physical-Mechanical and Dissolution Properties of Tablets Containing Poly(DL-Lactic Acid)Marcelo O. Omelczuk and James W. McGinity
549-552Uptake of Phosphatidylserine Liposomes by Rat Peyer's Patches Following Intraluminal AdministrationHitoshi Tomizawa, Yukihiko Aramaki, Yoshimine Fujii, Toshifumi Kara and Norio Suzuki, et al.
553-561In Vitro Nasal Transport Across Ovine Mucosa: Effects of Ammonium Glycyrrhizinate on Electrical Properties and Permeability of Growth Hormone Releasing Peptide, Mannitol, and Lucifer YellowPatricia M. Reardon, Caroline H. Gochoco, Kenneth L. Audus, Glynn Wilson and Philip L. Smith
562-566Development of Activity Assays for High-Volume Evaluation of Human Immunodeficiency Virus (HIV) Protease Inhibitors in Rat Serum: Results with DitekirenKaren F. Wilkinson, Bob D. Rush, Satish K. Sharma, David B. Evans and Mary J. Ruwart, et al.
567-572Pharmacokinetics of Recombinant Human Interferon-βser in Healthy Volunteers and Its Effect on Serum NeopterinJanie Chiang, Carol A. Gloff, Carl N. Yoshizawa and Gary J. Williams
573-576Decreased Cellular Toxicity of Neomycin in a Clonal Cell Line Isolated from LLC-PK1Ryohei Hori, Masahiro Okuda, Yoshiko Ohishi, Masato Yasuhara and Ken-ichi Inui, et al.
577-582Physicochemical Stability of Phenobarbital Polymorphs at Various Levels of Humidity and TemperatureMakoto Otsuka, Mika Onoe and Yoshihisa Matsuda
583-587An in Vitro Study of Diamorphine Permeation Through Premature Human Neonatal SkinDavid A. Barrett, Nicholas Rutter and Stanley S. Davis
588-592In Vivo/in Vitro Correlation of Experimental Sustained-Release Theophylline FormulationsKah-Hay Yuen, Arvind A. Desmukh and John M. Newton
593-597Comparison of the Pharmacokinetics and Pharmacodynamics of the Aldose Reductase Inhibitors, AL03152 (RS), AL03802 (R), and AL03803 (S)Young Han Park, Philip R. Mayer, Ronnie Barker, Mark DuPriest and Brenda W. Griffin, et al.
598-602Pharmacokinetic Monitoring in Subcutaneous Tissue Using in Vivo Capillary Ultrafiltration ProbesMichael C. Linhares and Peter T. Kissinger
603-605Clinical Pharmacokinetics and Relative Bioavailability of Oral ProcaterolMichael A. Eldon, Michele M. Battle, Michael J. Coon, Gerald D. Nordblom and Allen J. Sedman, et al.
606-610Distinction Between the Depletion of Opsonins and the Saturation of Uptake in the Dose-Dependent Hepatic Uptake of LiposomesHideyoshi Harashima, Kazuya Sakata and Hiroshi Kiwada
611-615Formycin B Elimination from the Cerebrospinal Fluid of the RatXiaochun Wu, Andrew C. Hui and Kathleen M. Giacomini
616-620The Determination of Diffusion Coefficients in Semisolids by Fourier Transform Infrared (FT-IR) SpectroscopyDale Eric Wurster, Varaporn Buraphacheep and Jatin M. Patel
621-626Optimization of Conditions for Preparing 2- to 5-Micron-Range Gelatin Microparticles by Using Chilled Dehydration AgentsLevent Öner and Michael J. Groves
627-630Molecular Cloning of the Alcohol/Hydroxysteroid Form (mSTa1) of Sulfotransferase from Mouse LiverAh-Ng Tony Kong, Deling Tao, Meihui Ma and Linding Yang
631-634Micellar Solubilization of Clofazimine Analogues in Aqueous Solutions of Ionic and Nonionic SurfactantsKhairi M. S. Fahelelbom, Richard F. Timoney and Owen I. Corrigan
635BOOK REVIEWS
635-637Letters to the EditorRussell O. Potts, Richard H. Guy, Philip S. Burton, Norman F. H. Ho and Robert A. Conradi, et al.
638Association News and Announcements

Volume 10, Number 5 / May 1993

639-648Hydrolysis of Carbonates, Thiocarbonates, Carbamates, and Carboxylic Esters of α-Naphthol, β-Naphthol, and p-Nitrophenol by Human, Rat, and Mouse Liver CarboxylesterasesTien L. Huang, András Székács, Tamon Uematsu, Eiichi Kuwano and Andrew Parkinson, et al.
649-659Formulation Design of Acidic Fibroblast Growth FactorP. K. Tsai, David B. Volkin, Jonathan M. Dabora, Karen C. Thompson and Mark W. Bruner, et al.
660-661Enkephalin Antisense Peptides: Design, Synthesis, and Biological ActivityPravin K. Misra, Wahajul Haq, Seturam B. Katti, Krishna B. Mathur and Ram Raghubir, et al.
662-666Decomposition of Arteether in Simulated Stomach Acid Yielding Compounds Retaining Antimalarial ActivityJohn K. Baker, James D. McChesney and Hsien Tao Chi
667-673Thyrotropin-Releasing Hormone (TRH) Uptake in Intestinal Brush-Border Membrane Vesicles: Comparison with Proton-Coupled Dipeptide and Na+-Coupled Glucose TransportDavid T. Thwaites, Nicholas L. Simmons and Barry H. Hirst
674-681Passive Transepithelial Absorption of Thyrotropin-Releasing Hormone (TRH) via a Paracellular Route in Cultured Intestinal and Renal Epithelial Cell LinesDavid T. Thwaites, Barry H. Hirst and Nicholas L. Simmons
682-686Nasal Insulin Delivery with Dimethyl-β-Cyclodextrin as an Absorption Enhancer in Rabbits: Powder More Effective than Liquid FormulationsNicolaas G. M. Schipper, Stefan G. Romeijn, J. Coos Verhoef and Frans W. H. M. Merkus
687-691Aggregates Formed During Storage of β-Galactosidase in Solution and in the Freeze-Dried StateSumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and Tadao Terao
692-696Development of a Sensitive Radioimmunoassay for Fab Fragments: Application to Fab Pharmacokinetics in HumansCorinne Vo Thanh-Barthet, Michel Urtizberea, Alain E. Sabouraud, Nathalie J. Cano and Jean-Michel G. Scherrmann
697-702Hydrogel-Based lontotherapeutic Delivery Devices for Transdermal Delivery of Peptide/Protein DrugsAjay K. Banga and Yie W. Chien
703-708Prolongation of the Circulation Time of Doxorubicin Encapsulated in Liposomes Containing a Polyethylene Glycol-Derivatized Phospholipid: Pharmacokinetic Studies in Rodents and DogsAlberto A. Gabizon, Yechezkel Barenholz and Meir Bialer
709-714Absorption, Gastrointestinal Transit, and Tablet Erosion of Felodipine Extended-Release (ER) TabletsBertil Abrahamsson, Magne Alpsten, Morgan Hugosson, Ulf E. Jonsson and Mats Sundgren, et al.
715-721Targeted Delivery of a Heme Oxygenase Inhibitor with a Lyophilized Liposomal Tin Mesoporphyrin FormulationJohn B. Cannon, Carrie Martin, George S. Drummond and Attallah Kappas
722-726The Effect of Meal Composition on the Gastrocolonic Response: Implications for Drug Delivery to the ColonJennifer M. C. Price, Stanley S. Davis, Robert A. Sparrow and Ian R. Wilding
727-731Dose-Dependent Intestinal Absorption and Significant Intestinal Excretion (Exsorption) of the β-Blocker Pafenolol in the RatHans Lennernäs and Carl-Gunnar Regårdh
732-736The Development of a Predictive Method for the Estimation of Flux Through Polydimethylsiloxane Membranes. III. Application to a Series of Substituted PyridinesMeng-wei Hu and Lloyd E. Matheson
737-742Effects of Solute Characteristics and Concentration on a Lyotropic Liquid Crystal: Solute-Induced Phase ChangeHussein G. Ibrahim, El-Sayed Sallam, Mahmoud Takieddin and Mayssoun Habboub
743-749Drug Absorption Limited by P-Glycoprotein-Mediated Secretory Drug Transport in Human Intestinal Epithelial Caco-2 Cell LayersJanice Hunter, Barry H. Hirst and Nicholas L. Simmons
750-756Influence of Poly(DL-Lactide) Nanocapsules on the Biliary Clearance and Enterohepatic Circulation of Indomethacin in the RabbitFawaz Fawaz, François Bonini, Michel Guyot, Anne-Marie Lagueny and Hatem Fessi, et al.
757-762Pharmacokinetic Analysis of an Oral Sustained-Release Diltiazem Preparation Using Multifraction Absorption ModelsKazuo Murata and Kazuo Noda
763-770Absorption of 2′, 3′-Dideoxyinosine from Lower Gastrointestinal Tract in Rats and Kinetic Evidence of Different Absorption Rates in Colon and RectumSteven L. Bramer, M. Guillaume Wientjes and Jessie L.-S. Au
771-773Simplified Synthesis of Mono(4-aminophenyl)-3′ -Thymidilic Acid Ester Used as Thymidine Kinase Specific Ligand for Affinity ChromatographyKurt Eger, Eberhard Klünder, Rainer A. Beck and Ulrich Schloz
774-776The Influence of Free Fatty Acid Formation on the pH of Phospholipid-Stabilized Triglyceride EmulsionsClifford J. Herman and Michael J. Groves
777-782Theoretical Considerations for the Design and Development of a Drug: Influence of Pharmacokinetics and Dosage Regimen on Receptor InteractionsJoyce Mordenti and Aldo Rescigno

Volume 10, Number 6 / June 1993

783-790Interferon-γ in Starch Microparticles: Nitric Oxide-Generating Activity in Vitro and Antileishmanial Effect in MiceLena Degling, Peter Stjärnkvist and Ingvar Sjöholm
791-799Molecular Mobility in Mixtures of Absorbed Water and Solid Poly(vinylpyrrolidone)Cynthia A. Oksanen and George Zografi
800-809Mechanism and Kinetics of Metal Ion-Mediated Degradation of Fosinopril SodiumAjit B. Thakur, Kenneth Morris, John A. Grosso, Kenneth Himes and John K. Thottathil, et al.
810-815Tensile Properties of Free Films Cast from Aqueous Ethylcellulose DispersionsNilesh H. Parikh, Stuart C. Porter and Bhagwan D. Rohera
816-822Calibration of a Compaction Simulator for the Measurement of Tablet Thickness During CompressionLovelace E. Holman and Keith Marshall
823-827Disposition Characteristics of Protein Drugs in the Perfused Rat KidneyKiyoshi Mihara, Takami Hojo, Makoto Fujikawa, Yoshinobu Takakura and Hitoshi Sezaki, et al.
828-833A New Route of Drug Administration: Intrauterine Delivery of Insulin and CalcitoninGershon Golomb, Avi Avramoff and Amnon Hoffman
834-838The Pharmacokinetics of Recombinant Human Relaxin in Nonpregnant Women After Intravenous, Intravaginal, and Intracervical AdministrationSharon A. Chen, Andrew J. Perlman, Noreen Spanski, C. Matthew Peterson and Steven W. Sanders, et al.
839-842The Development of a Predictive Method for the Estimation of Flux Through Polydimethylsiloxane Membranes. IV. Application to a Series of Substituted QuinolinesLloyd E. Matheson and Meng-wei Hu
843-852A Drug Absorption Model Based on the Mucus Layer Producing Human Intestinal Goblet Cell Line HT29-HAgneta Wikman, Johan Karlsson, Ingemar Carlstedt and Per Artursson
853-856In Vitro/in Vivo Correlation of the Bioadhesive Properties of a Buccal Bioadhesive Miconazole Slow-Release TabletStefan Bouckaert, Remain A. Lefebvre and Jean-Paul Remon
857-864Sodium Caprate Elicits Dilatations in Human Intestinal Tight Junctions and Enhances Drug Absorption by the Paracellular RouteEva Karin Anderberg, Tuulikki Lindmark and Per Artursson
865-870Comparison of the Mechanism of Dissolution of Hydrocortisone in Simple and Mixed Micelle SystemsLori J. Naylor, Vassiliki Bakatselou and Jennifer B. Dressman
871-878Deposition Patterns of Aerosolized Drugs Within Human Lungs: Effects of Ventilatory ParametersTed B. Martonen and Ira M. Katz
879-883Evidence for an Interaction Between the β-Blocker Pafenolol and Bile Salts in the Intestinal Lumen of the Rat Leading to Dose-Dependent Oral Absorption and Double Peaks in the Plasma Concentration–Time ProfileHans Lennernäs and Carl-Gunnar Regårdh
884-888Influence of Anesthetic Regimens on Intestinal Absorption in RatsHiroaki Yuasa, Kenji Matsuda and Jun Watanabe
889-894Interpretation and Utilization of Effect and Concentration Data Collected in an in Vivo Pharmacokinetic and in Vitro Pharmacodynamic StudySuneel K. Gupta, Stephen S. Hwang, Leslie Z. Benet and Mark Gumbleton
895-899Analysis of Micelle Formation of an Adriamycin-Conjugated Poly(Ethylene Glycol)–Poly(Aspartic Acid) Block Copolymer by Gel Permeation ChromatographyMasayuki Yokoyama, Takumichi Sugiyama, Teruo Okano, Yasuhisa Sakurai and Mayumi Naito, et al.
900-904A Spectroscopic Investigation of Losartan PolymorphsKrishnaswamy Raghavan, Anil Dwivedi, G. Creston Campbell Jr, Eric Johnston and Dorothy Levorse, et al.
905-912Structure of 3-Acetyl-5-fluorouracil (5-FU): Implication for Its Rearrangements During Hydrolysis and upon HeatingHoward D. Beall, Richard J. Prankerd, Louis J. Todaro and Kenneth B. Sloan
913-917The Liposome Partitioning System for Correlating Biological Activities of Imidazolidine DerivativesJames A. Rogers and Young W. Choi
918-923A Structured–Activity Relationship Study of Batracylin AnaloguesYilin Luo, Yun-Feng Ren, Ting-Chao Chou, Allan Y. Chen and Chiang Yu, et al.
924-926Intranasal Delivery of the Bisphosphonate Alendronate in the Rat and DogSteven C. Sutton, Karen Engle and Joseph A. Fix
927-929Modification of the Dialysis Membrane Method for Drug Release from SuppositoriesMasaru Yamazaki, Soichi Itoh, Naomi Sasaki, Kazuhisa Tanabe and Mitsuru Uchiyama
930-931Can We Assign an Upper Limit to Skin Permeability?Gerald B. Kasting and Peter J. Robinson
932ERRATUM

Volume 10, Number 7 / July 1993

933-944Degradation Pathways for Recombinant Human Macrophage Colony-Stimulating Factor in Aqueous SolutionJay A. Schrier, Richard A. Kenley, Rick Williams, Robert J. Corcoran and Yangkil Kim, et al.
945-953Determinants of Release Rate of Tetanus Vaccine from Polyester MicrospheresMaria J. Alonso, Smadar Cohen, Tae G. Park, Rajesh K. Gupta and George R. Siber, et al.
954-962Techniques for Assessing the Effects of Pharmaceutical Excipients on the Aggregation of Porcine Growth HormoneSusan A. Charman, Kaye L. Mason and William N. Charman
963-969Low Molecular Weight Proteins as Carriers for Renal Drug Targeting: Naproxen Coupled to Lysozyme via the Spacer L-Lactic AcidEric J. F. Franssen, Frits Moolenaar, Dick de Zeeuw and Dirk K. F. Meijer
970-974Biodistribution of Micelle-Forming Polymer–Drug ConjugatesGlen S. Kwon, Masayuki Yokoyama, Teruo Okano, Yasuhisa Sakurai and Kazunori Kataoka
975-979Identification of an Escherichia coli Protein Impurity in Preparations of a Recombinant PharmaceuticalDonald O. O'Keefe, Peter DePhillips and Mark L. Will
980-985Swelling and Dissolution Kinetics During Peptide Release from Erodible Anionic Gel BeadsPing I. Lee
986-990Effect of Receiver Fluid pH on in Vitro Skin Flux of Weakly lonizable DrugsJim H. Kou, Samir D. Roy, Jie Du and Jean Fujiki
991-997Regulation of Tight Junction Permeability by Calcium Mediators and Cell Cytoskeleton in Rabbit Tracheal EpitheliumMeenakshi Bhat, David Toledo-Velasquez, LiYing Wang, Carl J. Malanga and Joseph K. H. Ma, et al.
998-1004Characterization of Antacid Compounds Containing Both Aluminum and Magnesium. I. Crystalline PowdersCheryl L. Peterson, Darold L. Perry, Hamid Masood, Huahua Lin and Joe L. White, et al.
1005-1007Characterization of Antacid Compounds Containing Both Aluminum and Magnesium. II. Codried PowdersCheryl L. Peterson, Darold L. Perry, Hamid Masood, Joe L. White and Stanley L. Hem, et al.
1008-1014Growth and Morphology of L-Alanine Crystals: Influence of Additive AdsorptionDavid Lechuga-Ballesteros and Nair Rodriguez-Hornedo
1015-1019ε-Aminocaproic Acid Esters as Transdermal Penetration Enhancing AgentsPavel Doležal, Alexandr Hrabálek and Vladimir Semecký
1020-1026In Vivo Validation of the Release Rate and Palatability of Remoxipride-Modified Release SuspensionRolf Sjöqvist, Christina Graffner, Inger Ekman, Wendy Sinclair and Jonathan P. Woods
1027-1030Effect of Sodium Acid Pyrophosphate on Ranitidine Bioavailability and Gastrointestinal Transit TimeKevin M. Koch, Alan F. Parr, Julie J. Tomlinson, Erik P. Sandefer and George A. Digenis, et al.
1031-1036The Impact of Lag Time on the Estimation of Pharmacokinetic Parameters. I. One-Compartment Open ModelNadhamuni G. Nerella, Lawrence H. Block and Patrick K. Noonan
1037-1045The Effect of Gastric pH on the Absorption of Controlled-Release Theophylline Dosage Forms in HumansMarvin C. Meyer, Arthur B. Straughn, Eric J. Jarvi, George C. Wood and Vijaykumar I. Vashi, et al.
1046-1051Increased Sensitivity to the Anticonvulsant Effect of Valproate in Aging BN/BiRij RatsAnnemiek M. Stijnen, Suzanne Hovinga, Mariska W. E. Langemeijer, Arendien Hoogerkamp and Cornells F. A. van Bezooijen, et al.
1052-1058Application of the Periodic Bond Chain (PBC) Theory and Attachment Energy Consideration to Derive the Crystal Morphology of HexamethylmelaminePiet Hartman and Hak-Kim Chan
1059-1065Albumin Microspheres as a Drug Delivery System: Relation Among Turbidity Ratio, Degree of Cross-linking, and Drug ReleaseOrapin P. Rubino, Richard Kowalsky and James Swarbrick
1066-1070Zero-Order Drug Release from Hydrocolloid MatricesJörn E. Möckel and Bernhard C. Lippold
1071-1075Solid-State Emulsions: The Effects of Process and Storage ConditionsMerrick L. Shively and Scott Myers
1076-1082Solubilization and Stabilization of an Anti-HIV Thiocarbamate, NSC 629243, for Parenteral Delivery, Using Extemporaneous EmulsionsRobert G. Strickley and Bradley D. Anderson
1083-1086Intranasal Absorption of a Kappa Agonist AnalgesicMunir A. Hussain, William K. Schmidt and John D. Buehler
1087-1089Controlled Gastric Emptying. III. Gastric Residence Time of a Nondisintegrating Geometric Shape in Human VolunteersJoseph A. Fix, Robyn Cargill and Karen Engle
1090-1092Transient Steady-State Analysis: Application in the Determination of the Relative Formation and Elimination Clearances of Two Major Carbamazepine Metabolites in HumansLillian E. Riad, Keith K. H. Chan and Ronald J. Sawchuk
1093-1095Physiological Parameters in Laboratory Animals and HumansBrian Davies and Tim Morris
1096Editorial

Volume 10, Number 8 / August 1993

1097-1105Tertiary Amines Related to Brompheniramine: Preferred Conformations for N-Oxygenation by the Hog Liver Flavin-Containing MonooxygenaseJohn R. Cashman, Joy R. Celestial, Andrew Leach, Julie Newdoll and Sang Bum Park
1106-1114Proteolysis of Human Growth Hormone by Rat Thyroid Gland in Vitro: Application of Electrospray Mass Spectrometry and N-Terminal Sequencing to Elucidate a Metabolic PathwayVictor J. Wroblewski, Raymond E. Kaiser and Gerald W. Becker
1115-1122Gelatin-Acacia Microcapsules for Trapping Micro Oil Droplets Containing Lipophilic Drugs and Ready Disintegration in the Gastrointestinal TractHiroaki Jizomoto, Eri Kanaoka, Katsuji Sugita and Koichiro Hirano
1123-1129Selective Paracellular Permeability in Two Models of Intestinal Absorption: Cultured Monolayers of Human Intestinal Epithelial Cells and Rat Intestinal SegmentsPer Artursson, Anna-Lena Ungell and Jan-Erik Löfroth
1130-1135Liposome-Mediated Delivery of Gallium to Macrophage-Like Cells in Vitro: Demonstration of a Transferrin-Independent Route for Intracellular Delivery of Metal IonsJukka Mönkkönen, Carolyn S. Brown, Tormaine T. Thompson and Timothy D. Heath
1136-1143Solubilization of Thiazolobenzimidazole Using a Combination of pH Adjustment and Complexation with 2-Hydroxypropyl-β-CyclodextrinAbdi Y. Tinwalla, Barbara L. Hoesterey, Tian-xiang Xiang, Kap Lim and Bradley D. Anderson
1144-1152Programmable Drug Delivery from an Erodible Association Polymer SystemXin Xu and Ping I. Lee
1153-1156Characterization of Oil-in-Water Emulsions Prepared from Solid-State Emulsions: Effect of Matrix and Oil PhaseMerrick L. Shively
1157-1164Biopharmaceutics of Didanosine in Humans and in a Model for Acid-Labile Drugs, the Pentagastrin-Pretreated DogCatherine A. Knupp, Wen Chyi Shyu, Elizabeth A. Morgenthien, James S. Lee and Rashmi H. Barbhaiya
1165-1168Pharmacokinetics of Diltiazem and Its Metabolites in Dogs After Oral Administration of a Multiparticulate Sustained-Release PreparationKazuo Murata, Hiroshi Yamahara and Kazuo Noda
1169-1173Stereoselective Interactions of Organic Cations with the Organic Cation Transporter in OK CellsRonda J. Ott and Kathleen M. Giacomini
1174-1180Demethylation Kinetics of Aspartame and L-Phenylalanine Methyl Ester in Aqueous SolutionRaymond D. Skwierczynski and Kenneth A. Connors
1181-1186Phenytoin–Lipid Conjugates: Chemical, Plasma Esterase-Mediated, and Pancreatic Lipase-Mediated Hydrolysis in VitroGerhard K. E. Scriba
1187-1190Substituted Xanthones as Selective and Reversible Monoamine Oxidase A (MAO-A) InhibitorsUlrike Thull, Silvia Kneubühler, Bernard Testa, M. Fernanda M. Borges and Madalena M. M. Pinto
1191-1199Synthesis and Evaluation of Morpholinoalkyl Ester Prodrugs of Indomethacin and NaproxenVijay K. Tammara, Milind M. Narurkar, A. Michael Crider and Mansoor A. Khan
1200-1205Conformational Analysis of the Opioid Phenylmorphan and Its 9α-Methyl Analogue in Solution Using High-Resolution Nuclear Magnetic Resonance SpectroscopyChristine M. DiMeglio, Mark Froimowitz and Alexandros Makriyannis
1206-1211The Hypolipidemic Effects of l-Acetyl-4-phenyl-l,2,4-triazolidine-3,5-dione in RodentsIris H. Hall, Rupenra Simlot, Patricia Day, O. T. Wong and Hamby ElSourady, et al.
1212-1218Evaluation of Moisture Sorption by Tablet Cores Containing Superdisintegrants During the Aqueous Film Coating ProcessNazaneen Pourkavoos and Garnet E. Peck
1219-1227Dissolution, Stability, and Morphological Properties of Conventional and Multiphase Poly(DL-Lactic-Co-Glycolic Acid) Microspheres Containing Water-Soluble CompoundsMotokazu Iwata and James W. McGinity
1228-1231Stability of Liposomes in Vitro and Their Uptake by Rat Peyer's Patches Following Oral AdministrationYukihiko Aramaki, Hitoshi Tomizawa, Toshifumi Hara, Kiyoto Yachi and Hiroshi Kikuchi, et al.
1232-1237Decreased Protein-Stabilizing Effects of Cryoprotectants Due to CrystallizationKen-ichi Izutsu, Sumie Yoshioka and Tadao Terao
1238-1242Transforming Growth Factor-α (TGF-α) in a Semisolid Dosage Form: Preservative and Vehicle SelectionElizabeth L, Tan, Hemanshu S. Shah, Kirk J. Leister, Linda M. Kozick and Pamela Pasciak, et al.
1243-1247Oral Immunization of Rats with Proteinoid Microspheres Encapsulating Influenza Virus AntigensNoemi Santiago, Sam Milstein, Theresa Rivera, Elisa Garcia and Tabassum Zaidi, et al.
1248-1251The Use of Statistical Indices to Gauge the Mixing Efficiency of a Conical Screening MillRichard P. Poska, Thomas R. Hill and Jan W. van Schaik
1252Association News and Announcements

Volume 10, Number 9 / September 1993

1253-1261Synthesis and Pharmacokinetics of a New Liver-Specific Carrier, Glycosylated Carboxymethyl-Dextran, and Its Application to Drug TargetingMakiya Nishikawa, Akiko Kamijo, Takuya Fujita, Yoshinobu Takakura and Hitoshi Sezaki, et al.
1262-1267The Use of Solution Theories for Predicting Water Vapor Absorption by Amorphous Pharmaceutical Solids: A Test of the Flory–Huggins and Vrentas ModelsBruno C. Hancock and George Zografi
1268-1273Peptide Stability in Drug Development. II. Effect of Single Amino Acid Substitution and Glycosylation on Peptide Reactivity in Human SerumMichael F. Powell, Tracy Stewart, Laszlo Otvos, Laszlo Urge and Federico C. A. Gaeta, et al.
1274-1279Preparation, Characterization, and Pharmaceutical Application of Linear Dextrins. I. Preparation and Characterization of Amylodextrin, Metastable Amylodextrins, and Metastable AmyloseGerrit H. P. Te Wierik, Anko C. Eissens, Arie C. Besemer and Coenraad F. Lerk
1280-1284Preparation, Characterization, and Pharmaceutical Application of Linear Dextrins. II. Complexation and Dispersion of Drugs with Amylodextrin by Freeze-Drying and KneadingGerrit H. P. Te Wierik, Anko C. Eissens, Arie C. Besemer and Coenraad F. Lerk
1285-1290Evaluation of the Physicochemical Properties and Dissolution Characteristics of Mesalamine: Relevance to Controlled Intestinal Drug DeliveryDonna L. French and John W. Mauger
1291-1294In Vivo Skin Penetration of Acitretin in Volunteers Using Three Sampling TechniquesChristian Surber, Klaus-P. Wilhelm, David Bermann and Howard I. Maibach
1295-1300The Dissolution and Bioavailability of Etodolac from Capsules Exposed to Conditions of High Relative Humidity and TemperaturesMike Dey, Robin Enever, Mike Kraml, David G. Prue and Doug Smith, et al.
1301-1307Lack of Effect of Ammonium Glycyrrhizinate on the Morphology of Ovine Nasal Mucosa in VitroPatricia M. Reardon, Doris A. Wall, Timothy K. Hart, Philip L. Smith and Caroline H. Gochoco
1308-1314Dissolution Modeling: Factors Affecting the Dissolution Rates of Polydisperse PowdersAllan T. K. Lu, Mary E. Frisella and Kevin C. Johnson
1315-1320Convective Solvent Flow Across the Skin During IontophoresisAeri Kim, Philip G. Green, Girish Rao and Richard H. Guy
1321-1325A Floating Controlled-Release Drug Delivery System: In Vitro-in Vivo EvaluationSubhash Desai and Sanford Bolton
1326-1331Topical Penetration of Piroxicam Is Dependent on the Distribution of the Local Cutaneous VasculatureNancy A. Monteiro-Riviere, Alfred O. Inman, Jim E. Riviere, Stephen C. McNeill and Michael L. Francoeur
1332-1337Rates of Systemic Degradation and Reticuloendothelial System (RES) Uptake of Thermosensitive Liposome Encapsulating Cisplatin in RatsKatsumi Iga, Yasuaki Ogawa and Hajime Toguchi
1338-1340Effect of Age on Distribution of Zidovudine (Azidothymidine) into the Cerebrospinal Fluid of Macaca nemestrinaArturo Lopez-Anaya, Jashvant D. Unadkat, Dianne F. Calkins and Arnold L. Smith
1341-1345Effect of Apparent Elimination Half-Life on Nitroglycerin-Induced Hemodynamic Rebound in Experimental Heart FailureJohnAnthony Bauer and Ho-Leung Fung
1346-1349Correlation Between the Plasma Concentration of Mepirodipine and Its Occupancy of Ca2+ Antagonist Receptors in RatsShizuo Yamada, Youmei Matsuoka and Ryohei Kimura
1350-1355Phosphoryloxymethyl Carbamates and Carbonates—Novel Water-Soluble Prodrugs for Amines and Hindered AlcoholsMuhammad Safadi, Reza Oliyai and Valentino J. Stella
1356-1362The Effect of Dihydronicotinate N-Substitution on the Brain-Targeting Efficacy of a Zidovudine Chemical Delivery SystemMarcus E. Brewster, Emil Pop, Andrew J. Braunstein, Andreea C. Pop and Pascal Druzgala, et al.
1363-1371The Effect of Swelling Characteristics of Superdisintegrants on the Aqueous Coating Solution Penetration into the Tablet Matrix During the Film Coating ProcessNazaneen Pourkavoos and Garnet E. Peck
1372-1377Absorption of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) from Rat Nasal MucosaMinoru Machida, Keiko Sano, Masayuki Arakawa, Masahiro Hayashi and Shoji Awazu
1378-1380The Influence of Blood Sampling Site in Nasal Drug Delivery Studies in RatsHing Char, Saran Kumar, Giuseppe Ciccone, David Piemontese and A.Waseem Malick, et al.
1381-1384Single-Puff Particle-Size Analysis of Albuterol Metered-Dose Inhalers (MDIs) by High-Pressure Liquid Chromatography with Electrochemical Detection (HPLC-EC)Moheb M. Nasr
1385-1388Preparation of Small Gelatin and Albumin Microparticles by a Carbon Dioxide Atomization ProcessLevent Öner and Michael J. Groves
1389-1391Solid-State Emulsions: The Effects of Maltodextrin on Microcrystalline AgingScott L. Myers and Merrick L. Shively
1392Association News and Announcements

Volume 10, Number 10 / October 1993

1393-1401Biotechnology and Bone Graft SubstitutesRichard A. Kenley, Kalvin Yim, Joan Abrams, Eyal Ron and Tom Turek, et al.
1402-1410Enhancement of Tissue Delivery and Receptor Occupancy of Methylprednisolone in Rats by a Liposomal FormulationElena V. Mishina, Robert M. Straubinger, Nancy A. Pyszczynski and William J. Jusko
1411-1419Microdialysis Calibration Using Retrodialysis and Zero-Net Flux: Application to a Study of the Distribution of Zidovudine to Rabbit Cerebrospinal Fluid and ThalamusYanfeng Wang, Shekman L. Wong and Ronald J. Sawchuk
1420-1426Precision, Accuracy, and Data Acceptance Criteria in Biopharmaceutical AnalysisH. Thomas Karnes and Clark March
1427-1433Inhibition of the Friend Retrovirus by Antisense Oligonucleotides Encapsulated in Liposomes: Mechanism of ActionC. Ropert, C. Malvy and P. Couvreur
1434-1441Modulation of Human Ovarian Tumor Cell Sensitivity to N-(Phosphonacetyl)-L-Aspartate (PALA) by Liposome Drug CarriersAmarnath Sharma, Ninfa L. Straubinger and Robert M. Straubinger
1442-1445Pharmacokinetics, Mass Balance, and Induction Potential of a Novel GABA Uptake Inhibitor, CI-966 HC1, in Laboratory AnimalsLouis L. Radulovic, Howard N. Bockbrader and Tsun Chang
1446-1450Oral Absorption of FK506 in RatsAkira Kagayama, Sachiyo Tanimoto, Jiro Fujisaki, Atunori Kaibara and Kaname Ohara, et al.
1451-1457Plasma Pharmacokinetics of the Lactone and Carboxylate Forms of 20(S)-Camptothecin in Anesthetized RatsDennis O. Scott, Dilbir S. Bindra and Valentine J. Stella
1458-1460The Effect of Aluminum Hydroxide Dissolution on the Bleeding of Aluminum Lake DyesArchana Desai, Garnet E. Peck, Janet E. Lovell, Joe L. White and Stanley L. Hem
1461-1465The Interconversion Kinetics, Equilibrium, and Solubilities of the Lactone and Hydroxyacid Forms of the HMG-CoA Reductase Inhibitor, CI-981Albert S. Kearney, Lee F. Crawford, Surendra C. Mehta and Galen W. Radebaugh
1466-1470Synthesis and Stability of Isotopically Labeled p-Chloro-m-Xylenol (PCMX)John C. Reepmeyer, Walter L. Zielinski, Julian E. A. Leakey and Ying Si
1471-1477Validation of a Peptide Map for Recombinant Porcine Growth Hormone and Application to Stability AssessmentSusan A. Charman, Louise E. McCrossin and William N. Charman
1478-1483Stabilization of Lyophilized Porcine Pancreatic ElastaseByeong S. Chang, Cynthia S. Randall and Yong S. Lee
1484-1487The Effect of Salts on the Stability of β-Galactosidase in Aqueous Solution, as Related to the Water MobilitySumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and Tadao Terao
1488-1492Development of New Lipophilic Derivatives of Tetragastrin: Physicochemical Characteristics and Intestinal Absorption of Acyl-tetragastrin Derivatives in RatsTakehiro Tenma, Etsuo Yodoya, Shigeru Tashima, Takuya Fujita and Masahiro Murakami, et al.
1493-1499Histocultures of Patient Head and Neck Tumors for Pharmacodynamics StudiesJessie L.-S. Ail, M. Guillaume Wientjes, Thomas J. Rosol, Antoinette Koolemans-Beynen and Eric A. Goebel, et al.
1500-1506Validation of Reflectance Infrared Spectroscopy as a Quantitative Method to Measure Percutaneous Absorption In VivoNaruhito Higo, Aarti Naik, D. Bommi Bommannan, Russell O. Potts and Richard H. Guy
1507-1515Physicochemical Characterization of High- and Low-Melting Phenylephrine OxazolidinesYihong Qiu, Ronald D. Schoenwald and J. Keith Guillory
1516-1520Enhanced Bioavailability of Cefoxitin Using Palmitoylcarnitine. II. Use of Directly Compressed Tablet Formulations in the Rat and DogSteven C. Sutton, Edward L. LeCluyse, Karen Engle, James D. Pipkin and Joseph A. Fix
1521-1526Flow-Through System Effects on in Vitro Analysis of Transdermal SystemsJoseph Sclafani, James Nightingale, Puchun Liu and Tamie Kurihara-Bergstrom
1527-1532Sustained Local Anesthetic Release from Bioerodible Polymer Matrices: A Potential Method for Prolonged Regional AnesthesiaDavid B. Masters, Charles B. Berde, Sanjoy Dutta, Tom Turek and Robert Langer
1533-1543Salt and Mesophase Formation in Aqueous Suspensions of Lauric AcidScott W. Smith and Bradley D. Anderson
1544-1547Preparation and Characterization of Thermal- and pH-Sensitive NanospheresXiao Yu Wu and Ping I. Lee
1548-1551Intrapulmonary Delivery of Renin Inhibitory Peptides Results in Sustained Release Because of Saturable TransportAnn M. Sheehy, Jennifer L. Hoover, Bob D. Rush, Karen F. Wilkinson and Thomas J. Vidmar, et al.
1552Association News and Announcements

Volume 10, Number 11 / November 1993

1553-1562In Vitro Evaluation of Dexamethasone-β-D-Glucuronide for Colon-Specific Drug DeliveryBarbara Haeberlin, Werner Rubas, Harold W. Nolen III and David R. Friend
1563-1571The Kinetics of Relaxin Oxidation by Hydrogen PeroxideTue H. Nguyen, John Burnier and Wei Meng
1572-1579Chemical Pathways of Peptide Degradation. V. Ascorbic Acid Promotes Rather than Inhibits the Oxidation of Methionine to Methionine Sulfoxide in Small Model PeptidesShihong Li, Christian Schöneich, George S. Wilson and Ronald T. Borchardt
1580-1586Origin of the Isoelectric Heterogeneity of Monoclonal Immunoglobulin h1B4P. K. Tsai, Mark W. Bruner, Joseph I. Irwin, Charlotte C. Yu Ip and Cynthia N. Oliver, et al.
1587-1590Determination of Acrolein in Urine by Liquid Chromatography and Fluorescence Detection of Its Quinoline DerivativeSameer Al-Rawithi, Adnan El-Yazigi and Paul J. Nicholls
1591-1596Sterilization of Liposomes by Heat TreatmentNicolaas J. Zuidam, Stephen S. L. Lee and Daan J. A. Crommelin
1597-1603Evaluation of Preflo® Modified Starches as New Direct Compression Excipients. I. Tabletting CharacteristicsPradeepkumar P. Sanghvi, Charles C. Collins and Atul J. Shukla
1604-1610Pulmonary Absorption of Recombinant Methionyl Human Granulocyte Colony Stimulating Factor (r-huG-CSF) After Intratracheal Instillation to the HamsterRalph W. Niven, Fred D. Lott and Judith M. Cribbs
1611-1614Pharmacokinetic Analysis and Cellular Distribution of the Anti-HIV Compound Succinylated Human Serum Albumin (Suc-HSA) in Vivo and in the Isolated Perfused Rat LiverRobert W. Jansen, Peter Olinga, Geert Harms and Dirk K. F. Meijer
1615-1619Recovery and Elimination of the Biotherapeutic Agent, Saccharomyces boulardii, in Healthy Human VolunteersSusan M. Klein, Gary W. Elmer, Lynne V. McFarland, Christina M. Surawicz and René H. Levy
1620-1626Utilization of a Human Intestinal Epithelial Cell Culture System (Caco-2) for Evaluating Cytoprotective AgentsAlbert S. Tang, Prashant J. Chikhale, Praful K. Shah and Ronald T. Borchardt
1627-1631Formulation, in Vitro Dissolution, and Ocular Bioavailability of High- and Low-Melting Phenylephrine OxazolidinesYihong Qiu, J. Keith Guillory and Ronald D. Schoenwald
1632-1637Synthesis and Enhancing Effect of Dodecyl 2-(N,N-Dimethylamino)propionate on the Transepidermal Delivery of Indomethacin, Clonidine, and HydrocortisoneServet Büyüktimkin, Nadir Büyüktimkin and J. Howard Rytting
1638-1641Chemical and α-Chymotrypsin-Mediated Proteolytic Degradation of Insulin in Bile Salt-Unsaturated Fatty Acid Mixed Micellar SystemsYuping Li, Zezhi Shao and Ashim K. Mitra
1642-1647A Critical Comparison of Some Raman Spectroscopic Techniques for Studies of Human Stratum CorneumAdrian C. Williams, Brian W. Barry, Howell G. M. Edwards and Dennis W. Farwell
1648-1653Stereoselective Dissolution of Propranolol Hydrochloride from Hydroxypropyl Methylcellulose MatricesSarma P. Duddu, Majid Vakilynejad, Fakhreddin Jamali and David J. W. Grant
1654-1661Diffusion of lonizable Solutes Across Planar Lipid Bilayer Membranes: Boundary-Layer pH Gradients and the Effect of BuffersTian-xiang Xiang and Bradley D. Anderson
1662-1667Transport and Hydrolysis of Enkephalins in Cultured Alveolar Epithelial MonolayersLiYing Wang, David Toledo-Velasquez, Diane Schwegler-Berry, Joseph K. H. Ma and Yongyut Rojanasakul
1668-1674Dipeptide Transport Across Rat Alveolar Epithelial Cell MonolayersKazuhiro Morimoto, Hiroshi Yamahara, Vincent H. L. Lee and Kwang-Jin Kim
1675-1682Absorption and Disposition of a New Antiarrhythmic Agent Bidisomide in ManChyung S. Cook, Gregory B. Ames, Margaret E. Smith, Kenneth G. Kowalski and Aziz Karim
1683-1687Evaluation of Sustained/Controlled-Release Dosage Forms of 3-Hydroxy-3-methylglutaryl–Coenzyme A (HMG-CoA) Reductase Inhibitors in Dogs and HumansHaiyung Cheng, Steven C. Sutton, James D. Pipkin, Gaylen M. Zentner and J. Douglas Rogers, et al.
1688-1692Application of Dual Radiotelemetric Technique in Studying Drug–Drug Interaction Between Diclofenac Sodium and Ranitidine HCl in VolunteersCatherine Alioth, Robert A. Blum, David T. D'Andrea, Gregory M. Kochak and Lichen Teng, et al.
1693-1695Prediction of Drug Release from Hydroxypropyl Methylcellulose (HPMC) Matrices: Effect of Polymer ConcentrationNavnit Shah, Guohua Zhang, Vahe Apelian, Fuwen Zeng and Martin H. Infeld, et al.
1696Oligonucleotides Get a Face-LiftSarah Noonberg
1697BOOK REVIEWS
1697-1698BOOK REVIEWS

Volume 10, Number 12 / December 1993

1699-1709Transport of Ionic Species in Skin: Contribution of Pores to the Overall Skin ConductanceErik R. Scott, Ana I. Laplaza, Henry S. White and J. Bradley Phipps
1710-1714A Correlation Between the Permeability Characteristics of a Series of Peptides Using an in Vitro Cell Culture Model (Caco-2) and Those Using an in Situ Perfused Rat Ileum Model of the Intestinal MucosaDong-Chool Kirn, Philip S. Burton and Ronald T. Borchardt
1715-1721Interleukin-2-Containing Liposomes: Interaction of Interleukin-2 with Liposomal Bilayers and Preliminary Studies on Application in Cancer VaccinesJoep J. Bergers, Willem Den Otter, Hub F. J. Dullens, Catherina T. M. Kerkvliet and Daan J. A. Crommelin
1722-1725Mechanism of Intestinal Absorption of Ranitidine and Ondansetron: Transport Across Caco-2 Cell MonolayersLiang-Shang Gan, Poe-Hirr Hsyu, J. Frederick Pritchard and Dhiren Thakker
1726-1731Phonophoresis of Methyl Nicotinate: A Preliminary Study to Elucidate the Mechanism of ActionJames C. McElnay, Heather A. E. Benson, Robin Harland and Jonathan Hadgraft
1732-1737In Vitro Extended-Release Properties of Drug-Loaded Poly(DL-Lactic Acid) Nanoparticles Produced by a Salting-Out ProcedureEric Allémann, Jean-Christophe Leroux, Robert Gurny and Eric Doelker
1738-1744Site-Specific Drug Delivery to Pilosebaceous Structures Using Polymeric MicrospheresAlain Rolland, Nathalie Wagner, Alain Chatelus, Braham Shroot and Hans Schaefer
1745-1750Disparity of in Vitro and in Vivo Oleic Acid-Enhanced β-Estradiol Percutaneous Absorption Across Human SkinLynn K. Pershing, Greg E. Parry and Lyssa D. Lambert
1751-1755Reverse Iontophoresis: Development of a Noninvasive Approach for Glucose MonitoringGirish Rao, Peretz Glikfeld and Richard H. Guy
1756-1759Influence of Skin Irritants on Percutaneous AbsorptionAvinash Nangia, Etienne Camel, Bret Berner and Howard Maibach
1760-1764Dose Proportionality and Population Characteristics of Oral Fadrozole Hydrochloride, an Aromatase Inhibitor, in Postmenopausal WomenGregory M. Kochak, R. Leslie Choi and Elizabeth A. Entwistle
1765-1771Assessment of Valproic Acid Serum–Cerebrospinal Fluid Transport by MicrodialysisPamela L. Golden, Kenneth R. Brouwer and Gary M. Pollack
1772-1776The Qualitative and Quantitative Analysis of Chlorpropamide Polymorphic Mixtures by Near-Infrared Fourier Transform Raman SpectroscopyAndrew M. Tudor, Steven J. Church, Patrick J. Hendra, Martyn C. Davies and Colin D. Melia
1777-1784Identification and Isolation of Chlorhexidine Digluconate ImpuritiesLarry K. Revelle, William H. Doub, Roger T. Wilson, Monica H. Harris and Aaron M. Rutter
1785-1789Kinetic Analysis of Molecular Interconversion of Immunosuppressant FK506 by High-Performance Liquid ChromatographyTakashi Nishikawa, Hideyo Hasumi, Satomi Suzuki, Hiroaki Kubo and Hideki Ohtani
1790-1792In Vitro/in Vivo Models for Peptide Oral Absorption: Comparison of Caco-2 Cell Permeability with Rat Intestinal Absorption of Renin Inhibitory PeptidesRobert A. Conradi, Karen F. Wilkinson, Bob D. Rush, Allen R. Hilgers and Mary J. Ruwart, et al.
1793-1795Thermal Analysis and Solution Calorimetry Studies on Losartan PolymorphsLei-Shu Wu, Christine Gerard and Munir A. Hussain
1796-1799Binding and Transport of Some Bioadhesive Plant Lectins Across Caco-2 Cell MonolayersClaus-Michael Lehr and Vincent H. L. Lee
1800-1805Scaleup of Oral Extended-Release Dosage FormsJ. P. Skelly, G. A. Van Buskirk, H. M. Arbit, G. L. Amidon and L. Augsburger, et al.
1806-1811Bio-International '92, Conference on Bioavailability, Bioequivalence and Pharmacokinetic StudiesHenning H. Blume and Kamal K. Midha
1812BOOK REVIEWS
1812-1813BOOK REVIEWS
1814Association News and Announcements
1815-1818Author Index to Volume 10 (1993)
1819-1822Subject Index to Volume 10 (1993)

Volume 11, Number 1 / January 1994

1Editorial
2-11Immunopotentiation and Delivery Systems for Antigens for Single-Step Immunization: Recent Trends and ProgressM. Zahirul I. Khan, Joan P. Opdebeeck and Ian G. Tucker
12-20Feasibility Study on Spray-Drying Protein Pharmaceuticals: Recombinant Human Growth Hormone and Tissue-Type Plasminogen ActivatorMarco Mumenthaler, Chung C. Hsu and Rodney Pearlman
21-29Moisture-Induced Aggregation of Lyophilized InsulinHenry R. Costantino, Robert Langer and Alexander M. Klibanov
30-37Transcellular Transport of Benzole Acid Across Caco-2 Cells by a pH-Dependent and Carrier-Mediated Transport MechanismAkira Tsuji, Hitomi Takanaga, Ikumi Tamai and Tetsuya Terasaki
38-46Intracellular Visualization of Ampicillin-Loaded Nanoparticles in Peritoneal Macrophages Infected in Vitro with Salmonella typhimuriumHuguette Pinto-Alphandary, Olivier Balland, Michel Laurent, Antoine Andremont and Francis Puisieux, et al.
47-53Conformational Analysis, Molecular Modeling, and Quantitative Structure–Activity Relationship Studies of Agents for the Inhibition of Astrocytic Chloride TransportChris L. Waller, Steven D. Wyrick, W. Evans Kemp, Hee Moon Park and Forrest T. Smith
54-59Measurement of Glass Transition Temperatures of Freeze-Concentrated Solutes by Differential Scanning CalorimetryLih-Min Her and Steven L. Nail
60-64Clearance Mechanisms of Atrial and Brain Natriuretic Peptides in RatsYukiya Hashimoto, Kazuwa Nakao, Norio Hama, Hiroo Imura and Sachiyo Mori, et al.
65-71Acidic Fibroblast Growth Factor: Evaluation of Topical Formulations in a Diabetic Mouse Wound Healing ModelBozena Matuszewska, Martina Keogan, Dennis M. Fisher, Keith A. Soper and Chao-Min Hoe, et al.
72-76Acid-Catalyzed Peptide Bond Hydrolysis of Recombinant Human Interleukin 11Richard A. Kenley and Nicholas W. Warne
77-82Primary Culture of Rat Gastric Epithelial Cells as an in Vitro Model to Evaluate Antiulcer AgentsHongjian Zheng, Praful K. Shah and Kenneth L. Audus
83-89Diffusion Rates and Transport Pathways of Fluorescein Isothiocyanate (FITC)-Labeled Model Compounds Through Buccal EpitheliumA. Janet Hoogstraate, Christopher Cullander, J. Fred Nagelkerke, Sevda Senel and J. Coos Verhoef, et al.
90-95Effect of Cyclodextrins on Protein Binding of Drugs: The Diflunisal/Hydroxypropyl-β-Cyclodextrin Model CaseEvangelos E. Sideris, Michael A. Koupparis and Panayotis E. Macheras
96-103Analysis of the Combined Effect of 1-Menthol and Ethanol as Skin Permeation Enhancers Based on a Two-Layer Skin ModelDaisuke Kobayashi, Takayasu Matsuzawa, Kenji Sugibayashi, Yasunori Morimoto and Masayuki Kimura
104-107Interaction Between Drugs and Pressure-Sensitive Adhesives in Transdermal Therapeutic SystemsTakemasa Kokubo, Kenji Sugibayashi and Yasunori Morimoto
108-110Preparation, Characterization, and Pharmaceutical Application of Linear Dextrins. III. Drug Release from Fatty Suppository Bases Containing AmylodextrinGerrit H. P. Te Wierik, Anko C. Eissens and Coenraad F. Lerk
111-116An Organic Acid-Induced Sigmoidal Release System for Oral Controlled-Release PreparationsShinji Narisawa, Minako Nagata, Chieko Danyoshi, Hiroyuki Yoshino and Kazuo Murata, et al.
117-121Bioavailability of Flumequine After Semisimultaneous Administration to Veal CalvesBert A. Meijer, Kristel G. F. Ceyssens, Wytze Th. de Jong and Ben I. J. A. C. de Grève
122-127Biodistribution of Mixed Fluorocarbon–Hydrocarbon Dowel Molecules Used as Stabilizers of Fluorocarbon Emulsions: A Quantitative Study by Fluorine Nuclear Magnetic Resonance (NMR)Leila Zarif, Michéle Postel, Bernard Septe, Leo Trevino and Jean G. Riess, et al.
128-135Validation of a Variable Direction Hysteresis Minimization Pharmacodynamic Approach: Cardiovascular Effects of AlfentanilNishit B. Modi and Peter Veng-Pedersen
136-143pH-Related Changes in the Absorption of Dipyridamole in the ElderlyTanya L. Russell, Rosemary R. Berardi, Jeffrey L. Barnett, Tami L. O’Sullivan and John G. Wagner, et al.
144-150Disposition of Glycosidase Inhibitors in the Isolated Perfused Rat Liver: Hepatobiliary and Subcellular Concentration Gradients of 1-Deoxymannojirimycin and N-Methyl-1-DeoxynojirimycinEsther D. Faber, Johannes H. Proost, Roelof Oosting and Dirk K. F. Meijer
151-155Influence of a Fat-Rich Meal on the Pharmacokinetics of a New Oral Formulation of Cyclosporine in a Crossover Comparison with the Market FormulationEdgar A. Mueller, John M. Kovarik, Johannes B. van Bree, Joachim Grevel and Peter W. Lücker, et al.
156-159Comparison of the Pharmacokinetics of an Ondansetron Solution (8 mg) When Administered Intravenously, Orally, to the Colon, and to the RectumPoe-Hirr Hsyu, J. Frederick Pritchard, Haig P. Bozigian, Thomas L. Lloyd and Rita H. Griffin, et al.
160-164Pharmacokinetic Analysis of in Vivo Metabolism of Amino Acid or Dipeptide Conjugates of Salicylic Acid in Rabbit Intestinal MicroorganismsKoyo Nishida, Mitsuhiko Kido, Hitoshi Sasaki and Junzo Nakamura
165-170Epimerization and Hydrolysis of Dalvastatin, a New Hydroxymethylglutaryl Coenzyme A (HMG-CoA) Reductase InhibitorChong Min Won
171-180Psychometric Evaluation of Measures of Organizational Commitment and Intention to Quit Among Pharmaceutical ScientistsSheldon Xiaodong Kong, Albert I. Wertheimer, Joaquima Serradell and William F. McGhan
181-183Interaction of Zidovudine (Azidothymidine) with Isoprinosine and Probenecid in Macaca fascicularisSayed M. H. Al-Habet, Connie Nosbisch, Tracy Williamson, Che-Chung Tsai and Jashvant D. Unadkat
184LEIDEN/AMSTERDAM CENTER FOR DRUG RESEARCH

Volume 11, Number 2 / February 1994

185-191In Vivo and in Vitro Analysis of Skin Penetration Enhancement Based on a Two-Layer Diffusion Model with Polar and Nonpolar Routes in the Stratum CorneumFumiyoshi Yamashita, Hiroto Bando, Yasuo Koyama, Shuji Kitagawa and Yoshinobu Takakura, et al.
192-200Evaluation of Retinoids as Therapeutic Agents in DermatologyAnita H. Lewin, Mary E. Bos, F. Christopher Zusi, Xina Nair and Gary Whiting, et al.
201-205Solubility Predictions for Solid Nitriles and Tertiary Amides Based on the Mobile Order TheoryPaul Ruelle and Ulrich W. Kesselring
206-212A Mixed Micellar Formulation Suitable for the Parenteral Administration of TaxolHayat Alkan-Onyuksel, Suganthi Ramakrishnan, Hee-Byung Chai and John M. Pezzuto
213-220Pharmacokinetics and Tissue Distribution of Recombinant Human Transforming Growth Factor Beta1 After Topical and Intravenous Administration in Male RatsThomas F. Zioncheck, Sharon A. Chen, Louise Richardson, Marina Mora-Worms and Catherine Lucas, et al.
221-225Solute Absorption from the Airways of the Isolated Rat Lung. IV. Mechanisms of Absorption of Fluorophore-Labeled Poly-α,β-[N(2-Hydroxyethyl)-DL-Aspartamide]Peter R. Byron, Zhuang Sun, Hirokazu Katayama and Frantisek Rypacek
226-230Colonic Absorption of Insulin-like Growth Factor I in VitroElizabeth Quadros, Nancy M. Landzert, Sheryl LeRoy, Francis Gasparini and Gregory Worosila
231-236Formulation and in Vitro–in Vivo Evaluation of Buccoadhesive Morphine Sulfate TabletsŞule Anlar, Yilmaz Çapan, Olgun Güven, Ahmet Göğüş and Turgay Dalkara, et al.
237-242The Physicochemical Properties, Plasma Enzymatic Hydrolysis, and Nasal Absorption of Acyclovir and Its 2′-Ester ProdrugsZezhi Shao, Gee-Bae Park, Ramesh Krishnamoorthy and Ashim K. Mitra
243-250Bile Salt–Fatty Acid Mixed Micelles as Nasal Absorption Promoters. III. Effects on Nasal Transport and Enzymatic Degradation of Acyclovir ProdrugsZezhi Shao and Ashim K. Mitra
251-256Identification of the Pathway of lontophoretic Drug Delivery: Light and Ultrastructural Studies Using Mercuric Chloride in PigsNancy A. Monteiro-Riviere, Alfred O. Inman and Jim E. Riviere
257-266Comparative Molecular Field Analysis Combined with Physicochemical Parameters for Prediction of Polydimethylsiloxane Membrane Flux in IsopropanolRong Liu and Lloyd E. Matheson
267-271Intestinal Absorption of (–)-Carbovir in the RatInmaculada Soria and Cheryl L. Zimmerman
272-277The Controlled Release of Prednisolone Using Alginate GelShinya Sugawara, Teruko Imai and Masaki Otagiri
278-282Effect of Formulation Additives upon the Intranasal Bioavailability of a Peptide Drug: Tetracosactide (ACTH1−24)Patrick Wüthrich, Myriam Martenet and Pierre Buri
283-287Determination of Transport Rates for Arginine and Acetaminophen in Rabbit Intestinal Tissues in VitroPeter W. Swaan, Gary J. Marks, Frederick M. Ryan and Philip L. Smith
288-294Effect of Some Penetration Enhancers on Epithelial Membrane Lipid Domains: Evidence from Fluorescence Spectroscopy StudiesT. Marjukka Turunen, Arto Urtti, Petteri Paronen, Kenneth L. Audus and J. Howard Rytting
295-300Effect of the H2-Receptor Antagonist Cimetidine, on the Pharmacokinetics and Pharmacodynamics of the H1-Receptor Antagonists Hydroxyzine and Cetirizine in RabbitsXueyu Chen, F. Estelle R. Simons and Keith J. Simons
301-304Improved Dose Linearity of Cyclosporine Pharmacokinetics from a Microemulsion FormulationEdgar A. Mueller, John M. Kovarik, Johannes B. van Bree, Wolfgang Tetzloff and Joachim Grevel, et al.
305-311In Vivo and in Vitro Blood–Brain Barrier Transport of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase InhibitorsAkira Saheki, Tetsuya Terasaki, Ikumi Tamai and Akira Tsuji
312-317Efflux of Zidovudine and 2′,3′-Dideoxyinosine Out of the Cerebrospinal Fluid When Administered Alone and in Combination to Macaca nemestrinaTove Tuntland, Rashid J. Ravasco, Sayed Al-Habet and Jashvant D. Unadkat
318-323Phenobarbital Removal Characteristics of Three Brands of Activated Charcoals: A System Analysis ApproachNishit B. Modi, Peter Veng-Pedersen, Dale Eric Wurster, Mary J. Berg and Dorothy D. Schottelius
324-330In Vitro and in Vivo Transport of Zidovudine (AZT) Across the Blood–Brain Barrier and the Effect of Transport InhibitorsRosalinde Masereeuw, Ulrich Jaehde, Mariska W. E. Langemeijer, Albertus G. de Boer and Douwe D. Breimer
331-336Fluorometric Study of the Molecular States of 2,5-Diphenyloxazole in Ground Mixtures with γ-CyclodextrinKeiji Yamamoto, Toshio Oguchi, Etsuo Yonemochi, Yoshisuke Matsumura and Yoshinobu Nakai
337-340Entrapment of Proteins in Poly(L-Lactide) Microspheres Using Reversed Micelle Solvent EvaporationYoshiki Hayashi, Sumie Yoshioka, Yukio Aso, Alain Li Wan Po and Tadao Terao
341-344Lack of Pharmacokinetic Interaction Between Cimetidine and Tirilazad MesylateJoseph C. Fleishaker, Laura K. Hulst and Gary R. Peters
345-348Degradation of the Antiarthritic Prodrug, 3-Carboxy-5-methyl-N-[4-(trifluoromethoxy)phenyl]-4-isoxazolecarboxamide, in Aqueous SolutionMichael Brandl and James A. Kennedy
349-350Further Commentary: Physiological Parameters in Laboratory Animals and HumansRobert B. Sothern and Scott A. Gruber

Volume 11, Number 3 / March 1994

351-352Controlled Drug Release of Highly Water-Soluble Pentoxifylline from Time-Limit Disintegration-Type Wax Matrix TabletsMakoto Otsuka and Yoshihisa Matsuda
355-360Physicomechanical Characterization of the Extrusion-Spheronization Process. I. Instrumentation of the ExtruderRajen D. Shah, Mohan Kabadi, David G. Pope and Larry L. Augsburger
361-364Transport of Low and High Molecular Peptides Across Rabbit Peyer's PatchesShingo Haseto, Hiroyuki Ouchi, Tomonori Isoda, Takashi Mizuma and Masahiro Hayashi, et al.
365-371An Enzyme-Linked Immunosorbent Assay (ELISA) for Quantitation of Adducts of Granulocyte–Macrophage Colony Stimulating Factor (GM-CSF) and Human Serum Albumin (HSA) in Stressed Solution MixturesRamasamy Kumarasamy, James Bausch, Diane Kopcha, Suman Patel and Eugene McGonigle
372-376Plasma Factor Triggering Alternative Complement Pathway Activation by LiposomesKouichi Funato, Chikamasa Yamashita, Junko Kamada, Sachiko Tominaga and Hiroshi Kiwada
377-383Comparative Analysis of Percutaneous Absorption Enhancement by d-Limonene and Oleic Acid Based on a Skin Diffusion ModelYasuo Koyama, Hiroto Bando, Fumiyoshi Yamashita, Yoshinobu Takakura and Hitoshi Sezaki, et al.
384-387Controlled Release of Paracetamol from Amylodextrin Tablets: In Vitro and in Vivo ResultsJacoba van der Veen, Anko C. Eissens and Coenraad F. Lerk
388-392Pharmacokinetic Analysis of the Absorption Enhancing Action of Decanoic Acid and Its Derivatives in RatsKoji Takahashi, Teruo Murakami, Atsuko Kamata, Ryoko Yumoto and Yutaka Higashi, et al.
393-397Diffusion and Metabolism of Prednisolone Farnesylate in Viable Skin of the Hairless MouseKakuji Tojo, Kayoko Yamada and Tomohiro Hikima
398-401Solubility Enhancement of Nucleosides and Structurally Related Compounds by Complex FormationAndrew X. Chen, S. William Zito and Robert A. Nash
402-406Enhanced Hepatic Uptake of Liposomes Through Complement Activation Depending on the Size of LiposomesHideyoshi Harashima, Kazuya Sakata, Kouichi Funato and Hiroshi Kiwada
407-411Stereospecific Distribution of Methylphenidate Enantiomers in Rat Brain: Specific Binding to Dopamine Reuptake SitesTakao Aoyama, Hajime Kotaki, Yasufumi Sawada and Tatsuji Iga
412-419Hydrogen Bonding Potential as a Determinant of the in Vitro and in Situ Blood–Brain Barrier Permeability of PeptidesElsbeth G. Chikhale, Ka-Yun Ng, Philip S. Burton and Ronald T. Borchardt
420-425Accumulation Kinetics of Propranolol in the Rat: Comparison of Michaelis– Menten-Mediated Clearance and Clearance Changes Consistent with the “Altered Enzyme Hypothesis”Cornelia Weber, Klaus Stoeckel and David Lalka
426-431Pharmacokinetics and Pharmacodynamics of L-703,014, a Potent Fibrinogen Receptor Antagonist, After Intravenous and Oral Administration in the DogJeffrey S. Barrett, Robert J. Gould, Joan D. Ellis, Marie M. Holahan and Maria T. Stranieri, et al.
432-437Site-Differential Gastrointestinal Absorption of Benazepril Hydrochloride in Healthy VolunteersKeith K. H. Chan, Akshay Buch, Robert D. Glazer, Vivian A. John and William H. Barr
438-441Dose-Dependent Pharmacokinetics of L-693,612, a Carbonic Anhydrase Inhibitor, Following Oral Administration in RatsBradley K. Wong, Patrick J. Bruhin and Jiunn H. Lin
442-448Quantification and Visualization of the Transport of Octreotide, a Somatostatin Analogue, Across Monolayers of Cerebrovascular Endothelial CellsUlrich Jaehde, Rosalinde Masereeuw, Albertus G. De Boer, Gert Fricker and J. Fred Nagelkerke, et al.
449-454Analytical Chiral Separation of the Stereoisomers of a Novel Carbonic Anhydrase Inhibitor and Its Deethylated Metabolite, and the Assignment of Absolute Configuration of the Human Metabolite and Chiral Degradation ProductsBogdan K. Matuszewski, Marvin L. Constanzer and Mary Kiganda
455-457Novel Stabilizing Method for Antisense OligodeoxynucleotidesToshihiko Sueishi, Toshinobu Seki, Kazuhiko Juni, Tetsuya Hasegawa and Mineo Saneyoshi, et al.
458-4651H-NMR and 13C-NMR Spectral Assignments of Spiramycins I and IIIKumar Ramu, Sachin Shringarpure, Steven Cooperwood, John M. Beale and John S. Williamson
466-469Rapid Synthesis of 3-[18F]Fluoro-l-(2′-Nitro-1′-Imidazolyl)-2-Propanol ([18F]Fluoromisonidazole)Abdallah Cherif, David J. Yang, Wayne Tansey, E. Edmund Kim and Sidney Wallace
470Pharmaceutical Research Reviewers for the Editorial Office, Japan (October 1992-September 1993)

Volume 11, Number 4 / April 1994

471-477The Relationship Between the Glass Transition Temperature and the Water Content of Amorphous Pharmaceutical SolidsBruno C. Hancock and George Zografi
478-484Preparation of Agglomerated Crystals for Direct Tabletting and Microencapsulation by the Spherical Crystallization Technique with a Continuous SystemToshiyuki Niwa, Hirofumi Takeuchi, Tomoaki Hino, Akira Itoh and Yoshiaki Kawashima, et al.
485-490Chromatographic Methods for Quantitative Analysis of Native, Denatured, and Aggregated Basic Fibroblast Growth Factor in Solution FormulationsVictoria Sluzky, Zahra Shahrokh, Pamela Stratton, Gert Eberlein and Y. John Wang
491-498Characterization of Aerosols of Human Recombinant Deoxyribonuclease I (rhDNase) Generated by Jet NebulizersDavid Cipolla, Igor Gonda and Steven J. Shire
499-502Controlled Release of Theophylline Monohydrate from Amylodextrin Tablets: In Vitro ObservationsJacoba Van der Veen, Gerrit H. P. Te Wierik, Liesbeth Van der Wal, Anko C. Eissens and Coenraad F. Lerk
503-507Entrapping Efficiency and Drug Release Profile of an Oil-in-Water (o/w) Emulsion Formulation Using a Polydimethylsiloxane-Coated Glass Bead AssayToshiya Minagawa, Yoshiro Kohno, Toshio Suwa and Akira Tsuji
508-512A Quantitative Concept of the Mechanism of Intestinal Lymphatic Transfer of Lipophilic MoleculesTeruhisa Ichihashi, Toru Nagasaki, Yasushi Takagishi and Hideo Yamada
513-517Alveolar Permeability Enhancement by Oleic Acid and Related Fatty Acids: Evidence for a Calcium-Dependent MechanismLi Ying Wang, Joseph K. H. Ma, Wei Fang Pan, David Toledo-Velasquez and Carl J. Malanga, et al.
518-521Activation of Fc Receptor-Mediated Phagocytosis by Mouse Peritoneal Macrophages Following the Intraperitoneal Administration of LiposomesYukihiko Aramaki, Makoto Murai and Seishi Tsuchiya
522-527The Effect of Temperature and pH on the Solubility of Quinolone Compounds: Estimation of Heat of FusionXuanqiang Yu, Gail L. Zipp and G. W. Ray Davidson III
528-535Oral Absorption of Peptides: The Effect of Absorption Site and Enzyme Inhibition on the Systemic Availability of MetkephamidPeter Langguth, Hans P. Merkle and Gordon L. Amidon
536-540Pharmacodynamics of Phenobarbital Anesthesia and Pentylenetetrazol-Induced Maximal Seizures in a Rat Model of Neoplastic Spinal Cord CompressionAmnon Hoffman, Jose Alfon, Tzony Siegal and Tali Siegal
541-544Effects of Acute and Chronic Inflammation on the Pharmacokinetics of Prednisolone in RatsVarun Garg, Yuen Yi Hon and William J. Jusko
545-548Simulation for the Analysis of Distorted Pharmacodynamic DataYukiya Hashimoto, Junko Ozaki, Toshiko Koue, Atsuko Odani and Masato Yasuhara, et al.
549-555Pharmacokinetics of Levodopa and Carbidopa in Rats Following Different Routes of AdministrationEva Bredberg, Hans Lennernäs and Lennart Paalzow
556-560An Assessment of the 4-6-20 Rule for Acceptance of Analytical Runs in Bioavailability, Bioequivalence, and Pharmacokinetic StudiesRobert O. Kringle
561-565The Use of Fourier Transform Infrared (FT-IR) Spectroscopy to Determine the Diffusion Coefficients of Alcohols in PolydimethylsiloxaneVaraporn Buraphacheep, Dale Eric Wurster and Dale E. Wurster
566-570A Simple and Rapid Fluorometric Determination Method of α1-Acid Glycoprotein in Serum Using Quinaldine RedHitoshi Imamura, Toru Maruyama, Hiroaki Okabe, Hidekata Shimada and Masaki Otagiri
571-574Synthesis and Evaluation of Amino Analogues of Valproic AcidK. R. Scott, Sandra Adesioye, Patricia B. Ayuk, Ivan O. Edafiogho and Dolly John, et al.
575-579Development and Evaluation of Sustained-Release Ibuprofen–Wax Microspheres. II. In Vitro Dissolution StudiesChristianah M. Adeyeye and James C. Price
580-584Dosing Reproducibility from Experimental Albuterol Suspension Metered-Dose InhalersPeter R. Byron
585-588Adsorption of Beta-Blockers onto Polyisobutylcyanoacrylate Nanoparticles Measured by Depletion and Dielectric MethodsEmmanuelle Benoit, Odile Prot, Philippe Maincent and Jacques Bessière
589-591A Novel Assay to Determine the Hemolytic Activity of Drugs Incorporated in Colloidal Carrier SystemsThomas K. Bock and Bernd W. Müller
592-594Variability in Gastric pH and Delayed Gastric Emptying in Yucatan Miniature PigsRebecca L. Oberle and Helena Das
595-599Mathematical Analysis and Optimization of a Flow-Through Diffusion Cell SystemHoo-Kyun Choi and James T. Angello
600-603Videomicroscopy Techniques for Agglomeration StudiesLorraine E. Pena, Barbara L. Lee and James F. Stearns
604-607Effects of Sampling Chamber Volume and Geometry on Aerodynamic Size Distributions of Metered-Dose Inhalation Aerosols Measured with the Andersen Cascade ImpactorMichiel Van Oort, Rebecca O. Gollmar and Robert J. Bohinski
608ROCKEFELLER SCIENCE FOR DEVELOPMENT PRIZE CURRENT RESEARCH INTO THERAPIES FOR ALZHEIMER'S DISEASE LEIDEN/AMSTERDAM CENTER FOR DRUG RESEARCH FOURTH SYMPOSIUM OF THE PHARMACEUTICAL COMPACTION RESEARCH LABORATORY & INFORMATION CENTER

Volume 11, Number 5 / May 1994

609-615Cellular Toxicity of Aminoglycoside Antibiotics in G418-Sensitive and -Resistant LLC-PK1 CellsMikihisa Takano, Masahiro Okuda, Masato Yasuhara and Ryohei Hori
616-623Hardness Anisotropy of Acetaminophen CrystalsWendy C. Duncan-Hewitt, David L. Mount and Alfred Yu
624-632The Stabilization of a Human IgM Monoclonal Antibody with Poly(vinylpyrrolidone)Wayne R. Gombotz, Susan C. Pankey, Duke Phan, Randy Drager and Karen Donaldson, et al.
633-641Differential Disposition of Soluble and Liposome-Formulated Human Recombinant Interleukin-7: Effects on Blood Lymphocyte Population in Guinea PigsTot Bui, Connie Faltynek and Rodney J. Y. Ho
642-647Improved Intestinal Absorption of an Enteric-Coated Sodium Ursodeoxycholate FormulationAldo Roda, Enrico Roda, Egidio March, Patrizia Simoni and Carolina Cerrè, et al.
648-653The Contribution of Intestinal Secretion to the Dose-Dependent Absorption of CeliprololShiu-Ming Kuo, Brian R. Whitby, Per Artursson and John A. Ziemniak
654-658An Application of the Hydrodynamic Pore Theory to Percutaneous Absorption of DrugsTomomi Hatanaka, Eiichiro Manabe, Kenji Sugibayashi and Yasunori Morimoto
659-664Estradiol Permeation from Nonionic Surfactant Vesicles Through Human Stratum Corneum in VitroHans E. J. Hofland, Ronald van der Geest, Harry E. Bodde, Hans E. Junginger and Joke A. Bouwstra
665-673Transcellular Permeability of Chlorpromazine Demonstrating the Roles of Protein Binding and Membrane PartitioningGeri A. Sawada, Norman F. H. Ho, Larry R. Williams, Craig L. Barsuhn and Thomas J. Raub
674-679Mucoadhesion of Latexes. I. Analytical Methods and Kinetic StudiesCarlo Durrer, Juan Manuel Irache, Francis Puisieux, Dominique Duchêne and Gilles Ponchel
680-683Mucoadhesion of Latexes. II. Adsorption Isotherms and Desorption StudiesCarlo Durrer, Juan Manuel Irache, Francis Puisieux, Dominique Duchêne and Gilles Ponchel
684-686Application of in Vivo Microdialysis to Transdermal Absorption of Methotrexate in RatsKenji Matsuyama, Mikiro Nakashima, Yukiko Nakaboh, Masataka Ichikawa and Tadanori Yano, et al.
687-697Studies on the Effects of Applied Voltage and Duration on Human Epidermal Membrane Alteration/Recovery and the Resultant Effects upon IontophoresisHirohiko Inada, Abdel-Halim Ghanem and William I. Higuchi
698-703Pharmacokinetics and Metabolism of Diclofenac Sodium in Yucatan Miniature PigsRebecca L. Oberle, Helena Das, Shekman L. Wong, Keith K. H. Chan and Ronald J. Sawchuk
704-708The Effect of Immunosuppression by Total-Body Irradiation on the Pharmacodynamics of Centrally Active Drugs in RatsAmnon Hoffman, Jose Alfon, Gustav Habib, Evelyne Pinto and Raphael Gorodetsky
709-714NM-Win: A Personal Computer-Based Microsoft® Windows Front-End to NONMEM IVJonathan P. Vielhaber and Jeffrey S. Barrett
715-722Bioequivalence: Performance of Several Measures of Extent of AbsorptionFrédéric Y. Bois, Thomas N. Tozer, Walter W. Hauck, Mei-Ling Chen and Rabindra Patnaik, et al.
723-727Fourier Transform Infrared (FTIR) Spectrometry for the Assay of Polyhedral Boron Compounds in Plasma and Pharmaceutical FormulationsYohanes Setiawan, Tor Rise and Douglas E. Moore
728-732On-Line Moisture Detection for a Microwave Vacuum DryerJackie G. White
733-737A Novel Nuclear Magnetic Resonance (NMR) Imaging Method for Measuring the Water Front Penetration Rate in Hydrophilic Polymer Matrix Capsule Plugs and Its Role in Drug ReleaseMuhammad Ashraf, Virginia L. luorno, David Coffin-Beach, C. Anderson Evans and Larry L. Augsburger
738-746Transport of Human Recombinant Brain-Derived Neurotrophic Factor (BDNF) Through the Rat Blood−Brain Barrier in Vivo Using Vector-Mediated Peptide Drug DeliveryWilliam M. Pardridge, Young-Sook Kang and Jody L. Buciak
747-750The Bioavailability of Intranasal Salmon Calcitonin in Healthy Volunteers with and Without a Permeation EnhancerWilliam A. Lee, Richard D. Ennis, John P. Longenecker and Per Bengtsson
751-758Chemical Pathways of Peptide Degradation. VI. Effect of the Primary Sequence on the Pathways of Degradation of Aspartyl Residues in Model HexapeptidesCecilia Oliyai and Ronald T. Borchardt
759-763A Sensitive, High-Volume, Colorimetric Assay for Protein PhosphatasesDiana K. Fisher and Terry J. Higgins
764-771Chemical and Physical Stability of Chimeric L6, a Mouse−Human Monoclonal AntibodyMehdi Paborji, Nancy L. Pochopin, William P. Coppola and Joseph B. Bogardus
772-773Effect of Hepatic Cirrhosis on the Pharmacodynamics and Pharmacokinetics of Mivacurium in HumansGerhard Levy
774-775Determination of Solute–Polymer Interaction Properties via Two-Stage ExtractionDennis R. Jenke
776ROCKEFELLER SCIENCE FOR DEVELOPMENT PRIZECURRENT RESEARCH INTO THERAPIES FOR ALZHEIMER'S DISEASEINDUSTRIAL RHEOLOGY: PRINCIPLES AND PRACTICE

Volume 11, Number 6 / June 1994

777-783Pharmaceutical Applications of MicrocalorimetryMichael J. Koenigbauer
784-793The Role of Intramolecular Nucleophilic Catalysis and the Effects of Self-Association on the Deamidation of Human Insulin at Low pHRichard T. Darrington and Bradley D. Anderson
794-799Mucus Gel Thickness and Turnover in the Gastrointestinal Tract of the Rat: Response to Cholinergic Stimulus and Implication for MucoadhesionAbraham Rubinstein and Boaz Tirosh
800-808Predictions of in Vivo Plasma Concentrations from in Vitro Release Kinetics: Application to Doxepin Parenteral (I.M.) Suspensions in Lipophilic Vehicles in DogsChristina Gido, Peter Langguth and Ernst Mutschler
809-815Percutaneous Absorption of 2′,3′-Dideoxyinosine in RatsElora Mukherji, Nancy J. Millenbaugh and Jessie L.-S. Au
816-823Pharmacodynamic Models of Nitroglycerin-Induced Hemodynamic Tolerance in Experimental Heart FailureJohn Anthony Bauer and Ho-Leung Fung
824-830Pharmacokinetics and Bioinversion of Ibuprofen Enantiomers in HumansHaiyung Cheng, J. Douglas Rogers, Joan L. Demetriades, Sherry D. Holland and James R. Seibold, et al.
831-834The Cutoff Time Point of the Partial Area Method for Assessment of Rate of Absorption in Bioequivalence StudiesPanos Macheras, Mira Symillides and Christos Reppas
835-838Microdialysis: An Alternative for in Vitro and in Vivo Protein Binding StudiesAnne Le Quellec, Sylvie Dupin, Ala Eldin Tufenkji, Patrick Genissel and Georges Houin
839-843Oral Bioavailability of the Antiretroviral Agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from Three Formulations of the Prodrug Bis(pivaloyloxymethyl)-PMEA in Fasted Male Cynomolgus MonkeysKenneth C. Cundy, James A. Fishback, Jeng-Pyng Shaw, Min L. Lee and Kenneth F. Soike, et al.
844-847HPLC Assay for FK 506 and Two Metabolites in Isolated Rat Hepatocytes and Rat Liver MicrosomesBeatrice Y. T. Perotti, Thomayant Prueksaritanont and Leslie Z. Benet
848-854Inhibition of Rat Splenocyte Proliferation with Methylprednisolone: In Vivo Effect of Liposomal FormulationElena V. Mishina and William J. Jusko
855-859Comparison of Two Otitis Media Models for the Study of Middle Ear Antimicrobial PharmacokineticsDaniel M. Canafax, Henry Russlie, Michael J. Lovdahl, Gary R. Erdmann and Chap T. Le, et al.
860-864Effect of Streptococcus pneumoniae and Influenza A Virus on Middle Ear Antimicrobial Pharmacokinetics in Experimental Otitis MediaGregg H. Jossart, Daniel M. Canafax, Gary R. Erdmann, Michael J. Lovdahl and Henry Q. Russlie, et al.
865-868Chemical Interactions Between Drugs Containing Reactive Amines with Hydrolyzable Insoluble Biopolymers in Aqueous SolutionsAbraham J. Domb, Ludmila Turovsky and Raphael Nudelman
869-874Poly(Alkylcyanoacrylate) Nanocapsules: Physicochemical Characterization and Mechanism of FormationFrançois Chouinard, Stéphane Buczkowski and Vincent Lenaerts
875-881Structural Rheology of a Model OintmentLorraine E. Pena, Barbara L. Lee and James F. Stearns
882-888Mechanical Properties of Dry and Wet Cellulosic and Acrylic Films Prepared from Aqueous Colloidal Polymer Dispersions Used in the Coating of Solid Dosage FormsRoland Bodmeier and Ornlaksana Paeratakul
889-896Novel Taxol Formulations: Preparation and Characterization of Taxol-Containing LiposomesAmarnath Sharma and Robert M. Straubinger
897-900Distribution of Brush-Border Membrane Peptidases Along the Rat IntestineJane P. F. Bai
901-908Chemical Pathways of Peptide Degradation. VII. Solid State Chemical Instability of an Aspartyl Residue in a Model HexapeptideCecilia Oliyai, Jitendra P. Patel, Linda Carr and Ronald T. Borchardt
909-913Improvement of the Pulmonary Absorption of (Asu1,7)-Eel Calcitonin by Various Protease Inhibitors in RatsTakahiro Morita, Akira Yamamoto, Yoshinobu Takakura, Mitsuru Hashida and Hitoshi Sezaki
914-916Geometric Approach for Zero-Order Release of Drugs Dispersed in an Inert MatrixMohsen A. Bayomi
917-920Interaction Between Ciprofloxacin and Metal Cations: Its Influence on Physicochemical Characteristics and Antibacterial ActivityRonald C. Li, David E. Nix and Jerome J. Schentag
921-924Inhibition of Human CYP3A Catalyzed 1′-Hydroxy Midazolam Formation by Ketoconazole, Nifedipine, Erythromycin, Cimetidine, and NizatidineSteven A. Wrighton and Barbara J. Ring
925-928A Regulatory and Industrial Perspective of the Use of Carbon-14 and Tritium Isotopes in Human ADME StudiesJeremy G. Dain, Jerry M. Collins and William T. Robinson

Volume 11, Number 7 / July 1994

929-935Characterization of Convective Solvent Flow During IontophoresisM. Begoña Delgado-Charro and Richard H. Guy
936-944Major Degradation Products of Basic Fibroblast Growth Factor: Detection of Succinimide and Iso-aspartate in Place of Aspartate15Zahra Shahrokh, Gert Eberlein, Doug Buckley, Mallik V. Paranandi and Dana W. Aswad, et al.
945-950Interspecies Scaling of Cimetidine–Theophylline Pharmacokinetic Interaction: Interspecies Scaling in Pharmacokinetic InteractionsAlicia R. Gascón, Begoña Calvo, Rosa María Hernández, Alfonso Domínguez-Gil and José-Luis Pedraz
951-960Disposition of Azole Antifungal Agents. II. Hepatic Binding and Clearance of Dichlorophenyl-Bis-triazolylpropanol (DTP) in the RatHelen L. Bomont, Michael H. Tarbit, Michael J. Humphrey and J. Brian Houston
961-965Disposition of Azole Antifimgal Agents. III. Binding of Fluconazole and Other Azoles in Rat LiverChristopher M. Ervine and J. Brian Houston
966-974Bioequivalence: Performance of Several Measures of Rate of AbsorptionFrédéric Y. Bois, Thomas N. Tozer, Walter W. Hauck, Mei-Ling Chen and Rabindra Patnaik, et al.
975-978Carrier-Mediated Transport of H1-Antagonist at the Blood–Brain Barrier: Mepyramine Uptake into Bovine Brain Capillary Endothelial Cells in Primary Monolayer CulturesMasahiro Yamazaki, Tetsuya Terasaki, Kuniaki Yoshioka, Osamu Nagata and Hideo Kato, et al.
979-983A Drug Dissolution Monitor Employing Multiple Fiber Optic Probes and a UV/Visible Diode Array SpectrophotometerChi-Shi Chen and Chris W. Brown
984-989Drug Binding by Reservoirs in Elastomeric Infusion DevicesDennis R. Jenke
990-994Microbial and Mammalian Metabolism Studies of the Semisynthetic Antimalarial, AnhydrodihydroartemisininSherief I. Khalifa, John K. Baker, Robin D. Rogers, Farouk S. El-Feraly and Charles D. Hufford
995-999Physical Stability and Protein Stability of Freeze-Dried Cakes During Storage at Elevated TemperaturesKen-ichi Izutsu, Sumie Yoshioka and Shigeo Kojima
1000-1003Transdermal lontophoretic Delivery of Luteinizing Hormone Releasing Hormone (LHRH): Effect of Repeated AdministrationMark C. Heit, Nancy A. Monteiro-Riviere, Friederike L. Jayes and Jim E. Riviere
1004-1008Thermal Stability of Low Molecular Weight Urokinase During Heat Treatment. II. Effect of Polymeric AdditivesMichael Vrkljan, Thomas M. Foster, Michael E. Powers, Jack Henkin and William R. Porter, et al.
1009-1015Dose and Load Studies for Subcutaneous and Oral Delivery of Poly(lactide-co-glycolide) Microspheres Containing OvalbuminTakahiro Uchida, Stephen Martin, Todd P. Foster, Richard C. Wardley and Susan Grimm
1016-1022Polystyrene-Poly (Ethylene Glycol) (PS-PEG2000) Particles as Model Systems for Site Specific Drug Delivery. 2. The Effect of PEG Surface Density on the in Vitro Cell Interaction and in VivoBiodistributionSusan E. Dunn, Anne Brindley, Stanley S. Davis, Martyn C. Davies and Lisbeth Illum
1023-1029Measurement of Glass Transition Temperatures in Freeze Concentrated Solutions of Non-Electrolytes by Electrical Thermal AnalysisLih-Min Her, Raymond P. Jefferis, Larry A. Gatlin, Bryan Braxton and Steven L. Nail
1030-1034Accelerated Degradation of Poly(ε-caprolactone) by Organic AminesWen-Jen Lin, Douglas R. Flanagan and Robert J. Linhardt
1035-1041Estimation of Skin Target Site Acyclovir Concentrations Following Controlled (Trans)dermal Drug Delivery in Topical and Systemic Treatment of Cutaneous HSV-1 Infections in Hairless MiceGeorge Imanidis, Wei-qi Song, Paul H. Lee, Muh-Hwan Su and Earl R. Kern, et al.
1042-1047Effects of Surfactants on Amiodarone Intestinal Absorption. I. Sodium LaurylsulfateRafael V. Martín-Algarra, Rosa M. Pascual-Costa, Matilde Merino and Vicente G. Casabó
1048-1055Pulmonary Delivery of Detirelix by Intratracheal Instillation and Aerosol Inhalation in the Briefly Anesthetized DogDavid B. Bennett, Elizabeth Tyson, Clinton A. Nerenberg, Sylvia Mah and Jennifer S. de Groot, et al.
1056-1059Pharmacokinetics of Detirelix Following Intratracheal Instillation and Aerosol Inhalation in the Unanesthetized Awake SheepHans Schreier, Kenneth J. McNicol, David B. Bennett, Zvi Teitelbaum and Hartmut Derendorf
1060-1064Degradation of O6-Benzylguanine in Aqueous Polyethylene Glycol 400 (PEG 400) Solutions: Concerns with Formaldehyde in PEG 400Dilbir S. Bindra, Todd D. Williams and Valentino J. Stella
1065-1067The Requirement for a Retinoic Acid Lactone of 11-cis, 13-cis-Stereochemistry for Topical Dermatologic ActivityAnita H. Lewin, R. Richard Goehring, F. Christopher Zusi, Gerald J. Gendimenico and Xina Nair, et al.
1068BOOK REVIEWS
1068INDUSTRIAL RHEOLOGY: PRINCIPLES AND PRACTICE

Volume 11, Number 8 / August 1994

1069-1076Use of Stable Isotopes for Evaluation of Drug Delivery Systems: Comparison of Ibuprofen Release in Vivo and in Vitro from Two Biphasic Release Formulations Utilizing Different Rate-Controlling PolymersDon L. Theis, Leo J. Lucisano and Gordon W. Halstead
1077-1081Chemical Stability of Ethyl Icosapentate Against Autoxidation. II. Effect of Photoirradiation on Oxidation KineticsReiko Teraoka, Makoto Otsuka and Yoshihisa Matsuda
1082-1087Synthesis and in Vitro Study of a Diglyceride Prodrug of a PeptideFlorence Delie, Patrick Couvreur, Dino Nisato, Jean-Baptiste Michel and Francis Puisieux, et al.
1088-1092Conformation of Amiodarone · HC1: A Solution and Solid State 13C-NMR StudyRenée C. Rao, Frédéric Lefebvre, Gérard Commenges, Catherine Castet and Lygie Miguel, et al.
1093-1097Evaluation of Solubilizers in the Drug Release Testing of Hydrophilic Matrix Extended-Release Tablets of FelodipineBertil Abrahamsson, Dick Johansson, Arne Torstensson and Karin Wingstrand
1098-1100An Improved Microscope Stage for Direct Observation of Freezing and Freeze DryingSteven L. Nail, Lih-Min Her, Christopher P. B. Proffitt and Lisa L. Nail
1101-1109Pulmonary Delivery of Powders and Solutions Containing Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) to the RabbitRalph W. Niven, Fred D. Lott, Anna Y. Ip and Judith M. Cribbs
1110-1114Novel Delivery of Antioxidant Enzyme Catalase to Alveolar Macrophages by Fc Receptor-Mediated EndocytosisJeannine Harrison, Xianglin Shi, LiYing Wang, Joseph K. H. Ma and Yongyut Rojanasakul
1115-1120Stability of Acyl Derivatives of Insulin in the Small Intestine: Relative Importance of Insulin Association Characteristics in Aqueous SolutionHiroyuki Asada, Takayuki Douen, Yoshiko Mizokoshi, Takuya Fujita and Masahiro Murakami, et al.
1121-1126Receptor-Mediated Peptide Delivery in Pulmonary Epithelial MonolayersDeepa Deshpande, David Toledo-Velasquez, Li Ying Wang, Carl J. Malanga and Joseph K. H. Ma, et al.
1127-1131Comparison of Cell Proliferation and Toxicity Assays Using Two Cationic LiposomesKatriina Lappalainen, Ilpo Jääskeläinen, Kari Syrjänen, Arto Urtti and Stina Syrjänen
1132-1142Intestinal Permeability Enhancement: Efficacy, Acute Local Toxicity, and ReversibilityE. Scott Swenson, William B. Milisen and William Curatolo
1143-1147Preparation of Three-Month Depot Injectable Microspheres of Leuprorelin Acetate Using Biodegradable PolymersHiroaki Okada, Yayoi Doken, Yasuaki Ogawa and Hajime Toguchi
1148-1154Effect of Medium-Chain Glycerides on Physiological Properties of Rabbit Intestinal Epithelium in VitroPing-Yang Yeh, Philip L. Smith and Harma Ellens
1155-1159Characterization of Esterase and Alcohol Dehydrogenase Activity in Skin. Metabolism of Retinyl Palmitate to Retinol (Vitamin A) During Percutaneous AbsorptionJames Boehnlein, Adel Sakr, J. Leon Lichtin and Robert L. Bronaugh
1160-1165Uptake of Nanoparticles by Rat Glomerular Mesangial Cells in Vivo and in VitroLuc Manil, Jean-Claude Davin, Charles Duchenne, Christine Kubiak and Jacqueline Foidart, et al.
1166-1173Non-Isothermal and Isothermal Crystallization of Sucrose from the Amorphous StateAzita Saleki-Gerhardt and George Zografi
1174-1179Cyclodextrins as Mucosal Absorption Promoters of Insulin. II. Effects of β-Cyclodextrin Derivatives on α-Chymotryptic Degradation and Enteral Absorption of Insulin in RatsZezhi Shao, Yuping Li, Todd Chermak and Ashim K. Mitra
1180-1185Enhanced Delivery and Antitumor Activity of Doxorubicin Using Long-Circulating Thermosensitive Liposomes Containing Amphipathic Polyethylene Glycol in Combination with Local HyperthermiaSakae Unezaki, Kazuo Maruyama, Noriyuki Takahashi, Masataka Koyama and Tsutomu Yuda, et al.
1186-1189Chitosan as a Novel Nasal Delivery System for Peptide DrugsLisbeth Illum, Nidal F. Farraj and Stanley S. Davis
1190-1198A Modified Product Inhibition Model Describes the Nonlinear Pharmacokinetics of Nicorandil in RatsElizabeth L. Bachert, Zhuang-wu Li, Lin Zhao, Suk Jae Chung and Ho-Leung Fung
1199-1203Sustained Suppression of the Pituitary-Gonadal Axis by Leuprorelin Three-Month Depot Microspheres in Rats and DogsHiroaki Okada, Yayoi Doken, Yasuaki Ogawa and Hajime Toguchi
1204-1206Phenobarbital Disposition in Adult and Neonatal RabbitsSun Dong Yoo, David E. Burgio and Patrick J. McNamara
1207-1210Study of the Interaction Between β-Cyclodextrin and ChlorhexidineHong Qi, Toshiaki Nishihata and J. Howard Rytting
1211-1215Synthesis of Novel Aminopropylguanidine Derivatives with Potential Antihypertensive ActivityUnsal Calis, John R. Finch, Edward E. Soltis and George A. Digenis
1216-1220Workshop III Report: Scaleup of Liquid and Semisolid Disperse SystemsG. A. Van Buskirk, V. P. Shah, D. Adair, H. M. Arbit and S. V. Dighe, et al.
1221Normal Volunteers Should Not Be Used for Bioavailability or Bioequivalence Studies of ClozapineRolf Pokorny, Marion J. Finkel and William T. Robinson
12222ND EUROPEAN CONGRESS OF PHARMACEUTICAL SCIENCES EIGHTH ANNUAL PHARMACOKINETICS COURSE FOR PHARMACEUTICAL SCIENTISTS ONE-WEEK WORKSHOP ON ADVANCED METHODS IN PHARMACOKINETICS
1222ERRATUM

Volume 11, Number 9 / September 1994

1223-1232Investigation of the Distribution of EAB 515 to Cortical ECF and CSF in Freely Moving Rats Utilizing MicrodialysisBimal K. Malhotra, Michel Lemaire and Ronald J. Sawchuk
1233-1238Effect of Moisture Sorption on Tabletting Characteristics of Spray Dried (15% Amorphous) LactoseTesfai Sebhatu, Ainin A. Elamin and Claes Ahlneck
1239-1243Study on Pulmonary Delivery of Salmon Calcitonin in Rats: Effects of Protease Inhibitors and Absorption EnhancersShinzo Kobayashi, Shuji Kondo and Kazuhiko Juni
1244-1249Effect of Epidermal Growth Factor on Cu, Zn-Superoxide Dismutase Expression in Cultured Fibroblasts from Rat SkinKohshi Nishiguchi, Yoshifumi Kiyohara, Fusao Komada, Seigo Iwakawa and Katsuhiko Okumura
1250-1256Transepithelial Transport of Tyramine Across Filter-Grown MDCK Cells via a Poly(D-lysine) CarrierMitchell E. Taub, Jiansheng Wan and Wei-Chiang Shen
1257-1264Brain Delivery of Biotin Bound to a Conjugate of Neutral Avidin and Cationized Human AlbuminYoung-Sook Kang and William M. Pardridge
1265-1269Effect of Ultrafilterable Platinum Concentration on Cisplatin and Carboplatin Cytotoxicity in Human Tumor and Bone Marrow Cells in VitroHenk-Jan Guchelaar, Elisabeth G. E. de Vries, Coby Meijer, Mariet T. Esselink and Edo Vellenga, et al.
1270-1277Preparation and Characterization of Novel Poly(methylidene Malonate 2.1.2.)-Made NanoparticlesFrançois Lescure, Christine Seguin, Pascal Breton, Philippe Bourrinet and Didier Roy, et al.
1278-1282Controlled Ocular Timolol Delivery: Systemic Absorption and Intraocular Pressure Effects in HumansArto Urtti, Harr Rouhiainen, Timo Kaila and Veyo Saano
1283-1287Effects of Cholesterol and Cholesteryl Oleate on Lipolysis and Liver Uptake of Triglyceride/Phosphatidylcholine Emulsions in RatsTetsurou Handa, Yuko Eguchi and Koichiro Miyajima
1288-1295A Convective-Diffusion Model for Dissolution of Two Non-interacting Drug Mixtures from Co-compressed Slabs Under Laminar Hydrodynamic ConditionsSeshadri Neervannan, Lloyd S. Dias, Marylee Z. Southard and Valentine J. Stella
1296-1300Iontophoresis of a Model Peptide Across Human Skin in Vitro: Effects of Iontophoresis Protocol, pH, and Ionic Strength on Peptide Flux and Skin ImpedanceW. H. M. Craane-van Hinsberg, L. Bax, N. H. M. Flinterman, J. Verhoef and H. E. Junginger, et al.
1301-1305Solid-State Emulsions: Evaluation by 1H and 13C Solid-State Nuclear Magnetic ResonanceMerrick L. Shively and Steven F. Dec
1306-1314Hindered Diffusion of Polar Molecules Through and Effective Pore Radii Estimates of Intact and Ethanol Treated Human Epidermal MembraneKendall D. Peck, Abdel-Halim Ghanem and William I. Higuchi
1315-1319Liquid Scintillation Spectrometry of 5-Fluorouracil in Cervical Tissue Following in Vitro Surface Application of a Bioadhesive Cervical PatchA. David Woolfson, Dermot F. McCafferty, Paul A. McCarron and John H. Price
1320-1324Pulmonary Deposition and Clinical Response of99mTc-Labelled Salbutamol Delivered from a Novel Multiple Dose Powder InhalerMika Vidgren, Jukka Arppe, Petra Vidgren, Liisa Hyvärinen and Pauli Vainio, et al.
1325-1329The Determination of Interfacial Transfer Constants Using Side-by-Side Diffusion CellsGerold L. Mosher
1330-1336Comparison of Single and Multiple Dose Pharmacokinetics Using Clinical Bioequivalence Data and Monte Carlo SimulationsAhmed A. El-Tahtawy, André J. Jackson and Thomas M. Ludden
1337-1345Distribution Kinetics of Salicylic Acid in the Isolated Perfused Rat Liver Assessed Using Moment Analysis and the Two-Compartment Axial Dispersion ModelZiad Hussein, Andrew J. McLachlan and Malcolm Rowland
1346-1351Modeling of the Saturable Time-Constrained Amoxicillin Absorption in HumansVladimir K. Piotrovskij, Gilles Paintaud, Gunnar Alván and Tomáš Trnovec
1352-1354Peptide Liquid Crystals: Inverse Correlation of Kinetic Formation and Thermodynamic Stability in Aqueous SolutionMichael F. Powell, Jeffrey Fleitman, Lynda M. Sanders and Victoria C. Si
1355-1357Impedance Spectroscopy in Human Skin. A Refined ModelKyösti Kontturi and Lasse Murtomäki
1358-1361Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)Per Artursson, Tuulikki Lindmark, Stanley S. Davis and Lisbeth Illum
1362-1365Characterization of the Crystallinity of Drugs: B02669, a Case StudyKaren C. Thompson, Jerome P. Draper, Michael J. Kaufman and Gerald S. Brenner
1366-1369Leucine Enkephalin Effects on Brain Microvessel Endothelial Cell Monolayer PermeabilitySuzanne E. Thompson and Kenneth L. Audus
1370-1378Adsorption of Oligonucleotides onto Polyisohexylcyanoacrylate Nanoparticles Protects Them Against Nucleases and Increases Their Cellular UptakeChristine Chavany, Tula Saison-Behmoaras, Trung Le Doan, Francis Puisieux and Patrick Couvreur, et al.

Volume 11, Number 10 / October 1994

1379-1384Probing the Mechanisms of Drug Release from Hydroxypropylmethyl Cellulose MatricesAnh Thu Pham and Ping I. Lee
1385-1390Formulation and Intestinal Absorption Enhancement Evaluation of Water-in-Oil Microemulsions Incorporating Medium-Chain GlyceridesPanayiotis P. Constantinides, Jean-Paul Scalart, Cindy Lancaster, Joseph Marcello and Gary Marks, et al.
1391-1395Dependence of Dissolution Rate on Surface Area: Is a Simple Linear Relationship Valid for Co-Compressed Drug Mixtures?Seshadri Neervannan, Marylee Z. Southard and Valentine J. Stella
1396-1400Vehicle Effects on in Vitro Percutaneous Absorption Through Rat and Human SkinJennifer Hilton, Bruce H. Woollen, Robert C. Scott, Timothy R. Auton and Kathryn L. Trebilcock, et al.
1401-1404Decanoic Acid Induced Enhancement of Rectal Absorption of Hydrophilic Compounds in RatsKoji Takahashi, Teruo Murakami, Ryoko Yumoto, Tomomi Hattori and Yutaka Higashi, et al.
1405-1413Mechanism and Kinetics of Transcellular Transport of a New β-Lactam Antibiotic Loracarbef Across an Intestinal Epithelial Membrane Model System (Caco-2)Ming Hu, Jiyue Chen, Yanping Zhu, Anne H. Dantzig and Robert E. Stratford, Jr, et al.
1414-1418Organization of Stratum Corneum Lipids in Relation to Permeability: Influence of Sodium Lauryl Sulfate and PreheatingChristèle Ribaud, Jean-Claude Garson, Jean Doucet and Jean-Luc Lévêque
1419-1423Follicular (Pilosebaceous Unit) Deposition and Pharmacological Behavior of Cimetidine as a Function of FormulationLinda Margaret Lieb, Gordon Flynn and Norman Weiner
1424-1428Relationship Between Enoxacin and Ciprofloxacin Plasma Concentrations and Theophylline DispositionJohn D. Davis, Leon Aarons and J. Brian Houston
1429-1434Comparative Pharmacokinetic and Pharmacodynamic Analysis of Phthaloyl Glycine Derivatives with Potential Antiepileptic ActivityOmar Abu Salach, Salim Hadad, Abdullah Haj-Yehia, Sherbel Sussan and Meir Bialer
1435-1442Pharmacokinetic and Pharmacodynamic Aspects of an Ophthalmic Pilocarpine Nanoparticle-Delivery-SystemAndreas Zimmer, Ernst Mutschler, Günter Lambrecht, Dieter Mayer and Jörg Kreuter
1443-1447Renin Inhibitor: Relationship Between Molecular Structure and Oral AbsorptionNaofumi Hashimoto, Toshihiro Fujioka, Kunio Hayashi, Kunihiro Odaguchi and Tatsuo Toyoda, et al.
1448-1451Renin Inhibitor: Transport Mechanism in Rat Small Intestinal Brush-Border Membrane VesiclesNaofumi Hashimoto, Toshihiro Fujioka, Tatsuo Toyoda, Noriyuki Muranushi and Koichiro Hirano
1452-1457Interaction of Benzothiadiazides with Human Serum Albumin Studied by Dialysis and Spectroscopic MethodsNorito Takamura, Mohamed Habibur Rahman, Keishi Yamasaki, Michio Tsuruoka and Masaki Otagiri
1458-1461Cyclosporin Absorption Is Impaired by the Fat Substitutes, Sucrose Polyester and Tricarballylate Triester, in the RatKamel Benmoussa, Alain Sabouraud, Jean-Michel Scherrmann and Jean-Marie Bourre
1462-1466A Bayesian Approach to Arrhenius Prediction of Shelf-LifeXiang-Yao Su, Alain Li Wan Po and Sumie Yoshioka
1467-1473The Effect of Bulking Agent on the Solid-State Stability of Freeze-Dried Methylprednisolone Sodium SuccinateBeth D. Herman, Brent D. Sinclair, Nathaniel Milton and Steven L. Nail
1474-1478Processing Considerations for an EC Latex Coating System: Influence of Curing Time and TemperatureDawn Hutchings, Barbara Kuzmak and Adel Sakr
1479-1484Polylactide Microparticles Prepared by Double Emulsion/Evaporation Technique. I. Effect of Primary Emulsion StabilityNicole Nihant, Chantal Schugens, Christian Grandfils, Robert Jérôme and Philippe Teyssié
1485-1491Gamma Sterilization of a Semi-Solid Poly(ortho ester) Designed for Controlled Drug Delivery—Validation and Radiation EffectsAlain Merkli, Jorge Heller, Cyrus Tabatabay and Robert Gurny
1492-1495Selective Precipitation of Interleukin-4 Using Hydrophobic Ion Pairing: A Method for Improved Analysis of Proteins Formulated with Large Excesses of Human Serum AlbuminJeffrey D. Meyer, James E. Matsuura, James A. Ruth, Eli Shefter and Suman T. Patel, et al.
1496-1500Effects of Various Protease Inhibitors on the Intestinal Absorption and Degradation of Insulin in RatsAkira Yamamoto, Toshio Taniguchi, Kaori Rikyuu, Tomoko Tsuji and Takuya Fujita, et al.
1501-1504Intestinal Permeability Enhancement: Structure-Activity and Structure-Toxicity Relationships for Nonylphenoxypolyoxyethylene Surfactant Permeability EnhancersE. Scott Swenson, William B. Milisen and William Curatolo
1505-1508A Simple Method of Correlating Pharmacodynamic Equivalence with Absolute Bioavailability Following Noninvasive Delivery of InsulinYuping Li and Ashim K. Mitra
1509BOOK REVIEWS
1510EIGHTH ANNUAL PHARMACOKINETICS COURSE FOR PHARMACEUTICAL SCIENTISTS ONE-WEEK WORKSHOP ON ADVANCED METHODS IN PHARMACOKINETICS

Volume 11, Number 11 / November 1994

1511-1515Hepatic Blood Flow Measurements and Indocyanine Green Kinetics in a Chronic Dog ModelAndrej Skerjanec, Darryl W. O’Brien and Yun K. Tam
1516-1518Carrier-Mediated Transport of H1-Antagonist at the Blood-Brain Barrier: A Common Transport System of H1-Antagonists and Lipophilic Basic DrugsMasahiro Yamazaki, Tetsuya Terasaki, Kuniaki Yoshioka, Osamu Nagata and Hideo Kato, et al.
1519-1523Effect of Renal or Hepatic Dysfunction on Neurotoxic Convulsion Induced by Ranitidine in MiceMasafumi Shimokawa, Koujirou Yamamoto, Junichi Kawakami, Yasufumi Sawada and Tatsuji Iga
1524-1529First-Pass Effect of cis-3,4-Dichloro-N-methyl-N-(2-(l-pyrrolidinyl)-cyclohexyl)-benzamide (U-54494) in Rats— A Model with Multiple Cannulas for Investigation of Gastrointestinal and Hepatic MetabolismWei-Zhu Zhong, Marta G. Williams, Kathleen J. Cook, Terri L. VandeGiessen and Brian W. Jones, et al.
1530-1534Pharmacokinetics of Intranasally-Administered Dihydroergotamine in the RatDavid T.-W. Lau, Zhiling Yu, Renee L. Aun, Alan E. Hassell and Francis L. S. Tse
1535-1539Identification of the Diastereomers of Pentobarbital N-Glucosides Excreted in Human UrineWilliam H. Soine, Phyllis J. Soine, Terry M. England, Ruth M. Graham and Gerald Capps
1540-1544The Influence of Net Water Absorption on the Permeability of Antipyrine and Levodopa in the Human JejunumDag Nilsson, Urban Fagerholm and Hans Lennernäs
1545-1548Quantitative Analysis of a Drug in an Animal Feed Employing Sample Preparation by Supercritical Fluid ExtractionDale C. Messer, Larry T. Taylor, William E. Weiser, John W. McRae and Christopher C. Cook
1549-1556Effects of Configuration Around the Chiral Carbon Atoms on the Crystal Properties of Ephedrinium and Pseudoephedrinium SalicylatesSarma P. Duddu and David J. W. Grant
1557-1561The Measurement of Mixture Homogeneity and Dissolution to Predict the Degree of Drug Agglomerate Breakdown Achieved Through Powder MixingMelgardt M. Villiers and Jakkie G. Watt
1562-1567Properties of Free Films Prepared from Aqueous Polymers by a Spraying TechniqueSakae Obara and James W. McGinity
1568-1574Development and Characterization of Microencapsulated MicrospheresAchim Göpferich, Maria Jose Alonso and Robert Langer
1575-1580Transepithelial Transport and Metabolism of Thyrotropin-Releasing Hormone (TRH) in Monolayers of a Human Intestinal Cell Line (Caco-2): Evidence for an Active Transport Component?Elke Walter and Thomas Kissel
1581-1587Aggregation Pathway of Recombinant Human Keratinocyte Growth Factor and Its StabilizationBao-lu Chen, Tsutomu Arakawa, Charles F. Morris, William C. Kenney and Christina M. Wells, et al.
1588-1592Preparation of Sterically Stabilized Human Serum Albumin Nanospheres Using a Novel Dextranox-MPEG Crosslinking AgentWu Lin, Allan G. A. Coombes, Martin C. Garnett, Martyn C. Davies and Etienne Schacht, et al.
1593-1598In Vitro Cutaneous and Percutaneous Delivery and in Vivo Efficacy of Tetracaine from Liposomal and Conventional VehiclesMarianna Foldvari
1599-1604Intestinal Uptake of Cimetidine and Ranitidine in RatsVanaja Mummaneni and Jennifer B. Dressman
1605-1609A New Bioerodible Polymer Insert for the Controlled Release of MetronidazoleKimberly A. Gates, Helen Grad, Peter Birek and Ping I. Lee
1610-1616Subzero Thermal Analysis of Human Stratum CorneumHanafi Tanojo, Joke A. Bouwstra, Hans E. Junginger and Harry E. Boddé
1617-1622Effects of Protease Inhibitors on Vasopressin Transport Across Rat Alveolar Epithelial Cell MonolayersHiroshi Yamahara, Kazuhiro Morimoto, Vincent H. L. Lee and Kwang-Jin Kim
1623-1630Nasal Absorption in the Rat. III. Effect of Lysophospholipids on Insulin Absorption and Nasal HistologySusan G. Chandler, Norman W. Thomas and Lisbeth Illum
1631-1639Dermal Microdialysis Sampling in VivoJoseph M. Ault, Christopher M. Riley, Noel M. Meltzer and Craig E. Lunte
1640-1645Colonic Absorption and Bioavailability of the Pentapeptide Metkephamid in the RatPeter Langguth, Gerhard Breves, Arthur Stökli, Hans P. Merkle and Siegfried Wolffram
1646-1651Kinetic Analysis of the Drug Permeation Process Across the Intestinal EpitheliumShinji Yamashita, Masako Yoshida, Yoko Taki, Toshiyasu Sakane and Tanekazu Nadai
1652-1656Antiinflammatory Drug-Induced Small Intestinal Permeability: The Rat Is a Suitable ModelNeal M. Davies, Matthew R. Wright and Fakhreddin Jamali
1657-1662Transdermal Delivery of Metoprolol by ElectroporationRita Vanbever, Nathalie Lecouturier and Véronique Préat
1663-1668In Vitro and in Vivo Evaluation in Dogs and Pigs of a Hydrophilic Matrix Containing PropylthiouracilLouis Kabanda, Romain Adelin Lefebvre, Henri Jacques Bree and Jean Paul Remon
1669-1672Pharmacokinetics of Two Enteric-Coated Ketoprofen Products in Humans with or Without Coadministration of Omeprazole and Comparison with Dissolution FindingsSaeed A. Qureshi, Gilles Caillé, Yves Lacasse and Iain J. McGilveray
1673-1676In Vitro Plasma Metabolism of RMP-7Julie Ann Straub, Alan Akiyama and Parul Parmar
1677-1679Entrapping Efficiency of an Oil-in-Water Emulsion Containing Isocarbacyclin Methyl Ester (TEI-9090) in Dog and Human SeraToshiya Minagawa, Yoshiro Kohno, Toshio Suwa and Akira Tsuji
1680EIGHTH ANNUAL PHARMACOKINETICS COURSE FOR PHARMACEUTICAL SCIENTISTS ONE-WEEK WORKSHOP ON ADVANCED METHODS IN PHARMACOKINETICS

Volume 11, Number 12 / December 1994

1681-1688Insulin Fragments as a Carrier for Peptide Delivery Across the Blood–Brain BarrierMakoto Fukuta, Hiroaki Okada, Satoshi Iinuma, Shigeo Yanai and Hajime Toguchi
1689-1697Transsynovial Drug Distribution: Synovial Mean Transit Time of Diclofenac and Other Nonsteroidal Antiinflammatory DrugsWilliam F. Elmquist, Keith K. H. Chan and Ronald J. Sawchuk
1698-1703The Effect of Cyclodextrins on the Stability of Peptides in Nasal Enzymic SystemsWilliam J. Irwin, Anil K. Dwivedi, Paula A. Holbrook and Michael J. Dey
1704-1706Mechanism of Optical Isomerization of(S)-N-[1-(2-Fluorophenyl)-3,4,6,7-tetrahydro-4-oxopyrrolo[3,2,1-jk] [l,4]-benzodiazepine-3-y1]-1H-indole-2-carboxamide (FK480) in Soft Capsules Containing Polyethylene Glycol 400 and GlycerolShinichi Fukuyama, Noriaki Kihara, Keiichi Nakashima, Noritsugu Morokoshi and Shigetaka Koda, et al.
1707-1711Menthol-β-D-Glucuronide: A Potential Prodrug for Treatment of the Irritable Bowel SyndromeHarold W. Nolen III and David R. Friend
1712-1720Aqueous Stability of Human Epidermal Growth Factor 1-48Richard I. Senderoff, Scott C. Wootton, Amal M. Boctor, Tsun Ming Chen and Anne B. Giordani, et al.
1721-1725Is Stability Prediction Possible for Protein Drugs? Denaturation Kinetics of β- Galactosidase in SolutionSumie Yoshioka, Yukio Aso, Ken-ichi Izutsu and S. Kojima
1726-1730Natriuretic Peptide-Potentiating Actions of Neutral Endopeptidase Inhibition in Rats with Experimental Heart FailureMasato Yasuhara, Masayuki Yamaguchi, Hiromasa Shimizu, Yukiya Hashimoto and Norio Hama, et al.
1731-1736Targeted Gene Delivery to Alveolar Macrophages via Fc Receptor-Mediated EndocytosisYongyut Rojanasakul, Li Ying Wang, Carl J. Malanga, Joseph K. H. Ma and Jiahorng Liaw
1737-1741The Relation Between Swelling Properties and Enzymatic Degradation of Azo Polymers Designed for Colon-Specific Drug DeliveryGuy Van den Mooter, Celest Samyn and Renaat Kinget
1742-1746Effect of Current Magnitude and Drug Concentration on lontophoretic Delivery of Octreotide Acetate (Sandostatin®) in the RabbitDavid T.-W. Lau, John W. Sharkey, Lew Petryk, Frank A. Mancuso and Zhiling Yu, et al.
1747-1754Improving the Sensitivity of in Vitro Skin Penetration ExperimentsGerald B. Kasting, Thomas G. Filloon, William R. Francis and Michael P. Meredith
1755-1760The Effects of Bile Salts and Lipids on the Physicochemical Behavior of GemfibrozilPaul E. Luner, Suresh R. Babu and Galen W. Radebaugh
1761-1765Characteristics of Ceftibuten Uptake into Caco-2 CellsNoriyuki Muranushi, Kazutoshi Horie, Kazuyoshi Masuda and Koichiro Hirano
1766-1770Effect of 2-Hydroxypropyl-β-cyclodextrin on Crystallization and Polymorphic Transition of Nifedipine in Solid StateFumitoshi Hirayama, Zheng Wang and Kaneto Uekama
1771-1776Comparison of the Transport Characteristics of D- and L-Methionine in a Human Intestinal Epithelial Model (Caco-2) and in a Perfused Rat Intestinal ModelLixing Zheng, Jiyue Chen, Yanping Zhu, Hua Yang and William Elmquist, et al.
1777-1784Transport of β-Estradiol in Freshly Excised Human Skin in Vitro: Diffusion and Metabolism in Each Skin LayerPuchun Liu, William I. Higuchi, Abdel-Halim Ghanem and William R. Good
1785-1791The Role of Rheological Properties in Mucociliary Transport by Frog Palate Ciliated ModelDanny M. Yu, Gordon L. Amidon, Norman D. Weiner, David Fleisher and Arthur H. Goldberg
1792-1799Formation and Characterization of Cisplatin-Loaded Poly(benzyl 1-glutamate) Microspheres for ChemoembolizationChun Li, David J. Yang, Sarah Nikiforow, Wayne Tansey and Li-Ren Kuang, et al.
1800-1808Surface Modification of Poly(lactide-co-glycolide) Nanospheres by Biodegradable Poly(lactide)-Poly(ethylene glycol) CopolymersSnjezana Stolnik, Susan E. Dunn, Martin C. Garnett, Martyn C. Davies and Allan G. A. Coombes, et al.
1809-1814Effect of Electroporation on Transdermal lontophoretic Delivery of Luteinizing Hormone Releasing Hormone (LHRH) in VitroD. Bommi Bommannan, Janet Tamada, Lewis Leung and Russell O. Potts
1815-1819Enantioselective Kinetics of Verapamil and Norverapamil in Isolated Perfused Rat LiversReza Mehvar, James M. Reynolds, Megan A. Robinson and James A. Longstreth
1820-1824Effect of Perfusate pH on Reduction of Quinidine Capillary Permeability by Albumin in Isolated Perfused Rat HeartDenis J. Morgan and Cao Ling Xu
1825-1828The Use of Multiple Doses and Pharmacodynamic System Analysis to Distinguish Between Dispositional Delays and Time-Variant PharmacodynamicsMarc R. Gastonguay and Sorell L. Schwartz
1829-1833Effect of Substituted Benzoylglycines (Hippurates) and Phenylacetylglycines on p-Aminohippurate Transport in Dog Renal Membrane VesiclesFrans G. M. Russel and Wim G. Vermeulen
1834-1837Rapid Temporal Control of Transdermal Drug Delivery by ElectroporationMark R. Prausnitz, Uwe Pliquett, Robert Langer and James C. Weaver
1838-1841Author Index to Volume 11 (1994)
1842-1845Subject Index to Volume 11 (1994)
1847ERRATUM

Volume 12, Number 1 / January 1995

1EDITORIAL
2-11Stability of Protein Formulations: Investigation of Surfactant Effects by a Novel EPR Spectroscopic TechniqueNarendra B. Bam, Theodore W. Randolph and Jeffrey L. Cleland
12-17Hepatic Uptake of Octreotide, a Long-Acting Somatostatin Analogue, via a Bile Acid Transport SystemTetsuya Terasaki, Hiroko Mizuguchi, Chizuru Itoho, Ikumi Tamai and Michel Lemaire, et al.
18-23Vitamin K Prodrugs: 1. Synthesis of Amino Acid Esters of Menahydroquinone-4 and Enzymatic Reconversion to an Active FormJiro Takata, Yoshiharu Karube, Mitsunobu Hanada, Kazuhisa Matsunaga and Yoshikazu Matsushima, et al.
24-38Investigation of 3,5-Isoxazolidinediones as Hypolipidemic Agents in RodentsTyrone Woodard, Manik L. Debnath, Rupendra Simlot, Robert A. Izydore and Dwayne L. Daniels, et al.
39-48Structures of Nanoparticles Prepared from Oil-in-Water EmulsionsBrita Sjöström, Alon Kaplun, Yeshayahu Talmon and Bernard Cabane
49-52Rates of Systemic Degradation and Reticuloendothelial System Uptake of Calcein in the Dipalmitoylphosphatidylcholine Liposomes with Soybean-Derived Sterols in MiceXian-rong Qi, Yoshie Maitani and Tsuneji Nagai
53-59Some Factors Associated with the Ultrasonic Nebulization of ProteinsRalph W. Niven, Anna Y. Ip, S. Mittelman, S. J. Prestrelski and T. Arakawa
60-68Reversible Adsorption of Soluble Hexameric Insulin onto the Surface of Insulin Crystals Cocrystallized with Protamine: An Electrostatic InteractionSteven W. Dodd, Henry A. Havel, Paul M. Kovach, Chitra Lakshminarayan and Martin P. Redmon, et al.
69-77Surface Denaturation at Solid-Void Interface—A Possible Pathway by Which Opalescent Participates Form During the Storage of Lyophilized Tissue-Type Plasminogen Activator at High TemperaturesChung C. Hsu, Hoc M. Nguyen, Douglas A. Yeung, Dennis A. Brooks and Gary S. Koe, et al.
78-84Differential Effects of Sulfate and Sulfobutyl Ether of β-Cyclodextrin on Erythrocyte Membranes in VitroKazufumi Shiotani, Keiko Uehata, Tetsumi Irie, Kaneto Uekama and Diane O. Thompson, et al.
85-87Acute Renal Toxicity of Doxorubicin (Adriamycin)-Loaded Cyanoacrylate NanoparticlesLuc Manil, Philippe Mahieu and Patrick Couvreur
88-95A New Method for Estimating Dermal Absorption from Chemical Exposure: 2. Effect of Molecular Weight and Octanol-Water PartitioningAnnette L. Bunge and Robert L. Cleek
96-102Aerosol Deposition as a Function of Airway Disease: Cystic FibrosisTed Martonen, Ira Katz and William Cress
103-107Evaluation of Different Metrics as Indirect Measures of Rate of Drug Absorption from Extended Release Dosage Forms at Steady-StateCristos Reppas, Larry F. Lacey, Oliver N. Keene, Panos Macheras and Alan Bye
108-112Penetration Kinetics of 2′,3′-Dideoxyinosine in Dermis Is Described by the Distributed ModelElora Gupta, M. Guillaume Wientjes and Jessie L.-S. Au
113-116Pharmacokinetics of Antimony in Patients Treated with Sodium Stibogluconate for Cutaneous LeishmaniasisMay Al laser, Adnan El-Yazigi and Simon L. Croft
117-123Assessment of Toxicokinetics and Toxicodynamics Following Intravenous Administration of Etoposide Phosphate in Beagle DogsLinus N. Igwemezie, Sanjeev Kaul and Rashmi H. Barbhaiya
124-128Applying Bailer's Method for AUC Confidence Intervals to Sparse SamplingJerry R. Nedelman, Ekaterina Gibiansky and David T. W. Lau
129-133The Use of Intracerebral Microdialysis to Determine Changes in Blood-Brain Barrier Transport CharacteristicsElizabeth C. M. de Lange, Mayke B. Hesselink, Meindert Danhof, Albertus G. de Boer and Douwe D. Breimer
134-137Assessment of Glucocorticoid Lung Targeting by ex-Vivo Receptor Binding Studies in RatsGuenther Hochhaus, Ricardo J. Gonzalez-Rothi, Anatoly Lukyanov, Hartmut Derendorf and Hans Schreier, et al.
138-143Sumatriptan Absorption from Different Regions of the Human Gastrointestinal TractPatricia E. Warner, Kirn L. R. Brouwer, Elizabeth K. Hussey, George E. Dukes and Karl H. Donn, et al.
144-148Comparison of Simulated and in-Vivo Plasma Levels of Cilastatin Following Intravenous in-Line Drug AdministrationJoseph Wong, Wei-Youh Kuu, Ronald Burke, Robert Johnson and Ray W. Wood
149-154Evaluation of the Intestinal Absorption of Erythromycin in Man: Absolute Bioavailability and Comparison with Enteric Coated ErythromycinAndrew A. Somogyi, Felix Bochner, David Hetzel and Desmond B. Williams
155-160Determination of Aliphatic Thiols by Fluorometric High-Performance Liquid Chromatography After Precolumn Derivatization with 2-(4-N-Maleimidophenyl)-6-MethylbenzothiazoleAbdullah I. Haj-Yehia and Leslie Z. Benet
161-163Determination of Moisture in Intact Gelatin Capsules by Near-Infrared SpectrophotometryRobert G. Buice, Jr, Thomas B. Gold, Robert A. Lodder and George A. Digenis
164-167Metabolism of Acetylneurotensin(8–13) by Proteolytic Activities of Intestinal EnterocytesJane P. F. Bai and Li-Ling Chang
168-170The Influence of the Shape of the Plasma Drug Concentration Profile upon the Pharmacological EffectMark Knowles and Stephen S. Hwang
171-175Cultured Human Sweat Gland Epithelia: Isolation of Glands Using Neutral RedDavid J. Brayden and Joan Fitzpatrick
176BOOK REVIEWS
177EDITORIAL

Volume 12, Number 2 / February 1995

179-186Transfollicular Drug DeliveryAndrea C. Lauer, Linda M. Lieb, C. Ramachandran, Gordon L. Flynn and Norman D. Weiner
187-191Synthesis and Pharmacological Properties of 2-[S-Acetylthiorphan]-l,3-diacylaminopropan-2-ol Derivatives as Chimeric Lipid Drug Carriers Containing an Enkephalinase InhibitorDidier M. Lambert, Frank Mergen, Catherine F. Berens, Jacques H. Poupaert and Pierre Dumont
192-195Physical Entrapment of Adriamycin in AB Block Copolymer MicellesGlen S. Kwon, Mayumi Naito, Masayuki Yokoyama, Teruo Okano and Yasuhisa Sakurai, et al.
196-200Construction of an Intermittent-Motion Capsule Filling Machine SimulatorJeffrey R. Britten, Michael I. Barnett and N. Anthony Armstrong
201-208Preparation and Physicochemical Characterization of Aqueous Dispersions of Coenzyme Q10 NanoparticlesBritta Siekmann and Kirsten Westesen
209-214Design for Cell-Specific Targeting of Proteins Utilizing Sugar-Recognition Mechanism: Effect of Molecular Weight of Proteins on Targeting EfficiencyMakiya Nishikawa, Hideki Hirabayashi, Yoshinobu Takakura and Mitsuru Hashida
215-222Stabilization of Chimeric BR96-Doxorubicin ImmunoconjugateNancy P. Barbour, Mehdi Paborji, Thomas C. Alexander, William P. Coppola and Joseph B. Bogardus
223-230Efficacy Evaluation of a Novel Submicron Miconazole Emulsion in a Murine Cryptococcosis ModelMenashe Y. Levy, Itzhack Polacheck, Yechezkel Barenholz and Simon Benita
231-236Comparison of Gamma Scintigraphy and a Pharmacokinetic Technique for Assessing Pulmonary Deposition of Terbutaline Sulphate Delivered by Pressurized Metered Dose InhalerStephen Newman, Karen Steed, Gerard Hooper, Anders Källén and Lars Borgström
237-243Estimation of Agitation Intensity in the GI Tract in Humans and Dogs Based on in Vitro/in Vivo CorrelationNoriko Katori, Nobuo Aoyagi and Tadao Terao
244-247In Vivo Evaluation of a Colon-Specific Drug Delivery System: An Absorption Study of Theophylline from Capsules Coated with Azo Polymers in RatsGuy Mooter, Celest Samyn and Renaat Kinget
248-256Drug Transport Across Nylon 610 Films: Influence of Synthesis VariablesKenneth Phares, Moo Cho, Keith Johnson and James Swarbrick
257-262Effect of Norfloxacin on Theophylline Disposition: A Comparison with Other FluoroquinolonesJohn D. Davis, Leon Aarons and J. Brian Houston
263-269Incorporation of First-Order Uptake Rate Constants from Simple Mammillary Models into Blood-Flow Limited Physiological Pharmacokinetic Models via Extraction EfficienciesWilliam L. Roth, L. W. D. Weber and Karl K. Rozman
270-274Pharmacokinetic Study of Zeolite A, Sodium Aluminosilicate, Magnesium Silicate, and Aluminum Hydroxide in DogsEugenio A. Cefali, Joseph C. Nolan, William R. McConnell and Denise Lowe Walters
275-283Comparative Tissue Distribution and Elimination of Amphotericin B Colloidal Dispersion (Amphocil®) and Fungizone® After Repeated Dosing in RatsLaurence H. Wang, Robert M. Fielding, Philip C. Smith and Luke S. S. Guo
284-290Age-Dependent Intestinal Absorption of Valproic Acid in the RatAllen Cato III, Gary M. Pollack and Kim L. R. Brouwer
291-294Microdialysis Sampling to Determine the Pharmacokinetics of Unbound SDZ ICM 567 in Blood and Brain in Awake, Freely-Moving RatsMaria J. Alonso, Armin Bruelisauer, Pierrette Misslin and Michel Lemaire
295-298Estimation of Impurity Profiles of Drugs and Related Materials. 12. Isolation and Identification of an Isomeric Impurity in DanazolGábor Balogh, Éva Csizér, György G. Ferenczy, Zsuzsanna Halmos and Bulcsu Herényi, et al.
299-304Changes in Solid-State Structure of Cyclophosphamide Monohydrate Induced by Mechanical Treatment and StorageJarkko Ketolainen, Antti Poso, Veijo Viitasaari, Jukka Gynther and Jukka Pirttimäki, et al.
305-308Chemical Pathways of Degradation of the Bradykinin Analog, RMP-7Julie Ann Straub, Alan Akiyama, Parul Parmar and Gary F. Musso
309-312Differential Expression of the Phenol Family of UDP-Glucuronosyltransferases in Hepatoma Cell LinesAh-Ng Tony Kong, Peiwen Fei and Bradley K. Wong
313-316Pharmacokinetics of Caffeine and Its Demethylated Metabolites in Lactation: Predictions of Milk to Serum Concentration RatiosCheah Y. Oo, David E. Burgio, Robert C. Kuhn, Nirmala Desai and Patrick J. McNamara
317-319Structural Requirements for Interaction with the Oligopeptide Transporter in Caco-2 CellsIsmael J. Hidalgo, Pradip Bhatnagar, Chao-Pin Lee, Joanne Miller and Gregory Cucullino, et al.
320-321Reviewers for Pharmaceutical Research (January 1, 1994 - November 30, 1994)
322European Reviewers for Pharmaceutical Research (January 1, 1994 - November 23, 1994)

Volume 12, Number 3 / March 1995

323-328The Importance of Structural Factors on the Rate and the Extent of N,O-acyl Migration in Cyclic and Linear PeptidesReza Oliyai, Teruna J. Siahaan and Valentine J. Stella
329-336Soft Drugs. XX. Design, Synthesis, and Evaluation of Ultra-Short Acting Beta-BlockersHee-Sun Yang, Whei-Mei Wu and Nicholas Bodor
337-341Crystal Structure of 2-Debenzoyl, 2-Acetoxy Paclitaxel (Taxol®): Conformation of the Paclitaxel Side-ChainQi Gao, Jian-Mei Wei and Shu-Hui Chen
342-347Physicochemical Characterization of Parenteral Lipid Emulsion: Determination of Hamaker Constants and Activation Energy of CoalescenceTetsuo Yamaguchi, Kaori Nishizaki, Shigeru Itai, Hidefumi Hayashi and Hiroyuki Ohshima
348-355Chemical Pathways of Peptide Degradation. VIII. Oxidation of Methionine in Small Model Peptides by Prooxidant/Transition Metal Ion Systems: Influence of Selective Scavengers for Reactive Oxygen IntermediatesShihong Li, Christian Schöneich and Ronald T. Borchardt
356-359The Influence of Regional Deposition on the Pharmacokinetics of Pulmonary-Delivered Human Growth Hormone in RabbitsPaul Colthorpe, Stephen J. Fair, Ian J. Smith, David Wyatt and Glyn Taylor
360-365Transepithelial Transport Properties of Peptidomimetic Thrombin Inhibitors in Monolayers of a Human Intestinal Cell Line (Caco-2) and Their Correlation to in Vivo DataElke Walter, Thomas Kissel, Martin Reers, Gerhard Dickneite and Dieter Hoffmann, et al.
366-369A Non-Ionic Vesicle Lipid Enhances Mastoparan-Stimulated GTPase Activity of Heterotrimeric G-ProteinsBernd Nürnberg, Ralph Hoppe, Ulrich Rümenapp, Rainer Harhammer and Eberhard Nürnberg
370-375Tumor Selective Effect of RS-1541 (Palmitoyl-Rhizoxin) in M5076 Sarcoma and Host Tissues in VivoTaro Tokui, Naoyuki Maeda, Chitose Kuroiwa, Kazuhiko Sasagawa and Takashi Inoue, et al.
376-379The Description of the Gastrointestinal Transit of Pellets Assessed by Gamma Scintigraphy Using Statistical MomentsFridrun Podczeck, John Michael Newton and Kay-Hay Yuen
380-386The Application of Malononitriles as Microviscosity Probes in Pharmaceutical SystemsSherry L. LaPorte, Abizer Harianawala and Robin H. Bogner
387-392Drug Delivery Studies in Caco-2 Monolayers. Synthesis, Hydrolysis, and Transport of O-Cyclopropane Carboxylic Acid Ester Prodrugs of Various β-Blocking AgentsLars Hovgaard, Helle Brøndsted, Anders Buur and Hans Bundgaard
393-396The Effect of Different Concentrations of Mannitol in Solution on Small Intestinal Transit: Implications for Drug AbsorptionDawn A. Adkin, Stanley S. Davis, Robert A. Sparrow, Paul D. Huckle and Anthony J. Phillips, et al.
397-405In Vitro and in Vivo Evaluation of Mucoadhesive Microspheres Prepared for the Gastrointestinal Tract Using Polyglycerol Esters of Fatty Acids and a Poly(acrylic acid) DerivativeYohko Akiyama, Naoki Nagahara, Toshio Kashihara, Shinichiro Hirai and Hajime Toguchi
406-412Neural Network Predicted Peak and Trough Gentamicin ConcentrationsMichael E. Brier, Jacek M. Zurada and George R. Aronoff
413-420A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo BioavailabilityGordon L. Amidon, Hans Lennernäs, Vinod P. Shah and John R. Crison
421-425Analysis of Tissue Distribution of Valproate in Guinea-Pigs: Evidence for Its Capacity-Limited Tissue DistributionHsiu-Ying Yu and Yu-Zen Shen
426-432Regional Rectal Perfusion: A New in Vivo Approach to Study Rectal Drug Absorption in ManHans Lennernäs, Urban Fagerholm, Yngve. Raab, Bengt Gerdin and Roger Hällgren
433-437A Compartmental Model for the Ocular Pharmacokinetics of Cyclosporine in RabbitsClifford Oh, Bradley A. Saville, Yu-Ling Cheng and David S. Rootman
438-445Pharmacodynamic Analysis of Analgesic Clinical Trials Using Empirical MethodsChui Yu Liu and Nancy C. Sambol
446-450Second Derivative Infrared Spectroscopy as a Non-Destructive Tool to Assess the Purity and Structural Integrity of ProteinsD. Michael Byler, Rachel M. Wilson, Cynthia S. Randall and Theodore D. Sokoloski
451-454Stabilization of Human Epidermal Growth Factor (hEGF) in Aqueous FormulationKyonghee Son and Changhyuk Kwon
455-458Functional Evaluation of Anchored Skin Equivalent Cultured in Vitro: Percutaneous Absorption Studies and Lipid AnalysisMartine Michel, Lucie Germain, Pierre Maxime Bélanger and François A. Auger
459-463Pharmacodynamic Modeling of Prednisolone Effects on Natural Killer Cell TraffickingZhi-Xin Xu, Mi-Jeong Lee, Robert A. Blum and William J. Jusko

Volume 12, Number 4 / April 1995

465-483Antigene, Ribozyme and Aptamer Nucleic Acid Drugs: Progress and ProspectsRobert A. Stull and Francis C. Szoka, Jr
484-490Thermal Analysis of the Tertiary Butyl Alcohol-Water System and Its Implications on Freeze-DryingKasra Kasraian and Patrick P. DeLuca
491-495The Effect of Tertiary Butyl Alcohol on the Resistance of the Dry Product Layer During Primary DryingKasra Kasraian and Patrick P. DeLuca
496-507Physico-Mechanical Characterization of the Extrusion-Spheronization Process. Part II: Rheological Determinants for Successful Extrusion and SpheronizationRajen D. Shah, Mohan Kabadi, David G. Pope and Larry L. Augsburger
508-512Monosialoganglioside GMl Shortens the Blood Circulation Time of Liposomes in RatsDexi Liu, Feng Liu and Young K. Song
513-517Insulin-Degrading Enzyme in a Human Colon Adenocarcinoma Cell Line (Caco-2)Jane P. F. Bai, Matt J. P. Hsu and W. Thomas Shier
518-522Is the Beneficial Effect of Calcium Channel Blockers Against Cyclosporine A Toxicity Related to a Restoration of ATP Synthesis?Marie D. Salducci, Anne M. Chauvet-Monges, Bertrand M. Dussol, Yvon F. Berland and Aimé D. Crevat
523-528Characterization of Drug Transport Through Tight-Junctional Pathway in Caco-2 Monolayer: Comparison with Isolated Rat Jejunum and ColonYoshihiro Tanaka, Yoko Taki, Toshiyasu Sakane, Tanekazu Nadai and Hitoshi Sezaki, et al.
529-533Ocular Absorption and Irritation of Pilocarpine Prodrug Is Modified with Buffer, Polymer, and Cyclodextrin in the EyedropPekka Suhonen, Tomi Järvinen, Kari Lehmussaari, Timo Reunamäki and Arto Urtti
534-540Evaluation of Poly(isobutylcyanoacrylate) Nanoparticles for Mucoadhesive Ocular Drug Delivery. I. Effect of Formulation Variables on Physicochemical Characteristics of NanoparticlesSudip K. Das, Ian G. Tucker, David J. T. Hill and Nandita Ganguly
541-548Carrier-Mediated Transport Can Obey Fractal KineticsPanos Macheras
549-555Measurement of Rapid Release Kinetics for Drug DeliveryUwe Pliquett, Mark R. Prausnitz, Yuri A. Chizmadzhev and James C. Weaver
556-559Effect of Humidity-Dependent Changes in Crystal Structure on the Solid-State Fluorescence Properties of a New HMG-CoA Reductase InhibitorHarry G. Brittain, Sunanda A. Ranadive and Abu T. M. Serajuddin
560-564Effects of Inclusion Complexation on the Transepithelial Transport of a Lipophilic Substance in VitroM. J. Cho, F. J. Chen and Dennis L. Huczek
565-571Development of a Human Nasal Epithelial Cell Culture Model and Its Suitability for Transport and Metabolism Studies Under in Vitro ConditionsUte Werner and Thomas Kissel
572-575Use of ATR-FTIR Spectroscopy to Study the Diffusion of Ethanol Through Glycerogelatin FilmsA. Margarida L. Tralhão, Adam C. Watkinson, Keith R. Brain, Jonathan Hadgraft and N. Anthony Armstrong
576-582In Vitro Evaluation of Polymerized Liposomes as an Oral Drug Delivery SystemJun'ichi Okada, Smadar Cohen and Robert Langer
583-587QSAR Analysis of Skin Permeability of Various Drugs in Man as Compared to in Vivo and in Vitro Studies in RodentsEric J. Lien and Hua Gaot
588-593The in Vitro Characterization and Biostability of 99mTc-Dextran and Its Accumulation Within the Inflamed Paws of Adjuvant-Induced Arthritic RatsIan W. Kellaway, Lisa Seale and Paul S. J. Spencer
594-598Relationship Between the Phasic Period of Interdigestive Migrating Contraction and the Systemic Bioavailability of Acetaminophen in DogsKazuyoshi Sagara, Hiroaki Mizuta, Minoru Ohshiko, Masahiro Shibata and Keiichiro Haga
599-604Isothermal and Nonisothermal Decomposition of Famotidine in Aqueous SolutionGunjan H. Junnarkar and Salomon Stavchansky
605-608Transport Mechanism of Ceftibuten, a Dianionic Cephem, in Rat Renal Brush-Border MembraneImad Naasani, Mitsuru Sugawara, Michiya Kobayashi, Ken Iseki and Katsumi Miyazaki
609-614Metabolism of Diltiazem in Hepatic and Extrahepatic Tissues of Rabbits: InVitro StudiesWalid Homsy, Marc Lefebvre, Gilles Caillé and Patrick du Souich
615-620A Cellular Automata Model of the Hydrophobia EffectLemont B. Kier, Chao-Kun Cheng, Bernard Testa and Pierre-Alain Carrupt
621-629A Solution Conformation Analysis of Forocidins I and Isoforocidins I Using NMR and Molecular ModelingKumar Ramu, Sachin Shringarpure and John S. Williamson
630-633Amoebicidal in Vitro Activity Shown by Some Metronidazole Analogues: Biological Response-Reduction Potential CorrelationMa. Elena Campos, Marco Meraz, Hugo Sánchez and Héctor Salgado-Zamora
634-635Solution Properties of Two Fluoroquinolone AntibacterialsRichard J. Prankerd

Volume 12, Number 5 / May 1995

637-641The Effect of pH and Temperature on the Self-Association of Recombinant Human Interleukin-2 as Studied by Equilibrium SedimentationSiddharth J. Advant, Emory H. Braswell, C. Vijaya Kumar and Devendra S. Kalonia
642-648Interdomain Interactions in the Chimeric Protein Toxin sCD4(178)-PE40: A Differential Scanning Calorimetry (DSC) StudyStephen R. Davio, Kathryn M. Kienle and Brian E. Collins
649-652Primary Interactions of Three Quaternary Ammonium Compounds with Blastospores of Candida albicans (MEN Strain)Leo J. Schep, David S. Jones and Max G. Shepherd
653-657Antitumor Effect of Arterial Administration of a Medium-Chain Triglyceride Solution of an Angiogenesis Inhibitor, TNP-470, in Rabbits Bearing VX-2 CarcinomaShigeo Yanai, Hiroaki Okada, Kazuhiro Saito, Yuji Kuge and Masafumi Misaki, et al.
658-662Selective Inhibition of Bitter Taste of Various Drugs by LipoproteinYoshihisa Katsuragi, Yoko Sugiura, Cao Lee, Kazuya Otsuji and Kenzo Kurihara
663-668Prolonged Blood Circulation in Rats of Nanospheres Surface-Modified with Semitelechelic Poly[N-(2-Hydroxypropyl)methacrylamide]Shigeru Kamei and Jindřich Kopeček
669-675Modelling Mucoadhesion by Use of Surface Energy Terms Obtained from the Lewis Acid–Lewis Base Approach. II. Studies on Anionic, Cationic, and Unionisable PolymersMaria Rillosi and Graham Buckton
676-681Autoradiographic Imaging of the Distribution of 5-Fluorouracil Through Cervical Tissue Following in Vitro Surface Application of a Bioadhesive Cervical PatchA. David Woolfson, Dermot F. McCafferty, Paul A. McCarron and John H. Price
682-686Interaction Between Bile Salts and β-Adrenoceptor AntagonistsMartin P. Grosvenor and Jan-Erik Löfroth
687-692Enhanced Transdermal Delivery of Diazepam by Submicron Emulsion (SME) CreamsJoseph S. Schwarz, Michael R. Weisspapir and Doron I. Friedman
693-699Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and inSitu Models: Relationship to Absorption in HumansBarbra H. Stewart, O. Helen Chan, Rosalind H. Lu, Eric L. Reyner and Heidi L. Schmid, et al.
700-708The Role of Metabolites in Bioequivalency Assessment. II. Drugs with Linear Pharmacokinetics and First-Pass EffectMei-Ling Chen and Andre J. Jackson
709-714Monoclonal Digoxin-Specific Antibodies Induce Dose-and Affinity-Dependent Plasma Digoxin Redistribution in RatsNathalie J. Cano, Alain E. Sabouraud, Kamel Benmoussa, Francoise Roquet and Isabelle Navarro-Teulon, et al.
715-719The Distribution of Oleic Acid Between Salbutamol Base Drug and Different Propellant BlendsPatrik M. Eriksson, Kenneth B. Sandström and Jarl B. Rosenholm
720-728Pharmacokinetics of Oral Extended-Release Dosage Forms. I. Release Kinetics, Concentration, and Absorbed FractionFang-Yu Liu, Nancy C. Sambol, Robert P. Giannini and Chui Yu Liu
729-737Experimental Design and Efficient Parameter Estimation in Preclinical Pharmacokinetic StudiesEne I. Ette, Catherine A. Howie, Andrew W. Kelman and Brian Whiting
738-745Gradient High Performance Liquid Chromatographic Assay for Degradation Products of Adinazolam Mesylate in a Sustained Release Tablet FormulationNick L. Stemm, John W. Skoug and Russell H. Robins
746-750Quantitative Microdialysis for Studying the in Vivo L-DOPA Kinetics in Blood and Skeletal Muscle of the DogSophie Sarre, Dirk Deleu, Kristel Van Belle, Guy Ebinger and Yvette Michotte
751-755The Electrophoretic Mobility of Tripeptides as a Function of pH and Ionic Strength: Comparison with lontophoretic Flux DataBarbara VanOrman Huff, Gary G. Liversidge and Gregory L. McIntire
756-762Analysis of Diclofenac and Four of Its Metabolites in Human Urine by HPLCRonald J. Sawchuk, Jill A. Maloney, Linda L. Cartier, Russell J. Rackley and Keith K. H. Chan, et al.
763-767Prodrugs to Improve the Oral Bioavailability of a Diacidic Nonpeptide Angiotensin II AntagonistBruce J. Aungst, Judy A. Blake, Nancy J. Rogers, Hiroshi Saitoh and Munir A. Hussain, et al.
768-772Electrolyte-Induced Changes in Glass Transition Temperatures of Freeze-Concentrated SolutesLih-Min Her, Michael Deras and Steven L. Nail
773-779Process-Induced Crystallinity Changes in Albuterol Sulfate and Its Effect on Powder Physical StabilityGary H. Ward and Robert K. Schultz
780-786Gastric pH Influences the Appearance of Double Peaks in the Plasma Concentration-Time Profiles of Cimetidine After Oral Administration in DogsVanaja Mummaneni, Gordon L. Amidon and Jennifer B. Dressman
787-789Drug Release from Semisolids: Effect of Membrane Permeability on Sensitivity to Product ParametersJoel L. Zatz
790-795Model Features of a Cardiac lontophoretic Drug Delivery ImplantSteven P. Schwendeman, Vinod Labhasetwar and Robert J. Levy
796-798Dose-Dependent Brain Delivery of Zidovudine Through the Use of a Zidovudine Chemical Delivery SystemMarcus E. Brewster, Wesley R. Anderson, Danny O. Helton, Nicholas Bodor and Emil Pop

Volume 12, Number 6 / June 1995

799-806Molecular Mobility of Amorphous Pharmaceutical Solids Below Their Glass Transition TemperaturesBruno C. Hancock, Sheri L. Shamblin and George Zografi
807-816Human Insulin Receptor Monoclonal Antibody Undergoes High Affinity Binding to Human Brain Capillaries in Vitro and Rapid Transcytosis Through the Blood–Brain Barrier in Vivo in the PrimateWilliam M. Pardridge, Young-Sook Kang, Jody L. Buciak and Jing Yang
817-824Radiolabeling of Methylphosphonate and Phosphorothioate Oligonucleotides and Evaluation of Their Transport in Everted Rat Jejunum SacsJeffrey A. Hughes, Anna V. Avrutskaya, Kim L. R. Brouwer, Eric Wickstrom and R. L. Juliano
825-830The Fate of Plasmid DNA After Intravenous Injection in Mice: Involvement of Scavenger Receptors in Its Hepatic UptakeKenji Kawabata, Yoshinobu Takakura and Mitsuru Hashida
831-837Development of an Efficient Single-Step Freeze-Drying Cycle for Protein FormulationsByeong S. Chang and Norman L. Fischer
838-843Increased Stabilizing Effects of Amphiphilic Excipients on Freeze-Drying of Lactate Dehydrogenase (LDH) by Dispersion into Sugar MatricesKen-ichi Izutsu, Sumie Yoshioka and Shigeo Kojima
844-850Comprehensive Pharmacokinetics of Urinary Human Follicle Stimulating Hormone in Healthy Female VolunteersJ.-Y. le Cotonnec, H. C. Porchet, V. Beltrami, A. Khan and S. Toon, et al.
851-856Gamma Irradiation Effects on Molecular Weight and in Vitro Degradation of Poly(D,L-Lactide-CO-Glycolide) MicroparticlesAngela G. Hausberger, Richard A. Kenley and Patrick P. DeLuca
857-863Controlled Release of a Contraceptive Steroid from Biodegradable and Injectable Gel Formulations: In Vitro EvaluationZhi-Hui Gao, Atul J. Shukla, James R. Johnson and William R. Crowley
864-868Controlled Release of Contraceptive Steroids from Biodegradable and Injectable Gel Formulations: In Vivo EvaluationZhi-hui Gao, William R. Crowley, Atul J. Shukla, James R. Johnson and James F. Reger
869-874Soft Drugs 18. Oral and Rectal Delivery of Loteprednol Etabonate, a Novel Soft Corticosteroid, in Rats—for Safer Treatment of Gastrointestinal InflammationNicholas Bodor, Teruo Murakami and Whei-Mei Wu
875-879Soft Drugs 19. Pharmacokinetics, Metabolism and Excretion of a Novel Soft Corticosteroid, Loteprednol Etabonate, in RatsNicholas Bodor, Whei-Mei Wu, Teruo Murakami and Steven Engel
880-883Evaluation of Intestinal Absorption into the Portal System in Enterohepatic Circulation by Measuring the Difference in Portal–Venous Blood Concentrations of DiclofenacKenji Tabata, Kiyoshi Yamaoka, Takako Fukuyama and Terumichi Nakagawa
884-888Regiospecific Intestinal Absorption of the HIV Protease Inhibitor L-735,524 in Beagle DogsGloria Y. Kwei, Linda B. Novak, Lisa A. Hettrick, Elisabeth R. Reiss and Drazen Ostovic, et al.
889-894Method to Estimate the Rate and Extent of Intestinal Absorption in Conscious Rats Using an Absorption Probe and Portal Blood SamplingDaniel J. Hoffman, Terese Seifert, Anthony Borre and Hugh N. Nellans
895-901Interspecies Scaling of Tebufelone Pharmacokinetic Data and Application to Preclinical ToxicologyCharles A. Cruze, Gary R. Kelm and Michael P. Meredith
902-904Effect of Corticosteroid Binding Globulin on the Pharmacokinetics of Prednisolone in RatsHui C. Ko, Richard R. Almon and William J. Jusko
905-910Pharmacokinetic Analysis and Antiepileptic Activity of N-Valproyl Derivatives of GABA and GlycineSalim Hadad and Meir Bialer
911-915Comparative Brain Exposure to (-)-Carbovir After (-)-Carbovir or (-)-6-Aminocarbovir Intravenous Infusion in RatsYan-Dong Wen, Rory P. Remmel, Phuong T. Pham, Robert Vince and Cheryl L. Zimmerman
916-922Effect of Liposomal and Free Bisphosphonates on the IL-1β, IL-6 and TNFα Secretion from RAW 264 Cells in VitroNiina Pennanen, Seppo Lapinjoki, Arto Urtti and Jukka Mönkkönen
923-929The Effect of Moisture on the Mechanical and Powder Flow Properties of Microcrystalline CelluloseGregory E. Amidon and Michael E. Houghton
930-9365-Bromomethyl Fluorescein (5-BMF) for Derivatization of Carboxyl Containing Analytes for Use with Laser-Induced Fluorescence DetectionPartha S. Mukherjee, Kapila H. DeSilva and H. Thomas Karnes
937-942Without Extrapolation, Cmax/AUC is an Effective Metric in Investigations of BioequivalenceLaszlo Tothfalusi and Laszlo Endrenyi

Volume 12, Number 7 / July 1995

943-944Patient-Oriented Pharmaceutical Research: Focus on the IndividualGerhard Levy
945-954Pharmaceutical Solids: A Strategic Approach to Regulatory ConsiderationsStephen Byrn, Ralph Pfeiffer, Michael Ganey, Charles Hoiberg and Guirag Poochikian
955-964Diffusion in HPMC Gels. I. Determination of Drug and Water Diffusivity by Pulsed-Field-Gradient Spin-Echo NMRPing Gao and Paul E. Fagerness
965-971Diffusion in HPMC Gels. II. Prediction of Drug Release Rates from Hydrophilic Matrix Extended-Release Dosage FormsPing Gao, Phillip R. Nixon and John W. Skoug
972-982A New Method for Estimating Dermal Absorption from Chemical Exposure. 3. Compared with Steady-State Methods for Prediction and Data AnalysisAnnette L. Bunge, Robert L. Cleek and Brent E. Vecchia
983-992Evaluation of Retinoid Lactones as Topical Therapeutic Agents in DermatologyAnita H. Lewin, Sherry L. Black, Mary E. Bos, R. Richard Goehring and Xina Nair, et al.
993-997In Vitro Percutaneous Absorption of Arildone, a Highly Lipophilic Drug, and the Apparent No-Effect of the Penetration Enhancer Azone in Excised Human SkinE. J. Baker and J. Hadgraft
998-1002Mechanisms Involved in lontophoretic Transport of AngiotensinMartine Clemessy, Guy Couarraze, Bruno Bevan and Francis Puisieux
1003-1010A New Large-Scale Process for Taxol and Related Taxanes from TaxusbrevifoliaKoppaka V. Rao, Jampani B. Hanuman, Claudio Alvarez, Mark Stoy and John Juchum, et al.
1011-1018Characterization of Alkylating Versus Intercalating Anticancer Drug-Induced Effects on Cell Survival, Cell Cycle Kinetic and Morphonuclear Pattern of Three Neoplastic Cells Lines Growing in VitroOlivier Pauwels, Robert Kiss, Jean-Lambert Pasteels and Ghanem Atassi
1019-1024Distribution, Metabolism and Tumoricidal Activity of Doxorubicin Administered in Sorbitan Monostearate (Span 60) Niosomes in the MouseIjeoma F. Uchegbu, John A. Double, John A. Turton and Alexander T. Florence
1025-1030Development of a Flow Microcalorimetry Method for the Assessment of Surface Properties of PowdersP. Louise Sheridan, Graham Buckton and David E. Storey
1031-1039The Effect of Particle Fragmentation and Deformation on the Interparticulate Bond Formation Process During Powder CompactionMaria Eriksson and Göran Alderborn
1040-1044Improved Static Compression Behaviors and Tablettabilities of Spherically Agglomerated Crystals Produced by the Spherical Crystallization Technique with a Two-Solvent SystemYoshiaki Kawashima, Fude Cui, Hirofumi Takeuchi, Toshiyuki Niwa and Tomoaki Hino, et al.
1045-1048Compressed Donut-Shaped Tablets with Zero-Order Release KineticsCherng-ju Kim
1049-1054Oral Solid Controlled Release Dosage Forms: Role of GI-Mechanical Destructive Forces and Colonic Release in Drug Absorption Under Fasted and Fed Conditions in HumansMohammed Shameem, Noriko Katori, Nobuo Aoyagi and Shigeo Kojima
1055-1059Physicochemical, Pharmacokinetic and Pharmacodynamic Evaluation of Liposomal Tacrolimus (FK 506) in RatsMi-Jeong Lee, Robert M. Straubinger and William J. Jusko
1060-1064Long-Circulating Emulsions (Oil-in-Water) as Carriers for Lipophilic DrugsFeng Liu and Dexi Liu
1065-1071Pharmacokinetics of lopromide Liposomes in RabbitsGabriele Schuhmann-Giampieri, Jens Leike, Andreas Sachse and Werner Krause
1072-1076Adsorption of Salmon Calcitonin to PLGA MicrospheresSema Calis, Ramasubbu Jeyanthi, Tsuimin Tsai, Rahul C. Mehta and Patrick P. DeLuca
1077-1084Effects of Insulin Concentration and Self-Association on the Partitioning of Its A-21 Cyclic Anhydride Intermediate to Desamido Insulin and Covalent DimerRichard T. Darrington and Bradley D. Anderson
1085-1091Effect of Aging on the Kinetics of Blood–Brain Barrier Uptake of Tryptophan in RatsJian-Ping Tang and Srikumaran Melethil
1092-1095Uptake of Fractionated 3H-Heparin by Isolated Rat Kupffer CellsJim Watanabe, Masami Haba and Hiroaki Yuasa
1096-1100Pharmacokinetic/Pharmacodynamic Evaluation of Deflazacort in Comparison to Methylprednisolone and PrednisoloneHelmut Möllmann, Günther Hochhaus, Shashank Rohatagi, Jürgen Barth and Hartmut Derendorf
1101-1104pGlu-L-Dopa-Pro: A Tripeptide Prodrug Targeting the Intestinal Peptide Transporter for Absorption and Tissue Enzymes for ConversionJane P. F. Bai
1105-1108Differential Induction of UDP-Glucuronosyltransferase Activity and Gene Expression in Rat LiverBradley K. Wong, Peiwen Fei and A.-N. Tony Kong
1109-1114Hepatic Membrane Transport of Organic Cations Using Isolated Rat Hepatocyte Membrane Vesicles: Structure–Transport RelationshipsYounggil Kwon and Marilyn E. Morris

Volume 12, Number 8 / August 1995

1115-1119Permeability of Peptides and Proteins in Human Cultured Alveolar A549 Cell MonolayerShinzo Kobayashi, Shuji Kondo and Kazuhiko Juni
1120-1125Mechanisms of Transport of Quinapril in Caco-2 Cell Monolayers: Comparison with CephalexinMing Hu, Lixing Zheng, Jiyue Chen, Lijuan Liu and Yanping Zhu, et al.
1126-1133Enhanced Oral Bioavailability of DDI After Administration of 6-Cl-ddP, an Adenosine Deaminase-Activated Prodrug, to Chronically Catheterized RatsBradley D. Anderson, Michael E. Morgan and Dharmendra Singhal
1134-1139Echo-Planar Magnetic Resonance Imaging to Assess Water Volume in the Distal Small BowelDawn A. Adkin, Penny Gowland, Robin C. Spiller, Alan Freeman and Jonathon Hykin, et al.
1140-1145Transport of Biologically Active Interferon-gamma Across Human Skin in VitroSarah M. Short, Werner Rubas, Brian D. Paasch and Randall J. Mrsny
1146-1150Different Effects of Absorption Promoters on Corneal and Conjunctival Penetration of Ophthalmic Beta-BlockersHitoshi Sasaki, Yoshiaki Igarashi, Toshiaki Nagano, Koyo Nishida and Junzo Nakamura
1151-1157Effects of Absorption Enhancers on Rat Nasal Epithelium in Vivo: Release of Marker Compounds in the Nasal CavityEmmeline Marttin, J. Coos Verhoef, Stefan G. Romeijn and Frans W. H. M. Merkus
1158-1164Species Dependent Esterase Activities for Hydrolysis of an Anti-HIV Prodrug Glycovir and Bioavailability of Active SC-48334Chyung S. Cook, Peter J. Karabatsos, Grant L. Schoenhard and Aziz Karim
1165-1170Metabolism of Dynorphin A 1-13 in Human Blood and PlasmaStefan Müller and Günther Hochhaus
1171-1175Transepithelial Transport of Insulin: I. Insulin Degradation by Insulin-Degrading Enzyme in Small Intestinal EpitheliumJane P. F. Bai and L. L. Chang
1176-1183Preparation and Characterization of Dextran Magnetite-Incorporated Thermosensitive Liposomes: An on-line Flow System for Quantifying Magnetic ResponsivenessEkapop Viroonchatapan, Masaharu Ueno, Hitoshi Sato, Isao Adachi and Hideo Nagae, et al.
1184-1188Influence of Nonionic Liposomal Composition on Topical Delivery of Peptide Drugs into Pilosebaceous Units: An in Vivo Study Using the Hamster Ear ModelSusan M. Niemiec, Chandrasekharan Ramachandran and Norman Weiner
1189-1198Liposomal Formulations of Cyclosporin A: Influence of Lipid Type and Dose on PharmacokineticsA. Fahr, M. Holz and G. Fricker
1199-1204Quantitative Structure Activity Relationships of Catechol Derivatives on Nerve Growth Factor Secretion in L-M CellsAngeliki Kourounakis and Nicholas Bodor
1205-1210The Effect of Electrostatic Charge Interactions on Release Rates of Gentamicin from Collagen MatricesManish P. Singh, Joseph Stefko, Janice A. Lumpkin and Joel Rosenblatt
1211-1217Polymeric Microspheres Prepared by Spraying into Compressed Carbon DioxideRoland Bodmeier, Hui Wang, David J. Dixon, Simon Mawson and Keith P. Johnston
1218-1224Measurements of Size Distribution and Density of a Pharmaceutical Fat Emulsion, Using Field-Programmed Sedimentation Field-Flow Fractionation (SdFFF)Shulamit Levin and Eytan Klausner
1225-1230MicroPharm-K, a Microcomputer Interactive Program for the Analysis and Simulation of Pharmacokinetic ProcessesSaïk Urien
1231-1237Solubilisation of Drugs in Micellar Systems Studied by Eluent Gel Permeation ChromatographyMichael Draper, Matthew Savage, John H. Collett, David Attwood and Colin Price, et al.
1238-1239Unbound Total (Plasma) Clearance Approach in Interspecies Pharmacokinetics Correlation: Theophylline-Cimetidine InteractionWin L. Chiou and Young M. Choi
1240-1243Synthesis and Pharmacological Evaluation of Spiro-Analogues of 5-Benzyl-5-ethyl Barbituric AcidS. Bruce King, Eugene S. Stratford, Charles R. Craig and E. Kim Fifer
1244ERRATUM

Volume 12, Number 9 / September 1995

1245-1246EDITORIAL
1247The Many Faces of Pharmaceutical ResearchBernard Testa
1248-1249Methodologies for Pharmaceutical Effectiveness and Pharmacoeconomics ResearchCarol B. Gable
1250-1259Optimization of Lyophilization Conditions for Recombinant Human Interleukin-2 by Dried-State Conformational Analysis Using Fourier-Transform Infrared SpectroscopySteven J. Prestrelski, Katherine A. Pikal and Tsutomu Arakawa
1260-1263Vial Lyophilization: Calculations on Rate Limitation During Primary DryingHester Ybema, Lia Kolkman-Roodbeen, Marcel P. W. M. te Booy and Herman Vromans
1264-1268Computer Simulation of Tablet Motion in Coating DrumKenji Yamane, Toshiharu Sato, Toshitsugu Tanaka and Yutaka Tsuji
1269-1272Preparation of Controlled-Release Coevaporates of Dipyridamole by Loading Neutral Pellets in a Fluidized-Bed Coating SystemDeniz B. Beten, Karim Amighi and André J. Moës
1273-1278Physicochemical Characterization of Parenteral Lipid Emulsion: Influence of Cosurfactants on Flocculation and CoalescenceTetsuo Yamaguchi, Kaori Nishizaki, Shigeru Itai, Hidefumi Hayashi and Hiroyuki Ohshima
1279-1283Hydrophobic Contribution Constants of Amino Acid Residues to the Hydrophobicities of OligopeptidesHua Gao, Fengzhen Wang and Eric J. Lien
1284-1288Precipitation of Insulinotropin in the Presence of Protamine: Effect of Phenol and Zinc on the Isophane Ratio and the Insulinotropin Concentration in the SupernatantYesook Kim and Carol A. Rose
1289-1292Cholate-Induced Disruption of Calcitonin-Loaded Liposomes: Formation of Trypsin-Resistant Lipid-Calcitonin-Cholate ComplexesAlbertina Ariën, Nelly Toulmé-Henry and Bernard Dupuy
1293-1298Mucoadhesive Polymers in Peroral Peptide Drug Delivery. II. Carbomer and Polycarbophil Are Potent Inhibitors of the Intestinal Proteolytic Enzyme TrypsinHenrik L. Lueßen, J. Coos Verhoef, Gerrit Borchard, Claus-M. Lehr and A. (Bert) G. de Boer, et al.
1299-1303The Intestinal Transport Mechanism of Fluoroquinolones: Inhibitory Effect of Ciprofloxacin, an Enoxacin Derivative, on the Membrane Potential-Dependent Uptake of EnoxacinTakeshi Hirano, Ken Iseki, Izumi Sato, Shozo Miyazaki and Masahiko Takada, et al.
1304-1310Possible Involvement of Multiple P-Glycoprotein-Mediated Efflux Systems in the Transport of Verapamil and Other Organic Cations Across Rat IntestineHiroshi Saitoh and Bruce J. Aungst
1311-1315Regional Gastrointestinal Absorption of Ranitidine in the RatBenjamin Suttle and Kim L. R. Brouwer
1316-1322Gastrointestinal Transit and Distribution of Ranitidine in the RatA. Benjamin Suttle and Kim L. R. Brouwer
1323-1327First-Pass Accumulation of Salicylic Acid in Gut Tissue After Absorption in Anesthetized RatYoung M. Choi, Sang M. Chung and Win L. Chiou
1328-1332Drug Delivery Studies in Caco-2 Monolayers. IV. Absorption Enhancer Effects of CyclodextrinsLars Hovgaard and Helle Brøndsted
1333-1337New Evaluation Method for in Vitro/in Vivo Correlation of Enteric-Coated Multiple Unit Dosage FormsTakashi Hayashi, Toshihiro Ogura and Yasushi Takagishi
1338-1342Development and in Vitro-in Vivo Evaluation of a Multiparticulate Sustained Release Formulation of DiltiazemShun Por Li, Robert G. Felt, Louis C. Di Paolo, Mei-Ying Huang and Robert O. Williams III
1343-1349The Pulmonary Absorption of Aerosolized and Intratracheally Instilled rhG-CSF and monoPEGylated rhG-CSFRalph W. Niven, K. Lane Whitcomb, Linda Shaner, Anna Y. Ip and Olaf B. Kinstler
1350-1353Pharmacokinetics of 1 -(2-Deoxy-2-fluoro-β-L-arabino-furanosyl)-5-methyluracil (L-FMAU) in RatsJennifer D. Wright, Tianwei Ma, Chung K. Chu and F. Douglas Boudinot
1354-1360Absorption of Sunscreens and Other Compounds Through Human Skin inVivo: Derivation of a Method to Predict Maximum FluxesUrsula Hagedorn-Leweke and Bernhard C. Lippold
1361-1370Hydrolysis of the Prodrug, 2′, 3′, 5′ -Triacetyl-6-azauridineC. M. Riley, M. A. Mummert, J. Zhou, R. L. Schowen and D. G. Vander Velde, et al.
1371-1375Hydroxypropyl-β-Cyclodextrin Increases the Aqueous Solubility and Stability of Pilocarpine ProdrugsPekka Jarho, Arto Urtti and Tomi Järvinen
1376-1379Measurement of the Diffusion of 2,2,2-trifluoroacetamide Within Thermoresponsive Hydrogels Using NMR ImagingR. Dinarvand, B. Wood and A. D'Emanuele
1380-1384Particle Size Distribution of Single and Multiple Sprays of Salbutamol Metered-Dose Inhalers (MDIs)Susan J. Graham, Robert C. Lawrence, Eric D. Ormsby and Richard K. Pike
1385-1387Influence of Surface Properties on the Inflammatory Response to Polymeric NanoparticlesRocío Fernández-Urrusuno, Elias Fattal, Dominique Porquet, Jeanne Féger and Patrick Couvreur
1388-1390Evidence for the Lack of a Human Metabolic Isotope Effect of a Deuterium Analog of FluphenazineSalim Hadad, John W. Hubbard, Gordon McKay, Edward M. Hawes and Satishche Shrikhande, et al.

Volume 12, Number 10 / October 1995

1391-1392EDITORIAL
1393-1394Quo Vadis, Pharmaceutical Sciences, and AAPS?Wolfgang Sadée
1395-1406Cerebrovascular Permeability to Peptides: Manipulations of Transport Systems at the Blood-Brain BarrierBerislav V. Zlokovic
1407-1416Thermosensitive Sterically Stabilized Liposomes: Formulation and in Vitro Studies on Mechanism of Doxorubicin Release by Bovine Serum and Human PlasmaMohamed H. Gaber, Keelung Hong, Shi Kun Huang and Demetrios Papahadjopoulos
1417-1422Application of a Membrane Fusion Assay for Rapid Drug ScreeningSteven S. Vogel, Sven Beushausen and David S. Lester
1423-1429An Improved Method for Determination of Acid Dissociation Constants of PeptidesXiaojun Fang, Quintus Fernando, Sydney O. Ugwu and James Blanchard
1430-1434Conformational Analysis of Methylphenidate and Its Structural Relationship to Other Dopamine Reuptake Blockers Such as CFTMark Froimowitz, Kennerly S. Patrick and Vivian Cody
1435-1438Determination of the Surface Tension of Block Copolymer Micelles by PhagocytosisAlain Rolland, Frank Paul, Katherine M. Stott and Cedric J. Olliff
1439-1446Characterization of the MN gp120 HIV-1 Vaccine: Antigen Binding to AlumRobert P. Weissburg, Phillip W. Berman, Jeffrey L. Cleland, Donna Eastman and Francis Farina, et al.
1447-1452A New Strategy for Enhancing the Stability of Lyophilized Protein: The Effect of the Reconstitution Medium on Keratinocyte Growth FactorMei Z. Zhang, Jie Wen, Tsutomu Arakawa and Steven J. Prestrelski
1453-1456Thermodynamic Study of Sulfanilamide Polymorphism: (I) Monotropy of the α-VarietySiro Toscani, Sven Thorén, Viatcheslav Agafonov, René Céolin and Jérôme Dugué
1457-1461Glycine Crystallization During Freezing: The Effects of Salt Form, pH, and Ionic StrengthMichael J. Akers, Nathaniel Milton, Stephen R. Byrn and Steven L. Nail
1462-1465The Effect of Food on Pharmacokinetics of Zalcitabine in HIV-Positive PatientsL. A. Nazareno, A. A. Holazo, R. Limjuco, S. Passe and S. K. Twardy, et al.
1466-1469Renal Clearance of a Recombinant Granulocyte Colony-Stimulating Factor, Nartograstim, in RatsTakashi Kuwabara, You Ishikawa, Hiroyuki Kobayashi, Satoshi Kobayashi and Yuichi Sugiyama
1470-1473Snake F(ab′)2 Antivenom from Hyperimmunized Horse: Pharmacokinetics Following Intravenous and Intramuscular Administrations in RabbitsStephanie Pepin, Charles Lutsch, Michel Grandgeorge and Jean-Michel Scherrmann
1474-1477Pharmacokinetic Studies of Methotrexate in Plasma and Synovial Fluid Following IV Bolus and Topical Routes of Administration in DogsG. W. Lu, H. W. Jun, M. T. Dzimianski, H. C. Qiu and J. W. McCall
1478-1482Enhanced Intestinal Absorption of Oxytocin Peptide Analogues in the Absence of Pancreatic Juice in PigsPål D. P. Lundin, Stefan Lundin, Håkan Olsson, Börje W. Karlsson and Björn R. Weström, et al.
1483-1487Transport Characteristics of Ceftibuten, a New Cephalosporin Antibiotic, via the Apical H+/Dipeptide Cotransport System in Human Intestinal Cell Line Caco-2: Regulation by Cell GrowthShin-ichi Matsumoto, Hideyuki Saito and Ken-ichi Inui
1488-1492Transport Characteristics of S-1090, A New Oral Cephem, in Rat Intestinal Brush-Border Membrane VesiclesNoriyuki Muranushi, Naofumi Hashimoto and Koichiro Hirano
1493-1498Microbial and Mammalian Metabolism Studies on the Semisynthetic Antimalarial, DeoxoartemisininSherief I. Khalifa, John K. Baker, Mankil Jung, James D. McChesney and Charles D. Hufford
1499-1505Development and Characterization of Rabbit Tracheal Epithelial Cell Monolayer Models for Drug Transport StudiesNeil R. Mathias, Kwang-Jin Kim, Timothy W. Robison and Vincent H. L. Lee
1506-1512Role of Appendages in Skin Resistance and lontophoretic Peptide Flux: Human Versus Snake SkinW. (Ine) H. M. Craane-van Hinsberg, J. Coos Verhoef, Leo. J. Bax, Hans E. Junginger and Harry E. Boddé
1513-1520Controlled Release of Substituted Benzole and Naphthoic Acids Using Carbopol ® Gels: Measurement of Drug Concentration Profiles and Correlation to Release Rate KineticsDonna L. French, Bert O. Häglund, Kenneth J. Himmelstein and John W. Mauger
1521-1525A Cellular Automata Model of DissolutionLemont B. Kier and Chao-Kun Cheng
1526-1529A Solubility and Related Physicochemical Property Comparison of Buprenorphine and Its 3-Alkyl EstersAudra L. Stinchcomb, Rajesh Dua, Anupam Paliwal, Ronald W. Woodard and Gordon L. Flynn
1530-1534Age-Related Changes in Pharmacokinetic Parameters of Phenytoin After Liver Resection in RatsEmi Nakashima, Ryo Matsushita, Yasunori Iida, Tohru Ohshima and Fujio Ichimura
1535-1538Influence of Lipophilicity on the Protein Binding Affinity of CephalosporinsFabienne Demotes-Mainard Péhourcq, Ahmed Radouane, Laurence Labat and Bernard Bannwarth
1539-1544Identification of Enzymatic Degradation Products of Luteinizing Hormone Releasing Hormone (LHRH)/[D-Ala6] LHRH in Rabbit Mucosal HomogenatesKun Han, Jeong Sook Park, Youn Bok Chung, Mi Jeong Lee and Dong Cheul Moon, et al.
1545-1547Poly(D,L-Lactide) Nanocapsules Containing Non-Steroidal Anti-Inflammatory Drugs: Gastrointestinal Tolerance Following Intravenous and Oral AdministrationSilvia Stanisçuaski Guterres, Hatem Fessi, Gillian Barratt, Francis Puisieux and Jean-Philippe Devissaguet
1548-1553Improved Cellular Delivery of Antisense Oligonucleotides Using Transferrin Receptor Antibody-Oligonucleotide ConjugatesIan Walker, William J. Irwin and Saghir Akhtar
1554-1555BOOK REVIEWS

Volume 12, Number 11 / November 1995

1557-1559EDITORIAL
1560WHAT IS THE CURRENT NIGMS SCORING EXPERIMENT? HOW DOES IT WORK? WHAT IS IT ATTEMPTING TO ACCOMPLISH?Rochelle M. Long
1561-1572Lipid Microemulsions for Improving Drug Dissolution and Oral Absorption: Physical and Biopharmaceutical AspectsPanayiotis P. Constantinides
1573-1582Does Fluid Flow Across the Intestinal Mucosa Affect Quantitative Oral Drug Absorption? Is It Time for a Reevaluation?Hans Lennernäs
1583-1591Stabilization of the Hydrophilic Sphere of lobitridol, an lodinated Contrast Agent, as Revealed by Experimental and Computational InvestigationsDominique Meyer, Marie-Hélène Fouchet, Myriam Petta, Pierre-Alain Carrupt and Patrick Gaillard, et al.
1592-1597Pharmacokinetics and Anticonvulsant Effect of a New Hypnotic, CL 284,846, in RatsJacques Gaudreault, France Varin and Gary M. Pollack
1598-1604Human MCAF Gene Transfer Enhances the Metastatic Capacity of a Mouse Cachectic Adenocarcinoma Cell Line in VivoEmi Nakashima, Naofumi Mukaida, Yuri Kubota, Kouji Kuno and Kazuo Yasumoto, et al.
1605-1613The Electrical Characteristics of Human Skin in VivoYogeshvar N. Kalia and Richard H. Guy
1614-1617Apparent pKa of the Fatty Acids Within Ordered Mixtures of Model Human Stratum Corneum LipidsRenate Lieckfeldt, José Villalaín, Juan-Carlos Gómez-Fernández and Geoffrey Lee
1618-1622Effect of PGML Excipient Mixture in a Transdermal System on the in Vitro Transport of Estradiol Across SkinGretchen D. Irion, Michael D. Garrison and William Abraham
1623-1627Iontophoresis Enhances the Transport of Acyclovir Through Nude Mouse Skin by Electrorepulsion and ElectroosmosisNadia Maria Volpato, Patrizia Santi and Paolo Colombo
1628-1633A Predictive Algorithm for Skin Permeability: The Effects of Molecular Size and Hydrogen Bond ActivityRussell O. Potts and Richard H. Guy
1634-1641Evaluation of Bioequivalence of Highly Variable Drugs Using Monte Carlo Simulations. I. Estimation of Rate of Absorption for Single and Multiple Dose Trials Using CmaxAhmed A. El-Tahtawy, André J. Jackson and Thomas M. Ludden
1642-1646Effect of Omeprazole on Diazepam Disposition in the Rat: in Vitro and in Vivo StudiesK. Zomorodi and J. B. Houston
1647-1651Effects of Gender, Pregnancy, and Anesthesia on the Pharmacokinetics of Zidovudine in RatsChristine S.-H. Huang, F. Douglas Boudinot and Stuart Feldman
1652-1657The Problem of Racemization in the Stereospecific Assay and Pharmacokinetic Evaluation of Ketorolac in Human and RatsMajid Vakily, Brian Corrigan and Fakhreddin Jamali
1658-1663Inhibition of Pulmonary Surfactant Biophysical Activity by Cationic Polyamino AcidsPaul M. Bummer, Shewan Aziz and Mark N. Gillespie
1664-1670The Application of Crystal Soaking Technique to Study the Effect of Zinc and Cresol on Insulinotropin Crystals Grown from a Saline SolutionYesook Kim and Anne M. Haren
1671-1676Estimation of Recombinant Bovine Somatotropin Solubility by Excluded-Volume Interaction with Polyethylene GlycolsCynthia L. Stevenson and Michael J. Hageman
1677-1681Loading Effect on Particle Size Measurements by Inertial Sampling of Albuterol Metered Dose InhalersMoheb M. Nasr and James F. Allgire
1682-1688Nebulization of Fluids of Different Physicochemical Properties with Air-Jet and Ultrasonic NebulizersOrla N. M. McCallion, Kevin M. G. Taylor, Marian Thomas and Anthony J. Taylor
1689-1693A Microcalorimetric Investigation of the Interaction of Surfactants with Crystalline and Partially Crystalline Salbutamol Sulphate in a Model Inhalation Aerosol SystemPeter M. Blackett and Graham Buckton
1694-1700Structure of Disintegrating Pellets with Regard to Fractal GeometryMartin Schröder and Peter Kleinebudde
1701-1707Thermophysical Properties of Some Pharmaceutical Excipients Compressed in TabletsJarkko Ketolainen, L'udovit Kubičár, Vlastimil Boháč, Marián Markovič and Petteri Paronen
1708-1715Photoinstability of Some Tyrphostin Drugs: Chemical Consequences of CrystallinityNarendra Kumar, Vincent Windisch and Herman L. Ammon
1716-1721Absorption and Presystemic Metabolism of Nefazodone Administered at Different Regions in the Gastrointestinal Tract of HumansPunit H. Marathe, Daniel E. Salazar, Douglas S. Greene, John Brennan and Umesh A. Shukla, et al.
1722-1726The Site of Absorption in the Small Intestine Determines Diltiazem Bioavailability in the RabbitWalid Homsy, Gilles Caillé and Patrick du Souich
1727-1732Proton-Cotransport of Pravastatin Across Intestinal Brush-Border MembraneIkumi Tamai, Hitomi Takanaga, Hiroshi Maeda, Takuo Ogihara and Masaru Yoneda, et al.
1733-1736Sucrose Urinary Excretion in the Rat Measured Using a Simple Assay: A Model of Gastroduodenal PermeabilityNeal M. Davies, Brian W. Corrigan and Fakhreddin Jamali
1737-1740Contribution of Parenchymal and Non-Parenchymal Liver Cells to the Clearance of Hepatocyte Growth Factor From the Circulation in RatsKe-Xin Liu, Yukio Kato, Tetsuya Terasaki, Shoichi Aoki and Kazuo Okumura, et al.
1741-1745Evaluation of the Uptake of Pravastatin by Perfused Rat Liver and Primary Cultured Rat HepatocytesMichi Ishigami, Taro Tokui, Toru Komai, Kosyo Tsukahara and Masayo Yamazaki, et al.
1746-1755Kinetic Analysis of Hepatobiliary Transport for Conjugated Metabolites in the Perfused Liver of Mutant Rats (EHBR) with Hereditary Conjugated HyperbilirubinemiaOsamu Takenaka, Toru Horie, Kazuo Kobayashi, Hiroshi Suzuki and Yuichi Sugiyama
1756-1760Hepatoprotective Activity of Xanthones and Xanthonolignoids Against tert-Butylhydroperoxide-Induced Toxicity in Isolated Rat Hepatocytes—Comparison with SilybinEduarda R. Fernandas, Félix D. Carvalho, Fernando G. Remião, Maria Lourdes Bastos and Madalena M. Pinto, et al.
1761-1768Gamma-Irradiation of Non-Frozen, Frozen, and Freeze-Dried LiposomesNicolaas J. Zuidam, Stephen S. L. Lee and Daan J. A. Crommelin
1769-1774Enhanced Therapeutic Effect of Cytidine-5′ -Diphosphate Choline when Associated with GM1 Containing Small Liposomes as Demonstrated in a Rat Ischemia ModelMassimo Fresta, Ernst Wehrli and Giovanni Puglisi
1775-1780Antibody Dependent, Complement Mediated Liver Uptake of Liposomes Containing GM1Dexi Liu, Young K. Song and Feng Liu
1781-1785Drug Release From Hydrocolloid Embeddings with High or Low Susceptibility to Hydrodynamic StressWolfram D. Lindner and Bernhard C. Lippold
1786-1790The Release of 5-Fluorouracil from a Swellable Matrix of a Triblock Copolymer of ε-Caprolactone and Ethylene OxideLuigi G. A. Martini, John H. Collett and David Attwood
1791-1795Ocular Availability of Gentamicin in Small Animals After Topical Administration of a Conventional Eye Drop Solution and a Novel Long Acting Bioadhesive Ophthalmic Drug InsertFlorian Gurtler, Vassilios Kaltsatos, Bernard Boisramé, Jean Deleforge and Marianne Gex-Fabry, et al.
1796-1800Biodegradable Delivery System for a Birth Control Vaccine: Immunogenicity Studies in Rats and MonkeysManmohan Singh, Om Singh and G. P. Talwar
1801-1805Transport of Peptidomimetic Renin Inhibitors Across Monolayers of a Human Intestinal Cell Line (Caco-2): Evidence for Self-Enhancement of Paracellular Transport RouteElke Walter, Thomas Kissel and Peter Raddatz
1806-1809Reconversion of Fosphenytoin in the Presence of Intestinal Alkaline PhosphataseChristopher N. TenHoor and Barbra H. Stewart
1810-1812A Novel Isolation Method of a Stable Crystalline Salt of a Cyclic RGD Peptide ZwitterionMichael B. Maurin and Munir A. Hussain
1813-1816Ionic Strength Dependence of Dissolution for Eudragit S-100 Coated PelletsTugrul T. Kararli, Carol F. Kirchhoff and James E. Truelove

Volume 12, Number 12 / December 1995

1817-1819EDITORIAL
1820WHAT INFORMATION ABOUT THE NIGMS IS PRESENTLY AVAILABLE ON THE WORLD WIDE WEB? WHAT IS COMING NEXT?Rochelle M. Long
1821-1822Imaging Can Be Much More Than Pretty PicturesWalter Wolf
1823-1837Biology of Membrane Transport ProteinsWolfgang Sadée, Volkmar Drübbisch and Gordon L. Amidon
1838-1844Study on Brain Interstitial Fluid Distribution and Blood-Brain Barrier Transport of Baclofen in Rats by MicrodialysisYoshiharu Deguchi, Kazimori Inabe, Koichi Tomiyasu, Kenji Nozawa and Shizuo Yamada, et al.
1845-1855Population Pharmacokinetic Modeling: The Importance of Informative GraphicsEne I. Ette and Thomas M. Ludden
1856-1864Sensitive and Specific Determination of the Equivalence of Absorption RatesLaszlo Endrenyi and Passant Al-Shaikh
1865-1868An Approach for Widening the Bioequivalence Acceptance Limits in the Case of Highly Variable DrugsAlexander W. Boddy, Fred C. Snikeris, Robert O. Kringle, Greg C. G. Wei and James A. Oppermann, et al.
1869-1873Reverse Iontophoresis: Noninvasive Glucose Monitoring in Vivo in HumansG. Rao, R. H. Guy, P. Glikfeld, W. R. LaCourse and L. Leung, et al.
1874-1877Dose-Dependent Pharmacokinetics of Warfarin in Healthy VolunteersShang-Ying P. King, Mark A. Joslin, Karen Raudibaugh, Henry J. Pieniaszek and Irma H. Benedek
1878-1882Intra- and Inter-Subject Variabilities of CGP 33101 after Replicate Single Oral Doses of Two 200-mg Tablets and 400-mg SuspensionWing K. Cheung, Farid Kianifard, Audrey Wong, Josette Mathieu and Terry Cook, et al.
1883-1888Prolonged Circulation of Recombinant Human Granulocyte–Colony Stimulating Factor by Covalent Linkage to Albumin Through a Heterobifunctional Polyethylene GlycolAimee Guider Paige, K. Lane Whitcomb, Jennifer Liu and Olaf Kinstler
1889-1895Systemic Absorption and Activity of Recombinant Consensus Interferons After Intratracheal Instillation and Aerosol AdministrationRalph W. Niven, K. Lane Whitcomb, Melissa Woodward, Jennifer Liu and Concesa Jornacion
1896-1900The Effect of Cetylpyridinium Chloride (CPC) on the Cell Surface Hydrophobicity and Adherence of Candida albicansto Human Buccal Epithelial Cells in VitroDavid S. Jones, Leo J. Schep and Max G. Shepherd
1901-1906Extensive Absorption of 2′,3′-Dideoxyinosine by Intratracheal Administration in RatsXiang Gao, M. Guillaume Wientjes and Jessie L.-S. Au
1907-1916Diffusion of an Anti-Transferrin Receptor Antibody in Cultured Murine Melanoma Cell LayersVenkatramani Vijaykumar and Elizabeth M. Topp
1917-1923A Semisynthetic Quillaja Saponin as a Drug Delivery Agent for Aminoglycoside AntibioticsJoanne Recchia, Maria H. A. Lurantos, Jennifer A. Amsden, James Storey and Charlotte R. Kensil
1924-1931The Use of Intracerebral Microdialysis for the Determination of Pharmacokinetic Profiles of Anticancer Drugs in Tumor-Bearing Rat BrainE. C. M. de Lange, J. D. de Vries, C. Zurcher, M. Danhof and A. G. de Boer, et al.
1932-1936Transport of a Hydrophilic Compound into the Cerebrospinal Fluid During Experimental Allergic Encephalomyelitis and After Lipopolysaccharide AdministrationHelga E. de Vries, Elaine F. Eppens, Martine Prins, Johan Kuiper and Theo J. C. van Berkel, et al.
1937-1942A Novel Oligodeoxynucleotide Inhibitor of Thrombin. I. In VitroMetabolic Stability in Plasma and SerumJeng-Pyng Shaw, James A. Fishback, Kenneth C. Cundy and William A. Lee
1943-1947A Novel Oligodeoxynucleotide Inhibitor of Thrombin. II. Pharmacokinetics in the Cynomolgus MonkeyWilliam A. Lee, James A. Fishback, Jeng-Pyng Shaw, Louis C. Bock and Linda C. Griffin, et al.
1948-1952Acceleration of Nitric Oxide (NO) Release from FK409, a Spontaneous NO Releaser, in the Presence of Sulfhydryl-bearing CompoundsShinichi Fukuyama, Yoshimi Hirasawa, Dermot Cox, Shigetaka Koda and Yasuhiro Kita
1953-1957Effect of Acute Renal Failure on Neurotoxicity of Cimetidine in RatsYu Nakada, Koujirou Yamamoto, Junichi Kawakami, Yasufumi Sawada and Tatsuji Iga
1958-1963Renal Disposition and Drug Interaction Screening of (–)-2′-deoxy-3′-thiacytidine (3TC) in the Isolated Perfused Rat KidneyKevin R. Sweeney, Poe-Hirr Hsyu, Paul Statkevich and David R. Taft
1964-1967Effect of Probenecid on the Enantioselective Pharmacokinetics of Oxprenolol and Its Glucuronides in the RabbitMartine E. Laethem, Frans M. Belpaire, Pascal Wijnant and Marc G. Bogaert
1968-1972Characterization of LLC-PK1 Kidney Epithelial Cells as an in Vitro Model for Studying Renal Tubular Reabsorption of Protein DrugsYoshinobu Takakura, Takahiro Morita, Makoto Fujikawa, Mitsuko Hayashi and Hitoshi Sezaki, et al.
1973-1979Vitamin K Prodrugs: 2. Water-Soluble Prodrugs of Menahydroquinone-4 for Systemic Site-Specific DeliveryJiro Takata, Yoshiharu Karube, Mitsunobu Hanada, Kazuhisa Matsunaga and Yoshikazu Matsushima, et al.
1980-1986Regional Drug Delivery I: Permeability Characteristics of the Rat 6-Day-Old Air Pouch Model of InflammationSteven W. Martin, Alexander J. Stevens, Beverley S. Brennan, Marina L. Reis and Lawrence A. Gifford, et al.
1987-1996Regional Drug Delivery II: Relationship Between Drug Targeting Index and Pharmacokinetic Parameters for Three Non-Steroidal Anti-Inflammatory Drugs Using the Rat Air Pouch Model of InflammationAlexander J. Stevens, Steven W. Martin, Beverley S. Brennan, Andrew McLachlan and Lawrence A. Gifford, et al.
1997-2002Controlled Release of Lidocaine from Injectable Gels and Efficacy in Rat Sciatic Nerve BlockAnne Paavola, Jouko Yliruusi, Yoji Kajimoto, Eija Kalso and Torsten Wahlström, et al.
2003-2011Accurate Determination of Skin Flux from Flow-Through Diffusion Cell DataDaniel J. Harrison and Kristine Knutson
2012-2017Use of Drug Kinetics in Dermis to Predict in VivoBlood Concentration After Topical ApplicationXiang Gao, M. Guillaume Wientjes and Jessie L.-S. Au
2018-2023Radial Spread of Sodium Lauryl Sulfate After Topical ApplicationSunita Patil, Parminder Singh and Howard Maibach
2024-2029Absorption of an Oxytocin Antagonist (Antocin) and a Vasopressin Analogue (dDAVP) Through a Standardized Skin Erosion in VolunteersStefan Lundin, Pål Svedman, Peter Höglund, Karin Jönsson and Anja Breeders, et al.
2030-2035Analysis of Drug Distribution in Hydrogels Using Fourier Transform Infrared MicroscopyMary Tanya am Ende and Nikolaos A. Peppas
2036-2040A Graphical Method for the Determination of the Mode of Hydrolysis of Biodegradable PolymersChung Shih
2041-2048Calculation of Hydrolytic Rate Constants of Poly(ortho ester)s from Molecular Weights Determined by Gel Permeation ChromatographyChung Shih
2049-2052Oxidation of Recombinant Human Parathyroid Hormone: Effect of Oxidized Position on the Biological ActivityYoshiaki Nabuchi, Eri Fujiwara, Kenjyu Ueno, Hitoshi Kuboniwa and Yoshinori Asoh, et al.
2053-2056Regioselectivity and Enantioselectivity of Metoprolol Oxidation by Two Variants of cDNA-Expressed P4502D6Douglas S. Mautz, Danny D. Shen and Wendel L. Nelson
2057-2059The Effects of Sub-Inhibitory Concentrations of Cationic, Non-Antibiotic, Antimicrobial Agents on the Morphogenesis of Candida albicans in VitroDavid S. Jones
2060-2064Biodegradable Indium-111 Labeled Microspheres for in Vivo Evaluation of Distribution and EliminationBagavathikanun C. Thanoo, Walter J. Doll, Rahul C. Mehta, George A. Digenis and Patrick P. DeLuca
2065-2070The Effect of Absorption Enhancers on the Oral Absorption of the GP IIB/IIIA Receptor Antagonist, DMP 728, in Rats and DogsDeborah L. Burcham, Bruce A. Aungst, Munir Hussain, Mary Ann Gorko and Check Y. Quon, et al.
2071-2074Use of Parent Drug and Metabolite Data in Bioavailability Assessment of a Novel Diltiazem HC1 Once-Daily ProductOkponanabofa Eradiri and Kamal K. Midha
2075-2078AAPS Workshop on Designing the Global Chemistry, Manufacturing, and Controls (CMC) DossierChristine Carrico
2079-2081Reviewers for Pharmaceutical Research January through October 1995
2082-2086Author Index to Volume 12 (1995)
2087-2095Subject Index to Volume 12 (1995)

Volume 13, Number 1 / January 1996

1-5Editorial
6-9AAPS/USP Workshop on Dissolution Calibration and TestingChristine K. Carrico
10-11How Much Compliance Is Enough?John Urquhart
12-17Intravenous Microdialysis in the Mouse and the Rat: Development and Pharmacokinetic Application of a New ProbePierre A. Evrard, G. Deridder and Roger K. Verbeeck
18-22Concentration-Dependent Plasma Protein Binding of Flurbiprofen in the Rat: An in Vivo Microdialysis StudyPierre A. Evrard, Jean Cumps and Roger K. Verbeeck
23-26An Integrated Method to Determine Epithelial Transport and Bioactivity of Oral Drug Candidates in VitroWerner Rubas, Mary E. M. Cromwell, Randall J. Mrsny, Gladys Ingle and Kathleen A. Elias
27-31Targeting of Drug to the Hepatocytes by Fatty Acids. Influence of the Carrier (Albumin or Galactosylated Albumin) on the Fate of the Fatty Acids and Their AnalogsVinciane Charbon, Isabella Latour, Didier M. Lambert, Pedro Buc-Calderon and Laurence Neuvens, et al.
32-37Albumin Nanospheres as Carriers for Passive Drug Targeting: An Optimized Manufacturing TechniqueBernhard G. Müller, Hans Leuenberger and Thomas Kissel
38-43Pharmacokinetics and Biodistribution of Oligonucleotide Adsorbed onto Poly(isobutylcyanoacrylate) Nanoparticles After Intravenous Administration in MiceYuichiro Nakada, Elias Fattal, Monique Foulquier and Patrick Couvreur
44-51Physicochemical Characterization of Protein-Free Low Density Lipoprotein Models and Influence of Drug LoadingAstrid Gerke, Kirsten Westesen and Michel H. J. Koch
52-56The Influence of Buffer Species and Strength on Diltiazem HC1 Release from Beads Coated with the Aqueous Cationic Polymer Dispersions, Eudragit RS, RL 30DRoland Bodmeier, Xiaodi Guo, Rafael E. Sarabia and Paul F. Skultety
57-61Enhanced Cellular Uptake of Oligonucleotides by EGF Receptor-Mediated Endocytosis in A549 CellsDeepa Deshpande, David Toledo-Velasquez, Deepak Thakkar, WeiWen Liang and Yon Rojanasakul
62-69Derivatives of Dexanabinol. I. Water-Soluble Salts of Glycinate EstersEmil Pop, Zong Zheng Liu, Marcus E. Brewster, Yechezkel Barenholz and Veronica Korablyov, et al.
70-75Acyloxymethyl as a Drug Protecting Group. Part 3. Tertiary O-Amidomethyl Esters of Penicillin G: Chemical Hydrolysis and Anti-Bacterial ActivityRui Moreira, Teresa Calheiros, José Cabrita, Eduarda Mendes and Madalena Pimentel, et al.
76-79Effects of Phospholipid Chain Length, Concentration, Charge, and Vesicle Size on Pulmonary Insulin AbsorptionYuping Li and Ashim K. Mitra
80-83Pulmonary Delivery of Salmon Calcitonin Dry Powders Containing Absorption Enhancers in RatsShinzo Kobayashi, Shuji Kondo and Kazuhiko Juni
84-90A Pharmacokinetic Approach for Evaluating Cytokine Binding Macromolecules as AntagonistsMurali Ramanathan
91-96Pharmacokinetic-Pharmacodynamic Modeling of the Antibiotic Effect of Piperacillin in VitroArno Nolting, Teresa Dalla Costa, Kenneth H. Rand and Hartmut Derendorf
97-101Interspecies Scaling of Bosentan, A New Endothelin Receptor Antagonist and Integration of in Vitro Data into Allometric ScalingThierry Lave, Philippe Coassolo, Geneviève Ubeaud, Roger Brandt and Christophe Schmitt, et al.
102-107Enteral Bioavailability of Human Granulocyte Colony Stimulating Factor Conjugated with Poly(ethylene glycol)Kathleen E. Jensen-Pippo, K. Lane Whitcomb, Randolph B. DePrince, Lloyd Ralph and Alan D. Habberfield
108-113Determining Intestinal Metabolism and Permeability for Several Compounds in Rats. Implications on Regional Bioavailability in HumansPatrick J. Sinko and Peidi Hu
114-119Intestinal Absorption Barriers and Transport Mechanisms, Including Secretory Transport, for a Cyclic Peptide, Fibrinogen AntagonistBruce J. Aungst and Hiroshi Saitoh
120-123In Vitro Permeability Through Caco-2 Cells is not Quantitatively Predictive of in Vivo Absorption for Peptide-Like Drugs Absorbed via the Dipeptide Transporter SystemSaeho Chong, Sandra A. Dando, Kathleen M. Soucek and Richard A. Morrison
124-128First-Pass Metabolism of Diltiazem in Anesthetized Rabbits: Role of Extrahepatic OrgansMarc Lefebvre, Walid Homsy, Gilles Caillé and Patrick du Souich
129-136Atom Level Electrotopological State Indexes in QSAR: Designing and Testing Antithyroid AgentsRafiq R. A. Abou-Shaaban, Hamad A. Al-Khamees, Hisham S. Abou-Auda and Anthony. P. Simonelli
137-140FK506 (Tacrolimus) and Its Immunoreactive Metabolites in Whole Blood of Liver Transplant Patients and Subjects with Mild Hepatic DysfunctionYuji Tokunaga and Ala M. Alak
141-145Liposomal Methylprednisolone in Rats: Dose-Proportionality and Chronic-Dose Pharmacokinetics/PharmacodynamicsElena V. Mishina and William J. Jusko
146-150Maltodextrins as Lyoprotectants in the Lyophilization of a Model Protein, LDHSam Corveleyn and Jean-Paul Remon
151-154Polymorphism of Sulfanilamide: (II) Stability Hierarchy of α-, β- and γ- Forms from Energy Calculations by the Atom-Atom Potential Method and from the Construction of the p, T Phase DiagramS. Toscani, A. Dzyabchenko, V. Agafonov, J. Dugué and R. Céolin
155-162Effect of Change in Shape Factor of a Single Crystal on Its Dissolution BehaviorMandar V. Dali and J. T. Carstensen
163-167Estimation of the Increase in Solubility of Drugs as a Function of Bile Salt ConcentrationSabena D. Mithani, Vassiliki Bakatselou, Christopher N. TenHoor and Jennifer B. Dressman
168-172Percutaneous Absorption of Ketoprofen from Different Anatomical Sites in ManAjit K. Shah, Greg Wei, Robert C. Lanman, Vijay O. Bhargava and Scott J. Weir
173-178The Effect of Octanoic Acid on the Binding of the Enantiomers of Ibuprofen and Naproxen to Human Serum Albumin: A Chromatographic ImplicationVandana K. Cheruvallath, Christopher M. Riley, Sunanda R. Narayanan, Siegfried Lindenbaum and John H. Perrin
179-182Triazolines 34. Structure and Stability Relationships of Novel Δ2-l,2,3-Triazoline AnticonvulsantsAlbert H. L. Chow, Francis C. K. Chiu, L. A. Damani and Pankaja K. Kadaba
183ERRATUM

Volume 13, Number 2 / February 1996

185WHAT ARE THE DIFFERENCES BETWEEN A REQUEST FOR APPLICATION (RFA) AND A PROGRAM ANNOUNCEMENT (PA)? WHAT ARE THE ADVANTAGES AND DISADVANTAGES OF EACH?Rochelle M. Long
186-195Erythrocytes and the Transport of Drugs and Endogenous CompoundsMartin S. Highley and Ernst A. De Bruijn
196-201Temperature and pH-sensitive Polymers for Human Calcitonin DeliveryAnne Serres, Miroslav Baudyš and Sung Wan Kim
202-209The Influence of Sodium Glycocholate and Other Additives on the in vivo Transfection of Plasmid DNA in the LungsDaniel J. Freeman and Ralph W. Niven
210-215Water-in-Oil Microemulsions Containing Medium-chain Fatty Acids/Salts: Formulation and Intestinal Absorption Enhancement EvaluationPanayiotis P. Constantinides, Gus Welzel, Harma Ellens, Philip L. Smith and Sandra Sturgis, et al.
216-221Comparison of HT29-18-C1 and Caco-2 Cell Lines as Models for Studying Intestinal Paracellular Drug AbsorptionAndrew Collett, Erika Sims, David Walker, Yan-Ling He and John Ayrton, et al.
222-226Oral Delivery of Sodium Cromolyn: Preliminary Studies In Vivo and In VitroAndrea Leone-Bay, Harry Leipold, Donald Sarubbi, Bruce Variano and Theresa Rivera, et al.
227-233Effects of Structural Modifications on the Intestinal Permeability of Angiotensin II Receptor Antagonists and the Correlation of In Vitro, In Situ, and In Vivo AbsorptionMaria D. Ribadeneira, Bruce J. Aungst, Charles J. Eyermann and Shiew-Mei Huang
234-237Near-Infrared Spectroscopic Monitoring of the Film Coating ProcessJohn D. Kirsch and James K. Drennen
238-242Aggregation of rhDNase Occurred During the Compression of KBr Pellets Used for FTIR SpectroscopyHak-Kim Chan, Boonsri Ongpipattanakul and Jacky Au-Yeung
243-249Development of a Stable Freeze-dried Formulation of Recombinant Human Interleukin-1 Receptor AntagonistByeong S. Chang, Gail Reeder and John F Carpenter
250-255Oxidative Degradation of Antiflammin 2Jennifer M. Ye and Janet L. Wolfe
256-264The Interaction of Charged and Uncharged Drugs with Neutral (HP-β-CD) and Anionically Charged (SBE7-β-CD) β-CyclodextrinsKazuto Okimoto, Roger A. Rajewski, Kaneto Uekama, Janan A. Jona and Valentino J. Stella
265-271Interaction Between Superoxide Dismutase and Dipalmitoylphosphotidylglycerol Bilayers: A Fourier Transform Infrared (FT-IR) Spectroscopic StudyYu-Li Lo and Yueh-Erh Rahman
272-278Formulation and Antitumor Activity Evaluation of Nanocrystalline Suspensions of Poorly Soluble Anticancer DrugsE. Merisko-Liversidge, P. Sarpotdar, J. Bruno, S. Hajj and L. Wei, et al.
279-283The Effects of Ageing on the Rheological, Dielectric and Mucoadhesive Properties of Poly(Acrylic Acid) Gel SystemsSlobodanka Tamburic and Duncan Q. M. Craig
284-289Pharmacokinetic Analysis and Antiepileptic Activity of Tetra-Methylcyclopropane Analogues of ValpromideMeir Bialer, Salim Hadad, Bashier Kadry, Ali Abdul-Hai and Abdulla Haj-Yehia, et al.
290-295Transport of Dopamine at the Blood-Brain Barrier of the Guinea Pig: Inhibition by Psychotropic Drugs and NicotineCynthia L. Martel, Jasmina B. Mackic, James D. Adams, J. Gordon McComb and Martin H. Weiss, et al.
296-300Analgesic and Immunomodulatory Effects of Codeine and Codeine 6-glucuronideVinayak Srinivasan, Donna Wielbo, James Simpkins, Janet Karlix and Kenneth Sloan, et al.
301-304Effect of Cimetidine on the Pharmacokinetics and Pharmacodynamics of Chlorpheniramine and Diphenhydramine in RabbitsKeith J. Simons, Xueyu Chen, Terry G. Eraser and F. Estelle R. Simons
305-310Enhanced Tumor Delivery and Antitumor Activity of Palmitoyl Rhizoxin Using Stable Lipid Emulsions in MiceAtsushi Kurihara, Yoko Shibayama, Atsuko Mizota, Akiko Yasuno and Masaru Ikeda, et al.
311-315Polyester Nanocapsules as New Topical Ocular Delivery Systems for Cyclosporin APilar Calvo, Alejandro Sánchez, Jesús Martínez, María Isabel López and Margarita Calonge, et al.
316-323Ion-Pairing Interactions between 99MTc-Based Myocardial Imaging Agents and Oleic AcidCharles M. Heard and Jonathan Hadgraft
324-328Tmax: An Unconfounded Metric for Rate of Absorption in Single Dose Bioequivalence StudiesRodney P. Basson, Benito J. Cerimele, Karl A. DeSante and Daniel C. Howey
329-333Kinetics of Swelling of Compressed Cellulose Matrices: A Mathematical ModelTamotsu Koizumi, Suwannee P. Panomsuk, Tomomi Hatanaka and Kazunori Katayama

Volume 13, Number 3 / March 1996

335-343Lipophilicity in Molecular ModelingBernard Testa, Pierre-Alain Carrupt, Patrick Gaillard, Frédéric Billois and Peter Weber
344-351Targeted Drug Delivery for Boron Neutron Capture TherapySamir C. Mehta and D. Robert Lu
352-359Preparation and Characterization of Doxorubicin-Loaded Sterically Stabilized ImmunoliposomesNoam Emanuel, Eli Kedar, Elijah M. Bolotin, Nechama I. Smorodinsky and Yechezkel Barenholz
360-367A Novel Method of Preparing PLGA Microcapsules Utilizing Methylethyl KetoneHongkee Sah, Melissa S. Smith and Rey T. Chern
368-375Development of a Polymeric Surgical Paste Formulation for TaxolCharles I. Winternitz, John K. Jackson, Ann Marie Oktaba and Helen M. Burt
376-380Structure and Behavior in Hydrophilic Matrix Sustained Release Dosage Forms: 4. Studies of Water Mobility and Diffusion Coefficients in the Gel Layer of HPMC Tablets Using NMR ImagingAli R. Rajabi-Siahboomi, Richard W. Bowtell, Peter Mansfield, Martyn C. Davies and Colin D. Melia
381-386Determination of Tablet Coating Distribution by Deconvolution of Uncoated and Coated Tablet Weight DistributionsJi Zhou, Todd Williams, Herman Swopes and Thomas Hale
387-390Relationship Between Drug Percolation Threshold and Particle Size in Matrix TabletsIsidore Caraballo, Mónica Millan and Antonio María Rabasco
391-397A Cascade Impactor Entry Port for MDI Sprays with Collection Characteristics Imitating a Physical Model of the Human ThroatNicholas C. Miller and Annette M. Purrington
398-403The Simultaneous Estimation of the Influx and Efflux Blood-Brain Barrier Permeabilities of Gabapentin Using a Microdialysis-Pharmacokinetic ApproachYanfeng Wang and Devin R Welty
404-410Evaluation of Adjuvants that Enhance the Effectiveness of Antisense OligodeoxynucleotidesJ. A. Hughes, A. I. Aronsohn, A. V. Avrutskaya and R. L. Juliano
411-420Transdermal Drug Delivery Using Low-Frequency SonophoresisSamir Mitragotri, Daniel Blankschtein and Robert Langer
421-426Non Steady-state Descriptions of Drug Permeation Through Stratum Corneum. I. The Biphasic Brick-and-Mortar ModelMichael Heisig, Renate Lieckfeldt, Gabriel Wittum, George Mazurkevich and Geoffrey Lee
427-432Theoretical Design of Prodrug-Enhancer Combination Based on a Skin Diffusion Model: Prediction of Permeation of Acyclovir Prodrugs Treated with l-Geranylazacycloheptan-2-oneHiroto Bando, Toshihide Takagi, Fumiyoshi Yamashita, Yoshinobu Takakura and Mitsuru Hashida
433-439Effect of Nonionic Surfactant on Transport of Model Drugs in EmulsionsKyung Ae Yoon and Diane J. Burgess
440-444Effect of Food on the Bioavailability of SDZ DJN 608, an Oral Hypoglycemic Agent, from a Tablet and a Liquid-Filled Capsule in the DogFrancis L. S. Tse, D. Labbadia, K. Habucky, A. Karara and S. Au
445-448Pharmacokinetics, Bioavailability, and Safety of Montelukast Sodium (MK-0476) in Healthy Males and FemalesHaiyung Cheng, Jonathan A. Leff, Raju Amin, Barry J. Gertz and Marina De Smet, et al.
449-452The Effect of Probenecid on the Pharmacokinetics of Zalcitabine in HIV-Positive PatientsJ. W. Massarella, L. A. Nazareno, S. Passe and B. Min
453-456Absorption Rate Vs. Exposure: Which Is More Useful for Bioequivalence Testing?Thomas N. Tozer, Frédéric Y. Bois, Walter W. Hauck, Mei-Ling Chen and Roger L. Williams
457-461Nicanartine Improves in Vitro Resistance of Lipoproteins to OxidationEric Dailly, Saïk Urien, Petra Wülfroth and Jean Paul Tillement
462-468Differences in Lipoprotein Concentration and Composition Modify the Plasma Distribution of Free and Liposomal AnnamycinKishor M. Wasan and Richard E. Morton
469-475Derivatives of Dexanabinol. II. Salts of Amino Acid Esters Containing Tertiary and Quaternary Heterocyclic Nitrogen with Increased Water-SolubilityEmil Pop, Ferenc Soti, Marcus E. Brewster, Yechezkel Barenholz and Veronica Korablyov, et al.
476-480Anti-Inflammatory and Antishock Water-Soluble Polyesters of Glucocorticoids with Low Level Systemic ToxicitySerguei L. Timofeevski, Evgeny F. Panarin, Oleg L. Vinogradov and Michail V. Nezhentsev
481-484Characterization of the Salts of a Cyclic RGB PeptideMichael B. Maurin, Susan M. Rowe, Arlene Rockwell, C. M. Foris and Munir A. Hussain
485-487pH-Sensitive Nanoparticles: An Effective Means to Improve the Oral Delivery of HIV-1 Protease Inhibitors in DogsJean-Christophe Leroux, Robert M. Cozens, Johannes L. Roesel, Bruno Galli and Eric Doelker, et al.

Volume 13, Number 4 / April 1996

489-496Microtubule-based Motor Proteins: New Targets for Enhancing Drug Delivery?Sarah F. Hamm-Alvarez
497-513Recent Advances in Carrier-mediated Hepatic Uptake and Biliary Excretion of XenobioticsMasayo Yamazaki, Hiroshi Suzuki and Yuichi Sugiyama
514-522Evidence for Intestinal Secretion as an Additional Clearance Pathway of Talinolol Enantiomers: Concentration- and Dose-dependent Absorption in Vitro and in VivoUlrike Wetterich, Hildegard Spahn-Langguth, Ernst Mutschler, Bernd Terhaag and Wolfgang Rösch, et al.
523-527Characterization of the Transport Properties of a Quinolone Antibiotic, Fleroxacin, in Rat Choroid PlexusTsuyoshi Ooie, Hiroshi Suzuki, Tetsuya Terasaki and Yuichi Sugiyama
528-534The Use of Surfactants to Enhance the Permeability of Peptides Through Caco-2 Cells by Inhibition of an Apically Polarized Efflux SystemManoj M. Nerurkar, Philip S. Burton and Ronald T. Borchardt
535-541Diffusivity of Bile Salt/Phospholipid Aggregates in MucinChing-Yuan Li, Cheryl L. Zimmerman and Timothy S. Wiedmann
542-546The Relative Effect of Azone® and Transcutol® on Permeant Diffusivity and Solubility in Human Stratum CorneumJulian E. Harrison, Adam C. Watkinson, Darren M. Green, Jonathan Hadgraft and Keith Brain
547-552Response Surface Method: A Novel Strategy to Optimize lontophoretic Transdermal Delivery of Thyrotropin-releasing HormoneYi-You Huang, Shian-Min Wu and Cheng-Yi Wang
553-558Iontophoresis of Bases, Nucleosides, and NucleotidesRonald van der Geest, Frédérique Hueber, Francis C. Szoka and Richard H. Guy
559-565Transdermal Delivery of Fentanyl by Electroporation I. Influence of Electrical FactorsRita Vanbever, Eric Le Boulengé and Véronique Préat
566-569Theoretical Considerations on Two Equations for Estimating the Extent of Absorption After Oral Administration of DrugsYounggil Kwon and Philip B. Inskeep
570-576Analysis of Intestinal Perfusion Data for Highly Permeable Drugs Using a Numerical Aqueous Resistance—Nonlinear Regression MethodP. J. Sinko, G. D. Leesman, A. P. Waclawski, H. Yu and J. H. Kou
577-582Effects of Transfection with the Cu, Zn-Superoxide Dismutase Gene on Xanthine/Xanthine Oxidase-Induced Cytotoxicity in Fibroblasts from Rat SkinKohshi Nishiguchi, Kazue Ishida, Masanori Nakajima, Tetsuo Maeda and Fusao Komada, et al.
583-587The Effect of Formulation on the Antimicrobial Activity of Cetylpyridinium Chloride in Candy Based LozengesR. Michael E. Richards, James Z. Xing and Lindsay F. C. Weir
588-593Preparation and Characterization of Freeze-dried Chitosan-Poly(Ethylene Oxide) Hydrogels for Site-Specific Antibiotic Delivery in the StomachVijay R. Patel and Mansoor M. Amiji
594-598Relationship Between Gelation Rate of Controlled-release Acetaminophen Tablets Containing Polyethylene Oxide and Colonic Drug Release in DogsKazuhiro Sako, Hiroshi Nakashima, Toyohiro Sawada and Muneo Fukui
599-603Disposition Characteristics of Plasmid DNA in the Single-pass Rat Liver Perfusion SystemMitsunobu Yoshida, Ram I. Mahato, Kenji Kawabata, Yoshinobu Takakura and Mitsuru Hashida
604-610Immunoliposomes as Enzyme-Carriers (Immuno-Enzymosomes) for Antibody-Directed Enzyme Prodrug Therapy (ADEPT): Optimization of Prodrug Activating CapacityMonique H. Vingerhoeds, Hidde J. Haisma, Sheila O. Belliot, Roefke H. P. Smit and Daan J. A. Crommelin, et al.
611-615Determination of R(+)- and S(–)-Lansoprazole Using Chiral Stationary-Phase Liquid Chromatography and Their Enantioselective Pharmacokinetics in HumansHisakazu Katsuki, Hatsumi Yagi, Kazuhiko Arimori, Chizuko Nakamura and Masahiro Nakano, et al.
616-621Use of Near-Infrared Spectroscopy to Evaluate an Active in a Film Coated TabletBruce R. Buchanan, Mark A. Baxter, T.-Show Chen, Xue-Zhi Qin and Priscilla A. Robinson
622-627The Binding of Cyclosporin A to Human Plasma: An in Vitro Microdialysis StudyHua Yang and William F. Elmquist
628-632Pharmacokinetic Interaction Between Intravenous 2′,3′-Dideoxyinosine and Pentamidine in RatsTeng-Kuang Yeh, Hyo-Jeong K. Kang, M. Guillaume Wientjes and Jessie L.-S. Au
633-638Synergistic Effect of Electric Field and Ultrasound on Transdermal TransportJoseph Kost, Uwe Pliquett, Samir Mitragotri, Aye Yamamoto and Robert Langer, et al.
639-642Effects on the Pharmacokinetics and Pharmacodynamics in the Elderly of Coadministering Ramipril with Water, Apple Juice, and ApplesauceI-Der Lee, Thomas L. Hunt, Charles R. Bradley, Carol Copp and Lynne Griffiths, et al.
643-646The Effect of the Reconstitution Medium on Aggregation of Lyophilized Recombinant Interleukin-2 and Ribonuclease AMei Z. Zhang, Katherine Pikal, Thai Nguyen, Tsutomu Arakawa and Steven J. Prestrelski
647ERRATUM

Volume 13, Number 5 / May 1996

649-662Blood Radicals: Reactive Nitrogen Species, Reactive Oxygen Species, Transition Metal Ions, and the Vascular SystemVictor Darley-Usmar and Barry Halliwell
663-670A Fractal Approach to Heterogeneous Drug Distribution: Calcium PharmacokineticsPanos Macheras
671-682Chemotherapeutic Drugs Released from Polymers: Distribution of 1,3-bis(2-chloroethyl)-l-nitrosourea in the Rat BrainLawrence K. Fung, Marian Shin, Betty Tyler, Henry Brem and W. Mark Saltzman
683-691Morphological Characterization of Polyanhydride Biodegradable Implant Gliadel® During in Vitro and in Vivo Erosion Using Scanning Electron MicroscopyWenbin Dang, Todd Daviau and Henry Brem
692-700Deformation Kinetics Analysis of Polymeric MatricesSusan K. Lum and Wendy C. Duncan-Hewitt
701-709Polyvinyl Derivatives as Novel Interactive Polymers for Controlled Gene Delivery to MuscleRussell J. Mumper, John G. Duguid, Khursheed Anwer, Melisa K. Barron and Hiroaki Nitta, et al.
710-717Effects of Polyethyleneglycol Chain Length and Phospholipid Acyl Chain Composition on the Interaction of Polyethyleneglycol-phospholipid Conjugates with Phospholipid: Implications in Liposomal Drug DeliveryFrank K. Bedu-Addo, P. Tang, Y. Xu and Leaf Huang
718-724Interaction of Polyethyleneglycol-Phospholipid Conjugates with Cholesterol-Phosphatidylcholine Mixtures: Sterically Stabilized Liposome FormulationsR K. Bedu-Addo, P. Tang, Y. Xu and L. Huang
725-728Fat Emulsions Based on Structured Lipids (1,3-specific triglycerides): An Investigation of the in Vivo FateMarine Hedeman, Helle Brøndsted, Annette Müllertz and Sven Frokjaer
729-733In Vivo ESR Studies on Pharmacokinetics and Metabolism of Parenteral Lipid Emulsion in Living MiceTetsuo Yamaguchi, Shigeru Itai, Hidefumi Hayashi, Seiji Soda and Akira Hamada, et al.
734-738Delivery of Nasal Powders of β-Cyclodextrin by InsufflationAlessia De Ascentiis, Ruggero Bettini, Giovanni Caponetti, Pier Luigi Catellani and Maria Teresa Peracchia, et al.
739-743Enhancement of Nasal Salmon Calcitonin Absorption by Lauroylcarnitine Chloride in RatsSeiya Kagatani, Tatsuki Shinoda, Muneo Fukui, Tadayoshi Ohmura and Shunji Hasumi, et al.
744-748Pulmonary First-Pass and Steady-State Metabolism of PhenolsPaul A. Dickinson and Glyn Taylor
749-755Methanol Inhalation: Site and Other Factors Influencing Absorption, and an Inhalation Toxicokinetic Model for the RatRobert A. Perkins, Keith W. Ward and Gary M. Pollack
756-761Effects of Additives on Heat Denaturation of rhDNase in SolutionsHak-Kim Chan, Kwok-Leung Au-Yeung and Igor Gonda
762-769Isolation and Characterization of a Monomethioninesulfoxide Variant of Interferon α-2bGerry Gitlin, Anthony Tsarbopoulos, Suman T. Patel, Wasyl Sydor and Birendra N. Pramanik, et al.
770-774Skin Penetration and Sun Protection Factor of Ultra-Violet Filters from Two VehiclesP. Treffel and B. Gabard
775-778Predicting Blood-Brain Transport of Drugs: A Computational ApproachSubhash C. Basak, Brian D. Gute and Lester R. Drewes
779-783Vaginal Permeability and Enzymatic Activity Studies in Normal and Ovariectomized RabbitsFüsun Acartürk and Joseph R. Robinson
784-793Acute Gastrointestinal Toxic Effects of Suspensions of Unencapsulated and Encapsulated Ibuprofen in RatsChristianah Moji Adeyeye, J. Douglas Bricker, Vinod D. Vilivalam and William I. Smith
794-797Interspecies Pharmacokinetics of a Novel Hematoregulatory Peptide (SK&F 107647) in Rats, Dogs, and Oncologic PatientsDion R. Brocks, Martin I. Freed, David E. Martin, Teresa S. Sellers and Nabeel Mehdi, et al.
798-800Iontophoresis of Nafarelin Across Human Skin in VitroAmalia M. Rodríguez Bayón and Richard H. Guy
801-803Evidence for the Existence of Insulin-Degrading Enzyme on the Brush-Border Membranes of Rat EnterocytesLi-Ling Chang and Jane P. F. Bai
804-808Hot Melt Extrusion of Acrylic FilmsCarolyn Aitken-Nichol, Feng Zhang and James W. McGinity
809-811Model for Moisture Transport into Inhalation AerosolsJames M. Reynolds and Daniel P. McNamara

Volume 13, Number 6 / June 1996

813-814WHAT ARE “REINVENTION ACTIVITIES”? HOW IS THE NIH PARTICIPATING? WHAT CHANGES CAN BE EXPECTED AT THE NIH? HOW CAN I GET CURRENT INFORMATION?Rochelle M. Long Ph.D
815-819Biomaterials Science at a Crossroads: Are Current Product Liability Laws in the United States Hampering Innovation and the Development of Safer Medical Implants?Joachim Kohn
820-831Macromolecular Carrier Systems for Targeted Drug Delivery: Pharmacokinetic Considerations on BiodistributionYoshinobu Takakura and Mitsuru Hashida
832-838Population Pharmacokinetics of TerfenadineRichard L. Lalonde, Denis Lessard and Jacques Gaudreault
839-845Evaluation of Pharmacokinetic Studies: Is It Useful to Take into Account Concentrations Below the Limit of Quantification?Henri Humbert, Marie Danièle Cabiac, José Barradas and Christophe Gerbeau
846-850High Variability in Drug Pharmacokinetics Complicates Determination of Bioequivalence: Experience with VerapamilYu Chung Tsang, Radu Pop, Paul Gordon, John Hems and Michael Spino
851-854lontophoretic Delivery of a Telomeric OligonucleotideRhonda M. Brand and Patrick L. Iversen
855-860Analysis of Simultaneous Transport and Metabolism of Ethyl Nicotinate in Hairless Rat SkinKenji Sugibayashi, Teruaki Hayashi, Tomio Hatanaka, Masahiko Ogihara and Yasunori Morimoto
861-868Targeted Delivery of Doxorubicin via Sterically Stabilized Immunoliposomes: Pharmacokinetics and Biodistribution in Tumor-bearing MiceNoam Emanuel, Eli Kedar, Elijah M. Bolotin, Nechama I. Smorodinsky and Yechezkel Barenholz
869-874Erythrocytes as Carriers for Recombinant Human ErythropoietinMarina-Inmaculada Garín, Rosa-María López, Silvia Sanz, Montserrat Pinilla and José Luque
875-879Formulation of Polyiodinated Triglyceride Analogues in a Chylomicron Remnant-Like Liver-Selective Delivery VehicleMarc A. Longino, Douglas A. Bakan, Jamey P. Weichert and Raymond E. Counsell
880-884Development and Pharmacokinetics of Galactosylated Poly-L-Glutamic Acid as a Biodegradable Carrier for Liver-Specific Drug DeliveryHideki Hirabayashi, Makiya Nishikawa, Yoshinobu Takakura and Mitsuru Hashida
885-890Age-dependent Expression of P-Glycoprotein gp17O in Caco-2 Cell MonolayersKen-ichi Hosoya, Kwang-Jin Kim and Vincent H. L. Lee
891-895In Vivo Assessment of Intestinal, Hepatic, and Pulmonary First Pass Metabolism of Propofol in the RatAraz A. Raoof, Patrick R Augustijns and Roger K. Verbeeck
896-901Enteral Absorption of Insulin in Rats from Mucoadhesive Chitosan-Coated LiposomesHirofumi Takeuchi, Hiromitsu Yamamoto, Toshiyuki Niwa, Tomoaki Hino and Yoshiaki Kawashima
902-906Contribution of Lysosomes to the Subcellular Distribution of Basic Drugs in the Rat LiverJunko Ishizaki, Koichi Yokogawa, Masako Hirano, Emi Nakashima and Yoshimichi Sai, et al.
907-913Solubilization of Retinoids by Bile Salt/ Phospholipid AggregatesChing-Yuan Li, Cheryl L. Zimmerman and Timothy S. Wiedmann
914-919Permeation Behavior of Salbutamol Sulfate Through Hydrophilic and Hydrophobic Membranes Embedded by Thermo-responsive Cholesteryl Oleyl CarbonateShan-Yang Lin, Yih-Yih Lin and Ko-Shao Chen
920-925The Effect of Hydrophobic Character of Drugs and Helix-coil Transition of κ-Carrageenan on the Polyelectrolyte-drug InteractionNinus Caram-Lelham and Lars-Olof Sundelöf
926-930Determination of Molecular Mobility of Lyophilized Bovine Serum Albumin and γ-Globulin by Solid-State 1H NMR and Relation to Aggregation-SusceptibilitySuraie Yoshioka, Yukio Aso and Shigeo Kojima
931-938Effects of Polyaminocarboxylate Metal Chelators on Iron-thiolate Induced Oxidation of Methionine- and Histidine-Containing PeptidesFang Zhao, Jian Yang and Christian Schöneich
939-943Synthesis and Anti-proliferative Activity of 2-Hydroxy-l,2-dihydroacronycine GlycosidesSofia Mitaku, Alexios-Léandros Skaltsounis, François Tillequin, Michel Koch and Yves Rolland, et al.
944-949Investigations into the Relationship Between Drug Properties, Filling, and the Release of Drugs from Hard Gelatin Capsules Using Multivariate Statistical AnalysisJames Hogan, Pei-Inn Shue, Fridrun Podczeck and J. Michael Newton
950-951Effect of the Spermicide, Nonoxynol 9, on Vaginal Permeability in Normal and Ovariectomized RabbitsFüsun Acatürk and Joseph R. Robinson
952-956Primary Cell Culture of the Rabbit Choroid Plexus: An Experimental System to Investigate Membrane TransportVikram K. Ramanathan, Andrew C. Hui, Claire M. Brett and Kathleen M. Giacomini
957-960The Effect of Iontophoresis on Skin Barrier Integrity: Non-invasive Evaluation by Impedance Spectroscopy and Transepidermal Water LossYogeshvar N. Kalia, Lourdes B. Nonato and Richard H. Guy
961ERRATUM

Volume 13, Number 7 / July 1996

963-977Carrier-Mediated Intestinal Transport of DrugsAkira Tsuji and Ikumi Tamai
978-988In-vitro Cell Culture Models of the Nasal Epithelium: A Comparative Histochemical Investigation of Their Suitability for Drug Transport StudiesUte Werner and Thomas Kissel
989-995Characterization of Glucose Dependent Gel-Sol Phase Transition of the Polymeric Glucose-Concanavalin A Hydrogel SystemAiman A. Obaidat and Kinam Park
996-1002Characterization and Stability of N-terminally PEGylated rhG-CSFOlaf B. Kinstler, David N. Brems, Scott L. Lauren, Amiee G. Paige and James B. Hamburger, et al.
1003-1007Computer Simulation of Crystal-liquid Interface: Application to Wettability of SolidsJamshed Anwar and Sohrab Khoshkhoo
1008-1014Evidence for the Formation of Amphotericin B-phospholipid Complexes in Langmuir MonolayersMartin R. Lance, Clive Washington and Stanley S. Davis
1015-1019Mode of Interaction of Loop Diuretics with Human Serum Albumin and Characterization of Binding SiteNorito Takamura, Akihiko Haruta, Hirofumi Kodama, Michio Tsuruoka and Keishi Yamasaki, et al.
1020-1027Percutaneous Absorption of Biologically-Active Interferon-gamma in a Human Skin Graft-Nude Mouse ModelSarah M. Short, Brian D. Paasch, Jason H. Turner, Norman Weiner and Ann L. Daugherty, et al.
1028-1037Interactions of Phosphodiester and Phosphorothioate Oligonucleotides with Intestinal Epithelial Caco-2 CellsG. F. Beck, W. J. Irwin, P. L. Nicklin and S. Akhtar
1038-1042Effect of Size and Serum Proteins on Transfection Efficiency of Poly ((2-dimethylamino)ethyl Methacrylate)-Plasmid NanoparticlesJong-Yuh Cherng, Petra van de Wetering, Herre Talsma, Daan J. A. Crommelin and Wim E. Hennink
1043-1048Transcription Regulation of Rat Glutathione S-Transferase Ya Subunit Gene Expression by Chemopreventive AgentsPeiwen Fei, George A. Matwyshyn, Thomas H. Rushmore and Ah-Ng Tony Kong
1049-1054Species Difference in the Disposition of Liposomes Among Mice, Rats, and Rabbits: Allometric Relationship and Species Dependent Hepatic Uptake MechanismH. Harashima, S. Komatsu, S. Kojima, C. Yanagi and Y. Morioka, et al.
1055-1058The Role of Serum Complement on the Organ Distribution of Intravenously Administered Poly (methyl methacrylate) Nanoparticles: Effects of Pre-Coating with Plasma and with Serum ComplementGerrit Borchard and Jörg Kreuter
1059-1064In Vitro and in Vivo Evaluation in Rabbits of a Controlled Release 5-fluorouracil Subconjunctival Implant Based on Poly(D,L-lactide-co-glycolide)Guangji Wang, Ian G. Tucker, Michael S. Roberts and Lawrence W. Hirst
1065-1068Kinetics of Quinolone Antibiotics in Rats: Efflux from Cerebrospinal Fluid to the CirculationTsuyoshi Ooie, Hiroshi Suzuki, Tetsuya Terasaki and Yuichi Sugiyama
1069-1072Modulation of Organic Cation Transport and Lipid Fluidity by Benzyl Alcohol in Rat Renal Brush-border MembranesTomohiro Nabekura, Mikihisa Takano, Michio Kimura, Masato Yasuhara and Ken-ichi Inui
1073-1077Effect of Cyclosporin Analogues and FK506 on Transcellular Transport of Daunorubicin and Vinblastine via P-glycoproteinKumiko Tanaka, Midori Hirai, Yusuke Tanigawara, Masato Yasuhara and Ryohei Hori, et al.
1078-1082Suitability of Enalapril as a Probe of the Dipeptide Transporter System: InVitro and In Vivo StudiesRichard A. Morrison, Saeho Chong, Anthony M. Marino, Martin A. Wasserman and Peter Timmins, et al.
1083-1087Improved Oral Delivery of Desmopressin via a Novel Vehicle: Mucoadhesive Submicron EmulsionEhud Ilan, Shimon Amselem, Michael Weisspapir, Joseph Schwarz and Ayala Yogev, et al.
1088-1094Development and Validation of Two Solid-Phase Enzyme Immunoassays (ELISA) for Quantitation of Human Epidermal Growth Factors (hEGFs)Nywana Sizemore, Richard C. Dudeck, Charles M. Barksdale, Gerald D. Nordblom and Williams T. Mueller, et al.
1095-1104Determination of the Composition of Delavirdine Mesylate Polymorph and Pseudopolymorph Mixtures Using 13C CP/MAS NMRPing Gao
1105-1108Serial Versus Sparse Sampling in Toxicokinetic StudiesFrancis L. S. Tse and Jerry R. Nedelman
1109-1115Bioequivalence of a Highly Variable Drug: An Experience with NadololRobert G. Buice, Veerappan S. Subramanian, Kenneth L. Duchin and Samuel Uko-Nne
1116-1121Bioequivalence: Individual and Population Compartmental Modeling Compared to the Noncompartmental ApproachHelen S. Pentikis, James D. Henderson, Nhan L. Tran and Thomas M. Ludden
1122-1126Demonstration of Sucralfate-mediated Preservation of Growth Factor Bioactivity in the Presence of Low pH with a Human Gastric Epithelial Cell Line (AGS)Huaibao Sheng, Praful K. Shah and Kenneth L. Audus
1127-1129Study of the Influence of Several Stabilizing Agents on the Entrapment and InVitro Release of pBC 264 from Poly(Lactide-Co-Glycolide) Microspheres Prepared by a W/O/W Solvent Evaporation MethodMaría J. Blanco-Príeto, Eliana Leo, Florence Delie, Annette Gulik and Patrick Couvreur, et al.
1130-1131BOOK REVIEWS

Volume 13, Number 8 / August 1996

1133-1141Natural Products as a Resource for New DrugsAlice M. Clark
1142-1153Solid-State Stability of Human Insulin I. Mechanism and the Effect of Water on the Kinetics of Degradation in Lyophiles from pH 2–5 SolutionsRobert G. Strickley and Bradley D. Anderson
1154-1161Zinc Uptake in Five Sectors of the Rat Gastrointestinal Tract: Kinetic Study in the Whole ColonSonia Luz Gisbert-González and Francisca Torres-Molina
1162-1167Stratum Corneum Lipids of Human Epidermal Keratinocyte Air-Liquid Cultures: Implications for Barrier FunctionAlane H. Kennedy, Guia M. Golden, Carol L. Gay, Richard H. Guy and Michael L. Francoeur, et al.
1168-1173The Influence of an Electric Field on Ion and Water Accessibility to Stratum Corneum Lipid LamellaeLouk A. R. M. Pechtold, William Abraham and Russell O. Potts
1174-1180Characterization of Interactions Between Bile Salts and Drugs by Micellar Electrokinetic Capillary Chromatography. Part I.Maria A. Schwarz, Reinhard H. H. Neubert and Gerhard Dongowski
1181-1185Dielectric Analysis of Phosphorylcholine Head Group Mobility in Egg Lecithin LiposomesGeoff Smith, Boris Yu. Shekunov, Jie Shen, Alistair P. Duffy and Jamshed Anwar, et al.
1186-1190Insight into the Lipophilicity of the Aromatic N-Oxide MoietyGiulia Caron, Pierre-Alain Carrupt, Bernard Testa, Giuseppe Ermondi and Alberto Gasco
1191-1195Correlation of Physicochemical Parameters to the Hydrophobic Contribution Constants of Amino Acid Residues in Small PeptidesDarshana Palekar, Michael Shiue and Eric J. Lien
1196-1200Immunostimulating Polysaccharides from Panax notoginsengHua Gao, Fengzhen Wang, Eric J. Lien and Melvin D. Trousdale
1201-1204Local Absorption Kinetics of Levofloxacin from Intestinal Tract into Portal Vein in Conscious Rat Using Portal-Venous Concentration DifferenceYusuke Fujieda, Kiyoshi Yamaoka, Takashi Ito and Terumichi Nakagawa
1205-1209The Effect of Size on Uptake of Orally Administered Latex Microparticles in the Small Intestine and Transport to Mesenteric Lymph NodesKatharine E. Carr, Rosemary A. Hazzard, Shane Reid and Giséle M. Hodges
1210-1212Pectin/Ethylcellulose Film Coating Formulations for Colonic Drug DeliveryZ. Wakerly, J. T. Fell, D. Attwood and D. Parkins
1213-1218Metabolism, Uptake, and Transepithelial Transport of the Diastereomers of Val-Val in the Human Intestinal Cell Line, Caco-2Kiyoshi Tamura, Pradip K. Bhatnagar, Joanne S. Takata, Chao-Pin Lee and Philip L. Smith, et al.
1219-1227Effects of Permeation Enhancers on the Transport of a Peptidomimetic Thrombin Inhibitor (CRC 220) in a Human Intestinal Cell Line (Caco-2)Ute Werner, Thomas Kissel and Martin Reers
1228-1232Buccal Absorption of Testosterone and Its Esters Using a Bioadhesive Tablet in DogsJody Voorspoels, Jean-Paul Remon, Willy Eechaute and Walter De Sy
1233-1237In Vivo Buccal Delivery of the Peptide Drug Buserelin with Glycodeoxycholate as an Absorption Enhancer in PigsA. Janet Hoogstraate, J. Coos Verhoef, Anton Pijpers, Leo A. M. G. van Leengoed and Jos H. M. Verheijden, et al.
1238-1242Nitric Oxide (NO)-releasing Pathway of FK409 in the Presence of Sulfhydryl-bearing CompoundsShinichi Fukuyama, Toshio Azuma, Yoshimi Hirasawa, Noritugu Morokoshi and Toshihiro Akama, et al.
1243-1246Glucuronidation Metabolic Kinetics of Valproate in Guinea Pigs: Nonlinear at Clinical Concentration LevelsHsiu-Ying Yu and Yu-Zen Shen
1247-1251Transport of Drugs Across the Xenopus Pulmonary Membrane and Their Absorption Enhancement by Various Absorption EnhancersShigeki Okumura, Yoshimi Fukuda, Kanae Takahashi, Takuya Fujita and Akira Yamamoto, et al.
1252-1257Oxidation of Human Insulin-like Growth Factor I in Formulation Studies: Kinetics of Methionine Oxidation in Aqueous Solution and in Solid StateJonas Fransson, Ebba FIorin-Robertsson, Kent Axelsson and Christina Nyhlén
1258-1264Excipient Interaction with Cetylpyridinium Chloride Activity in Tablet Based LozengesR. Michael E. Richards, James Z. Xing and Kirsty M. B. Mackay
1265-1271The in Vitro Release of Some Antimuscarinic Drugs from Monoolein/ Water Lyotropic Liquid Crystalline GelsPauline B. Geraghty, David Attwood, John H. Collett and Yogesh Dandiker
1272-1275High-Performance Liquid Chromatographic Analysis of Dipyrone Metabolites to Study Their Formation in Human Liver MicrosomesGerd Geisslinger, Ronald Böcker and Micha Levy
1276-1278Mechanisms of 5-Fluorouracil (5-FU) Transport in Isolated Rabbit Choroid Plexus Tissue SlicesCarla B. Washington and Kathleen M. Giacomini

Volume 13, Number 9 / September 1996

1279WHAT ARE THE SMALL BUSINESS INNOVATION RESEARCH (SBIR) AND SMALL BUSINESS TECHNOLOGY TRANSFER (STTR) PROGRAMS? WHAT KINDS OF AWARDS ARE AVAILABLE? WHO CAN PARTICIPATE? HOW CAN I GET CURRENT INFORMATION AND AN APPLICATION?Rochelle M. Long
1280-1282Performance of Bailer's Method for AUC Confidence Intervals from Sparse Non-Normally Distributed Drug Concentrations in Toxicokinetic StudiesSudhakar M. Pai, Jerry R. Nedelman, Gerald Hajian, Ekaterina Gibiansky and Vijay K. Batra
1283-1290Characterization of AUCs from Sparsely Sampled Populations in Toxicology StudiesSudhakar M. Pai, Scott H. Fettner, Gerald Hajian, Mitchell N. Cayen and Vijay K. Batra
1291-1298A Reasoned Action Approach to Physicians' Utilization of Drug Information SourcesCaroline A. Gaither, Richard P. Bagozzi, Frank J. Ascione and Duane M. Kirking
1299-1304Increasing Clients' Knowledge of Community Pharmacists' RolesBetty Chewning and Jon C. Schommer
1305-1312Differential Effect of Taxol in Rat Primary and Metastatic Prostate Tumors: Site-Dependent PharmacodynamicsWan-Ching Yen, M. Guillaume Wientjes and Jessie L.-S. Au
1313-1316Steady-State Kinetics of Imipramine in Transgenic Mice with Elevated Serum AAG LevelsJohn W. Holladay, Michael J. Dewey and Sun D. Yoo
1317-1321Covalent Binding Between Bucillamine Derivatives and Human Serum AlbuminRyuichi Narazaki, Mizuho Hamada, Kumiko Harada and Masaki Otagiri
1322-1326PC-2, Linear Homoglucan with α-linkages, Peripherally Enhances the Hippocampal Long-Term PotentiationMiroslav Smriga, Hiroshi Saito, Shoji Shibata, Takao Narui and Toru Okuyama, et al.
1327-1330Purification and Partial Characterization of an Indomethacin Hydrolyzing Enzyme from Pig LiverKeisuke Terashima, Satomi Takai, Yoshiko Usami, Tetsuo Adachi and Tadashi Sugiyama, et al.
1331-1335Horseradish Peroxidase Transport Across Rat Alveolar Epithelial Cell MonolayersYasuhisa Matsukawa, Hiroshi Yamahara, Vincent H. L. Lee, Edward D. Crandall and Kwang-Jin Kim
1336-1342Comparison Between Permeability Coefficients in Rat and Human JejunumUrban Fagerholm, Monica Johansson and Hans Lennernäs
1343-1347Transport of Alpha-Tocopherol and Its Derivatives Through Erythrocyte MembranesFrancesco Bonina, Maria Lanza, Lucia Montenegro, Loredana Salerno and Patrizia Smeriglio, et al.
1348-1353Transdermal Permeation of Alniditan by Iontophoresis: In Vitro Optimization and Human Pharmacokinetic DataAnne Jadoul, Jean Mesens, Wim Caers, Frank de Beukelaar and R. Crabbé, et al.
1354-1359Passive Drug Diffusion via Standardized Skin Mini-erosion; Methodological Aspects and Clinical Findings with New DevicePaul Svedman, Stefan Lundin, Peter Höglund, Christer Hammarlund and Christer Malmros, et al.
1360-1366Transdermal Delivery of Fentanyl by Electroporation II. Mechanisms Involved in Drug TransportRita Vanbever, Nathalie De Morre and Véronique Préat
1367-1372Intracellular Distribution and Mechanism of Delivery of Oligonucleotides Mediated by Cationic LipidsOlivier Zelphati and Francis C. Szoka
1373-1377Comparison of Pharmacokinetic Parameters of a Polypeptide, the Bowman-Birk Protease Inhibitor (BBI), and Its Palmitic Acid ConjugateLaura Honeycutt, Jeff Wang, Hossein Ekrami and Wei-Chiang Shen
1378-1383Lectin-bearing Polymerized Liposomes as Potential Oral Vaccine CarriersHongming Chen, Vladimir Torchilin and Robert Langer
1384-1388In Vitro-In Vivo Myotoxicity of Intramuscular Liposomal FormulationsSaleh A. Al-Suwayeh, Ian R. Tebbett, Donna Wielbo and Gayle A. Brazeau
1389-1392Liposomal Induction of a Heat-stable Macrophage Priming Factor to Induce Nitric Oxide in Response to LPSYukihiko Aramaki, Hidetoshi Arima, Toshifumi Hara and Seishi Tsuchiya
1393-1400Effects of Sugars and Polymers on Crystallization of Poly(ethylene glycol) in Frozen Solutions: Phase Separation Between Incompatible PolymersKen-ichi Izutsu, Sumie Yoshioka, Shigeo Kojima, Theodore W. Randolph and John F. Carpenter
1401-1405Solubility Behavior, Phase Transition, and Structure-Based Nucleation Inhibition of Etanidazole in Aqueous SolutionsMichael B. Maurin, Susan M. Rowe, Kenneth S. Field, Robert C. Swintosky and Munir A. Hussain
1406-1410Evidence for Phospholipid Bilayer Formation in Solid Lipid Nanoparticles Formulated with Phospholipid and TriglycerideHashem Heiati, Nigel C. Phillips and Rashad Tawashi
1411-1416Atomic Force Microscopy Studies of Solid Lipid NanoparticlesA. zur Mühlen, E. zur Mühlen, H. Niehus and W. Mehnert
1417-1418Lack of Effect of Catheterization on the Pharmacokinetics of (-)-Carbovir in RatsCheryl L. Zimmerman, Kit J. Ha and Shu-hui Huang
1419-1422A Cellular Automata Model of Micelle FormationLemont B. Kier, Chao-Kung Cheng, Bernard Testa and Pierre-Alain Carrupt
1423ERRATUM

Volume 13, Number 10 / October 1996

1425-1426WHAT PROGRAM ANNOUNCEMENTS ARE CURRENTLY OPEN AT THE NIGMS? WHO ARE THE CONTACT PEOPLE? HOW CAN I GET MORE INFORMATION?Rochelle M. Long
1427-1437Design of Biological Equivalence Programs for Therapeutic Biotechnology Products in Clinical Development: A PerspectiveJoyce Mordenti, Joy A. Cavagnaro and James D. Green
1438-1444Pharmacokinetic Analysis of Drug Disposition After Intratumoral Injection in a Tissue-Isolated Tumor Perfusion SystemAkira Saikawa, Takehiko Nomura, Fumiyoshi Yamashita, Yoshinobu Takakura and Hitoshi Sezaki, et al.
1445-1452Design and Results of a Group Counter-detailing DUR Educational ProgramKaren B. Farris, Duane M. Kirking, Leslie A. Shimp and Ruth Ann C. Opdycke
1453-1459Intrinsic Solubility Estimation and pH-Solubility Behavior of Cosalane (NSC 658586), an Extremely Hydrophobic Diprotic AcidSrinivasan Venkatesh, Jianmin Li, Yuehong Xu, Rao Vishnuvajjala and Bradley D. Anderson
1460-1463Hydrotropic Solubilization— Mechanistic StudiesRenée E. Coffman and Dane O. Kildsig
1464-1475Stable Formulations of Recombinant Human Growth Hormone and Interferon-γ for Microencapsulation in Biodegradable MircospheresJeffrey L. Cleland and Andrew J. S. Jones
1476-1481Oxidation of Human Insulin-Like Growth Factor I in Formulation Studies, II. Effects of Oxygen, Visible Light, and Phosphate on Methionine Oxidation in Aqueous Solution and Evaluation of Possible MechanismsJonas Fransson and Anders Hagman
1482-1487Synthesis, Antiinflammatory, and Cytotoxic Activities of 2-Alkyl and 2-Benzyl-2-Dimethylaminomethyl-5-(E)-Arylidene Cyclopentanone HydrochloridesHaitao Chen, Zhizhong Ji, Lan K. Wong, Jerome F. Siuda and Ven L. Narayanan
1488-1494In Vitro and In Vivo Activity of 16,17-dehydro-epipregnanolones: 17,20-Bond Torsional Energy Analysis and D-ring ConformationMichael B. Bolger, Scott Wieland, Jon E. Hawkinson, Haiji Xia and Ravindra Upasani, et al.
1495-1500Structure-Activity Relationships for Substrates and Inhibitors of Mammalian Liver Microsomal CarboxylesterasesTien L. Huang, Takahiro Shiotsuki, Tamon Uematsu, Babak Borhan and Qing X. Li, et al.
1501-1506In Vitro-In Vivo Relationship of Oral Extended-Release Dosage FormsFang-Yu Liu, Nancy C. Sambol, Robert P. Giannini and Chui Yu Liu
1507-1513Predicting Injection Site Muscle Damage I: Evaluation of Immediate Release Parenteral Formulations in Animal ModelsSteven C. Sutton, Loreen A. F. Evans, Michelle T. S. Rinaldi and Kathy A. Norton
1514-1518Predicting Injection Site Muscle Damage II: Evaluation of Extended Release Parenteral Formulations in Animal ModelsSteven C. Sutton, Loreen A. F. Evans, Michelle T. S. Rinaldi and Kathy A. Norton
1519-1523Permeation of Buprenorphine and Its 3-Alkyl-Ester Prodrugs Through Human SkinAudra L. Stinchcomb, Anupam Paliwal, Rajesh Dua, Hirofumi Imoto and Ronald W. Woodard, et al.
1524-1529Evaluation of Stereoselective Transdermal Transport and Concurrent Cutaneous Hydrolysis of Several Ester Prodrugs of Propranolol: Mechanism of Stereoselective PermeationShamim Ahmed, Teruko Imai and Masaki Otagiri
1530-1534Influence of Vehicle, Distant Topical Delivery, and Biotransformation on the Chemopreventive Activity of Apigenin, a Plant Flavonoid, in Mouse SkinBoyong Li, Heather Pinch and Diane R Birt
1535-1540Absorption and Presystemic Metabolism of Selegiline Hydrochloride at Different Regions in the Gastrointestinal Tract in Healthy MalesJeffrey S. Barrett, Peter Szego, Shashank Rohatagi, Richard J. Morales and Kimberly E. DeWitt, et al.
1541-1546Effect of Destruction Force on Drug Release from Multiple Unit Controlled Release Dosage Forms in HumansNoriko Katori, Wen-Shi Ma, Nobuo Aoyagi and Shigeo Kojima
1547-1553A Novel Extravascular Input Function for the Assessment of Drug Absorption in Bioavailability StudiesMichael Weiss
1554-1558The Relationship Between Rat Intestinal Permeability and Hydrophilic Probe SizeMajella E. Lane, Caitriona M. O'Driscoll and Owen I. Corrigan
1559-1564Uptake Is the Rate-limiting Step in the Overall Hepatic Elimination of Pravastatin at Steady-state in RatsMasayo Yamazaki, Sayoko Akiyama, Ryuichiro Nishigaki and Yuichi Sugiyama
1565-1569Microdialysis Assessment of Microfibrous Collagen Containing a P-Glycoprotein-Mediated Transport Inhibitor, Cyclosporine A, for Local Delivery of EtoposideHitoshi Sato, Hidenori Kitazawa, Isao Adachi and Isamu Horikoshi
1570-1575Fluconazole Distribution to the Brain: A Crossover Study in Freely-moving Rats Using In Vivo MicrodialysisHua Yang, Qin Wang and William R Elmquist
1576-1580Controlled Systemic Absorption and Increased Anesthetic Effect of Bupivacaine Following Epidural Administration of Bupivacaine-Hydroxypropyl-β-Cyclodextrin ComplexJean Christophe Fréville, Gilles Dollo, Pascal Le Corre, François Chevanne and Roger Le Verge
1581-1584Effect of Iontophoresis in Combination with Ionic Enhancers on the Lipid Structure of the Stratum Corneum: An X-ray Diffraction StudySophie Chesnoy, Jean Doucet, Dominique Durand and Guy Couarraze
1585-1587Predicting Injection Site Muscle Damage III: Evaluation of Intramuscular Formulations in the L6 Cell ModelLoreen A. F. Evans, Paul E. Genereux, E. Michael Gibbs and Steven C. Sutton

Volume 13, Number 11 / November 1996

1589WHAT RESEARCH TRAINING OPPORTUNITIES ARE SPONSORED BY NIGMS AT THE NIH? HOW CAN I GET INFORMATION ABOUT THIS AND OTHER POSTDOCTORAL PROGRAMS AT THE NIH?Rochelle M. Long
1590-1594Evaluation of Orally Administered Highly Variable Drugs and Drug FormulationsVinod P. Shah, Avraham Yacobi, William H. Barr, Leslie Z. Benet and Douwe Breimer, et al.
1595-1614Pharmaceutical Approach to Somatic Gene TherapyFred D. Ledley
1615-1623Esterase-Sensitive Cyclic Prodrugs of Peptides: Evaluation of an Acyloxyalkoxy Promoiety in a Model HexapeptideGiovanni M. Pauletti, Sanjeev Gangwar, Franklin W. Okumu, Teruna J. Siahaan and Valentine J. Stella, et al.
1624-1630Structure-based Search for Peptide Ligands that Cross-react with Melanocortin ReceptorsJ. Mark Quillan and Wolfgang Sadée
1631-1634Human Dipeptide Transporter, hPEPTl, Stably Transfected into Chinese Hamster Ovary CellsKuang-Ming Y. Covitz, Gordon L. Amidon and Wolfgang Sadée
1635-1641Development of Caco-2 Cells Expressing High Levels of cDNA-Derived Cytochrome P4503A4Charles L. Crespi, Bruce W. Penman and Ming Hu
1642-1646Effect of Non-Ionic Surfactants on the Formation of DNA/Emulsion Complexes and Emulsion-Mediated Gene TransferFeng Liu, Jingping Yang, Leaf Huang and Dexi Liu
1647-1656Paclitaxel and Nocodazole Differentially Alter Endocytosis in Cultured CellsSarah F Hamm-Alvarez, Manisha Sonee, Kathleen Loran-Goss and Wei-Chiang Shen
1657-1662The Effect of Conformation on Membrane Permeability of an Acyloxyalkoxy-linked Cyclic Prodrug of a Model HexapeptideSanjeev Gangwar, Seetharama D. S. Jois, Teruna J. Siahaan, David G. Vander Velde and Valentine J. Stella, et al.
1663-1667Metabolism, Uptake, and Transepithelial Transport of the Stereoisomers of Val-Val-Val in the Human Intestinal Cell Line, Caco-2Kiyoshi Tamura, Chao-Pin Lee, Philip L. Smith and Ronald T. Borchardt
1668-1672Mucoadhesive Polymers in Peroral Peptide Drug Delivery. VI. Carbomer and Chitosan Improve the Intestinal Absorption of the Peptide Drug Buserelin In VivoHenrik. L. Lueßen, Bas. J. de Leeuw, Mariska W. E. Langemeÿer, A.(Bert) G. de Boer and J. Coos. Verhoef, et al.
1673-1678Oral Absorption of D-Oligopeptides in Rats via the Paracellular RouteYan-Ling He, Susan Murby, Larry Gifford, Andrew Collett and Geoff Warhurst, et al.
1679-1685Proteolysis of Human Calcitonin in Excised Bovine Nasal Mucosa: Elucidation of the Metabolic Pathway by Liquid Secondary lonization Mass Spectrometry (LSIMS) and Matrix Assisted Laser Desorption lonization Mass Spectrometry (MALDI)Steffen R. Lang, Werner Staudenmann, Peter James, Hans-Jörg Manz and Rudolf Kessler, et al.
1686-1692Chitosans as Absorption Enhancers for Poorly Absorbable Drugs. 1: Influence of Molecular Weight and Degree of Acetylation on Drug Transport Across Human Intestinal Epithelial (Caco-2) CellsNicolaas G. M. Schipper, Kjell M. Vårum and Per Artursson
1693-1698Improving Protein Delivery from Microparticles Using Blends of Poly(DL lactide co-glycolide) and Poly(ethylene oxide)-poly(propylene oxide) CopolymersMing-Kung Yeh, Stanley S. Davis and Allan G. A. Coombes
1699-1703Pulmonary Targeting of Liposomal Triamcinolone Acetonide PhosphateRicardo J. Gonzalez-Rothi, Sandra Suarez, Guenther Hochhaus, Hans Schreier and Anatoly Lukyanov, et al.
1704-1709Synergistic Effect Between Size and Cholesterol Content in the Enhanced Hepatic Uptake Clearance of Liposomes Through Complement Activation in RatsH. Harashima, T. M. Huong, T. Ishida, Y. Manabe and H. Matsuo, et al.
1710-1715In Vivo and In Vitro Percutaneous Absorption of Cancer Preventive Flavonoid Apigenin in Different Vehicles in Mouse SkinBoyong Li and Diane F. Birt
1716-1719Bioadhesion of Lectin-Latex Conjugates to Rat Intestinal MucosaJuan M. Irache, Carlo Durrer, Dominique Duchêne and Gilles Ponchel
1720-1724Applications and Simulations of a Discontinuous Oral Absorption Pharmacokinetic ModelJennifer Wright Witcher and F. Douglas Boudinot
1725-1729The Influence of Water on Electrostatic Charge Retention and Dissipation in Pharmaceutical Compacts for Powder CoatingM. P. Grosvenor and J. N. Staniforth
1730-1733The Effect of Temperature on the Surface Nature of an Adsorbed Layer of Poly(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) Block CopolymersDavid L Carthew, Graham Buckton, Gary E. Parsons and Stephen Poole
1734-1738Development and Mechanical Characterization of Bioadhesive Semi-Solid, Polymeric Systems Containing Tetracycline for the Treatment of Periodontal DiseasesDavid S. Jones, A. David Woolfson, Jasmina Djokic and W. A. Coulter
1739-1745A Comparison of Elastic Moduli Derived from Theory, Microindentation, and Ultrasonic TestingSusan K. Lum and Wendy C. Duncan-Hewitt
1746-1751Influence of Surface Free Energies and Cohesion Parameters on Pharmaceutical Material Interaction Parameters–Theoretical SimulationsJérôme Barra, François Lescure and Eric Doelker
1752-1754Effect of Charge on Oligopeptide Transporter-Mediated Permeation of Cyclic Dipeptides Across Caco-2 Cell MonolayersKiyoshi Tamura, Chao-Pin Lee, Philip L. Smith and Ronald T. Borchardtu
1755-1758An Improved Intercept Method for the Assessment of Absorption Rate in Bioequivalence StudiesPanos Macheras, Mira Symillides and Christos Reppas

Volume 13, Number 12 / December 1996

1759Controlled Release Technologies: Current Status and Future ProspectsRichard Guy, Michael Powell, Joseph Fix and Kinam Park
1760-1764Oral Controlled Release Technology for Peptides: Status and Future ProspectsJoseph A. Fix
1765-1769Current Status and Future Prospects of Transdermal Drug DeliveryRichard H. Guy
1770-1776Biocompatibility Issues of Implantable Drug Delivery SystemsHaesun Park and Kinam Park
1777-1785Drug Delivery Issues in Vaccine DevelopmentMichael R Powell
1786-1794Characterization of Lipid Membrane Dynamics by Simulation: 3. Probing Molecular Transport Across the Phospholipid BilayerB. Jin and J. Hopfinger
1795-1798Guidance in the Setting of Drug Particle Size Specifications to Minimize Variability in AbsorptionKevin C. Johnson and Archie C. Swindell
1799-1803In-Vitro Dissolution Profile Comparison: Statistics and Analysis, Model Dependent ApproachPradeep M. Sathe, Yi Tsong and Vinod P. Shah
1804-1810Feasibility of Effect-Controlled Clinical Trials of Drugs with Pharmacodynamic Hysteresis Using Sparse DataWilliam E Ehling, Yoshiaki Matsumoto and Gerhard Levy
1811-1814Characterization of a Solid State Reaction Product from a Lyophilized Formulation of a Cyclic Heptapeptide. A Novel Example of an Excipient-Induced OxidationDavid C. Dubost, Michael J. Kaufman, Jeffrey A. Zimmerman, Michael J. Bogusky and Arthur B. Coddington, et al.
1815-1820Degradation Kinetics of BMP 777, an Elastase InhibitorKrishnaswamy S. Raghavan, David B. Gray, Thomas H. Scholz, Gregory A. Nemeth and Munir A. Hussain
1821-1827Chemical and Swelling Evaluations of Amino Group Crosslinking in Gelatin and Modified Gelatin MatricesClyde M. Ofner, III and William A. Bubnis
1828-1832Stereoselective and Carrier-Mediated Transport of Monocarboxylic Acids Across Caco-2 CellsTakuo Ogihara, Ikumi Tamai, Hitomi Takanaga, Yoshimichi Sai and Akira Tsuji
1833-1837Biliary Excretion of Glycyrrhizin in Rats: Kinetic Basis for Multiplicity in Bile Canalicular Transport of Organic AnionsHisafumi Shimamura, Hiroshi Suzuki, Osamu Tagaya, Tohru Horie and Yuichi Sugiyama
1838-1845Gastrointestinal Uptake of Biodegradable Microparticles: Effect of Particle SizeManisha P. Desai, Vinod Labhasetwar, Gordon L. Amidon and Robert J. Levy
1846-1850Liver Targeting of Interferon Through Pullulan ConjugationKeli Xi, Yasuhiko Tabata, Kazuko Uno, Miwa Yoshimoto and Tsunataro Kishida, et al.
1851-1855The pH-Dependence in the Partitioning Behaviour of (RS)-[3H]Propranolol Between MDCK Cell Lipid Vesicles and BufferStefanie D. Krämer and Heidi Wunderli-Allenspach
1856-1860New Cationic Lipid Formulations for Gene TransferFeng Liu, Jingping Yang, Leaf Huang and Dexi Liu
1861-1864Riboflavin-Enhanced Transport of Serum Albumin Across the Distal Pulmonary EpitheliumO. Douglas Wangensteen, Marilyn M. Bartlett, Jonathan K. James, Zhen-fan Yang and Philip S. Low
1865-1870Anionic Gels as Vehicles for Electrically-Modulated Drug Delivery. I. Solvent and Drug Transport PhenomenaChang-Shan Hsu and Lawrence H. Block
1871-1874A New Method for Diffusion Measurement in Polymeric Films Based on a Stacked Sheet ConceptHans Sjöberg, Rolf Bergman and Lars-Olof Sundelöf
1875-1880Deacetylation of Diltiazem by Several Rabbit TissuesLorenzo J. Fraile, José J. Aramayona, Miguel A. Bregante, María A. García and Ana R. Abadía
1881-1886Localization of Purine Metabolizing Enzymes in Bovine Brain Microvessel Endothelial Cells: An Enzymatic Blood-Brain Barrier for Dideoxynucleosides?Mark D. Johnson and Bradley D. Anderson
1887-1891Different pH Dependency of Mitomycin C Activity in Monolayer and Three-Dimensional CulturesWan-Ching Yen, Thomas Schmittgen and Jessie L.-S. Au
1892-1895Application of the Electrotopological State Index to QSAR Analysis of Flavone Derivatives as HIV-1 Integrase InhibitorsJohn K. Buolamwini, Krishnamchari Raghavan, Mark R. Fesen, Yves Pommier and Kurt W. Kohn, et al.
1896-1901A Candidate for Cancer Gene Therapy: MIP-lα Gene Transfer to an Adenocarcinoma Cell Line Reduced T\imorigenicity and Induced Protective Immunity in Immunocompetent MiceEmi Nakashima, Akiko Oya, Yuri Kubota, Naomi Kanada and Ryo Matsushita, et al.
1902-1904BOOK REVIEWS
1905-1906Reviewers for Pharmaceutical Research November 1995 Through October 1996
1907-1910Author Index to Volume 13 (1996)
1911-1915Subject Index to Volume 13 (1996)